MAN (Melody) LUO
110 Misty Woods Circle, Apt T  Chapel Hill, NC 27514
919-360-6824  mluo@email.unc.edu
HIGHLIGHTS Two years of industry experience in GlaxoSmithKline (clinical and preclinical training).
Four years of graduate training at UNC in model-based drug discovery and development.
Excellent communication and proven leadership skills.
EDUCATION
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL,
Chapel Hill, NC
ESHELMAN SCHOOL OF PHARMACY
Ph.D. in Pharmaceutical Sciences, expected in May 2011.
Certificate in Bioinformatics and Computational Biology, expected in May 2011.
WUHAN UNIVERSITY, CHINA
BS in Biotechnology, Jun 2007.
SKILLS
Wuhan, China
NONMEN, R/S-plus, WinBUGS, SAS, MATLAB, Python, Java, C++, SQL, UNIX
EXPERIENCE GLAXOSMITHKLINE
RTP, NC
Aug. 10 ~ Present Co-op at Clinical Pharmacology Modeling & Simulation Group. Working in multidisciplinary development teams with physicians, statisticians, and clinical pharmacologists.
 Applied population PK and PK/PD modeling/simulation to aid in dose selection and
covariate identification for Phase IIa study using WinNonlin and NONMEN.
 Conducted literature meta-analysis of a viral dynamic model on short-term vs. long-term
change for a FTIH anti-viral agent.
May 10 ~ Jul. 10
Intern at Clinical Pharmacology Modeling & Simulation Group. Collaborating with crossfunctional matrix/project team members, including clinical virologists, computational chemists
and computational biologists, to inform decisions at clinical development milestones.
 Achieved over 80% prediction accuracy when mapping genotypes with phenotypes of an
anti-viral agent project, which will aid patient recruitment process for the phase IIb study.
 Accurately predicted all significant substitutions to resistant mutations by models and
identified viral genetic evolutionary mutation patterns using R packages.
Aug. 09 ~ Oct. 09 Co-op at Computational and Structural Chemistry Group. Effective collaborating and
building relationships between academic labs at UNC and industrial project teams in GSK.
 Validated the academic developed approach CoLiBRI, a structural-based virtual screening
methodology, against GSK in-house docking/scoring data set.
May 09 ~ Jul. 09
Summer intern at Computational and Structural Chemistry Group. Working closely with
crystallographers and data management experts for database curation and SAR analysis.
 Identified and curated 176 files out of over 4,000 GSK in-house protein structural files in
PDB and XML formats, with automated workflow conducted in Python scripts.
 Evaluated the predictive power of Free-Wilson analysis for structure-activity relationships,
with robust statistical summaries drawn from most of the data serious examined.
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Chapel Hill, NC
Aug. 08 ~ Present Research Assistant in Eshelman School of Pharmacy.
 Identified nanomolar potent 5-HT1A inhibitors using model-based drug discovery methods
and virtual screening approach.
 Discovered the false positives for HTS assays data in PubChem using quantitative structure
-activity relationship (QSAR) models, with results supported by experimental tests.
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Aug 07 ~ May 09
Sep. 05 ~ Jun. 07
Jun. 05 ~ Aug. 06
Identified pharmacophore for RecA inhibitors, built QSAR models and conducted virtual
screening for RecA inhibitors with novel scaffold.
Validated and compared the predictive accuracy of QSAR models for multi-target profile
predictions with several other popular algorithms.
Evaluated the coformulation feasibility of INH and SMX-TMP for HIV patients with TB.
Applied FFSM algorithm to aid structural classification of proteins by mining common 3D
spatial motifs among proteins with similar sequences, and validated the convergent
evolutionary relationships between two pairs of proteins with distinct sequence similarity.
Teaching Assistant in Eshelman School of Pharmacy.
Lecturing, grading and holding office hours for some Pharm. D. core courses.
WUHAN UNIVERSITY
Wuhan, China
Research Assistant in College of Life Sciences.
 Developed a novel assay to examine the onset of tumor or cancer by detecting telomerase
activity based on Rolling Circle Amplification (RCA) technique.
 Corporately worked on the study to elucidate the catalytic mechanism of the “10-23”
RNA-cleaving DNAzyme on various ionic conditions.
ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY
Wuhan, China
Clinical Assistant in Department of Hematology.
 Assisted the discovery that FANCF gene methylation is a rare event in hematological
malignancies by collecting blood samples from patients with AML and MDS, obtaining the
genomic DNA and performing the HpaII restriction enzyme digestion.
PUBLICATIONS AND SYPOSIUMS
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Bi-feng Yuan, Man Luo, Zheng Tan. et al. "Two DNAzymes targeting the telomerase mRNA with large
difference in Mg2+ concentration for maximal catalytic activity. Effect of flanking sequence on RNA
cleavage by DNAzyme". Int. J. Biochem. Cell Biol. 2007; 39(6):1119-1129
Man Luo, Alex Tropsha. et al. “Combinatorial QSAR analysis of RecA inhibitors and QSAR-based virtual
screening”. The 239th American Chemical Society National Meeting, San Francisco, CA, Mar. 2010.
Man Luo, Alex Tropsha. et al. “The use of QSAR models to validate the HTS assay data in PubChem:
Application to the serotonin receptor 5-HT1A Ligands”. The 239th American Chemical Society National
Meeting, San Francisco, CA, Mar. 2010.
Man Luo, Alex Tropsha. et al. “Combinatorial QSAR analysis of 5-HT1A receptor binders and application
of resulting models to virtual screening” The 239th American Chemical Society National Meeting, San
Francisco, CA, Mar. 2010.
Fei Chen, Man Luo. et al. "FANCF Gene Methylation is a Rare Event in Hematological Malignancies".
The 18th Annual Fanconi Anemia Research Fund Scientific Symposium, North Bethesda, MD, Oct. 2006.
The 45th American Society of Clinical Oncology (ASCO) Annual Meeting, Orlando, FL, May 2009.
The 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, Apr. 2008.
ADDITIONAL INFORMATION
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Secretary of the American Association of Pharmaceutical Sciences (AAPS) Pharmacogenomics Focus
Group (2010 ~ 2011).
Member of the Advisory Committee for Strategic Planning and Internationalization in Eshelman School of
Pharmacy, UNC (2008 ~ 2011, Chapel Hill, NC).
National Science Foundation travel grant for Cyberinfrastructure workshop (2010,Denver,CO).
Host of Tri-school Karaoke Competition for Chinese Students and Scholars(2007,Raleigh,NC).
REFERENCES available upon request