Gradients in Distribution of HLA-DRB1(star) Alleles in Castes and Tribes
of South India
By:Balakrishnan, K (Balakrishnan, K.)[ 1 ] ; Rathika, C (Rathika, C.); Kamaraj, R (Kamaraj, R.); Subashini, R (Subashini,
R.)[ 4 ] ; Saravanan, MP (Saravanan, M. P.)[ 2 ] ; Asha, KV (Asha, K. V.)[ 4 ] ; Kananan, M (Kananan, M.)[ 3 ] ; Kumar,
RV (Kumar, R. Vinoth)[ 4 ] ; Manikandan, T (Manikandan, T.)[ 4 ] ; Dhivakar, M (Dhivakar, M.)...More
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INTERNATIONAL JOURNAL OF HUMAN GENETICS
Volume: 12
Issue: 1
Pages: 45-55
Special Issue: SI
Published: MAR 2012
View Journal Information
Abstract
In the present study 520 individuals comprising eleven different populations (castes and tribes) from the states of Tamil
Nadu and Kerala, South India were genotyped for HLA-DRB1* allele profile by PCR-SSP method. HLA DRB1*15
(subtype of DR2) was the allele consistently showing higher frequency in all populations studied. HLA DRB1*15
revealed a highest frequency in Kani tribe (45.19%) and the lowest frequency in Narikkuravars (Gypsies) (1.02%). The
other predominant alleles based on their order of frequencies observed in each population were DRB1*10, 07 and 15
among lyers; DRB1*07, 04, 15 and 08 among Kallars; DRB1*03 and I 0,among Vanniyars and Vettuva Gounders;
DRB1* 07 and 10 among Sourashtrans; DRB1*07 and 04 among Pallars; DRB1*04, 03,07 and 11 among
Narikkuravars; DRB1*03 among Paliyar and Kani tribes; DRB1*13, 10, 04, 14 among Nairs; DRB1*10, 01, 13 and 11
among Namboothiris of Kerala. Alleles such as DRB1*01, 08, 09, 11, 12, 14 and 16 were either present in low
frequencies or completely absent in many of the south Indian populations studied. Predominantly Caucasian allele
DRB1*01 was present in higher frequencies in Namboothiris (12.85%) and Narikkuravars (8.53%) only. Allele DRB1*01
frequency in all other populations is significantly low. However, alleles DRB1*07 was present in many populations with
higher frequencies (highest in Kallars with 23.58%). This could have been due to the higher prevalence of HIV/TB
infectious and the presence of ancestral haplotype 57.1 in Indian populations. Implications of this differential distribution
of these HLA-DRB1*alleles in different castes and tribes of South India are discussed in the context of high prevalence
of infectious diseases such as AIDS and TB.
Keywords
Author Keywords:HLA DRB1 Alleles; South India; Castes and Tribes; Disease Associations; Phylogenetic Analysis
KeyWords Plus:RHEUMATOID-ARTHRITIS; HLA ANTIGENS; TAMILNADU; POPULATION; HAPLOTYPES; ASSOCIATION; PCR; IDENTIFICATION;HETEROGENEITY; FREQUENCIES
Author Information
Reprint Address: Balakrishnan, K (reprint author)
Madurai Kamaraj Univ, Sch Biol Sci, Dept Immunol, Madurai 625021, Tamil Nadu, India.
Addresses:
[ 1 ] Madurai Kamaraj Univ, Sch Biol Sci, Dept Immunol, Madurai 625021, Tamil Nadu, India
[ 2 ] KAPV Govt Med Coll, Tiruchchirappalli, Tamil Nadu, India
[ 3 ] Bharathidasan Univ, Dept Environm Biotechnol, Tiruchchirappalli 620024, Tamil Nadu, India
[ 4 ] Bharathidasan Univ, Dept Biotechnol, Tiruchchirappalli 620024, Tamil Nadu, India
E-mail Addresses:immunobala@rediffmail.com
Publisher
KAMLA-RAJ ENTERPRISES, 2273, GALI BARI PAHARWALI, CHAWRI BAZAR, DELHI, 00000, INDIA
Categories / Classification
Research Areas:Genetics & Heredity
Web of Science Categories:Genetics & Heredity
Document Information
Document Type:Article
Language:English
Accession Number: WOS:000304333300009
ISSN: 0972-3757
Other Information
IDS Number: 946EC
Cited References in Web of Science Core Collection: 62
Times Cited in Web of Science Core Collection: 0