Transitions among health states, using 12 different measures of health 7-8-2011 recup_44.doc Paula Diehr and Stephen Thielke Abstract Introduction A population may be conceptualized as comprising 3 states: healthy, sick, and (over time) dead. Persons move among those states with certain probabilities, which may vary by age and gender. There are many ways of defining the states, and transition probabilities are seldom available. Methods From a longitudinal study of older adults, we analyzed twelve different variables: self-rated health, ADL, IADL, depression (CESD), cognition (3MSE), time to walk 10 feet, number of days spent in bed, number of blocks walked, extremity strength, recent hospitalizations, feeling that life is worthwhile, and satisfaction with the purpose of life. We dichotomized responses for each variable into “healthy” or “sick”, and estimated transition probabilities among the states. We examined patterns in the prevalences and the probabilities by age, sex and variable type. Findings All 12 health variables had similar behavior. There were monotonic age effects, in the expected directions, which were non-linear except for the probability of resilience or of remaining sick. Men had a higher death rate than women, but men also had a higher healthy prevalence for most variables. Women were more likely to become and remain sick, and were less likely to recover on variables measuring aspects of physical health. Discussion The age patterns were expected. Women were usually favored for mortality, and men for the other variables. The only measures that favored women, COG and HOSP, were determined externally rather than self-reported. Perhaps men are clueless (stoic) while women are whiney (in touch with their feelings/bodies/etc.). Men are more rectangular. Conclusion Older adults were likely to be healthy and to maintain their health or to recover from the sick state, no matter how health was measured. There were substantial differences in the gender patterns of prevalence and transition probabilities for the differing health measures. By most measures, men were healthier, in spite of having a higher mortality rate. Women may self-report worse health than is appropriate. (315 words) 1 Transitions among health states, using 12 different measures of health 1 Introduction A population may be conceptualized as comprising 3 states, healthy, sick, or (if followed over time) dead. For example, for Activities of Daily Living (ADL), “healthy” may be defined as having no ADL difficulties, and “sick” may be defined as having one or more difficulties. Persons move among those states with certain probabilities, which may vary by age and gender. Figure 1 shows the 6 one-year transition probabilities for ADL (from a dataset described later), by age, for women. In order from the top are the probability of staying healthy from one year to the next, P(H to H); the probability of staying sick, P(S to S); the probability of getting sick, P(H to S); the probability of dying from the sick state, P(S to D); and the lowest is the probability of dying from the healthy state, P(H to D). Not surprisingly, P(H to H) and P(S to H) decline with age, while the other probabilities increase with age. At the oldest ages, P(S to H) is lower than P(S to D), meaning that a sick person is then more likely to die than to recover. Men had similar patterns (not shown). [Figure 1 about here] Figure 2 shows the prevalence of the healthy state (healthy prevalence) and two of the transition probabilities. The two heaviest lines represent the healthy prevalence (proportion of the living who had no ADL difficulties), with a solid line for males and a dotted line for females. The healthy prevalence is higher for men than for women. It declines over time, and the slope becomes steeper with age. The lowermost two lines represent the probability of recovering from the sick state to be in the healthy state one year later, P(S to H). The probability is initially near 0.4, 2 declines approximately linearly with age, and is higher for women than for men. The two topmost lines in the graph represent the probability of staying in the healthy state, P(H to H). This probability is initially about 0.9, but declines with age and is higher for men than for women. Figure 1 and Figure 2 suggest some hypotheses of interest about healthy prevalence and transition probabilities. [Figure 2 about here] “Healthy” may be operationalized in many other ways, such as having no IADL difficulties, or having fewer than 10 points on a scale of depressive symptoms. Transition probabilities are often used in life-table calculations and other analyses that model longitudinal health. The probabilities themselves, however, are rarely published. Transition probabilities based on ADL, IADL, or self-rated health have been published. 9 10 1234567 Transition probabilities are also available for disability, 8 depression, 11 exhaustion, 12 and body mass index.[2] To explore transition probabilities further, we will present and describe the transition probabilities for 12 different health variables commonly used in studies of older adults. [Stephen to write something about sex and old age here?] We hypothesize that healthy prevalence and transition probabilities will become less favorable with older age; that the changes will not be linear in age, but steeper at older ages; that transition probabilities will be different for men and women; that P(S to S) may not be monotone in age , based on relationships seen for self-rated health. [nsick paper 3] ; and that age and sex patterns for probabilities will depend on the particular definition of “Healthy” or “Sick”. 2 Methods 3 2.1 Data Data came from the Cardiovascular Health Study (CHS), a populationbased longitudinal study of risk factors for heart disease and stroke in 5888 adults aged 65 and older at baseline.13 Participants were recruited from a random sample of Medicare eligibles in four U.S. communities, and extensive data were collected during annual clinic visits and telephone calls. The original cohort of 5201 participants, recruited in about 1990, had up to ten annual clinic examinations. A second cohort of 687 African Americans, enrolled in about 1993, had up to seven annual examinations. Follow-up was virtually complete for surviving participants.14 The twelve variables used in this study, common descriptors of aging that were measured annually, are shown in Table 1. Each value was dichotomized into “Healthy” and “Sick”, using standard thresholds where available, or choosing new thresholds that ensured sufficient data for estimating transition probabilities. Definitions of “healthy” are as follows: not being hospitalized in the previous year (HOSP); no days spent in bed in the previous two weeks (BED); a score of 1 to 4 on a 10-point scale rating satisfaction with the purpose of life (SPL); a Center for Epidemiologic Studies Short Depression score < 10 (DEP);15 16 no difficulties with activities of daily living - walking, transferring, eating, dressing, bathing, or toileting (ADL); a score of 1 to 3 on a 6-point scale rating whether life was worthwhile; no problems with extremity strength - lifting, reaching, or gripping (EXSTR); being in excellent, very good, or good self-reported health (EVGG); able to walk 15 feet in less than 10 seconds (measured) (TWLK); no difficulties with instrumental activities of daily living—heavy or light housework, shopping, meal preparation, money 4 management, or telephoning (IADL); having a Modified Mini Mental State Examination score above 89 (COG);17 and walking more than 4 blocks per day, on average (BLK). Missing data were imputed, as explained in Appendix A. Age was divided into three categories 65-74, 76-84, and 85-94, in accordance with the common definitions of “young old”, “old old”, and “oldest old”. These groups are sometimes referred to by their midpoints, 70, 80, and 90. Persons could contribute data to more than one age category. The unit of analysis was the transition pair, defined as two measures of a variable, one year apart, for the same person. 2.2 Analysis The healthy prevalence of each variable was calculated as the percent of living persons who were healthy. The one-year probabilities of transitioning from state to state were estimated from crosstabulation of data collected one year apart, combining data from all years. General patterns were described. The associations of the prevalences and probabilities with age and sex were tested using cross-sectional time series logistic regression (XTLOGIT in Stata), which accounts for persons having contributed multiple observations to the prevalence and transition data. 3 Findings 3.1 Prevalence The first two lines of Table 1 show the sample size (number of transition pairs) and mean age, by age and sex. Mean age was similar for men and women. The following 12 lines show the healthy prevalence of each variable. For example, on line 3 (HOSP), 91.3% of the women aged 65-74 were “healthy”, defined as “having no hospital days”. For men in the same state, healthy prevalence was 88.0%. Over the 5 three age groups, women’s prevalence for HOSP declined from 91.3% to 87.8% to 84.9%. Not surprisingly, all of the prevalences in Table 1 decline with age. There was usually a significantly steeper (non-linear) decline from age 80 to 90 than from age 70 to 80. This non-linearity was statistically significant for EXSTR, TWLK, COG, and BLK (men and women) and BED and IADL (men only). The bolded entries in Table 1 show the situations where women had a higher healthy prevalence than men. This occurred only for COG and HOSP. The XTLOGIT analysis of prevalence for individual variables confirmed that women were significantly healthier than men only for HOSP and COG. (See also appendix table 1). [Table 1 about here] 3.2 Transition probabilities 3.2.1 Transition probabilities for Sick persons Table 2 shows the transition probabilities for persons who were initially in the sick state. For example, P(S to H) for the youngest women is .677 when the health measure is HOSP, and the corresponding P(S to S)= .262 and P(S to D) = .061. The three probabilities sum to 1.0. Columns 4-6 show those probabilities for age 75-84, and columns 7-9 show the probabilities for age 85-94. The lower half of the table shows the same quantities for men. The bolded entries in the top half indicate probabilities of resilience or death that were favorable to women (more likely to recover, or less likely to die). [Table 2 about here] 3.2.1.1 P(S to D) 6 P(S to D) always increased monotonically with age. As suggested above in Figure 1, in the oldest age group, especially for men, P(S to D) is often greater than P(S to H). Women were always less likely to die than men, no matter how the health states were defined. 3.2.1.2 P(S to H) P(S to H) always declined with age. The trend was fairly linear, but there was significantly more decline after age 80 (non-linearity) for TWLK, COG and BLK for women, and for EXSTR, TWLK, and COG for men. Women were more likely than men to recover from the sick state for about half the variables. Based on the XTLOGIT analysis, P(S to H) was significantly higher for women than for men in at least one age category for HOSP, BED, DEP, ADL, FLW, and EVGG. Men had significantly higher P(S to H) in at least one age group for EXSTR, TWLK, and BLK. (See also appendix table 2a). 3.2.1.3 P(S to S) We also analyzed the probability of staying sick, P(S to S). (See appendix table 2b). The age relationships for P(S to S) were complex. In half (12) of the comparisons there was no significant age relationships. In the other 12, age 70 was always significantly less than 80, meaning that P(S to S) increased from 70 to 80. However, compared to age 80, P(S to S) at age 90 was significantly lower for 2 variables, significantly higher 3 times, and not significantly different for 7 variables. This lack of monotonicity is not easy to summarize. 7 There was a strong gender effect, with women significantly more likely to stay sick then men in most cases. However, there was not a significant gender effect for HOSP, BED, and FLW, nor for ADL and COG at age 70. 3.2.2 Transitions probabilities for healthy persons Table 3 shows the transition probabilities for persons who were initially in the healthy state. For example, P(H to H) for the youngest women is .917 when the health measure is HOSP (column 1), and the corresponding P(H to S)= .075 and P(H to D) = .008 (columns 2 and 3). Columns 4-6 show those probabilities for age 75-84, and 7-9 show the probabilities for age 85-94. The lower half of the table shows the corresponding values for men. The shaded entries represent probabilities that favored women (higher probability of remaining healthy or lower probability of becoming sick or dying). [Table 3 about here] 3.2.2.1 P(H to D) P(H to D) increased with age, was always higher for men, no matter how the healthy state was defined. 3.2.2.2 P(H to H) P(H to H) declined with age. The decline usually accelerated significantly with older age, but was not significantly non-linear for HOSP and TWLK (women) and for ADL, EVGG, TWLK, and BLK (men). Women generally had less favorable P(H to H) than men. The XTLOGIT analysis found significant effects favoring women in at least one age category for 8 HOSP, FLW, and COG. Significant effects favoring men were found in at least one age category for DEP, ADL, EXSTR, TWLK, IADL, and BLK (See also appendix table 3A). 3.2.2.3 P(H to S) P(H to S) increased with monotonically age. There was significant nonlinearity for SPL, FLW, and BLK (women) and for IADL and COG (men). Women had favorable values of P(H to S) for HOSP and COG, and at some ages for FLW and EVGG. Women were significantly favored for at least one age category for HOSP and COG. There was no significant gender effect for P(H to S) when defined by FLW, at any age. For the remaining variables, women were significantly more likely to get sick than men in one or more age categories. (Also see appendix table 3B). 3.3 Initial State From Table 2 and Table 3, it can be seen that those in the healthy state were more likely to be healthy in the following year, and less likely to be sick or die. This was true for all variables. There was never a significant interaction between initial state and gender. Therefore “healthy” and “sick” mean substantially the same in predicting mortality for men and for women. 3.4 Principal Components and factor Analysis To further examine the similarities of the variables, we performed a principal component (PC) analysis of all twelve measures (not shown). (See appendix table 13). The first PC accounted for 32% of the variation, and the loadings for all variables had 9 the same sign. This supports findings seen above for the similarities of the variables. (see appendix table 13) The second PC also had an eigenvalue greater than one, and retaining it accounted for 42% of the variation. After a varimax rotation, and the first factor comprised TWLK, IADL, ADL, EXSTR, BLK, EVGG (loadings > .5). The second factor comprised FLW, DEP, SPL, and BED (loadings > .5). COG was also correlated with factor 1 (loading = .45). ADL, EVGG, and HOSP were also correlated with factor 2 (loadings 0.3 to 0.5). The two rotated factors could be taken, very loosely, as summaries of physical and mental health, respectively. Interestingly, the variables where women had a higher P(S to H) than men loaded most highly on factor 2 (mental health) and the variables that favored men were those that loaded on factor 1 (physical health). The average factor scores were higher for men than for women. 4 Discussion 4.1 Summary Analyses comparing patterns among the 12 health variables found many similarities. There were strong age effects in the prevalence and probabilities, in the expected direction, which were linear only for P(S to H). The exception was P(S to S) which often was not monotone in age. Men had a higher healthy prevalence for 10 of the variables, with women healthier only for COG and HOSP. In spite of their better health, men had a higher death rate in all but one comparison. Women were usually more likely to become sick and to stay sick. They were less likely than men to recover from sick states defined by the “physical health” variables, and more likely than men to recover on the “mental health” variables. 10 4.2 Prevalence and Probabilities The equilibrium - or steady state – healthy prevalence of a system can be calculated from the transition probabilities. 18 19 The equilibrium prevalence of the healthy state is K/(1+K), where K P( HtoH ) P( StoS ) [ P( HtoH ) P( StoS )]2 P( StoH ) . 2 P( HtoS ) [2 P( HtoS )]2 P( HtoS ) {1} If we may consider the CHS sample over time to be approximately at equilibrium, these relationships may help to explain some of the findings. To support this assumption, we noted that the observed healthy prevalence was fairly close to the calculated equilibrium prevalence, with the worst discrepancy being at age 90 for IADL. (See appendix table 4 and table 4b for detailed calculations for each health variable). The equilibrium prevalence increases with K. P(H to S) is in the denominator of every term, and is therefore a key component of healthy prevalence. The variables with the lowest P(H to S) in Table 3 (e.g., FLW, BED, and HOSP for the young-old women) should have the highest healthy prevalence in Table 1, which is the case. Table 3 also shows that P(H to S) is higher for men than for women only for HOSP and COG (and occasionally for EVGG). Because higher P(H to S) leads to lower healthy prevalence, it follows that HOSP and COG are the two variables for which women had a higher healthy prevalence. In the first term of equation {1}, P(H to H) – P(S to S) is in the numerator. This quantity is usually positive, meaning that a healthy person is more likely to remain healthy than a sick person is to remain sick. The term is negative, however, 11 for BLK, meaning that a person who is sick (inactive) is more likely to remain inactive that a person who is healthy (walks 4+ blocks a day) is to remain active. This term is more likely to be negative for the oldest old, meaning that, with increasing age, the probability of staying healthy becomes lower than the probability of staying sick. The second term under the radical in equation {1} is the ratio of P(S to H) to P(H to S). This ratio is greater than 1.0 for the young old (except for BLK), meaning that they are more likely to recover than to get sick. The ratio is below 1 for TWLK and COG at age 80, and is below 1 more than half the time at age 90. The relative probabilities of recuperating and getting sick thus change over time, as a feature of aging. 4.3 Age effects Healthy prevalence and five of the transition probabilities declined significantly in the expected direction with age. For P(S to H) only, the decline was linear. The other measures tended to show a significantly larger change after age 80. The one discrepant probability was P(S to S), which was often highest in the middle age group. A similar pattern was noted elsewhere, based on self-rated health. [3] P(S to S) increased from birth until about age 60, after which it declined. This pattern is caused by the different alternatives for a sick person with increasing age. At younger ages, the most likely change is to recuperate, but as P(S to H) decreases with age, P(S to S) increases. At the oldest ages, however, the most likely change from the sick state is death, and as the P(S to D) increases, P(S to S) decreases. The sick state thus has a somewhat ambiguous meaning, since it represents a failure to recuperate for younger persons (bad) but a resistance to dying for older persons (good). 12 4.4 Gender effects It is puzzling that although men always had a higher death rate, they usually also had a higher healthy prevalence (except for HOSP and COG). The findings suggest that men are closer than women to achieving the ideal of the compression of morbidity. 20 Sick women had a higher P(S to S) in 34 of 36 comparisons. Men had a higher P(H to H) in 23/36 comparisons, and higher P(S to H) in 21 of 36 comparisons. Women had a higher P(H to S) in 25 of 36 comparisons. Thus, most of the non-death transition probabilities tended to favor men. Similar observations have been made by Leveille et al. [8] That study defined “healthy” as being able to walk to miles and climb two flights of stairs without help. They found that men were more likely to die but also to remain healthy and to recover, while women were more likely to become sick and remain sick. They used life-table calculations, modifying various parameters, to conclude that the most important explanatory factor was that the probability of incidence, P(H to S) was higher for women. We extended that finding by using 12 different measures of health. We also used equation {1} to illustrate the key role of P(H to S) in determining the healthy prevalence. Finally, we determined that all of the non-death transition probabilities favored men somewhat, not just the probability of incidence. For example, we found that P(S to S) was higher for women in every case. Hardy [9] in a similar study (based on ADL disability, with 1 or 2 areas considered mild disability and 3 or more severe disability) found that the higher prevalence of disability in women versus men is due to a combination of higher incidence and longer duration, resulting from lower rates of recovery and mortality 13 among disabled women. We found also that women were less likely to recover from ADL difficulties. Resilience, P(S to H), is a major feature of aging theory.[ref?] Based on the principal components analysis, it may be appropriate to say that women have higher resilience for mental variables and men had higher resilience for physical variables. Equation {1} shows that healthy prevalence does not depend strictly on P(S to H), but rather on the ratio of P(S to H) to P(H to S). Healthy prevalence does depend directly (inversely) on P(H to S). Women had significantly higher P(H to H) than men only for HOSP and COG, and had lower P(H to S) only for HOSP and COG. This helps to explain why HOSP and COG were the only variables where women had a higher healthy prevalence than men. It may be that older women really are sicker than older men. Alternatively, women may have a more nuanced understanding of their health, or may be more willing to assume the sick role than men. [refs?] This possibility is supported by the fact that HOSP and COG, the only variables that favored women, are similar only in that neither was self-reported. If these variables had instead been measured by selfreport, perhaps women would have reported worse health on these measures as well. However, the third externally measured variable, the timed walk, favored men. It would be useful to repeat these analyses using other variables, datasets, and age groups. 4.5 Variables were similar 14 The twelve health-related variables included measures of physical and mental health, quality of life, and health behaviors. Some were self-reported, and some were reported by others. Some were completely subjective while others were based on structured responses. We had expected some of these features to make a difference, but 10 of the 12 variables behaved in very similar ways. Two published analyses of transitions in physical function also showed the same patterns, [leveille] [hardy] We had no longitudinally-collected measures of social, environmental or occupational health. It is likely that such measures would have similar behavior to those shown here. The principal components analysis supported the similar behavior of the various measures, and suggested that most of the information in the 12 variables could be summarized into 2 or 3 dimensions. 4.6 Healthy Aging One measure of healthy aging is the probability of resilience, P(S to H). We found that resilience was reasonably high but declined with age, and tended to be higher for women than for men. The “one hoss shay” model suggests that all dimensions of health might stay perfect until death, at which time all dimensions would crash “all at once and nothing first”. That model was not supported here, although the various measures did tend to decline in similar ways. A related model is the compression of morbidity [fries] which has the goal of spending most of the years before death in the healthy state. We found that the healthy prevalence declined with age, and was usually higher for men than for women, despite the higher death rates for men. Thus the goal of healthy aging was closer to being met for men than for women, for 10 of 12 measures of health. 15 4.7 Limitations. The significance tests that are reported here should be considered as descriptive only, due to the very large number of comparisons that were made in this analysis. The healthy states had different prevalences because of the way that “healthy” was defined. If all measures had been continuous, we could have chosen thresholds that would make all of the prevalences the same, but that was not possible here. We initially planned to study a thirteenth variable, whether a person had a flu shot in the past year. This measure was found to be essentially unrelated to health and mortality on other measures, and so was not included here. Because the goal of this paper was to compare twelve different measures of health, the amount of discussion given to each measure had to be limited. 5 Summary and Conclusion Transition probabilities among states of health are important for the study of aging, but are rarely reported. We provided transition probabilities for healthrelated variables that had not previously been studied, and that addressed different domains of health. In general these variables behaved in the same way. Healthy prevalence and all of the transition probabilities changed in the expected way with age and were usually more favorable for men that for women. If women have a more nuanced view of their health than men do, these gender differences could be partially explained. Extension of these findings to other health-related variables would be of interest. 16 Table 1 Healthy prevalence Table 1, Prevalence N Mean Age HOSP: No hospital days BED: No bed days SPL: Satisfied with Purpose of Life DEP: Not depressed ADL: No ADL difficulties FLW: Feel life is worthwhile EXSTR: Good extremity strength EVGG: Exc/ Very Good/ Good health TWLK: Walk 10 feet < 10 seconds IADL: No IADL difficulties COG: 3MSE > 90 BLK: Walked 4+ blocks per day *tables_graphs_paper_05.sps 4-23-2011 Sheet 3 Sex Female Male 65-74 75-84 85-94 65-74 75-84 85-94 12261 12433 2183 7801 8867 1752 71.0 78.6 87.5 71.1 78.6 87.7 91.3 87.8 84.9 88.0 85.6 81.7 94.3 92.3 89.3 95.9 94.6 91.3 75.7 69.8 59.6 80.7 75.2 67.4 80.2 73.8 64.3 87.6 81.4 70.9 86.3 76.1 56.7 90.2 82.7 67.6 94.4 91.0 83.6 95.3 91.7 85.6 67.6 57.6 42.1 84.6 78.8 65.4 79.0 70.8 60.7 80.0 73.6 64.7 64.3 44.5 16.9 73.8 58.6 30.0 71.8 58.7 39.5 80.9 70.5 50.7 70.9 54.6 27.6 67.2 53.1 25.7 33.3 20.9 8.5 47.7 37.8 22.3 Bolded entries favor women. 17 Table 2 Transition probabilities for sick persons Table 2 Transition Probabilities for Initially Sick Persons * 1 2 Young Old (65-74) female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK male HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK 3 4 Old Old (75-84) 5 6 7 8 Oldest Old (85-94) 9 P(S TO H) P(S TO S) P(S TO D) P(S TO H) P(S TO S) P(S TO D) P(S TO H) P(S TO S) P(S TO D) 0.677 0.262 0.061 0.605 0.290 0.105 0.535 0.267 0.198 0.550 0.370 0.080 0.443 0.408 0.148 0.335 0.369 0.296 0.367 0.601 0.031 0.297 0.640 0.063 0.235 0.607 0.158 0.345 0.620 0.034 0.286 0.642 0.073 0.203 0.628 0.169 0.359 0.589 0.051 0.253 0.667 0.080 0.151 0.703 0.146 0.370 0.541 0.089 0.291 0.562 0.147 0.175 0.532 0.292 0.314 0.661 0.026 0.230 0.717 0.053 0.140 0.736 0.124 0.314 0.644 0.042 0.253 0.674 0.073 0.239 0.608 0.154 0.293 0.678 0.029 0.157 0.795 0.048 0.058 0.841 0.101 0.295 0.674 0.032 0.221 0.727 0.052 0.156 0.732 0.112 0.274 0.700 0.026 0.169 0.779 0.052 0.070 0.825 0.105 0.140 0.842 0.018 0.084 0.878 0.038 0.025 0.884 0.091 0.632 0.494 0.411 0.373 0.311 0.293 0.368 0.323 0.338 0.335 0.271 0.208 0.286 0.353 0.528 0.543 0.586 0.548 0.566 0.598 0.609 0.590 0.685 0.756 0.082 0.153 0.061 0.084 0.103 0.159 0.066 0.078 0.053 0.075 0.043 0.036 0.560 0.329 0.315 0.271 0.229 0.200 0.306 0.250 0.207 0.243 0.176 0.142 0.278 0.356 0.562 0.568 0.603 0.518 0.556 0.623 0.699 0.639 0.742 0.786 * Bolded entries for P(H) and P(S) favor women. table2_tests_08.xslx , sheet 3 18 0.162 0.315 0.123 0.161 0.168 0.282 0.138 0.127 0.094 0.118 0.082 0.072 0.489 0.257 0.243 0.175 0.134 0.151 0.196 0.178 0.077 0.166 0.071 0.078 0.227 0.329 0.535 0.576 0.630 0.456 0.563 0.586 0.764 0.643 0.779 0.769 0.283 0.414 0.222 0.250 0.236 0.393 0.241 0.236 0.159 0.191 0.150 0.153 Table 3 Transition probabilities for healthy persons Table 3 female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK male HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK Transition Probabilities for Initially Health Persons 1 2 3 4 5 6 7 8 9 Young Old (65-74) Old Old (75-84) Oldest Old (85-94) P(H TO H) P(H TO S) P(H TO D) P(H TO H) P(H TO S) P(H TO D) P(H TO H) P(H TO S) P(H TO D) 0.917 0.075 0.008 0.876 0.102 0.021 0.804 0.130 0.066 0.947 0.045 0.009 0.921 0.058 0.021 0.858 0.082 0.061 0.849 0.145 0.007 0.804 0.178 0.018 0.697 0.266 0.037 0.883 0.110 0.007 0.844 0.140 0.017 0.769 0.192 0.039 0.904 0.090 0.007 0.846 0.138 0.016 0.722 0.238 0.040 0.956 0.036 0.008 0.922 0.058 0.020 0.850 0.105 0.045 0.826 0.167 0.006 0.770 0.214 0.016 0.664 0.304 0.033 0.902 0.296 0.005 0.846 0.370 0.014 0.730 0.395 0.042 0.826 0.170 0.004 0.717 0.272 0.011 0.537 0.453 0.011 0.848 0.147 0.005 0.772 0.211 0.017 0.606 0.349 0.045 0.864 0.129 0.007 0.806 0.180 0.014 0.666 0.299 0.035 0.650 0.013 0.002 0.546 0.011 0.007 0.486 0.027 0.027 0.884 0.947 0.860 0.905 0.921 0.950 0.899 0.893 0.850 0.875 0.831 0.724 0.098 0.033 0.123 0.078 0.062 0.031 0.083 0.350 0.134 0.111 0.153 0.017 0.018 0.020 0.017 0.017 0.017 0.019 0.018 0.012 0.016 0.014 0.017 0.014 0.850 0.921 0.817 0.864 0.865 0.916 0.847 0.839 0.762 0.811 0.780 0.629 0.116 0.042 0.155 0.109 0.108 0.053 0.124 0.343 0.216 0.165 0.195 0.021 0.033 0.037 0.028 0.027 0.028 0.031 0.029 0.025 0.022 0.024 0.025 0.018 * Bolded entries favor women. table3_tests_08.xslx , sheet 3 19 0.758 0.836 0.712 0.763 0.749 0.819 0.738 0.747 0.611 0.641 0.618 0.541 0.154 0.066 0.210 0.163 0.179 0.101 0.198 0.446 0.343 0.298 0.329 0.038 0.088 0.098 0.078 0.074 0.072 0.080 0.064 0.064 0.046 0.061 0.053 0.026 Figure 1, transition probabilities for ADL for women by age 20 Figure 2. Prevalence and Probabilities of Maintenance and Resilience for Activities of Daily Living By Age and Sex 21 Appendices A Tables 1 Missing Data 1 Significance tests for prevalence 1a summary comparisons for prevalence 2a significance tests for P(S to H) 2b significance tests for P(S to S) 3a significance tests for P(H to H) 3b significance tests for P(H to S) 4 calculations from equation {1}, equilibrium prevalence 4b prev_obs minus prev_equil 5 probability differences, female minus male 6 age differences on probability of getting sick 70-80, 80-90, dif dif 7 age differences on probability of staying sick 8 summary of sex results for all probabilities (#positive) 9 summary of age results for all probabilities (# positive) 10 summary of sex results for all healthy variables (sum of #8) 11 summary for age results for all healthy variables (sum of #9) 12 interaction of age and initial state in predicting mortality 13 principal components/factor analysis. 22 Appendix A. Missing Data In CHS, most measures were taken annually from 1990 to 1999. However, self-rated health was measured semi-annually from 1990 to 2005, and complete mortality was available (for the current analysis) through 2007. We imputed missing self-rated health data and used that, where necessary, to help impute data for the other variables. For self-rated health, we coded the original response categories (excellent, very good, good, fair, poor) to 95, 90, 80, 30, and 15. These values represent approximately the percent probability that a person in this state with be in excellent, very good, or good health in the following year. Under the assumption that a dead person is not healthy, and will not be healthy next year either, we can assign a value of 0 to values that were not made because the person had died. After this recoding, we imputed missing data by interpolation over time, whenever there was a valid value before and a valid value or death after the missing data. The remaining unimputed data, for persons alive but missing at the end of the sequence, we used last observation carried forward. Because so much information was collected after 1999, we rarely had to impute missing data from 1990 to 1999 by extrapolation (less than .3% of the time). We are thus comfortable with the imputation for EVGGFP. For the other variables, each variable was transformed to a new scale representing the probability of being in excellent, very good, or good health, deaths were set to zero, and data were interpolated. Data missing at the end of the sequence for persons still alive was imputed as the average of the last available observation from the variable of interest and the estimate from self-rated health at that time. These were both on the same scale because of the transformation. After imputation, the variables were transformed back to the original scales. 23 Appendix Table 1, includes the significance tests appendix table 1, prevalence (results of xtlogit) F>M b a female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK 70 a c 80 b 90 70 f 80 90 c d d d d e e e e d e e e e d d a M>F e d terminal drop early late g g f f f g f g f f g b d e male HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK f g g g g g g g g 24 Appendix table 1a, summary of stuff about the Prevalences of the Healthy States yrs 1990-1998 only Appendix table 1 Female minus male Female minus male female male male male a b a b 70-80 80-90 b-a 70-80 80-90 b-a ignore col labels 7801 8867 1752 ignore col labels 71.129 78.628 87.654 3.51 2.85 -0.67 2.38 3.97 1.58 2.02 2.93 0.91 1.35 3.23 1.88 5.85 10.20 4.35 5.55 7.80 2.25 6.35 9.53 3.18 6.17 10.44 4.27 10.15 19.45 9.30 7.48 15.06 7.58 3.40 7.43 4.03 3.61 6.09 2.48 9.98 15.54 5.56 5.88 13.40 7.52 8.13 10.18 2.05 6.42 8.93 2.51 19.78 27.64 7.86 15.28 28.59 13.31 13.11 19.17 6.05 10.43 19.71 9.28 16.24 27.05 10.81 14.14 27.41 13.27 -7.86 -0.04 7.82 0.00 0.00 0.00 12.45 12.43 -0.02 9.89 15.51 5.62 4.00 -4.00 -8.00 4.00 -3.00 -7.00 65-74 75-84 85-94 N 12261 12433 2183 mean age 70.999 78.561 87.503 HP: No hospital days 3.26 2.13 3.25 BD: No bed days -1.62 -2.30 -2.00 SPL: Satisfied with Purpose of Life-5.01 -5.31 -7.71 DP: Not depressed -7.38 -7.55 -6.63 ADL: No ADL difficulties -3.91 -6.58 -10.97 FLW: Feel life is worthwhile -0.94 -0.73 -2.06 XS: Good extremity strength -17.02 -21.12 -23.26 VG: Exc/ Very Good/ Good health-1.06 -2.77 -4.02 TW: Walk 10 feet < 10 seconds -9.51 -14.00 -13.05 YD: No IADL difficulties -9.07 -11.75 -11.21 CG: 3MSE > 90 3.63 1.53 1.89 FH: Flu shot last year -0.67 -4.17 -1.59 BK: Walked 4+ blocks per day -14.31 -16.87 -13.79 no pain -12 -12 -11 plus minus 2 10 2 10 2 10 12 0 25 12 0 11 1 12 0 12 0 12 0 Appendix Table 2a P(S to H) appendix table 2a, recuperation (XTLOGIT) f>m b a female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK 70 c 80 f<m e d 90 70 terminal drop terminal drop early late g g f 80 90 b b a b b b d e f d d e g e g g c d male HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK f g g g 26 Appendix Table 2b P(S to S) appendix table 2b, stay sick (XTLOGIT) female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK a 70 a a a a a a a f>m b 80 c 90 b b b c c c b b b b b b sig drop c c c c c c female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK signs n n,n n n n n n n,n n,p n,n n,p n,p n n,p male male HOSP HOSP BED BED SPL SPL DEP DEP ADL ADL FLW FLW EXSTR EXSTR EVGG EVGG n n,n TWLK TWLK IADL IADL COG COG BLK BLK n n,n a, b, c, women more likely to stay sick n=negative p=pos ns = not significant 27 sig f ns,ns ns,ns n,ns ns,ns n,ns ns,ns n,ns n,n n,p n,ns n,p n,ns m same ns,ns x ns,ns x ns,ns 0 ns,ns x ns,ns 0 ns,ns x ns,ns 0 ns,ns 0 n,p x n.ns x n,ns 0 n,ns x ns,ns ns,ns ns,ns ns,ns ns,ns ns,ns ns,ns ns,ns n,p n.ns n,ns n,ns x, m=f Appendix Table 3a P(H to H) appendix table 3A, maintaining health (XTLOGIT) F>M b a female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK 70 A c 80 B F<M e d 90 70 f 80 90 C D D E E D E F D D E E F D E C A terminal drop terminal drop early late g H B male HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK H H H H H H H H H H H H H H H H H 28 Appendix table 3b, xtlogit analysis of P(H to S) appendix table 3B, get sick (based on table 3) (XTLOGIT) F>M M>F a female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK b 70 c 80 d 90 70 D A A A A B B B B e f 80 E C terminal drop terminal drop early late g H 90 F H C H A B A A B B C C C C D A H B male HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK H H 29 Appendix Table 4, Mystery of Sex Differences table4_mystery_08.xlsx Young Old d (65-74) Old Old (75-84) Oldest Old (85-94) f d w q prev_equil k d w q k prev_equil d w q k p_eq HP 0.65 4.4 9.01 9.65 0.91 0.59 2.86 5.91 6.62 0.87 0.54 2.06 4.12 4.96 0.83 BD 0.58 6.4 12.29 13.78 0.93 0.51 4.43 7.66 9.65 0.91 0.49 3.00 4.11 6.62 0.87 SPL 0.25 0.9 2.54 2.66 0.73 0.16 0.46 1.67 1.83 0.65 0.09 0.17 0.88 1.13 0.53 DP 0.26 1.2 3.14 3.33 0.77 0.20 0.72 2.05 2.33 0.70 0.14 0.37 1.05 1.46 0.59 XD 0.31 1.8 4.01 4.42 0.82 0.18 0.65 1.83 2.14 0.68 0.02 0.04 0.63 0.84 0.46 FLW 0.41 5.7 10.20 12.25 0.92 0.36 3.13 5.05 6.98 0.87 0.32 1.51 1.67 3.50 0.78 XS 0.17 0.5 1.87 1.95 0.66 0.05 0.12 1.08 1.17 0.54 -0.07 -0.12 0.46 0.57 0.36 VG 0.26 1.4 3.36 3.67 0.79 0.17 0.61 1.81 2.09 0.68 0.12 0.27 1.05 1.33 0.57 TW 0.15 0.4 1.72 1.82 0.64 -0.08 -0.14 0.58 0.63 0.39 -0.30 -0.34 0.13 0.15 0.13 YD 0.17 0.6 2.00 2.13 0.68 0.04 0.11 1.04 1.13 0.53 -0.13 -0.18 0.45 0.51 0.34 CG 0.16 0.6 2.13 2.23 0.69 0.03 0.07 0.94 1.05 0.51 -0.16 -0.27 0.23 0.29 0.22 BK -0.19 -0.3 0.40 0.42 0.29 -0.33 -0.37 0.19 0.20 0.17 -0.40 -0.41 0.05 0.06 0.05 pain -0.06 -0.1 0.79 0.79 0.44 -0.07 -0.12 0.76 0.76 0.43 -0.01 -0.02 0.96 0.96 0.49 leveille 0.18 0.2 0.58 1.01 0.50 0.01 0.01 0.67 0.83 0.45 -0.25 -0.30 0.13 0.16 0.14 m dw q k prev_equil d w q k d w q k prev HP 0.60 3.0 6.44 7.01 0.88 0.57 2.46 4.81 5.75 0.85 0.53 1.72 3.17 4.19 0.81 BD 0.59 9.1 15.14 19.01 0.95 0.57 6.73 7.84 14.02 0.93 0.51 3.83 3.87 8.13 0.89 SPL 0.33 1.3 3.34 3.62 0.78 0.26 0.83 2.04 2.47 0.71 0.18 0.42 1.16 1.58 0.61 DP 0.36 2.3 4.78 5.50 0.85 0.30 1.37 2.49 3.45 0.78 0.19 0.58 1.08 1.77 0.64 XD 0.33 2.7 4.99 6.18 0.86 0.26 1.21 2.13 3.11 0.76 0.12 0.33 0.75 1.26 0.56 FLW 0.40 6.5 9.48 13.69 0.93 0.40 3.72 3.75 7.92 0.89 0.36 1.80 1.50 3.98 0.80 XS 0.33 2.0 4.43 4.91 0.83 0.29 1.17 2.46 3.13 0.76 0.17 0.44 0.99 1.53 0.60 VG 0.29 1.6 3.41 3.96 0.80 0.22 0.79 1.84 2.37 0.70 0.16 0.42 0.94 1.48 0.60 TW 0.24 0.9 2.52 2.73 0.73 0.06 0.15 0.96 1.14 0.53 -0.15 -0.22 0.23 0.30 0.23 YD 0.29 1.3 3.01 3.44 0.77 0.17 0.52 1.48 1.85 0.65 0.00 0.00 0.56 0.74 0.43 CG 0.15 0.5 1.78 1.89 0.65 0.04 0.10 0.91 1.05 0.51 -0.16 -0.24 0.22 0.28 0.22 BK -0.03 -0.1 0.79 0.83 0.45 -0.16 -0.22 0.40 0.45 0.31 -0.23 -0.26 0.18 0.24 0.19 pain 0.06 0.1 1.23 1.25 0.56 0.05 0.11 1.22 1.22 0.55 0.09 0.23 1.50 1.47 0.60 leveille 0.36 2.5 4.11 5.74 0.85 0.20 0.63 1.28 1.92 0.66 -0.06 -0.08 0.30 0.47 0.32 female minus male female minus male female minus male f Minus M= d w q prev_equil k d w q prev_equil k d w q k p_eq HP 0.1 1.3 2.57 2.64 0.03 0.0 0.40 1.10 0.87 0.02 0.0 0.35 0.95 0.77 0.02 BD 0.0 -2.7 -2.84 -5.24 -0.02 -0.1 -2.30 -0.18 -4.37 -0.03 0.0 -0.83 0.23 -1.52 -0.02 0.11 -0.1 -0.5 -0.79 -0.95 -0.06 -0.1 -0.37 -0.37 -0.64 -0.07 -0.1 -0.25 -0.27 -0.45 -0.08 DP -0.1 -1.1 -1.64 -2.17 -0.08 -0.1 -0.64 -0.45 -1.13 -0.08 0.0 -0.21 -0.02 -0.31 -0.05 XD 0.0 -0.9 -0.98 -1.76 -0.05 -0.1 -0.57 -0.30 -0.97 -0.07 -0.1 -0.29 -0.12 -0.43 -0.10 FLW 0.0 -0.8 0.72 -1.45 -0.01 0.0 -0.59 1.30 -0.94 -0.01 0.0 -0.29 0.17 -0.49 -0.02 XS -0.2 -1.5 -2.56 -2.96 -0.17 -0.2 -1.05 -1.38 -1.96 -0.22 -0.2 -0.56 -0.53 -0.96 -0.24 VG 0.0 -0.2 -0.05 -0.29 -0.01 0.0 -0.18 -0.03 -0.27 -0.03 0.0 -0.16 0.11 -0.16 -0.03 TW -0.1 -0.5 -0.80 -0.91 -0.09 -0.1 -0.29 -0.38 -0.51 -0.15 -0.2 -0.11 -0.10 -0.15 -0.10 YD -0.1 -0.7 -1.01 -1.32 -0.09 -0.1 -0.42 -0.43 -0.71 -0.12 -0.1 -0.18 -0.11 -0.23 -0.09 CG 0.0 0.2 0.35 0.34 0.04 0.0 -0.02 0.03 -0.01 0.00 0.0 -0.02 0.02 0.01 0.00 BK -0.2 -0.2 -0.39 -0.42 -0.16 -0.2 -0.15 -0.21 -0.25 -0.14 -0.2 -0.15 -0.13 -0.18 -0.14 pain -0.1 -0.2 -0.44 -0.47 -0.12 -0.1 -0.23 -0.46 -0.46 -0.12 -0.1 -0.25 -0.54 -0.51 -0.11 leveille -0.2 -2.3 -3.53 -4.73 -0.35 -0.2 -0.62 -0.61 -1.09 -0.20 -0.2 -0.23 -0.17 -0.31 -0.18 30 Table 4b prev_obs – prev_equil ADL looks bad, especially for age 90. Sample size? others agree within 2 percentage points Observed almost always > equilibrium OBSERVED MINUS EQUILIBRIUM F M 70 80 90 70 80 90 HOSP: No hospital days 0.0068 BED: No bed days 0.0104 SPL: Satisfied with Purpose of Life 0.0298 DEP: Not depressed 0.0329 ADL: No ADL difficulties 0.0473 FLW: Feel life is worthwhile 0.0193 EXSTR: Good extremity strength 0.0149 EVGG: Exc/ Very Good/ Good health 0.0035 TWLK: Walk 10 feet < 10 seconds -0.0017 IADL: No IADL difficulties 0.0380 COG: 3MSE > 90 0.0185 BLK: Walked 4+ blocks per day 0.0401 0.0090 0.0165 0.0515 0.0392 0.0792 0.0352 0.0375 0.0316 0.0593 0.0557 0.0351 0.0428 0.0171 0.0246 0.0670 0.0503 0.1111 0.0580 0.0576 0.0363 0.0350 0.0565 0.0527 0.0303 0.0051 0.0089 0.0237 0.0295 0.0411 0.0213 0.0155 0.0016 0.0068 0.0340 0.0184 0.0228 0.0046 0.0121 0.0393 0.0385 0.0702 0.0293 0.0299 0.0331 0.0535 0.0558 0.0178 0.0676 0.0095 0.0227 0.0618 0.0711 0.1183 0.0569 0.0491 0.0494 0.0674 0.0814 0.0371 0.0317 31 HP BD SPL DP XD FLW XS VG TW YD CG FH BK pain APPENDIX TABLE 5 PROBABILITY DIFFERENCES F MINUS M TABLE 3 SHEET 2 FEMALE MINUS MALE PROBS FOR HEALTHY FOLKS TABLE 3 Young Old (65-74) Old Old (75-84) Oldest Old (85-94) P(H) P(S) P(D) P(H) P(S) P(D) P(H) P(S) P(D) 0.033 -0.023 -0.010 0.026 -0.014 -0.012 0.047 -0.024 -0.022 -0.001 0.012 -0.011 -0.001 0.016 -0.015 0.022 0.015 -0.037 -0.011 0.022 -0.010 -0.013 0.023 -0.010 -0.014 0.056 -0.041 -0.022 0.032 -0.010 -0.021 0.031 -0.010 0.005 0.030 -0.035 -0.017 0.027 -0.011 -0.019 0.030 -0.012 -0.027 0.060 -0.032 0.005 0.005 -0.011 0.007 0.004 -0.011 0.030 0.005 -0.035 -0.072 0.084 -0.012 -0.077 0.090 -0.013 -0.074 0.105 -0.031 0.009 -0.054 -0.007 0.007 0.027 -0.011 -0.016 -0.051 -0.023 -0.024 0.036 -0.012 -0.046 0.057 -0.011 -0.075 0.110 -0.035 -0.027 0.036 -0.009 -0.039 0.047 -0.007 -0.035 0.051 -0.016 0.033 -0.024 -0.010 0.026 -0.015 -0.011 0.048 -0.030 -0.018 0.020 0.024 -0.012 0.014 0.029 -0.026 0.012 0.040 -0.037 -0.074 -0.004 -0.012 -0.084 -0.011 -0.011 -0.055 -0.011 0.001 -0.040 0.060 -0.020 -0.040 0.060 -0.020 0.030 0.040 -0.070 HP BD SPL DP XD FLW XS VG TW YD CG FH BK pain FEMALE MINUS MALE PROBS FOR THE SICK TABLE 2 Young Old (65-74) Old Old (75-84) Oldest Old (85-94) P(H) P(S) P(D) P(H) P(S) P(D) P(H) P(S) P(D) 0.045 -0.024 -0.022 0.045 0.012 -0.057 0.046 0.040 -0.086 0.056 0.017 -0.073 0.114 0.052 -0.166 0.078 0.040 -0.118 -0.043 0.073 -0.030 -0.018 0.078 -0.061 -0.008 0.072 -0.064 -0.028 0.077 -0.049 0.015 0.074 -0.089 0.028 0.052 -0.080 0.049 0.003 -0.052 0.023 0.064 -0.088 0.017 0.073 -0.090 0.077 -0.007 -0.070 0.091 0.044 -0.134 0.025 0.076 -0.100 -0.054 0.094 -0.040 -0.076 0.161 -0.085 -0.056 0.172 -0.116 -0.009 0.046 -0.036 0.003 0.052 -0.054 0.061 0.021 -0.082 -0.045 0.070 -0.025 -0.050 0.096 -0.046 -0.019 0.077 -0.058 -0.041 0.084 -0.043 -0.022 0.088 -0.066 -0.010 0.089 -0.079 0.003 0.014 -0.018 -0.007 0.037 -0.030 -0.001 0.046 -0.045 -0.027 0.041 -0.014 -0.018 0.029 -0.011 0.017 0.027 -0.044 -0.068 0.086 -0.018 -0.058 0.092 -0.035 -0.053 0.116 -0.062 -0.040 0.060 -0.020 -0.040 0.060 -0.020 0.030 0.040 -0.070 32 APPENDIX TABLE 6 PROBABILITY OF GETTING SICK HP BD SPL DP XD FLW XS VG TW YD CG FH BK pain HP BD SPL DP XD FLW XS VG TW YD CG FH BK pain TABLE3_TESTS_SHEET 2 GET SICK Young OldOld (65-74) Old (75-84) Oldest Old (85-94) P(H) P(H) P(H) dif 70-80 dif 80-90 dif-dif 0.075 0.102 0.130 -0.027 -0.028 0.000 0.045 0.058 0.082 -0.013 -0.024 0.010 0.145 0.178 0.266 -0.034 -0.088 0.054 0.110 0.140 0.192 -0.030 -0.053 0.023 0.090 0.138 0.238 -0.049 -0.100 0.052 0.036 0.058 0.105 -0.021 -0.048 0.026 0.167 0.214 0.304 -0.047 -0.090 0.043 0.296 0.370 0.395 -0.074 -0.025 -0.049 0.170 0.272 0.453 -0.102 -0.180 0.078 0.147 0.211 0.349 -0.064 -0.137 0.073 0.129 0.180 0.299 -0.051 -0.119 0.068 0.252 0.273 0.312 -0.021 -0.039 0.019 0.013 0.011 0.027 0.002 -0.017 0.019 0.280 0.290 0.240 -0.010 0.050 -0.060 0.098 0.033 0.123 0.078 0.062 0.031 0.083 0.350 0.134 0.111 0.153 0.228 0.017 0.220 0.116 0.042 0.155 0.109 0.108 0.053 0.124 0.343 0.216 0.165 0.195 0.244 0.021 0.230 0.154 0.066 0.210 0.163 0.179 0.101 0.198 0.446 0.343 0.298 0.329 0.272 0.038 0.200 -0.018 -0.009 -0.032 -0.031 -0.045 -0.022 -0.041 0.007 -0.082 -0.053 -0.042 -0.016 -0.004 -0.010 33 -0.038 -0.024 -0.055 -0.054 -0.071 -0.047 -0.074 -0.103 -0.127 -0.134 -0.134 -0.028 -0.017 0.030 0.020 0.015 0.024 0.023 0.026 0.025 0.033 0.110 0.046 0.080 0.092 0.012 0.013 -0.040 HP BD SPL DP XD FLW XS VG TW YD CG FH BK pain HP BD SPL DP XD FLW XS VG TW YD CG FH BK pain APPENDIX TABLE 7 FROM TABLE2_TESTS SHEET 2 PROBABILITY OF STAYING SICK BY AGE Young OldOld (65-74) Old (75-84) Oldest Old (85-94) P(S) P(S) P(S) dif 70-80 dif 80-90 dif-dif 0.262 0.290 0.267 -0.028 0.023 -0.051 0.370 0.408 0.369 -0.038 0.039 -0.077 0.601 0.640 0.607 -0.039 0.033 -0.071 0.620 0.642 0.628 -0.021 0.014 -0.035 0.589 0.667 0.703 -0.078 -0.036 -0.042 0.541 0.562 0.532 -0.021 0.030 -0.051 0.661 0.717 0.736 -0.057 -0.018 -0.038 0.644 0.674 0.608 -0.030 0.067 -0.097 0.678 0.795 0.841 -0.117 -0.046 -0.071 0.674 0.727 0.732 -0.054 -0.005 -0.049 0.700 0.779 0.825 -0.079 -0.046 -0.034 0.766 0.723 0.687 0.043 0.036 0.007 0.842 0.878 0.884 -0.036 -0.006 -0.030 0.280 0.290 0.240 -0.010 0.050 -0.060 0.286 0.353 0.528 0.543 0.586 0.548 0.566 0.598 0.609 0.590 0.685 0.725 0.756 0.220 0.278 0.356 0.562 0.568 0.603 0.518 0.556 0.623 0.699 0.639 0.742 0.694 0.786 0.230 0.227 0.329 0.535 0.576 0.630 0.456 0.563 0.586 0.764 0.643 0.779 0.660 0.769 0.200 0.008 -0.003 -0.033 -0.025 -0.017 0.030 0.010 -0.024 -0.091 -0.049 -0.057 0.031 -0.030 -0.010 34 0.051 0.027 0.027 -0.008 -0.027 0.062 -0.007 0.036 -0.065 -0.004 -0.037 0.034 0.017 0.030 -0.043 -0.030 -0.060 -0.017 0.010 -0.032 0.017 -0.061 -0.026 -0.045 -0.020 -0.003 -0.047 -0.040 appendix table 8 all_6_probs SUMMARY OF SEX RESULTS FEMALE MINUS MALE 0 PLUS MINUS 65-74 P(H) 4 8 P(S) 10 2 Sick Old Old (75-84) P(D) P(H) 0 5 12 7 P(S) 8 4 18 6 P(S) 12 0 Healthy Old Old (75-84) P(D) P(H) 0 4 12 8 0 24 2 Oldest Old (85-94) P(S) P(D) P(H) 12 0 6 0 12 6 FEMALE MINUS MALE Young Old (65-74) 0 P(H) PLUS 4 MINUS 8 A sumplus 8 summinus 16 panel 5/21/2011 9 15 P(D) 0 12 5 P(S) 9 3 P(D) 0 12 85-94 P(H) 5 7 P(S) 8 4 P(D) 1 11 21 3 0 24 11 13 20 4 1 23 8 Differences between healthy and sick (Sick minus Healthy) F minus M 65-74 Old Old (75-84) B P(H) P(S) P(D) P(H) P(S) PLUS 6 9 0 8 12 MINUS 6 3 12 4 0 P(D) higher for men 24, 24,A23 cases = P(S) higher for F 18,21, 20 = S H S H P(H) is mixed, men higher original probabilities Sick Minus Healthy 65-74 0 P(H) PLUS 0 MINUS 12 PLUS 0 MINUS 12 resilience_25.sps 4-23-2011 0 sumplus 0 summin 24 34 25 21 23 P(D) 0 12 85-94 P(H) 9 3 71 59 of 72 of 72 44 of 72 P(S) 11 1 P(D) 0 12 7 P(S) 12 0 12 0 0 24 0 Old Old (75-84) P(D) P(H) 12 0 0 12 12 0 0 12 0 0 24 0 0 24 P(S) 12 0 12 0 0 24 0 35 Oldest Old (85-94) P(D) P(H) 12 0 0 12 12 0 0 12 0 0 24 0 0 24 P(S) 12 0 12 0 0 24 0 P(D) 12 0 12 0 0 24 0 Appendix Table 9 summary of age results Appendix Table 9 all_6_probs SUMMARY OF AGE RESTULTS 0 panel 5/21/2011 AGE Sick differences 3 PLUS MINUS PLUS MINUS P(H) DROP1 70-80 11 1 11 1 sumplus summinus 22 2 F M DROP2 80-90 DROPDROP 12 6 0 6 12 8 0 4 24 0 14 10 P(S) DROP1 70-80 0 12 3 9 3 21 12 12 2 22 DROP2 80-90 0 12 0 12 DIF 12 0 10 2 0 24 0 24 22 2 Healthy F M PLUS MINUS PLUS MINUS P(H) DROP1 70-80 12 0 12 0 age differences P(S) DROP2 DROP1 80-90 DROPDROP 70-80 12 1 1 0 11 11 12 1 1 0 11 11 DROP2 80-90 DROPDROP 6 1 6 11 6 1 6 11 P(D) DROP1 70-80 0 12 0 12 6 DROP2 80-90 DROPDROP 0 11 12 1 0 12 12 0 P(D) DROP1 70-80 0 12 0 12 DROP2 80-90 1 11 0 12 DIF 11 1 12 0 sumplus summinus 24 24 2 22 2 22 0 24 23 1 0 24 1 23 23 1 plusall minusall 46 2 48 0 16 32 5 43 12 36 25 23 0 48 1 47 45 3 DROP2 80-90 0 12 0 12 12 0 7 5 0 24 19 5 sick minus healthy P(H) DROP1 70-80 F PLUS 10 MINUS 2 M PLUS 11 MINUS 1 sumplus summinus 21 3 age diffs DROP2 0 80-90 DROPDROP 4 11 8 1 1 11 11 1 5 19 22 2 DROP1 70-80 4 8 7 5 DROP2 80-90 12 0 12 0 0 12 0 12 P(D) DROP1 70-80 0 12 0 12 11 13 24 0 0 24 0 24 36 Appendix Table 10 (was), summary for sex TABLE 4 SUMMARY OF SEX RESULTS, OVER 12 HEALTH VARIABLES 1 2 3 4 5 6 7 8 9 10 11 12 SEX Probabilities start sick 1 F>M 2 F<M 3 4 start healthy F>M F<M 5 6 sum over initial state F>M F<M 70 80 90 P(H) P(S) P(D) P(H) P(S) P(D) P(H) P(S) P(D) 4 10 0 5 12 0 6 12 0 8 2 12 7 0 12 6 0 12 P(H) P(S) P(D) P(H) P(S) P(D) P(H) P(S) P(D) 4 8 0 4 9 0 5 8 1 8 4 12 8 3 12 7 4 11 8 16 18 6 all_6_probs…. sheet 3 all_6_probs_plusprev 0 24 9 15 21 3 0 24 11 13 20 4 1 23 sum over age P(H) P(S) P(D) 15 34 0 21 2 36 13 23 25 11 1 35 28 44 59 13 1 71 Bolded cells significant by the sign test (p<.01). critical vals. are 11/12, 19/24, 27/36, 48/72, 34/48 37 Appendix Table 11 (was Table 5), Summary for Age Results Table 5 SUMMARY OF AGE RESULTS, OVER 12 HEALTH VARIABLES 1 Probabilities sick 5 6 11 12 13 14 F PLUS MINUS M PLUS MINUS F+M 7 healthy 8 9 10 S+H 3 4 P(H) SEX 1 2 3 4 2 PLUS MINUS F PLUS MINUS M PLUS MINUS 5 6 7 P(S) 8 9 P(D) a b c a b c a b c 70-80 80-90 b-a 70-80 80-90 b-a 70-80 80-90 b-a 11 12 6 0 6 1 0 0 12 1 0 6 12 6 11 12 12 0 11 12 8 3 6 1 0 0 10 1 0 4 9 6 11 12 12 2 0 0 0 22 24 14 3 12 2 0 0 22 2 0 10 21 12 22 24 24 2 12 0 12 0 12 0 12 0 1 11 1 11 1 11 1 11 0 12 0 12 11 1 12 0 F+M PLUS MINUS 24 0 24 0 2 22 2 22 0 24 23 1 all PLUS MINUS 46 2 48 0 16 32 5 43 12 36 25 23 0 12 0 12 0 0 24 0 0 48 1 11 0 12 0 1 23 0 1 47 11 1 12 0 0 23 1 0 45 3 Bolded cells are significant by the sign test (p<.01). Critical vals. are 11/12, 19/24, 27/36, 48/72, 34/48 a Age 70 minus Age 80 Positive ==> decline b Age 80 minus age 90 Positive ==> decline b-a Age (80 to 90) minus (70 to 80) Positive ==> steeper with age all_6_probs…. sheet 3 38 Appendix Table 12 interaction of healthy and gender appendix table 12 female HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK mean male HOSP BED SPL DEP ADL FLW EXSTR EVGG TWLK IADL COG BLK mean pd:s/pd:h 70 7.74 9.31 4.67 4.67 7.83 10.90 4.14 8.62 7.83 6.23 3.55 9.19 7.06 4.64 7.64 3.60 4.83 6.05 8.38 3.62 6.34 3.42 5.45 2.59 2.64 4.93 ` does "healthy" mean the same thing wrt death for men and women? pd:s/pd:h F-M F/M 80 90 70 80 90 70 80 4.96 3.00 3.101 0.125 -0.217 1.668 1.026 6.92 4.89 1.677 -1.643 0.643 1.220 0.808 3.55 4.28 1.075 -0.827 1.432 1.299 0.811 4.33 4.33 -0.168 -1.671 0.954 0.965 0.721 4.94 3.68 1.788 -1.114 0.388 1.296 0.816 7.40 6.51 2.519 -1.652 1.595 1.301 0.817 3.34 3.80 0.510 -1.483 0.032 1.141 0.692 5.15 3.70 2.279 0.019 0.038 1.359 1.004 4.41 9.32 4.416 0.119 5.845 2.292 1.028 3.12 2.48 0.780 -1.757 -0.667 1.143 0.640 3.69 3.01 0.964 0.480 0.202 1.372 1.150 5.16 3.37 6.552 1.114 -2.614 3.479 1.275 4.75 4.36 2.12 -0.69 0.64 1.54 0.90 4.84 8.57 4.38 6.00 6.05 9.05 4.82 5.13 4.29 4.88 3.21 4.05 5.44 3.22 4.25 2.85 3.37 3.29 4.91 3.77 3.66 3.48 3.15 2.81 5.98 3.73 not monotonic always > 1, s more likely to die than h ratio higher for women than for men in 2 age groups 39 90 0.933 1.151 1.503 1.283 1.118 1.325 1.009 1.011 2.681 0.788 1.072 0.563 1.20 Appendix Table 13, principal component/factor analysis Total Vari ance Expl ai ned Comp onent 1 2 3 4 5 6 7 8 9 10 11 12 Tot al 3.839 1.175 .994 .942 .819 .778 .646 .629 .594 .568 .524 .492 Initial Eigenvalues % of Variance Cumulative % 31.990 31.990 9.790 41.779 8.280 50.059 7.851 57.910 6.828 64.738 6.485 71.223 5.382 76.604 5.240 81.845 4.949 86.794 4.733 91.526 4.371 95.897 4.103 100.000 Extraction Sums of Squared Loadings Tot al % of Variance Cumulative % 3.839 31.990 31.990 1.175 9.790 41.779 Extraction M ethod: Princip al Component Analysis. Component Matrixa XD_bef YD_bef VG_BACK_BEF DP_bef FLW_bef XS-Bef TW_bef SPL_bef BD_bef CG-bef BK_BEF HP_bef Comp onent 1 2 .683 .664 .658 .630 -.369 .623 -.477 .607 .580 .388 .539 -.441 .481 .431 .416 .403 .355 Extraction M ethod: Princip al Comp onent Analy sis. a. 2 comp onents extract ed. 40 Rot ation Sums of Squared Loadings Tot al % of Variance Cumulative % 2.614 21.783 21.783 2.400 19.997 41.779 Rotated Component Matrixa TW_bef YD_bef XD_bef XS-Bef BK_BEF VG_BACK_BEF CG-bef FLW_bef DP_bef SPL_bef BD_bef HP_bef Component 1 2 .690 .673 .608 .349 .606 .579 .535 .391 .451 .773 .698 .690 .546 .336 Extract ion M ethod: Princip al Component Analysis. Rotation M ethod: Varimax with Kaiser Normalization. a. Rotation converged in 3 iterat ions. 41 REFERENCES 1 Diehr P, Patrick DL. Probabilities of Transition among Health States for Older Adults. Quality of Life Research 10:431-422, 2001. (PMID: 11763205) 2 Diehr P, O’Meara ES, Fitzpatrick A, Newman AB, Kuller L, Burke G. Weight, mortality, years of healthy life and active life expectancy in older adults. J American Geriatric Soc. 2008; 56:76-83. (PMID: 18031486) 3 Diehr P, Derleth A, Newman AB, Cai L. The number of sick persons in a cohort. Research on aging 2007; 29:555-575. (PMID: 17411436) 4 Hardy SE, Dubin JA, Holford TR, Gill TM. Transitions between states of disability and independence among older persons. American Journal of Epidemiology 2005; 575584. 5 Chin MH, Zhang JX, Rathouz PJ. Transitions in health status in older patients with heart failue. Southern Medical Journal 2003; 96:1096-1106. 6 Wolf D, Gill TM. Modeling transition rates using panel current-status data: how serious is the bias? Demography 2009; 46:371-387. 7 Hardy SE, Allore HG, Guo Zhenchao, Gill, TM. Explaining the effect of gender on functional transitions in older persons. Gerontology 2008; 54:79-86. 8 Beckett LA, Brock DB, Lemke JH, Mendes de Leon CF, Guralnik JM, Fillenbaum GG, Branch LG, Wetle TT, Evans DA. Analysis of change in self-reported physical function among older persons in four population studies. Am J Epidemiol. 1996 Apr 15;143(8):766-78. PMID:8610686 9 Leveille SG, Penninx BW, Melzer D, Izmirlian G, Guralnik JM. Related citations Sex differences in the prevalence of mobility disability in old age: the dynamics of incidence, resilience, and mortality. J Gerontol B Psychol Sci Soc Sci. 2000 Jan;55(1):S41-50. PMID: 10728129 10 Hoffman JM, Ciol MA, Huynh M, Chan L. Archives of physical medicine and rehabilitation.2010; 91:1849-1855. 11 Thielke S, Diehr P, Unutzer J. Prevalence, incidence, and persistence of major depressive symptoms in the Cardiovascular Health Study. Aging and Mental Health 2010; 14:168-176. (PMID: 20336548) 12 Whitson HE, Thielke S, Diehr P, O’Hare AM, Chaves PH, Zakai NA, Arnold A, Chaudhry S, Ives D, Newman AB. Patterns and predictors of resilience from exhaustion in older adults: the Cardiovascular Health Study. J Am Geriatr Soc. 2011. (PMID: 21288229) doi: 10.1111/j.1532-5415.2010.03238.x. [Epub ahead of print] 42 13 Fried LP, Borhani NO, Enright PL, et al. The Cardiovascular Health Study: design and rationale. Annals of Epidemiology 1991. 1:263-276. 14 Ives G, Fitzpatrick A, Bild D, et al. Surveillance and ascertainment of cardiovascular events: the cardiovascular health study. Annals of Epidemiology 1995. 15 Radoff LL. The CESD Scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1977. 1:385-401. 16 Andresen EM, Malmgren JA, Carter WB, Patrick DL. Screening for depression in well older adults: evaluation of a short form of the CES-D (center for Epidemiologic Studies Depression Scale). Am J Prev Med 1994;10:77-84. 17 Teng EL, Shui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 1987;48:314-8. 18 Diehr P, Yanez D, Derleth A, Newman Anne B. Age-specific prevalence and years of healthy life in a system with 3 health states. Statistics in Medicine 2008; 27:1371-1386. (PMID: 17847058) 19 Diehr P, Yanez D. Multi-state Life Tables, Equilibrium Prevalence, and Baseline Selection Bias (June 15, 2010). UW Biostatistics Working Paper Series. Working Paper 365. http://www.bepress.com/uwbiostat/paper365 20 Fries JF. The compression of morbidity. Milbank quarterly 2005; 83:801-823. 43