THE NINTH INTERNATIONAL WORKSHOP CONFERENCE “THE FUNDAMENTAL SCIENCE ACHIEVEMENTS IN THE URGENT MEDICINE PROBLEMS SOLUTION” May 6-8, 2013 Astrakhan, Russia ASTRAKHAN STATE MEDICAL ACADEMY Tel.: (8512) 524143; 525320; Fax: (8512) 525133 e-mail:agma@astranet.ru; dimax@astranet.ru Website: http://agma.astranet.ru 121 Bakinskaya Street 414000, Astrakhan, Russia EVENT ORGANIZERS: The Ministry of Health of the Russian Federation The Ministry of Health of the Astrakhan region The Ministry of Education and Science of the Astrakhan region Astrakhan State Medical Academy “Kurchatov Institute” National Research Centre The organizing committee Chairpersons: H.M.Galimzyanov, Astrakhan D.M.Nikulina, Astrakhan Co-chairpersons: A.A.Terentyev, Moscow V.P.Chekhonin, Moscow I.E.Kvyatkovsky, Astrakhan V.A.Gutman, Astrakhan Responsible secretary: M.Yu. Voronkova, Astrakhan Members: S.V. Suchkov, Moscow V.I. Griganov, Astrakhan S.A. Zurnadzhan, Astrakhan I.N. Polunin, Astrakhan L.G. Sentyurova, Astrakhan L.I. Naumova, Astrakhan N.N.Trizno, Astrakhan Yu.A.Kriventsev, Astrakhan O.V. Boyko, Astrakhan T.S. Kirillova, Astrakhan E.A. Kchibekov, Astrakhan Secretariat: M.V. Ramazanov T.A. Shishkina A.V. Tabolina I.O. Ostroverkhova I.I. Basangov General Information The registration of the conference and workshop participants will be held on the 5th of May from 10.00 till 16.00 at the Biochemistry Department of the Astrakhan State Medical Academy (20, Mechnikova Street) and on the 6th of May from 9.00 till 9.30 in the foyer of the main building of the Astrakhan State Medical Academy (121, Bakinskaya Street). Official languages of the scientific events: Russian, English Name badges Each conference and workshop participant is given a name badge for participation in scientific and cultural conference events. The opening of the conference “The fundamental science achievements in the urgent medicine problems solution” workshop conference opening ceremony will take place on the 6th of May at 10.00 in the assembly hall of the main building of the Astrakhan State Medical Academy. Scientific Papers Lecture duration: 40-60 min Detailed papers duration: 20-40 min Papers duration: 10 min Other oral presentations: 3-5 min Plenary meetings are held on the 6th of May (10.00 – 14.00), on the 7th of May (9.30 – 13.30), and on the 8th of May (15.30 - 17.00) Breakout sessions, subject seminars and panel discussions are held on the 7th of May (15.0018.00) and on the 8th of May (9.30 - 14.00) in the Astrakhan State Medical Academy lecture rooms. Poster Session The poster session is held on the 6th of May from 10.00 till 15.00. Speakers are to be near their stands from 11.40 till 12.20. The posters are to be placed on the stands with a number which corresponds to the number in the conference program. Young scientists’ conference is held on the 6th (7th) of May from 14.30 till 17.00 in the Astrakhan State Medical Academy lecture rooms. MAY 6, MONDAY The main building of the Astrakhan State Medical Academy 9.00 - 10.00 – the registration of participants OPENING CEREMONY 10.00 – 10.30 - Welcoming speeches on the occasion of scientific events opening: THE 1ST PLENARY MEETING 10.30 – 14.00 Introduction to the predictive preventive and personalized medicine: experience of the past and future realities. S.V. Suchkov, Moscow, Russia; Brussels, EU Aging and happiness as applicable PPPM to patients in geriatric health and welfare facilities in Japan. MasakiTan, Japan Apoptosis products influence on the migration of mesenchymal stem cells and on the activity of cardiac hystiocytes precursors. A.I.Tyukavin, St.Petersburg, Russia Molecular Targeting in Translational Drug Design – «The Science of Safety». TrevorMarshall, USA Interferon inductors: promising class of medicines for clinical use. M.G.Romantsov, St. Petersburg, Russia The paper title is specified DrPhilippCotter, PhD, USA The paper title is specified A.S.Simbirtsev, St.Retersburg, Russia The paper title is specified S. Slavin, Israel DNA aptamers as therapeutic agents. V.A. Spiridonova, Moscow, Russia 14.00 - 15.00 – lunch POSTER SESSION 10.00 – 15.00 1.Webinars as a new element of educational noosphere. Odessa State Medical University V.I. Chernya, Odessa State Medical University, Ukraine 2.Thanatogenesis evaluation within the first day after the injury and the iatrogenic pathology influence on this process. Yu.A. Zbrueva Astrakhan State Medical Academy of the Ministry of Health of the Russian Federation. 3.Polyelectrolyte complexes of aptamer DNA to thrombin K.A.Glinkina Belozersky Institute of Physico-Chemical Biology MSU 4.Coupled processes of insulinotropic interaction and EPR- spectroscopy in experimental diabetes. A.E.Gurina, N.P.Mikaelyan North Ossetian State Medical Academy of the Ministry of Health of the Russian Federation, Vladikavkaz, Russia Pirogov Russian National Research Medical University Academy of the Ministry of Health of the Russian Federation, Moscow, Russia Coupled processes of insulinotropic interaction and EPR- spectroscopy in experimental diabetes. A.E.Gurina, Vladikavkaz, Russia 5. Biophysical mechanisms of intraocular fluid transport in the rabbit eye. L.V. Stepanova, Siberian Federal University, Krasnoyarsk, Russia G.M. Sychev, Abakan Medical College, Abakan, Khakassia, Russia 6.Combination therapy influence on metabolic and functional rates in patients with IHD. O.Yu. Garmash, S.G. Dzugkoev, E.A.Takoeva, V.T.Driaev, F.S. Dzugkoeva, Vladikavkaz, Russia 7.Biochemical and functional rates of endothelial function disorder during toxic angiopathy in experiment. E.A.Takoeva, I.V.Mozhaeva, L.V.Gigolaeva, V.T.Driaev, F.S.Dzugkoeva 8.Clinical resources of proteomics: protease antibodies as potential targets and diagnostic clinical instruments in future personalized protocols. M.Studneva, P.Antonov. I.M.Sechenov First Moscow State Medical University, Moscow, Russia 9.Immunotropic effect of Nelumbo nucifera extract during the experimental dislipidemia. E.I.Kondratenko, A.A. Boni, N.A. Lomteva, Astrakhan, Russia YOUNG SCIENTISTS CONFERENCE 15.30-18.30 Thrombin and prothombin interaction with aptamer DNA. K.V.Barinova A.N. Belozersky Institute of Physico-Chemical Biology MSU The study of Nelumbo nucifera pharmacological activity N.A. Lomteva 1, E.I. Kondartenko 1, M.A. Samotrueva 2 1 Astrakhan State University, Astrakhan, Russia 2 Astrakhan State Medical Academy of the Ministry of Health of the Russian Federation, Astrakhan, Russia Change of heart tissue mitochondrial enzymes activity under the condition of nitrogen oxide (II) synthesis deficit modeling. V.I.Zvyagina, E.S.Belskikh, D.V.Froltsov Ryazan State Medical University, Ryazan, Russia (young scientists) Biochemical markers of hemodynamic disorders and internals pathology in diabetes. Prospects of correction. S.G. Dzugkoev, D.M. Nikulina, I.V. Mozhaeva Institute for Biomedical Research, Vladikavkaz Scientific Centre of Russian Academy of Sciences and the Government of the Republic of North Ossetia-Alania (young scientists) Translational cellular immunotherapy in kidney transplantation A.V. Vatazin, A.V. Kildyushesky, V.A. Fedulkina, A.B. Zulkarnaev, A.Ya. Olshansky, R.O. Kantariya M. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia (young scientists) May 7, Tuesday CEREMONIAL PLENARY MEETING, devoted to the 50th anniversary of the first tumor markers discovery and to memory of professor Yu.S.Tatarinov. The residence of the Governor of the Astrakhan region. 9.30 – 13.30 A 50-year study of alpha-fetoprotein as an oncobiomarker. A.A. Terentyev, corresponding member of the Russian Academy of Medical Sciences, Russian National Research Medical University Clinical value of alpha-fetoprotein in viral hepatitis. B.P. Bogomolov, corresponding member of the Russian Academy of Medical Sciences, State Medical University of the General Affairs Department of the President of the Russian Federation, Lomonosov Moscow State University Selective drug delivery into tumor cells with the use of alpha-fetoprotein. (The use of alphafetoprotein for selective drug delivery into tumor cells) E.S. Severin, corresponding member of the Russian Academy of Sciences V.P.Chekhonin, academician of the Russian Academy of Medical Sciences, Russian National Research Medical University Biomarkers in the pregnancy monitoring and newborn child health prediction. D.M. Nikulina, Astrakhan State Medical Academy Biomarkers of Brain Diseases: A Metabolomic Approach. AfafEl-Ansary, Saudi Arabia The paper title is specified Yu.P. Reznikov, Moscow, Russia Modern biomarkers of myocardial injury. Yu. A. Morozov, Moscow, Russia Biomarkers in oncology - the present and perspectives. Ondrej Topolcan, Czech Republic Investigation of LDH in breast cancer patients. Vladimir Jurisic, Kragujevac and Belgrade, Serbia Biomarkers in kidney cancer diagnostics. Yu.E.Nikolsky, N.B. Zakharova, A.N. Ponukalin, Chehonatskaya. Saratov, Russia The unveiling of the Yu.S.Tatarinov memorial plaque on the academy building. 14.00 BREAKOUT SESSIONS, SUBJECT COURSE 15.00-18.00 May 8, Wednesday BREAKOUT SESSIONS, PANEL DISCUSSION, SUBJECT COURSE 9.30-14.00 PAPERS AND WRITTEN SPEECHES ON THE BREAKOUT SESSIONS AND PANEL DISCUSSION Hepatocyte apoptosis under the influence of antitubercular drugs of the basic series and its correction with hepatoprotectors. E.D. Bazhanova, D.S.Sukhanov, Yu.O.Kozlova, D.L.Teply “POLISAN” Scientific Technological Pharmaceutical Firm St. Petersburg, Russia Herpetic infection and hypercholesterolemia V.N. Khlyustov “APO-B” Company “Zagorskie dali” health resort of the General Affairs Department of the President of the Russian Federation, Moscow Glomerular affection index in the evaluation of glomerular function in surgical patients. M.A.Charnaya, Yu.A.Morozov Moscow, Russia Hypoglycemia progress in rats after insulin high dose injection. P.P. Potapov, P.K. Telushkin, N.B. Medvedeva, A.Yu. Stelmakh, Yaroslavl, Russia The study of inhibition effectiveness of carboxyanhydrase 9 – potential biomarker for tumors developing during scarcity of oxygen. K.V. Bolaeva, Elista, Russia Change of blood free radical oxidation rates in patients with diminished function of thyroid gland. A.A. Basov, K.I. Melkonyan, I.M. Bykov, E.E. Esaulenko, T.V. Eremina. Krasnodar, Russia On fatty hepatosis in convalescents of hemorrhagic fever with renal syndrome. B.A.Ibragimov, Ufa, Russia. Webinars as a new element of educational noosphere. Webinar role in accumulation of practical clinical experience and mental outlook formation of doctors. E.A. Yakimenko, O.Ya. Tyagay, V.V. Dets, V.S. Biryukov, O.E. Kravchuk, D.A. Oleynik, N.N. Antipova, V.V. Tbileli, L.I. Danilchenko, E.S. Chernyshova Odessa State Medical University. May 8, Wednesday THE SECOND PLENARY MEETING 15.30 – 17.30 Prophylaxis and healthy life-style. Risk factors of the chronic noninfectious diseases progression. K.G. Gurevich, Moscow, Russia; UNESCO (head of the department of UNESCO in Moscow State University of Medicine and Dentistry) Prospects of the use of genomic texts conformational analysis in personalized medicine. G.E. Pozmogova, Moscow, Russia Molecular mechanisms of hepatotropic drugs effects. S.V.Okovitiy, St. Petersburg, Russia Proteomics potential and results of proteomic studies transfer into the neuropathologist’s and preventologist’s practice. S.V. Suchkov, Moscow, Russia. The use of bioinformatics by preventologist. Predictive preventive personalized medicine from the perspective of heart information function. V.M. Uspensky. Moscow, Russia Preventive health care strategy in the modern armed forces: the programs of predictive and pre-clinical diagnostics in adaptive resource monitoring and its realization in emergency situations. V.B. Simonenko, N.I. Syuch Molecular genetic mechanisms of apoptosis of hypothalamus neuroendocrinal system during the aging. E.D. Bazhanova, St. Petersburg, Russia. May 7-8 Subject course: The ways of realization of the predictive, preventive and personalized medicine (PPPM) as a modern paradigm of public health. 1. Introduction to PPPM 2. Gemonics as a principle of PPPM 3. Genomic texts in personalized medicine 4. Modern technologies of medical genetics. 5. Proteomicts as a principle of PPPM 6. Biomarkers and biopredictors in PPPM. 7. Principles of immune system functional architectonics and of pharmacotherapeutic targets selection. 8. Postinfectious autoimmune syndrome from preventologist’s point of view. 9. Diabetes – prediction and prevention. Disseminated sclerosis - prediction and prevention. 11. Modern protocols of pharmacopreventive and medical therapy through the example of disseminated sclerosis. 12. PPPM and autoimmune diseases of gastrointestinal tract. 13. PPPM in oncologist’s practice. Protease antibodies as potential targets and diagnostic clinical instruments in future personalized protocols. M.Studneva1, M.Levitan2, D.Gnatenko1,3, P.Antonov6, A.Gabibov4, S.Suchkov1,4,5. 1 I.M.Sechenov First Moscow State Medical University, Moscow, Russia 2 Astrakhan State Medical Academy, Astrakhan, Russia 3 The Vishnevsky Institute of Surgery of the Russian Academy of Medical Sciences, Moscow, Russia 4 Institute of Bioorganic Chemistry of the Russian Academy of Sciences 5 EPMA. Brussels, EU 6 A.M. Gorky Educational Centre, Moscow, Russia OMITTED PAPERS 1.Change of heart tissue mitochondrial enzymes activity under the condition of nitrogen oxide (II) synthesis deficit modeling. V.I.Zvyagina, E.S.Belskikh, D.V.Froltsov Ryazan State Medical University, Ryazan, Russia (young scientists) 2. L- arginine influence on endothelial tissue function rates during the diabetes in experiment. S.G. Dzugkoev, D.M. Nikulina, I.V. Mozhaeva Institute for Biomedical Research, Vladikavkaz Scientific Centre of Russian Academy of Sciences and the Government of the Republic of North Ossetia-Alania (young scientists) 3.Remote course to support in-class learning in biochemistry. S.M.Ershikov Yaroslavl State Medical Academy, Yaroslavl, Russia (panel discussion) 4. Rates of bone strength and risk of fractures in workers of soda production chemical enterprise. I.A. Menshikova, F.H. Kamilov, G.V. Ivanova Bashkortostan State Medical University of the Ministry of Health of the Russian Federation, Ufa, Russia 5.Dynamics of serum aspartate transaminase after different methods of liver wound closure in experiment. O.V. Musatov Astrakhan State Medical Academy, Astrakhan, Russia (breakout session) 6.Clinical significance of mutational and immunogenotypic status in patients with chronic myeloleukemia. E.G.Ovsyannikova, E.A.Popov, L.V.Zaklyakova, B.N.Levitan, K.D.Kaplanov Astrakhan State Medical Academy of the Ministry of Health of the Russian Federation, Astrakhan, Russia (breakout session) 7. Translational cellular immunotherapy during the kidney transplantation A.V. Vatazin, A.V. Kildyushesky, V.A. Fedulkina, A.B. Zulkarnaev, A.Ya. Olshansky, R.O. Kantariya M. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia (young scientists) 8. Elements of constructive pedagogics to improve effectiveness of educational process. M.G. Romantsov, I.Yu.Melnikova, St.Petersburg, Russia