DONG SONG
Department of Biomedical Engineering
Center for Neural Engineering
University of Southern California
403 Hedco Neuroscience Building
Los Angeles, California 90089-1451
Tel: (213) 740-8063, Fax: (213) 740-5687
Email: dsong@usc.edu
Professional Experience:
2006-present
Research Assistant Professor
Hippocampal-Cortical Neural Prostheses, Experimental,
Mathematical Modeling Studies of Hippocampus
Center for Neural Engineering
University of Southern California
Los Angeles, California
Theoretical
and
2004-2006
Post-doctoral Research Associate
Experimental, theoretical and mathematical modeling studies of hippocampus
Center for Neural Engineering
University of Southern California
Los Angeles, California
1999-2003
Research Assistant
Nonlinear systems analysis, computer modeling of hippocampal neurons and in vitro
electrophysiological studies on hippocampal slices
Department of Biomedical Engineering
University of Southern California
Los Angeles, California
1998-1999
Research Assistant
Anatomy of hippocampus
University of Iowa
Iowa City, Iowa
1993-1994
Undergraduate Research
In vivo electrophysiological recording from anesthetized cats
University of Science and Technology of China
Hefei, Anhui, P. R. China
Education:
1999-2003
1998-1999
University of Southern California, Los Angeles
Ph.D. degree: Biomedical Engineering
Dissertation: Parametric and non-parametric models of short-term synaptic plasticity
Advisor: Dr. Theodore W. Berger
University of Iowa, Iowa City
Ph.D program: Anatomy and Cellular Biology
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1989-1994
University of Science and Technology of China, Hefei, China
B.S. degree: Biological Sciences (Biophysics)
Research Interests:
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Hippocampal-cortical cognitive neural prostheses
Nonlinear dynamic multiple-input, multiple-output modeling of physiological system
Combined parametric and non-parametric modeling of physiological systems
Realistic and mechanistic modeling of neurons and neuronal networks
Mechanisms of short-term and long-term synaptic plasticity
Competent Techniques:
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Nonlinear systems analysis
Statistical modeling of nervous system
Compartmental modeling of neurons
Extracellular, intracellular and whole-cell patch clamp recording techniques
Journal Papers:
1. Theodore W. Berger, Dong Song, Robert E. Hampson, Andrew J. Sweatt, Rosa H.M. Chan, Jack
Wills, Jeff LaCoss, Greg A. Gerhardt, John J. Granacki, , Dae C. Shin, Vasilis Z. Marmarelis, and
Sam A. Deadwyler (2012) REMIND: A Program to Develop a “Restorative Encoding Memory
Integrative Neural Device” as a Cognitive Neural Prosthesis. IEEE Engineering in Medicine and
Biology Magazine, in press.
2. Theodore W. Berger, Dong Song, Rosa H.M. Chan, Vasilis Z. Marmarelis, Jeff LaCoss, Jack
Wills, Robert E. Hampson, Sam A. Deadwyler, and John J. Granacki (2012) A Hippocampal
Cognitive Prosthesis: Multi-Input, Multi-Output Nonlinear Modeling and VLSI Implementation.
IEEE Transactions on Neural Systems and Rehabilitation Engineering, in press.
3. Robert E. Hampson, Dong Song, Rosa H.M. Chan, Andrew J. Sweatt, Joshua Fuqua, Greg A.
Gerhardt, Vasilis Z. Marmarelis, Theodore W. Berger, and Sam A. Deadwyler (2012) A
Nonlinear Model for Cortical Prosthetics: Memory Facilitation by Hippocampal Ensemble
Stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering, in press.
4. Robert E. Hampson, Dong Song, Rosa H.M. Chan, Andrew J. Sweatt, Mitchell Riley, Anushka
Goonawardena, Vasilis Z. Marmarelis, Greg A. Gerhardt, Theodore W. Berger, and Sam A.
Deadwyler (2011) Closing the Loop for Memory Prostheses: Detecting the Role of Hippocampal
Neural Ensembles using Nonlinear Models. IEEE Transactions on Neural Systems and
Rehabilitation Engineering, in press.
5. Will X. Y. Li, Rosa H. M. Chan, Wei Zhang, Ray C. C. Cheung, Dong Song, Theodore W.
Berger (2011) High-performance and Scalable System Architecture of Generalized LaguerreVolterra MIMO Model for Neural Population Spiking Activities. IEEE Journal on Emerging and
Selected Topics in Circuits and Systems, (pp: 99), 1-1.
6. Ude Lu, Shane M. Roach, Dong Song, and Theodore W. Berger (2011) Nonlinear Dynamic
Modeling of Neuron Action Potential Threshold during Synaptically-Driven Broadband
Intracellular
Activity.
IEEE
Transactions
on
Biomedical
Engineering,
doi:
10.1109/TBME.2011.2178241.
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7. Theodore W. Berger, Robert E. Hampson, Dong Song, Anushka Goonawardena, Vasilis Z.
Marmaralis, and Sam A. Deadwyler (2011) A Cortical Neural Prosthesis for Restoring and
Enhancing Memory. Journal of Neural Engineering, doi:10.1088/1741-2560/8/4/046017.
8. Robert E. Hampson, Andrew J. Sweatt, Anushka V. Goonawardena, Dong Song, Rosa H.M.
Chan, Theodore W. Berger, and Sam A. Deadwyler (2011) Memory Encoding in Hippocampus is
Negatively Influenced by Cannabinoid CB1 Receptors. Behavioural Pharmacology, 22(4): 335346.
9. Ude Lu, Dong Song, and Theodore W. Berger (2011) Nonlinear Dynamic Modeling of
Synaptically Driven Single Hippocampal Neuron Intracellular Activity. IEEE Transactions on
Biomedical Engineering, 58 (5): 1303-1313.
10. Theodore W. Berger, Dong Song, Rosa H. M. Chan, and Vasilis Z. Marmarelis (2010) The
Neurobiological Basis of Cognition: Identification by Multi-Input, Multi-Output Nonlinear
Dynamic Modeling. Proceedings of the IEEE, 98: 356-374.
11. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2009) Nonlinear Modeling of Neural Population Dynamics for
Hippocampal Prostheses. Neural Networks, 22: 1340-1351.
12. Dong Song, Vasilis Z. Marmarelis, and Theodore W. Berger (2009) Parametric and Nonparametric Modeling of Short-term Synaptic Plasticity, Part I: Computational Study. Journal of
Computational Neuroscience, 26: 1-19.
13. Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2009) Parametric and
Non-parametric Modeling of Short-term Synaptic Plasticity, Part II: Experimental Study. Journal
of Computational Neuroscience, 26: 21-37.
14. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2007) Nonlinear Dynamic Modeling of Spike Train Transformations
for Hippocampal-Cortical Prostheses. IEEE Transactions on Biomedical Engineering, 54: 10531066.
15. Ghassan Gholmieh, Walid Soussou, Martin Han, Ashish Ahuja, Min Chi Hsaio, Dong Song,
Armand R. Tanguay, Jr., Theodore W. Berger (2006) Custom-designed high-density conformal
planar multielectrode arrays for brain slice electrophysiology. Journal of Neuroscience Methods,
152 (1-2): 116-129.
16. Theodore W. Berger, Ashish Ahuja, Spiros H. Courellis, Samuel A. Deadwyler, Gopal
Erinjippurath, Gregory A. Gerhardt, Ghassan Gholmieh, John J. Granacki, Robert Hampson, Min
Chi Hsaio, Jeff LaCoss, Vasilis Z. Marmarelis, Patrick Nasiatka, Vijay Srinivasan, Dong Song,
Armand R. Tanguay, Jr., Jack Wills (2005) Restoring Lost Cognitive Function – HippocampalCortical Neural Prostheses. IEEE Engineering in Medicine and Biology Magazine, 24: 30-44.
17. Dong Song, Zhuo Wang, and Theodore W. Berger (2002) Contribution of T-type VDCC to TEAinduced long-term synaptic modification in hippocampal CA1 and dentate gyrus. Hippocampus,
12: 689-697.
18. Zhuo Wang, Dong Song, and Theodore W. Berger (2002) Contribution of NMDA receptor
channels to the expression of LTP in the hippocampal dentate gyrus. Hippocampus, 12: 680-688.
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19. Dong Song, Xiaping Xie, Zhuo Wang, and Theodore W. Berger (2001) Differential effect of TEA
on long-term synaptic modification in hippocampal CA1 and dentate gyrus in vitro. Neurobiology
of Learning and Memory, 76: 375-387.
Book Chapters:
1. Theodore W. Berger, Dong Song, Rosa H.M. Chan, Vasilis Z. Marmarelis, Jeff LaCoss, Jack
Wills, John J. Granacki, Greg A. Gerhardt, Robert E. Hampson, and Sam A. Deadwyler (2012)
Reverse Engineering the Brain: A Hippocampal Cognitive Prosthesis for Repair and
Enhancement of Memory Function. In Bin He (Ed.), Neural Engineering. New York, NY:
Springer, in press.
2. Catherine Y. Tu, Dong Song, F. Jay Breidt, Theodore W. Berger, and Haonan Wang (2011)
Functional model selection for sparse binary time series with multiple inputs. In Scott H. Holan,
William R. Bell, and Tucker S. McElroy (Eds.), Economic Time Series: Modeling and
Seasonality. Boca Raton, Florida: Chapman and Hall/CRC.
3. Robert E. Hampson, John D. Simeral, Theodore W. Berger, Dong Song, Rosa H. M. Chan,
Vasilis Z. Marmaralis, and Sam A. Deadwyler (2011) Cognitively relevant recording in
hippocampus: beneficial feedback of ensemble codes in a closed loop paradigm. In Robert P.
Vertes and Robert W. Stackman Jr. (Eds.), Electrophysiological Recording Techniques,
Neuromethods, vol. 54. New York: Humana Press, 215–39.
4. Dong Song, and Theodore W. Berger (2009) Identification of Nonlinear Dynamics in Neural
Population Activity. In Karim G. Oweiss (Ed.), Statistical Signal Processing for Neuroscience
and Neurotechnology. Amsterdam: Elsevier.
5. Stephens, M. L., Spencer, D. D., Cavus, I., Hsiao, M-C., Song, D., Deadwyler, S. A., Hampson,
R. E., Putz, D., Quintero, J. E., Bensalem-Owen, M. K., Hascup, K. N., Rutherford. E. C., Day,
B. K., Nickell, J. R., Pomerleau, F., Huettl, P., Burmeister, J. J., Talauliker, P. M., Marmarelis, V.
Z., Granacki, J. J., Berger, T. W., and Gerhardt, G. A. (2008) Microelectrode-based epilepsy
therapy: A hybrid neural prosthesis incorporating seizure prediction and intervention with
biomimetic maintenance of normal hippocampal function. In Ivan Soltesz and Kevin Staley
(Eds.), Computational Neuroscience in Epilepsy. Amsterdam: Elsevier.
6. Theodore W. Berger, Ashish Ahuja, Spiros H. Courellis, Gopal Erinjippurath, Ghassan
Gholmieh, John J. Granacki, Min Chi Hsaio, Jeff LaCoss, Vasilis Z. Marmarelis, Vijay
Srinivasan, Dong Song, Armand R. Tanguay, Jr., Jack Wills (2007) Brain-implantable
biomimetic electronics as neural prostheses to restore lost cognitive function. In M. Akay (Ed.),
Handbook of Neural Engineering. IEEE Press.
7. Theodore W. Berger, Ashish Ahuja, Spiros H. Courellis, Gopal Erinjippurath, Ghassan
Gholmieh, John J. Granacki, Min Chi Hsaio, Jeff LaCoss, Vasilis Z. Marmarelis, Vijay
Srinivasan, Dong Song, Armand R. Tanguay, Jr., Jack Wills (2006) Brain-implantable
biomimetic electronics as neural prostheses to restore lost cognitive function. In M. Akay (Ed.),
Neuro-Nanotechnology: Artificial Implants and Neural Prostheses. New York, Wiley/IEEE Press,
pp. 293-320
8. Theodore W. Berger, Ashish Ahuja, Spiros H. Courellis, Gopal Erinjippurath, Ghassan
Gholmieh, John J. Granacki, Min Chi Hsaio, Jeff LaCoss, Vasilis Z. Marmarelis, Vijay
Srinivasan, Dong Song, Armand R. Tanguay, Jr., Jack Wills (2005) Brain-implantable
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biomimetic electronics as neural prostheses to restore lost cognitive function. Synaptic Plasticity:
Basic Mechanisms to Clinical Applications. Informa Healthcare
9. Walid Soussou, Ghassan Gholmieh, Martin Han, Ashish Ahuja, Dong Song, Min-Chi Hsiao,
Zhuo Wang, Armand R. Tanguay Jr., Theodore Berger (2005) Mapping Spatio-Temporal
Electrophysiological Activity in Hippocampal Slices with Conformal Planar Multielectrode
Arrays, In: Advances in Network Electrophysiology Using Multielectrode Arrays. Springer
Patents:
1. Modeling Nonlinear Systems. Inventors: Dong Song, V. Z. Marmarelis, and T. W. Berger.
Publication date: 04/02/2009, Patent application number: 12/135,904, Patent Application Filed.
Reviewed conference papers:
1. Dong Song, Rosa H. M. Chan, Vasilis Marmarelis, Robert E. Hampson, Sam A. Deadwyler, and
Theodore W. Berger (2011) Estimation and Statistical Validation of Event-Invariant Nonlinear
Dynamic Models of Hippocampal CA3-CA1 Population Activities. Proceedings of the 33rd
Annual International Conference of the IEEE EMBS, 3330-3333.
2. Ude Lu, Shane Roach, Dong Song, and Theodore W. Berger (2011) A Two-Stage Cascade
Nonlinear Dynamical Model of Single Neurons for the Separation and Quantification of Pre- and
Post-synaptic Mechanisms of Synaptic Transmission. Proceedings of the 33rd Annual
International Conference of the IEEE EMBS, 1427-1430.
3. Rosa H. M. Chan, Dong Song, Anushka Goonawardena, Sarah Bough, John Sesay, Robert E.
Hampson, Sam A. Deadwyler, and Theodore W. Berger (2011) Tracking the Changes of
Hippocampal Population Nonlinear Dynamics in Rats Learning a Memory-Dependent Task.
Proceedings of the 33rd Annual International Conference of the IEEE EMBS, 3326-3329.
4. Vasilis Z. Marmarelis, Dae Shin, Dong Song, Robert E. Hampson, Sam A. Deadwyler, and
Theodore W. Berger (2011) Dynamic Nonlinear Modeling of Interactions between Neuronal
Ensembles using Principal Dynamic Modes. Proceedings of the 33rd Annual International
Conference of the IEEE EMBS, 3334-3337.
5. Robert E. Hampson, Dong Song, Rosa H. M. Chan, Andrew Sweatt, Dae Shin, Vasilis Z.
Marmarelis, Greg A. Gerhardt, John J. Granacki, Theodore W. Berger, and Sam A. Deadwyler
(2011) Restorative Encoding Memory Integrative Neural Device: "REMIND". Proceedings of the
33rd Annual International Conference of the IEEE EMBS, 3338-3341.
6. Will X. Y. Li, Rosa H. M. Chan, Wei Zhang, Ray C. C. Cheung, Dong Song, and Theodore W.
Berger (2011) A Hardware-based Computational Platform for Generalized Laguerre-Volterra
MIMO Model for Neural Activities. Proceedings of the 33rd Annual International Conference of
the IEEE EMBS, 7282-7285.
7. Will X. Y. Li, Rosa H. M. Chan, Wei Zhang, Ray C.C. Cheung, Dong Song and Theodore W.
Berger (2011) FPGA Architecture of Generalized Laguerre-Volterra MIMO Model for Neural
Population Spiking Activities. 21st International Conference on Field Programmable Logic and
Applications (FPL), 44-49.
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8. Dong Song, Haonan Wang, and Theodore W. Berger (2010) Estimating Sparse Volterra Models
using Group L1-Regularization. Proceedings of the 32nd Annual International Conference of the
IEEE EMBS, 4128-4131.
9. Ude Lu, Dong Song, and Theodore W. Berger (2010) Nonlinear Dynamic Analyses of Single
Hippocampal Neurons Before and After Long-term Potentiation. Proceedings of the 32nd Annual
International Conference of the IEEE EMBS, 2762-2765.
10. Rosa H. M. Chan, Dong Song, and Theodore W. Berger (2010) Changes of Hippocampal CA3CA1 Population Nonlinear Dynamics across Different Training Sessions in Rats Performing a
Memory-Dependent Task. Proceedings of the 32nd Annual International Conference of the IEEE
EMBS, 5464-5467.
11. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2009) Sparse Generalized Laguerre-Volterra Model of Neural
Population Dynamic. Proceedings of the 31st Annual International Conference of the IEEE
EMBS, 4555-4558.
12. Rosa H. M. Chan, Dong Song, and Theodore W. Berger (2009) Nonstationary Nonlinear
Dynamic Modeling of Hippocampal Synaptic Transmission. Proceedings of the 31st Annual
International Conference of the IEEE EMBS, 4559-4562.
13. Min-Chi Hsiao, Dong Song, and Theodore W. Berger (2009) Using an Open-Loop Inverse
Control Strategy to Regulate CA1 Nonlinear Dynamics for an in vitro Hippocampal Prosthesis
Model. Proceedings of the 31st Annual International Conference of the IEEE EMBS, 1529-1532.
14. Ude Lu, Dong Song, and Theodore W. Berger (2009) Nonlinear Model of Single Hippocampal
Neurons with Dynamical Thresholds. Proceedings of the 31st Annual International Conference of
the IEEE EMBS, 3330-3334.
15. Dong Song, Phillip Hendrickson, Vasilis Z. Marmarelis, Jose Aguayo, Jiping He,
Gerald E. Loeb, and Theodore W. Berger (2008) Predicting EMG with Generalized Volterra
Kernel Model. Proceedings of the 30th Annual International Conference of the IEEE EMBS, 2014.
16. Rosa H. M. Chan, Dong Song, and Theodore W. Berger (2008) Tracking Temporal Evolution of
Nonlinear Dynamics in Hippocampus using Time-Varying Volterra Kernels. Proceedings of the
30th Annual International Conference of the IEEE EMBS, 4996-9.
17. Min-Chi Hsiao, Dong Song, and Theodore W. Berger (2008) A Modeling-Control Paradigm for
the in vitro Neuroprosthetic. Proceedings of the 30th Annual International Conference of the
IEEE EMBS, 5535-8.
18. Ude Lu, Dong Song, and Theodore W. Berger (2008) Nonparametric Modeling of Single Neuron.
Proceedings of the 30th Annual International Conference of the IEEE EMBS, 2469-72.
19. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2007) Statistical Selection of Multiple-Input Multiple-Output
Nonlinear Dynamic Models of Spike Train Transformation. Proceedings of the 29th Annual
International Conference of the IEEE EMBS, 4727-4730.
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20. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2006) Physiologically Plausible Stochastic Nonlinear Kernel Models of
Spike Train to Spike Train Transformation. Proceedings of the 28th Annual International
Conference of the IEEE EMBS, 6129-6132.
21. Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2004) A Modeling
paradigm incorporating parametric and non-parametric methods. Proceedings of the 26th Annual
International Conference of the IEEE EMBS, 647-650.
22. Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2003) Non-parametric
interpretation and validation of the parametric short-term plasticity models. Proceedings of the
25th Annual International Conference of the IEEE EMBS, 3: 1901-1904.
23. Dong Song, Vasilis Z. Marmarelis, and Theodore W. Berger (2002) Parametric and nonparametric models of short-term plasticity. Proceedings of the Second Joint EMBS/BMES
Conference, 3: 1964-1965.
24. Min-Chi Hsiao, Chiu-Hsien Chan, Theodoros Zanos, Ashish Ahuja, Ghassan Gholmieh, Jack
Wills, Jeff LaCoss, Spiros Courellis, Dong Song, John Granacki, Vasilis Z. Marmarelis,
Theodore W. Berger (2006) VLSI Implementation of a Nonlinear Neuronal Model: A “Neural
Prosthesis” to Restore Hippocampal Trisynaptic Dynamics. Proceedings of the 28th Annual
International Conference of the IEEE EMBS, 4396-4399.
25. Xiaping Xie, Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, Theodore W. Berger (2006)
Interaction of Short-Term Neuronal Plasticity and Synaptic Plasticity Revealed by Nonlinear
Systems Analysis in Dentate Granule Cells. Proceedings of the 28th Annual International
Conference of the IEEE EMBS, 5543-5546.
26. Theodore W. Berger, Ghassan Gholmieh, Min Chi Hsaio, Dong Song, John J. Granacki, Jack
Wills, Jeff LaCoss, Vijay Srinivasan, Vasilis Z. Marmarelis, Spiros H. Courellis, Gopal
Erinjippurath, Armand R. Tanguay, Jr., Ashish Ahuja, Patrick Nasiatka, Sam A. Deadwyler,
Robert E. Hampson, Greg A. Gerhardt (2005) Implantable Biomimetic Electronics as Neural
Prostheses for Lost Cognitive Function. Proceedings of 6th Asian-pacific Conference on Medical
and Biological Engineering.
27. Alireza A. Dibazar, Dong Song, Walter Yamada, and Theodore W. Berger (2004) Speech
recognition based on fundamental functional principles of the brain. Proceedings of International
Joint Conference on Neural Networks, 3071-3076.
28. Zhuo Wang, Xiaping Xie, Dong Song, and Theodore W. Berger (2003) Probabilistic
transformation of temporal information at individual synapses. Proceedings of the EMBS
Conference, 3: 1909-1912.
29. Ghassan Gholmieh, Spiros H. Courellis, Dong Song, Vasilis Z. Marmarelis, and Theodore W.
Berger (2003) Characterization of the short-term plasticity of the dentate gyrus-CA3 system using
nonlinear systems analysis. Proceedings of the EMBS Conference, 3: 1929-1932.
30. Angelika Dimoka, Spiros H. Courellis, Dong Song, Vasilis Z. Marmarelis, and Theodore W.
Berger (2003) Identification of the lateral and medial perforant path of the hippocampus using
single and dual random impulse train stimulation. Proceedings of the EMBS Conference, 3: 19331936.
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31. Zhuo Wang, Dong Song, and Theodore W. Berger (2002) Experimental and modeling studies of
the contribution of NMDA receptor-channels to the expression of long-term potentiation.
Proceedings of the Second Joint EMBS/BMES Conference, 3: 1962 -1963.
Selected Conference Abstracts and Presentations:
1. Song, D., Chan, H.M., Marmarelis, V.Z., Hampson, R.E., Deadwyler, S.A., Berger, T.W. (2011)
Memory-invariant models of hippocampal CA3-CA1 population dynamics during delayed
nonmatch-to-sample tasks. Society for Neuroscience Abstracts, 410.07.
2. Hampson, R.E., Long, J.L., Noto, J.V., Parrish, B.C., Hong, K.S., Song, D., Chan, H.M., Shin, D.,
Marmarelis, V.Z., Berger, T.W., Gerhardt, G.A., and Deadwyler, S.A. (2011) Facilitation of
behavioral performance in NHPs as a test of a nonlinear model-based neural prosthesis. Society
for Neuroscience Abstracts, 410.08.
3. Sweatt, A.J., Hampson, R.E., Song, D., Chan, H.M., Collins, D.C., Riley, M.R., Dyson, C.H.,
Hiatt, N., Shin, D., Marmarelis, V.Z., Berger, T.W., and Deadwyler, S.A. (2011) Implementation
of a neural prosthesis facilitates normal brain correlates of memory. Society for Neuroscience
Abstracts, 410.09.
4. Roach, S., Lu, U., Song, D., and Berger, T.W. (2011) Nonlinear dynamical model for the
separation and quantification of pre- and post-synaptic transmission mechanisms. Society for
Neuroscience Abstracts, 449.07.
5. Dong Song and Theodore W. Berger (2011) Modeling the nonlinear dynamics and
nonstationarities underlying spike train transformations in the brain. Joint Statistical Meeting
Abstracts, 114 (206469).
6. Song, D., Wang, H., Hampson, R.E., Deadwyler, S.A., Berger, T.W. (2010) Identification of
functional hippocampal CA3-CA1 connectivity using a group regularized likelihood method.
Society for Neuroscience Abstracts, 99.28.
7. Lu, U., Song, D., Berger, T.W. (2010) Nonlinear dynamic analyses of single hippocampal neurons
before and after long-term potentiation. Society for Neuroscience Abstracts, 99.9.
8. Berger, T.W., Lu, U., Song, D. (2010) Nonlinear dynamic modeling of sub- and supra-threshold
activities of single hippocampal neurons. Society for Neuroscience Abstracts, 99.11.
9. Chan, R.H.M., Song, D., Goonawardena, A.V., Bough, S., Sesay, J., Hampson, R.E., Deadwyler,
S.A., and Berger, T.W. (2010) Changes of hippocampal CA3-CA1 population nonlinear dynamics
in rats learning a memory-dependent task. Society for Neuroscience Abstracts, 99.12.
10. Sweatt, A.J., Hampson, R.E., Song, D., Chan, H.M., Collins, D.C., Riley, M.R., Dyson, C.H.,
Marmarelis, V.Z., Berger, T.W., Deadwyler, S.A. (2010) Model-based identification and
manipulation of hippocampal ensemble firing patterns uncovers performance correlates common
across animals. Society for Neuroscience Abstracts, 99.25.
11. Hampson, R.E., Song, D., Chan, H.M., Sweatt, A., Fuqua, J., Gerhardt, G.A., Granacki, J., Berger,
T.W., Deadwyler, S.A. (2010) Restoration of Hippocampal Function using Patterned Neural
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Stimulation: Development a Neural Prosthetic using Multi-Input/Multi-Output Modeling of CA3
and CA1. Neural Interfaces Conference 2010, 96.
12. Song, D., and, Berger, T.W. (2010) Identification of Neural Functional Connectivity using a
Sparse Generalized Volterra Model. Joint Statistical Meetings Abstract, #206082.
13. Song, D., and, Berger, T.W. (2009) Generalized Volterra Model of Neural Population Dynamics
for Hippocampal Prostheses. Joint Statistical Meetings Abstract, #304805.
14. Song, D., Chan, H.M., Marmarelis, V.Z., Hampson, R.E., Deadwyler, S.A., Berger, T.W. (2009)
Functional hippocampal CA3-CA1 connectivity revealed by multiple-input multiple-output
nonlinear dynamic models. Society for Neuroscience Abstracts, 290.2.
15. Hampson, R.E., Song, D., Chan, H.M., Berger, T.W., Deadwyler, S.A. (2009) Similarities in
hippocampal firing patterns in CA1 and CA3 related to accuracy of behavioral performance across
different rats. Society for Neuroscience Abstracts, 290.7.
16. Taghva, A., Song, D., Berger, T.W. (2009) Time-delayed mutual information versus crosscorrelation in the detection of information transfer between CA3 and CA1 neurons in the rat
hippocampus. Society for Neuroscience Abstracts, 290.1.
17. Chan, H.M., Song, D., Berger, T.W. (2009) Nonstationary Modeling of Hippocampal Nonlinear
Dynamics. Society for Neuroscience Abstracts, 290.4.
18. Lu, U., Song, D., Berger, T.W. (2009) Nonlinear single neuron modeling with dynamic thresholds.
Society for Neuroscience Abstracts, 290.5.
19. Hsiao, M.-C., Song, D., Berger, T.W. (2009) Using a Modeling-Control Paradigm to Regulate
CA1 Nonlinear Dynamics. Society for Neuroscience Abstracts, 209.3.
20. Song, D., Chan, H.M., Marmarelis, V.Z., Hampson, R.E., Deadwyler, S.A., Berger, T.W. (2008)
Modeling Spike Train Transformations in the Brain Region. Joint Statistical Meetings Abstract,
#301195.
21. Song, D., Chan, H.M., Marmarelis, V.Z., Hampson, R.E., Deadwyler, S.A., Berger, T.W. (2008)
Generalized Volterra Model for Spike Train Transformations in the Hippocampus. Society for
Neuroscience Abstracts, 695.3.
22. Shi L., Miller F., Collins D., Mcleod G., Song D., Chan H.M., Berger T.W., Hampson R.E.,
Deadwyler S.A. (2008) Effects of local infusion of rimonabant on hippocampal neurons: in vitro
results extended to in vivo verification. Society for Neuroscience Abstracts, 485.26.
23. Chan, H.M., Song, D., Berger, T.W. (2008) Modeling of Non-Stationarities in Hippocampal
Nonlinear Dynamics. Society for Neuroscience Abstracts, 695.16.
24. Lu, U., Song, D., Berger, T.W. (2008) High-Order Non-Parametric Modeling of Single Neuron.
Society for Neuroscience Abstracts, 695.17.
25. Hsiao, M.-C., Song, D., Berger, T.W. (2008) Control theory-based regulation of hippocampal
CA1 nonlinear dynamics . Society for Neuroscience Abstracts, 695.15.
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26. Song, D., Chan, H.M., Marmarelis, V.Z., Hampson, R.E., Deadwyler, S.A., Berger, T.W.
Functional CA3-CA1 connections and CA3-CA3 interactions during performance of a delayednonmatch-to-sample task revealed by multiple-input multiple-output nonlinear dynamic models.
Society for Neuroscience Abstracts, 2007, 32, 305.5.
27. Chan, H.M., Song, D., Marmarelis, V.Z., Hampson, R.E., Deadwyler, S.A., Berger, T.W.
Tracking temporal evolution of nonlinear dynamics in hippocampus using time-varying kernels.
Society for Neuroscience Abstracts, 2007, 32, 305.2.
28. Hampson, R.E., Song, D., Chan, H.M., Shi, L., Collins, V.R., España, R.A., Gerhardt, G.A.,
Berger, T.W., Deadwyler, S.A. A nonlinear model that predicts hippocampal CA1 neural
ensemble firing during performance of a delayed-nonmatch-to-sample task in rats. Society for
Neuroscience Abstracts, 2007, 32, 305.3.
29. Berger, T.W., Song, D., Chan, H.M., Marmarelis, V.Z., Hampson, R.E., Deadwyler, S.A. A
unified nonlinear dynamic model for the transformations of multiple memories involved in the
delayed-nonmatch-to-sample task. Society for Neuroscience Abstracts, 2007, 32, 305.4.
30. Lu, U., Song, D., Berger, T.W., Modeling input-output property of single hippocampal CA1
pyramidal neuron using random-interval EPSP and spike train data. Society for Neuroscience
Abstracts, 2007, 32, 305.6.
31. Hsiao, M.-C., Jung, J., Song, D., and Berger, T.W. Modeling CA1 nonlinear dynamics in vitro for
a hybrid biological-VLSI hippocampal slice. Society for Neuroscience Abstracts, 2007, 32, 305.1.
32. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2007) Statistical selection of nonlinear dynamic model of spike train to
spike train transformation. Annual Conference of Biomedical Engineering Society.
33. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2006) Multiple-Input Multiple-Output Models of Spike Train
Transformation in Hippocampus. Biomedical Engineering Society Annual Conference, Abstract
No. 185.
34. Theodore W. Berger, Spiros H. Courellis, Sam A. Deadwyler, Greg A. Gerhardt, John J. Granacki,
Robert E. Hampson, Vasilis Z. Marmarelis, and Dong Song (2006) Neural Prosthesis for
Hippocampus: Biomimetic Microelectronic Implants for Restoring Memory Function. Annual
Conference of Biomedical Engineering Society.
35. Theodore W. Berger, Spiros H. Sam A. Deadwyler, Greg A. Gerhardt, John J. Granacki, Robert E.
Hampson, Vasilis Z. Marmarelis, and Dong Song (2006) A neural prosthesis for hippocampus:
concept and theoretical-experimental strategy. Society for Neuroscience Abstracts, 65.2.
36. Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler,
and Theodore W. Berger (2006)A neural prosthesis for hippocampus: physiologically plausible
stochastic nonlinear kernel models of CA3 spike train to CA1 spike train transformation. Society
for Neuroscience Abstracts, 65.3.
37. Ude Lu, Dong Song, and Theodore W. Berger (2006) Modeling input-output property of single
hippocampal CA1 pyramidal neuron using random-interval EPSC, EPSP, and spike train datasets.
Society for Neuroscience Abstracts, 65.5.
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38. Jaeyoung. Jung, Min-Chi Hsiao, Dong Song, and Theodore W. Berger (2006) A neural prosthesis
for the hippocampus: reproduce hippocampal CA1 output in vitro using control theory. Society for
Neuroscience Abstracts, 65.6.
39. Min-Chi Hsiao, Chiu-Hsien Chan, Theodoros Zanos, Gopal Erinjippurath, Ashish Ahuja, Ghassan
Gholmieh, Jack Wills, Jeff LaCoss, Spiros Courellis, Dong Song, John Granacki, Vasilis
Marmarelis, and Theodore Berger (2006) A neural prosthesis for hippocampus: Proof-of-concept
using the in vitro slice. Society for Neuroscience Abstracts, 65.8.
40. John Granacki, Jack Wills, Jeff LaCoss, Vijay Srinivasan, Spiros Courellis, Min-Chi Hsiao, Dong
Song, and Theodore W. Berger (2006) A neural prosthesis for hippocampus: mixed-signal systemon-chip. Society for Neuroscience Abstracts, 65.9.
41. Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2004) A doubleprocess presynaptic mechanism of short-term synaptic plasticity in hippocampal CA1 pyramidal
cell revealed by nonlinear systems analysis. Society for Neuroscience Abstracts, 921.18.
42. Xiaping Xie, Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2004)
Interaction between short-term neuronal plasticity and synaptic plasticity revealed by nonlinear
analysis in dentate granule cells. Society for Neuroscience Abstracts, 403.19.
43. Zhuo Wang, Dong Song, Xiaping Xie, and Theodore W. Berger (2004) Impact of probabilistic
synaptic release during train stimulation on the induction of frequency-dependent long-term
synaptic plasticity. Society for Neuroscience Abstracts, 403.18.
44. Spiros H. Courellis, Gopal Erinjippurath, Dong Song, Ghassan Gholmieh, Min-chin Hsiao, Vasilis
Z. Marmarelis, and Theodore W. Berger (2004) A biomimetic electronic prosthetic for the
hippocampus: nonlinear input/output model of CA3. Society for Neuroscience Abstracts, 190.2.
45. Ashish K. Ahuja1, Patrick Nasiatka, Dong Song, Theodore W. Berger, and Armand R. Tanguay
(2004) A biomimetic electronic prosthetic for hippocampus: planar conformal multielectrode
arrays for VLSI/hippocampal slice interface. Society for Neuroscience Abstracts, 190.4.
46. Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2003) Characterization
of presynaptic quantal plasticity using nonlinear systems analysis. Society for Neuroscience
Abstracts, 581.1.
47. Xiaping Xie, Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2003)
Characterization of multiple-input interaction of dentate granule cells using nonlinear modeling
methods. Society for Neuroscience Abstracts, 581.2.
48. Zhuo Wang, Xiaping Xie, Dong Song, and Theodore W. Berger (2003) Pattern of transmitter
release at individual hippocampal synapses during train stimulation. Society for Neuroscience
Abstracts, 122.10.
49. Dong Song, Zhuo Wang, Vasilis Z. Marmarelis, and Theodore W. Berger (2002) Nonlinear
system kernel analysis of short-term plasticity in hippocampal CA1 pyramidal cell. Society for
Neuroscience Abstracts, 146.1.
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50. Zhuo Wang, Dong Song, and Theodore W. Berger (2002) Experimental and modeling studies of
the contribution of NMDA receptor-channels to the expression of long-term potentiation. Society
for Neuroscience Abstracts, 146.5.
51. Dong Song, Xiaping Xie, Zhuo Wang, and Theodore W. Berger (2001) Experimental and
modeling decomposition of TEA-elicited calcium transients of hippocampal neurons. Society for
Neuroscience Abstracts, 27.719.
52. Dong Song, Xiaping Xie, Zhuo Wang, and Theodore W. Berger (2000) TEA induces LTP via both
T-type voltage-dependent calcium channels and NMDA receptors in CA1 but not dentate gyrus.
Society for Neuroscience Abstracts, 26.618.
53. Xiaping Xie, Dong Song, Zhuo Wang, and Theodore W. Berger (1999) Comparison of two forms
of LTP between hippocampal CA1 and dentate gyrus. Society for Neuroscience Abstracts, 182.12.
Invited Talks:
Nonlinear Dynamic Modeling of Neural Population Activity for the Development of Hippocampal
Prostheses. Neural Interface & Rehabilitation Tech Research Center, Huazhong University of
Science and Technology, Dec 6, 2011
Nonlinear Modeling of Neural Population Dynamics for Hippocampal Prostheses. Department of
Statistics, Colorado State University, March 29, 2010
Multiple-Input Multiple-Output Nonlinear Dynamic Models of Spike Train Transformation for
Hippocampal prostheses. IJCNN Workshop on Innovation in Computational Approaches for BrainMachine Interfaces, 2007
Organized Conference Sessions:
Organizer (with Dr. Haonan Wang): Statistical Modeling of Neural Spikes, Section on
Nonparametric Statistics. 2011 Joint Statistical Meetings, 2011
Teaching Experiences:
2011
Guest Lecturer at "BME 552: Neural Implant Engineering" of the USC Department of
Biomedical Engineering.
2010
Guest Lecturer at "BME 552: Neural Implant Engineering" of the USC Department of
Biomedical Engineering.
2009
Guest Lecturer at "BME 552: Neural Implant Engineering" of the USC Department of
Biomedical Engineering.
Guest Lecturer at "BME 452: Introduction to Biomimetic Neural Engineering" of the USC
Department of Biomedical Engineering.
2008
Guest Lecturer at "BME 452: Introduction to Biomimetic Neural Engineering" of the USC
Department of Biomedical Engineering.
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2007
Guest Lecturer at "BME 552: Neural Implant Engineering" of the USC Department of
Biomedical Engineering.
Guest Lecturer at "BME 452: Introduction to Biomimetic Neural Engineering" of the USC
Department of Biomedical Engineering.
2006
Guest Lecturer at "BME 552: Neural Implant Engineering" of the USC Department of
Biomedical Engineering.
2005
Guest Lecturer at "BME 599: Neural Implant Engineering" of the USC Department of
Biomedical Engineering.
Research Grants Participated as PI, Co-Investigator, and Senior Personnel
Collaborative Research: Non-Stationary Nonlinear Dynamic Modeling of Hippocampal System
Function during Learned Behavior and Memory Formation, NSF
$621,758
pending
Principal Investigator
Predictive Modeling of Bioelectric Activity on Mammalian Multilayered Neuronal Structures in the
Presence of Supraphysiological Electric Fields, NIH, U01
$4,000,000
pending
Co-Investigator
(USC-PI: T. W. Berger)
REMIND: Restorative Encoding Memory Integration Neural Device, DARPA
$16,000,000
2010 - 2013
Co-Investigator
(PI: T. W. Berger)
Nonlinear Dynamic Modeling of Hippocampal System Function during Learned Behavior and
Memory Formation, Zumberge Individual Award, USC
$27,000
2008 - 2009
Principal Investigator
An Engineering Research Center for Biomimetic MicroElectronics Systems, NSF
$17,000,000
2003 - 2013
Senior Personnel
(PI: M. Humayun)
Biomedical Simulations Resource – Core Project 4: Nonlinear Model of Hippocampus, National
Institute for Biomedical Imaging and Bioengineering
$5,854,519
2003 - 2013
Senior Personnel
(PI of Core Project 4: T. Berger)
Students Supervised
Shane Roach
Pen-Ning Yu
Phillip Hendrickson
Huijin Xu
Gene Yu
Brain Robinson
Ph.D. Student
Ph.D. Student
Ph.D. Student
Ph.D. Student
Ph.D. Student
Ph.D. Student
2010 – Present
2009 – Present
2005 – Present
2011 – Present
2011 – Present
2011 – Present
Dr. Rosa H. M. Chan
Dr. Ude Lu
Dr. Min-Chi Hsiao
Ph.D. Student
Ph.D. Student
Ph.D. Student
2005 – 2011
2005 – 2011
2005 – 2009
Dr. Tassanai Parittotokkaporn
Intern Ph.D. Student
2011
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Eric Cabral
Jonathan Arteaga
Samuel Felix
Nelson Jen
Alexandar Taghva
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
2010 – Present
2010
2010
2008
2007 – 2009
Christopher Girard
Richard Ponce
Dea Flores
Adam Baybutt
Alex Katz
Nathalie H. Pelka
Nora Shnorhokian
Andrew Barajas
Patrick Carriere
Anne Huang
Shengqi Ye
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
Undergraduate Student
2011
2011
2010
2010
2010 – Present
2007 – 2009
2007
2008
2008
2007
2007
Honors and Awards:
2008-2009
James H. Zumberge Individual Award, USC
2008
NIH/NIBIB EMBC08 conference support award, NIH Grant No. 1R3EB008957-01
2001
First Place Award for Platform Presentation
Fifth Annual Grodins Graduate Research Symposium, Department of Biomedical
Engineering, University of Southern California
1991-1992
Outstanding Student Award
University of Science and Technology of China, Hefei, China
Professional Affiliations and Services:
Peer Reviewer
Neural Computation
Brain Research
Neural Networks
IEEE Transactions on Signal Processing
Journal of Indian Mathematical Society
Cognitive Systems Research
IEEE Transactions on Neural Systems and Rehabilitation Engineering
IEEE-EMBC Annual Conference
Journal of Neurophysiology
Synapse
1999-present
2002-present
2002-present
2002-present
2008-present
Society for Neuroscience, Member
IEEE, Member
IEEE/EMBS, Member
BMES, Member
American Statistical Association (ASA), Member
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