Organ Transplant Policy Comparison I. Small Bowel 2/8/2016 Full Coverage Details BCBS A.) A small bowel transplant using cadaveric intestine may be considered medically necessary in adult and pediatric patients with intestinal failure (characterized by loss of absorption and the inability to maintain protein-energy, fluid, electrolyte, or micronutrient balance), who have established long-term dependency on total parenteral nutrition (TPN) and are developing or have developed severe complications due to TPN. B) A small bowel transplant using a living donor may be considered medically necessary only when a cadaveric intestine is not available for transplantation in a patient who meets the criteria for a cadaveric intestinal transplant. B.) Small bowel/liver transplant or multivisceral transplant may be considered medically necessary in pediatric and adult patients with intestinal failure (characterized by loss of absorption and the inability to maintain protein-energy, fluid, electrolyte, or micronutrient balance), who have who have been managed with total parenteral nutrition (TPN) and have developed evidence of impending end-stage liver failure. Medicaid a. Short bowel syndrome, with documented long-term TPN therapy and severe complications from TPN b. Multiple and prolonged hospitalizations to treat TPN-related complications c. Progressive, reversible liver failure d. A small bowel/liver multi-visceral transplant with short bowel syndrome with documented long-term TPN therapy with development of impending end stage liver failure Organ Transplant Policy Comparison II. Small Bowel 2/8/2016 Coverage Exclusion BCBS When the criteria listed above has not been met. A small bowel transplant is considered investigational for adults who are able to tolerate TPN. BCBSNC does not cover investigational services. Medicaid 4.1 Non-Covered Conditions The N.C. Medicaid program does not cover small bowel (intestinal), small bowel/liver, and multivisceral transplants when one of the following conditions exists (not all inclusive): a. Cardiovascular disease (ejection fraction < 40%, myocardial infarction within last six months) b. Age greater than 70 years old c. Psychosocial history that would limit ability to comply with medical care pre- and post-transplant d. Current patient and/or caretaker non-compliance that would make compliance with a disciplined medical regime improbable e. History of or active substance abuse—must have documentation of substance abuse program completion plus six months of negative sequential random drug screens *Note: To satisfy the requirement for sequential testing as designated in this policy, the Division of Medical Assistance (DMA) must receive a series of test (alcohol and drug) results spanning a minimum six-month period, allowing no fewer than a threeweek interval and no more than six-week interval between each test during the given time period. A complete clinical packet for prior approval must include at least one documented test performed within one month of the date of request to be considered. f. HIV positive g. Multi-organ failure h. Congenital immunodeficiency i. Advanced neurological disorders (neuroaxonal dystrophy, Tay-Sachs, Niemann-Pick disease, etc.) j. Chronic hepatitis k. Malignancy (primary or metastatic) patients with a history of cancer with remission less than 5 years l. Combining bone marrow infusion with intestinal allograft irradiation to prevent allograft rejection 4.2 Donors Living donor expenses are not covered for a small bowel or multi-visceral transplant. Organ Transplant Policy Comparison III. Small Bowel 2/8/2016 BCBS Policy Guidelines Cases requesting approval for transplants will be reviewed to determine medical necessity according to the Plan as outlined in this policy provided the certificate does not exclude benefits for Small Bowel Transplant, Small Bowel with Liver, or Multivisceral. IV. Medicaid Policy Guidelines None.