BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
C. Jeffrey Brinker
Distinguished and Regent’s Professor of Chemical
and Nuclear Engineering and Molecular Genetics
and Microbiology, the University of New Mexico.
Fellow; Sandia National Laboratories
eRA COMMONS USER NAME
CJBRINKER
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, include postdoctoral training.)
INSTITUTION AND LOCATION
Rutgers University, New Brunswick, NJ
Rutgers University, New Brunswick, NJ
Rutgers University, New Brunswick, NJ
DEGREE
(if applicable)
YEAR(s)
B.S.
M.S.
Ph.D
1972
1975
1978
FIELD OF STUDY
Ceramic Science
Ceramic Science
Ceramic Science
A. Personal Statement
Jeff Brinker pioneered so-called ‘sol-gel processing’ as a means of solution-based synthesis of a wide range of
inorganic nanomaterials. Recently by combining sol-gel processing with molecular self-assembly he has
devised powerful evaporation-induced self-assembly procedures (refs Science and Nature), enabling the facile
synthesis of highly ordered porous and composite nanostructured films and particles. During the past several
years Brinker used self-assembled porous nanoparticles in the development of the protocell (a nanoporous
particle supported lipid bilayer) as a generic targeted nanocarrier platform for selective delivery of
multicomponent cargoes to cancer, a principle focus of the proposed research on targeted delivery. Brinker is a
Distinguished Professor of Chemical and Nuclear Engineering and member of the Cancer Research and
Treatment Center at UNM. He is also the sole Lab Fellow at Sandia National Laboratories and Distinguished
Affiliate Scientist at the Center for Integrated Nanotechnologies (CINT) a Department of Energy/Office of
Science Nanoscale Science Research Center (NSRC) where he has access to a vast array of nanofabrication
and nano-characterization tools and platforms. Brinker directs research concerning the fabrication and
structural, chemical and functional characterization, and specialized targeting capabilities of synthetic and
natural nanocarriers. With Willman, he is leading the NCI Nanotechnology Platform Partnership at UNM (1 U01
CA151792-01) that is translating this science to cancer therapeutics.
B. Positions and Honors
1979 - 1991
Member of the Technical Staff, Chemistry and Ceramics Department, Sandia
National Laboratories (SNL)
1991 - 1999
Distinguished National Laboratory Professor of Chemistry and Chemical and Nuclear
Engineering, the University of New Mexico (UNM)
1991 - 1998
Distinguished Member of the Technical Staff, Direct Fabrication Department, SNL
1999 - 2003
Senior Scientist, Chemical Synthesis and Nanomaterials Department, SNL
1999 - 2006
Professor of Chemistry and Chemical & Nuclear Engineering, UNM
2003 - Current
Sandia Fellow (one of 2) Center for Self-Assembled Materials, SNL
2006 - 2008
Regent’s Professor of Chemical & Nuclear Engineering; Molecular Genetics and
Microbiology, UNM
2008 - Current
Distinguished Professor of Chemical and Nuclear Engineering and Molecular
Genetics and Microbiology, UNM
Honors
1988
1988
1994, 1992
1995, 1986
1996
Zachariasen Award for best contribution to the glass science literature 1985-1987
(awarded by the Journal of Non-Crystalline Solids).
Elected Fellow of the American Ceramic Society
Department of Energy Basic Energy Sciences Award for Significant Implications for
DOE Related Technologies in Metallurgy and Ceramics.
Department of Energy Basic Energy Sciences Award for Sustained Outstanding
Research in Metallurgy and Ceramics.
R&D100 Award - Low Temperature/Pressure Process to Produce Aerogels
1996
1996
19981998
2001
2002
2002
2003
2005
2006
2007
2008
2008
2009
2010
2011
Lockheed Martin NOVA (New Star) Award
American Chemical Society Ralph K. Iler Award in the Chemistry of Colloidal
Materials.
Motorola/CMEM Research Mentorship Award
Department of Energy Basic Energy Sciences Award for Outstanding Scientific
Accomplishment in Metallurgy and Ceramics
National Collegiate Inventors Competition Award for Optically-Adjustable
Nanostructures
Elected to National Academy of Engineering
DOE Ernest O. Lawrence Memorial Award in Materials Science
Materials Research Society MRS Medal
The University of New Mexico Research Excellence Award
Rutgers University Distinguished Alumnus Award
R&D100 Award - Self-Assembly of Nanoparticle Films
R&D100 Award - Patterned Superhydrophobic Surfaces
Edward R. Orton Jr. Memorial Award, American Ceramic Society and ASM
Elected
Fellow
of
the
Materials
Research
Society
Robert B. Sosman Award, American Ceramics Society
R&D100 Award Biomimetic Water Purification Membranes
Review and Advisory Committees
Peer Review: Editorial Boards for Chemistry of Materials; J. Sol-Gel Science/Technology; J. Porous
Materials; Current Opinion in Solid State and Materials Science, Small; Assoc Ed. J. American Ceramic
Society. Editor: Annual Review of Nanoresearch. Advisory Role: Advisory Boards for International
Workshop on Glasses and Ceramics from Gels; International Conference on Inorganic Membranes;
International Symposium on Aerogels. Founder and Co-Organizer, Materials Research Symposium Series:
Better Ceramics Through Chemistry I, II, III, IV, V, VI and Organic/Inorganic Hybrid Materials I, II, III. Federal
Advisory Roles: U.S. Air Force Scientific Advisory Board, Consultant; President’s Council of Advisors on
Science and Technology; National Research Council Committee on Polymer Science and Engineering, NSF
National Nanoscience Initiative review panel; Brookhaven National Laboratory, DOE/BES Materials Sciences
and Engineering Division program reviewer, 2011; Naval Research Laboratory, BioMolecular Materials
Program Reviewer, 2011 Honorary Affilations: Fellow American Ceramics Society, Fellow Materials
Research Society, Directeur de Recherche Universite Pierre et Marie Curie, Paris VI.
C. Selected peer-reviewed publications (CJB corresponding author, selected from > 250; (H-Index = 57)
1. Y.F. Lu, C.J. Brinker et al. Continuous formation of supported cubic and hexagonal mesoporous
films by sol gel dip-.coating. Nature 389: 364-8 (1997). Named ISI Top Twenty Papers, Materials
Science Paper of Decade.
2. A. Sellinger A, P.M. Weiss, A. Nguyen, Y.F. Lu, R.A. Assink, W.L. Gong, C.J. Brinker, Continuous selfassembly of organic-inorganic nanocomposite coatings that mimic nacre. Nature 394, 256-60 (1998)
3. Y.F. Lu, H. Y. Fan, A. Stump, T.L. Ward, T. Rieker, and C.J. Brinker, Aerosol-Assisted Self-Assembly of
Mesostructured Spherical Nanoparticles, Nature 398 (6724), 223-226 (1999).
4. Lu YF, Yang Y, Sellinger A, Lu MC, Huang JM, Fan HY, Haddad R, Lopez G, Burns AR, Sasaki DY,
Shelnutt J, Brinker CJ. Self-assembly of mesoscopically ordered chromatic polydiacetylene/silica
nanocomposites. Nature 410: 913-7 (2001). PMID: 11309612
5. H.Y. Fan, Y.F. Lu, A. Stump, S.T. Reed, T. Baer, R. Schunk, V. Perez-Luna V, G.P. Lopez, and C.J.
Brinker, Rapid prototyping of patterned functional nanostructures. Nature 405, 56-60 (2000). PMID:
10811215
6. H.Y. Fan, K. Yang K, D.M. Boye, T. Sigmon, K.J. Malloy, H.F. Xu, G.P. Lopez. And C.J. Brinker, Selfassembly of ordered, robust, three-dimensional gold nanocrystal/silica arrays, Science 304, 567-71 (2004).
PMID: 15105495
7. H. K. Baca, C. Ashley, E. Carnes, D. Lopez, J. Flemming, D. Dunphy, S. Singh, Z. Chen, N. G. Liu, H. Y.
Fan, G. P. Lopez, S. M. Brozik, M. Werner-Washburne, and C. J. Brinker, Cell-directed assembly of lipidsilica nanostructures providing extended cell viability, Science 313 (5785), 337-341 (2006). PMID:
16857936
8. E. C. Carnes, J. C. Harper, C. E. Ashley, D. M. Lopez, L. M. Brinker, J. W. Liu, S. Singh, S. M. Brozik, and
C. J. Brinker, Cell-Directed Localization and Orientation of a Functional Foreign Transmembrane Protein
within a Silica Nanostructure, J. American Chemical Society 131 (40), 14255-58 (2009). PMID: 19764723
9. J.W. Liu, X.M. Jiang, C. Ashley, and C.J. Brinker, Electrostatically Mediated Liposome Fusion and Lipid
Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and
Delivery, J. American Chemical Society 131, 7567-+.(2009). PMCID: PMC2724844
10. J. W. Liu, A. Stace-Naughton, and C. J. Brinker, Silica nanoparticle supported lipid bilayers for gene
delivery, Chemical Communications (34), 5100-5102 (2009). PMCID: PMC2867086
11. J. W. Liu, A. Stace-Naughton, X. M. Jiang, and C. J. Brinker, Porous Nanoparticle Supported Lipid
Bilayers (Protocells) as Delivery Vehicles, J. American Chemical Society 131 (4), 1354-56 (2009).
PMCID: PMC2649781
12. E.C. Carnes, D.M. Lopez, N.P. Donegan, A. Cheung, H. Gresham, G.S. Timmins, and C.J.Brinker,
Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria, Nature Chemical
Biology 6 (1), 41-45 (2010). PMID: 19935660
13. Z. Chen, Y. B. Jiang, D. R. Dunphy, D. P. Adams, C. Hodges, N. G. Liu, N. Zhang, G. Xomeritakis, X. Z.
Jin, N. R. Aluru, S. J. Gaik, H. W. Hillhouse, and C. J. Brinker, DNA translocation through an array of
kinked nanopores, Nature Materials 9 (8), 667-675 (2010). PMID: 20651807
14. H. K. Baca, E.C. Carnes, C.E. Ashley, D.M. Lopez, C. Douthit, S. Karlin, and C. J. Brinker, Cell-directedassembly: Directing the formation of nano/bio interfaces and architectures with living cells, Biochimica et
Biophysica Acta (BBA) - General Subjects. 2011, 1810 (3) pp. 259-267. PMCID: PMC3090153
15. C.E. Ashley, D.R. Dunphy, J. Zhang, E.C. Carnes, Z. Yuan, D.N. Petsev, P. Atanassov, O.D. Velev, M.
Sprung, J. Wang, C. J. Brinker, and D.S. Peabody, Convective Assembly of 2D Lattices of Virus-Like
Particles Visualized by In-situ Grazing Incidence Small-Angle Scattering, SMALL, 7: 1043-50. PMID:
21425464
16. C.E. Ashley, E.C. Carnes, G.K. Phillips, D. Padilla, P.N. Durfee, P.A. Brown, T. N. Hanna, J. Liu, B.
Philips, M.B.Carter, N. Carroll, X. Jiang, D.R. Dunphy, C.L. Willman, D.N. Petsev, D.G. Evans, A. N.
Parikh, B. Chackerian, W Wharton, D.S. Peabody, and C.J. Brinker. Targeted Delivery of Multicomponent
Cargos to Cancer Cells via Nanoporous Particle-Supported Lipid Bilayers, Nature Materials, 10: 389-97,
May 2011 (COVER). PMCID: PMC3287066
17. C.E. Ashley, E.C. Carnes, G.K. Phillips, P.N. Durfee, M. Buley, D.P. Padilla, B. Phillips, M.B. Carter,, C.L.
Willman, C.J. Brinker, B. Chackerian, W Wharton, and D.S. Peabody, Cell-Specific Delivery of Diverse
Cargos by Bacteriophage MS2 Virus-Like Particles, ACS Nano, 5 (7), 5729-5745 (July 2011). (COVER)
PMCID: PMC3144304
18. C.E. Ashley, E.C. Carnes, K.E. Epler, D.P. Padilla, G.K. Phillips, R.E. Castillo, D.C. Wilkinson, B.S.
Wilkinson, C.A. Burgard, R.M. Kalinich, J.L. Townson, B. Chackerian, C.L. Willman, D.S. Peabody, W
Wharton, and C.J. Brinker. Delivery of Small Interfering RNA by Peptide-Targeted Mesoporous Silica
Nanoparticle-Supported Lipid Bilayers, ACS Nano, published online February 2012. PMID: 22309035
19. K.E. Epler, D.P. Padilla, G.K. Phillips, R.E. Castillo, D.C. Wilkinson, B.S. Wilkinson, C.A. Burgard, R.M.
Kalinich, J.L. Townson, C.J. Brinker, C.E. Ashley, and E.C. Carnes. Delivery of Ricin Toxin A-Chain by
Peptide-Targeted Nanoporous Particle-Supported Lipid Bilayers, Advanced Healthcare Materials, in
press.
D. Research Support
Ongoing Research Support
RFA-GM-11-03
Jakobsson, Brinker, Malloy (PIs)
7/1/11 – 6/30/15
Development of Functional Protocells and Virus-Like Particles for Drug-Resistant Bacteria, NIH-NCI,
Exceptional, Unconventional Research Enabling Knowledge – EUREKA
We plan to develop lipid coated inorganic nanoparticles (termed functional protocells) and engineered virus-like
particles (VLPs) as carriers to deliver antisense nucleic acids into drug-resistant bacteria cells as a novel way
to treat bacterial infections.
1 U01 CA151792
Willman, Brinker (PIs)
9/1/10 – 8/31/15
Peptide-directed Protocells and Virus-Like Particles – new nanoparticle platforms for targeted delivery of
multicomponent drugs
The goal of the project is to develop nanoparticle platforms to target delivery of a variety of different cargos to
cancer cells.
Role: PI
1U19ES019528-01
Nel, UCLA (PI)
10/1/ 10 – 9/30/15
Center for Nanobiology and Predictive Toxicology
This center will study how properties of engineered nanomaterials may lead to lung health effects by creating
harmful interactions in cells and tissues that will come into contact with these materials.
Role: Co-investigator
0830117
Nel, UCLA (PI)
9/1/08—8/31/13
Center for Environmental Implications of Nanotechnology - CEIN
The goal of this project is to develop a broad-based model of predictive toxicology premised on the quantitative
structure-activity relationships and nanomaterial injury mechanisms at the biological level.
Role: Co-investigaaor
0820341
Ward, NYU (PI)
10/1/08 – 8/31/14
NYU Materials MRSEC for Semantophoretic Assemblies
The goal of this project is to establish collaboration between NYU, Princeton, UNM/SNL and industrial partners
with a focus on developing new materials through exploration and manipulation of molecular particles.
Role: Co-Investigator
1198779
Brinker (PI)
2/1/12—9/30/12
New Biotic-Abiotic Materials and Interfaces
Direct research toward creation of a new reductionist synthetic platform integrating protocells and molecular
networks in which to conduct biochemical assays with subcellular structures/environments that recapitulate
those of living systems.
Role: PI
FA 9550-10-1-0054
Brinker (PI)
4/15/10 – 4/14/13
Biocompatible and Biomimetic Self-Assembly of Functional Nanostructures
The major goal of this project is the discovery and integration of new classes of hybrid materials and devices
displaying a symbiotic relationship between the biotic and abiotic components
Role: PI
DE-FG02-02ER15368
Brinker (PI)
11/15/09 – 11/15/15
Catalytic and Transport Behaviors of Model Porous and Composite Nanostructures
Role: PI
The goal of this project is the design, synthesis and understanding of model self-assembled materials with
controlled nanocomposite architecturesfor studies in catalysis and transport in model reactive separation
systems.
DGE-0504276
Osinski (PI)
7/1/05 – 8/1/12
Integrative Nanoscience and Microsystems
NSF / IGERT – Integrative Graduate Education and Research Traineeship
Role: M. Osinski, PI; C.J. Brinker, collaborator
This program establishes a graduate education program tailored to the interdisciplinary nature of nanoscience
and nanotechnology that will exploit and extend the unique properties of the nanoscale to micro/macroscale
materials and systems.