OFFICE FOR HEALTH AND MEDICAL RESEARCH EXPRESSION OF INTEREST (EOI) FORM GENOMICS COLLABORATIVE GRANTS PROGRAM 2014 DEADLINE 5PM 25th August 2014 SECTION A – ADMINISTRATIVE SUMMARY A.1 Application Title Provide a short descriptive title (maximum 200 characters including spaces). A.2 Administering Institution Administering Institution Details Institute Name A.3 Administering Institution Contact Select a Title: Choose a Title Family Name: Given Name: Postal Address: Genomics Collaborative Grants Program 2014 Telephone: Mobile: Email: A.4 Chief Investigator Details Select a Title: Choose a Title Family Name: Given Name: Postal Address: Telephone: Mobile: Email: Are you an Australian Citizen/ Permanent Resident? Are you located in New South Wales? YES YES ☐ ☐ NO NO ☐ ☐ SECTION B – PROJECT PROPOSAL B.1 Lay Project Summary In lay terms summarise the application referring to aims, significance and expected outcomes suitable for NSW Health website and media releases (maximum 2500 characters including spaces). Guidelines 2|Page Genomics Collaborative Grants Program 2014 B.2 Short Form Proposal Summarise the application referring to aims, significance and expected outcomes. Please include how the project meets the aims and use the guidelines under each heading (maximum 500 words each): 1. Objectives, design and expected outputs and outcomes (50%) This should include an outline of the study design under the following headings: Aims and Objectives, Background, Research Plan, Analysis, Specific Outputs, Expected Outcomes. Responses should correspond with the Selection Criteria. It should include a description of the nature and number of bio-specimen samples to be sequenced, any tests already done, patient information linkages, subject selection criteria and any other relevant information. Short Form Proposal (500 Word Cap): Guidelines 3|Page Genomics Collaborative Grants Program 2014 2. Significance of the Expected Outcomes and/or Innovation of the Concept (25%) Outline the clinical relevance of the project and the likely impact it will have on clinical practice in NSW, Australia and the world. Proposals should focus on areas of substantial research need and benefit, where the outcomes are anticipated to be feasible for adoption into the health system. Briefly outline how the proposal will sit in the ‘bench to bedside’ continuum for research translation. Provide a brief analysis as to how the impacts of the project as described will deliver ‘value for money’ in the health system. Short Form Proposal (500 Word Cap): Guidelines 4|Page Genomics Collaborative Grants Program 2014 3. Team Quality and Capability, relative to opportunity (25%) The expertise and experience of the research team relevant to the project, their collaborative potential and potential collaborators and success in obtaining and delivering past grant funding. An overview of previous achievements of the team and/or of collaborative effort of team members should be provided. Short Form Proposal (500 Word Cap): SECTION C – BIOINFORMATICS AND GENOME SEQUENCES C.1 Requested Bioinformatics Services and Genome Sequence amounts. ITEM DETAILS NUMBER OF SEQUENCES COMMENTS DETAILS SERVICE SOURCE COMMENTS Whole Genome Sequencing at the Garvan Institute ITEM Bioinformatics services (indicate if sourced from the Garvan or elsewhere) Guidelines 5|Page Genomics Collaborative Grants Program 2014 SECTION D – ETHICS AND CONSENT D.1 Ethics Please outline whether ethics approval has been obtained; If yes – Please include which ethics committees have approved the project, If there are any conditions attached to the approval, please outline these as well. If no – Please outline your plan for ethics approval. D.2 Patient Consent Please outline whether patient consent has been obtained; If yes – for what components of the project and in what capacity. If no – Please outline your plan for gaining patient consent and what it will cover. SECTION E – PROJECT FUNDING E.1 Does the project have funding secured? If yes – list sources If no – Please outline how will funding be secured for the remainder of the project? Guidelines 6|Page