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Instructor: Office:
Dr. Mohammad Asif Hussain
Email: abujuveria@gmail.com
Bldg. 42B, Room: 320-B, Ext: 68093
Office Hours:
10 am – 11 am or by appointment
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Course Description:
Thermodynamics, biomolecular interactions, enzyme kinetics and bioenergetics. Biodesign, molecular modeling and case studies. Cellular warfare, bioreaction networks. Application examples and term project
Textbook:
1.
Molecular Cell Biology by H. Lodisch et al W.H.Freeman and Co., 2004.
2.
Enzyme Kinetics, by I.H.Segal Wiley Interscience, 1993.
3.
Comphrehensive Enzyme Kinetics by V. Leskovac Kluwer Academic/Plenum
Publishers, 2003.
4.
Thermodynamics and Kinetics For the Biological Sciences By G.G. Hammes,
Wiley Interscience, 2000.
Class Attendance:
Attendance is a must for all lectures, tutorials and will be strictly enforced.
Homework:
There will be home assignments (HW). Home assignments will be collected and graded
Exams:
There will be at least 3 quizzes/mini exams (it may be pre-announced or may be a surprise test).
No printed or written materials will be allowed in exams. There will be absolutely no make-ups for the missed exams.
Grading (subject to modification):
Attendance and Assignments
Quizzes/mini exams
Final Exam
Time Table:
Time Saturday
20%
20%
60%
Sunday Monday Tuesday Wednesday

9:30 am – 11:00 am
2:30 am – 4:30 am
Course Topics:
Lecture
Tutorial
Lecture
The following are the course outline covering the special topics. Students’ response to contents will determine the depth of the information on the given topic. Necessary background will be discussed to connect to the topic if needed.
Special Topics
Tools and Techniques of Molecular
Biology: (an Engineers perspective)
DNA / RNA, Structure (monomer, polymer, secondary structure), Replication,
Transcription, translation, bioinformatics,
NCBI, GenBank, Genetic Engineering
Biomolecular Interactions:
Thermodynamics of biomolecular interactions, noncovalent forces underlying bioenergetics: hydrogen bonding, van der Waals, hydrophobic effect, water in context of molecular recognition biomolecular stability.
Enzyme Kinetics:
Enzymes as Biological Catalysts, Enzyme
Activation, pH and Temperature Effects.
Reaction kinetics and enzyme energetics.
Bioenergetics:
Energetics of Biological Systems, Molecular
Recognition. Concepts of Free Energy,
Biodesign:
Rational Biotherapeutic Design: molecular modeling, computational approaches to predicting energetic.
Applications:
Biodegradable materials, Polymeric scaffolds for tissue engineering, applications. Design and production of biomaterials as biosensors. Nanoscale biosensors. Cellular warfare
By the end of lectures you will be able to

Understand and relate basics of genomics and proteomics

Describe how RNA, DNA and proteins are synthesized.

Demonstrate knowledge of current
NCBI suite of biological databases.

Describe the science of storing, extracting, organizing, analyzing, interpreting, and utilizing biological information.

Describe Enzymes as Biological
Catalyst and understand Enzyme
Activation

Describe Energetics of Biological
Systems, Molecular Recognition and understand Concepts of Free Energy,

Become familiar with bioenergetics: hydrogen bonding, van der Waals, hydrophobic effect, water in context of molecular recognition biomolecular stability and biomolecular modeling

Describe basic principles of protein structure including protein structure motifs, properties of alpha helices and beta sheets and protein folding.

Describe Rational Biotherapeutic
Design
Lecture
Hours
8
5
8
6
6
6