Potential MBBS Research Projects: Honours or MPhil
Students with a ‘genuine interest’ in any of the following areas of research are
encouraged to enquire by email to the contact person listed and discuss
possible project opportunities
NEW!! THREE CLINICAL RESEARCH PROJECTS
1. POEMSLUN Study
(Pharmacokinetics of Enteric Coated Mycophenolate Sodium in Lupus Nephritis)
Mycophenolate Sodium (MPS) is an immunosuppressive drug used in managing patients with Lupus
Nephritis (LN)). The active metabolite is Mycophenolic acid. (MPA).The amount of MPA in the blood
varies from patient to patient. The factors causing these differences were well studied in transplant
patients but not well documented in LN patients.
Aim of the study is to define the relationship between MPA exposure and clinical efficacy and toxicity.
Design: Thirty two participants with clinically defined signs and symptoms of LN who are more than
18 years and on MPS for more than two weeks will be recruited in to this study.MPA drug levels will
be measured in all participants. Patients will be block randomised to one of the treatment groups,
with 16 patients entering each group.
Exposure controlled group: Oral MPS dosage will be modified according to area under curve (AUC);
Fixed dose Group: Sixteen participants will receive a fixed dose regimen in line with current practice.
Primary endpoint: To assess the effect of MPS on clinical improvement in patients with LN
as measured by complete or partial remission
Secondary endpoint(s):
1) To determine the effect of MPS in improvement in SLE Disease;
2) To study the relationship between disease activity of LN and MPA blood concentration;
3) To develop a pharmacokinetic model that can be used to develop MPS dosing
recommendations in LN patients treated with MPS;
4) Cost effectiveness of Therapeutic drug monitoring analysis.
Investigators: Dr Dwarakanathan Ranganathan, Dr. George John , Dr.Jason Roberts, Prof. Jeffrey
Lipman, Prof. Robert Fassett, Dr. Helen Healy, Dr. Paul Kubler, Dr. Jacobus Ungerer
Contact: Dr Dwarakanathan Ranganathan , Ph: 07-36368576; d.ranganathan@uq.edu.au
Department of Renal Medicine, RBWH, Brisbane
2. Epidemiology of Biopsy proven Glomerulonephritis 1999- 2011
There is limited data on spectrum of glomerulonephritis in Australia. An insight into this can be
obtained from renal biopsy diagnoses.
This study aims to recognize any changes in the prevalence, gender ratios and mean age (at time of
diagnosis) of glomerular disease from 1999 to 2010.
Investigators:
Dr Dwarakanathan Ranganathan, Dr. George John, Dr Leo Francis
Contact: Dr Dwarakanathan Ranganathan , Ph: 07-36368576; d.ranganathan@uq.edu.au
Department of Renal Medicine, RBWH, Brisbane
3. TUMMIE Trial: Topical Use of Mupirocin vs. Medihoney at the Exit site of Peritoneal catheter to
prevent Infections in peritoneal dialysis. This is an international, multicenter, investigator initiated trial.
Contact: Dr. Dwarakanathan Ranganathan , Ph: 07-36368576; d.ranganathan@uq.edu.au
Department of Renal Medicine RBWH Brisbane
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NEW!
Three Research Projects within the Rural Clinical School
Osteoclast Biology: Role of M-CSF and other Receptor Tyrosine Kinases in the regulation of
differentiated human osteoclast function. The research team has recently shown that M-CSF is a
potent regulator of human osteoclast resorbing activity and survival. This project will exploit a unique
mature human osteoclast model, which uses CFU-GM cells derived from human umbilical cord
blood, to characterise the molecular mechanism of the M-CSF effect and to study possible similar
effects mediated by other agonists of c-fms kinase and other receptor tyrosine kinases.
Co-morbidities in Indigenous and non-Indigenous Australians with mental health disorders –
a Case-Control Study. Conditions such as cardiovascular disease, diabetes, obesity, hypertension,
hyperlipidaemia and cancer, and risk factors for these conditions, are increased in persons with
mental health disease. This study will characterise the burden of disease and risk factors in a
population-based study set in South Western Queensland. The study will involve collaboration with
Queensland Mental Health Services.
Randomly-selected, Population-based, Cohort study - The Australian Regional, Rural, and
Remote Area Health Study, “The A3R Health Study”). A major strategy of this population health
research set in the Darling Downs, South West and South Burnet regions of Queensland will be
the establishment of a large (n=1600 females and 1600 males), representative, cohort study, which
will provide both cross-sectional (prevalence) and prospective longitudinal (incidence) health-related
data. An additional 400 persons of Indigenous origin will be included in the sample. This will be a
unique study for Australia because of oversampling of the remote population, random selection and
high participation. Thus, it will provide unique insight into the health and health risk factors of the 40%
of Queenslanders who do not live in major cities. Of these 21.8%, 15%, 2.0% and 1.2% reside in
Inner Regional, Outer Regional, Remote and Very Remote areas, respectively.
Please contact:
Professor Geoff Nicholson
MBBS PhD FRACP FRCP
Acting Head of School & Director of Research, Rural Clinical School,
School of Medicine, The University of Queensland
152 West Street Toowoomba Qld Australia 4350
Tel:+617463339702
Mobile +61417545878
geoff.nicholson@uq.edu.au
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Head of Research
Chief Scientist
Daniel Chambers MBBS MRCP FRACP MD
Thoracic and Transplant Physician
Peter Hopkins MBBS FRACP
Thoracic and Transplant Physician
Stephanie Yerkovich PhD
Contact
3130 4050 or Stephanie_Yerkovich@health.qld.gov.au
Director
The Queensland Heart and Lung Transplant Unit was formed in June 1996 with the addition of lung
transplantation to the established Heart Transplant Unit. The first lung transplant was performed in
Queensland in September 1996. The Queensland Lung Transplant Unit was established as a
separate entity in April 2000 maintaining close professional links with the Heart Transplant Program.
Over 200 lung transplant operations have been performed and approximately 135 outpatients are
cared for the by the Queensland Lung Transplant Program, with approximately 18-24 lung
transplants performed each year. In March 2009 the Queensland Lung Transplant Unit was renamed
the Queensland Centre for Pulmonary Transplantation and Vascular Disease (QCPTVD). This was
to recognise the additional medical services undertaken by the Transplant Program inclusive of
pulmonary hypertension, interstitial lung disease, airway interventional techniques, lung volume
reduction surgery, pulmonary thromboendarterectomy and the care of other patients with advanced
lung disease.
Our Unit has a fully equipped laboratory on site at The Prince Charles Hospital campus and is a
world recognised leader in research in the areas of lung transplantation and pulmonary hypertension
medicine. The research program aims to improve patient outcomes post-transplant by better
understanding the cell biology of the allograft. Due to the unique nature of our research program
which is embedded within the clinical program, we have unprecedented access to patient samples. A
number of projects are available to students wishing to obtain a research higher degree, including:
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Adult lung stem cells
o Investigating the engraftment and role of recipient derived progenitor/stem cells in the
allograft.
Lung fibrosis
o Better understanding the role of airway epithelial injury and repair in obliterative
bronchiolitis.
Overcoming lung transplant rejection
o Phenotyping and understating the biology of immune cell subsets that influx into the
allograft.
What is lung ‘normal flora’?
o The human lung microbiome project – metagenomics of the lung in health and disease
Human papillomavirus and non-melanotic skin cancer
o Identifying if human papillomavirus has a role in the development of squamous cell
carcinomas (SCC) of the skin. Transplant patients have an increased risk of SCC
development and these are a major cause of morbidity and mortality.
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Mater Mothers' Hospital
Neonatology
Timing of elective caesarean section delivery and short term
Neonatal outcomes
In USA the rate of prematurity is 12.7% with the dramatic growth over the last 2 decades in late
preterm births [34-36+6 weeks]. Australia is following an identical course with consistent state-wide
data available from NSW and QLD. The Australian rate of prematurity is currently 8.7% and
constantly growing, almost exclusively in the late preterm sub-group. Data are now available for
relationship between birth and individual weeks of gestation and rates of ADHD, child protection
problems, learning difficulties, Aspergers, Autistic Spectrum Disorders etc .Rates are lowest at 40
and 41 weeks gestation and progressively increase week by week down to 35 weeks. Of course
there is a major inflection point at 32 weeks gestation.
MMH now has a unique data-set of 5000 public and 5000 private births per annum in 2009 2011 having increased from 7627 in 1998. The 13 year data-set 1998-2010 [about 110,000
births] would provide the opportunity to analyse various peri-natal risk factors against short term
neonatal outcomes.
Perinatal Variables
Gestational age
Public/Private
Mode of delivery
CS [repeat or initial]
Outcomes
Admission to Nurseries
Length of stay [days]
Respiratory distress [RDS or TTN]
requirement for CPAP or mechanical ventilation
CS [no labour]
pulmonary air leak
CS [labour
surfactant therapy
SVD
Breast feeding at discharge
Instrumental Delivery [forceps/vacuum] Duration of breast feeding
Anaesthetic for CS
GA, regional
The large sample size would allow for trend analysis over 4 triennia and would lend itself to an
economic evaluation.
The study has major implications for practice improvement and provide adequate evidence based
data for informed decision making by mothers about optimal time and mode of delivery .
Mater Medical Research Institute would be able to offer some infrastructure to facilitate the research.
Of course candidate would need to perform a literature review and further develop the research
project before developing submission to Mater Health Services HREC for Ethical Approval. I would
anticipate this phase of the research taking about 2-3 months. Arrangements regarding supervision
of Research between MMRI and UQ would need to be developed.
Please contact: Prof David Tudehope
David.Tudehope@mater.org.au
Director Neonatology Medical
Mater Mothers' Hospital
South Brisbane, Qld 4101
Australia
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NEW! The Queensland Heart and Lung Transplant Unit, Prince Charles Hospital: The Prince
Charles Hospital campus and is a world recognised leader in research in the areas of lung
transplantation and pulmonary hypertension medicine. The research program aims to improve
patient outcomes post-transplant by better understanding the cell biology of the allograft. Due to the
unique nature of our research program which is embedded within the clinical program, we have
unprecedented access to patient samples. For more information contact: Dr Stephanie Yerkovich,
3130 4050 or Stephanie_Yerkovich@health.qld.gov.au
Medicine - Greenslopes Clinical School
A/Prof Darrell CRAWFORD d.crawford@uq.edu.au
 Investigating the mechanisms of hepatic co-toxicity of iron, fat and alcohol
 Pathogenesis and Therapy of hepatic fibrosis
 The extent of liver disease in community patients with chronic viral hepatitis
 Non invasive measures of liver fibrosis
Centre for Clinical Research, Queensland Centre for Advanced Imaging.
A/Professor Stephen ROSE stephen.rose@cai.uq.edu.au
One exciting area of research currently underway at the QCPRRC is the use of advanced
neuroimaging technology to measure brain injury and neuroplasticity in newborn babies at high risk
of abnormal neurodevelopment and in children with cerebral palsy. Within the next 12 months there
will be a new state-of-the-art imaging facility located within the UQCCR dedicated to clinical imaging
research.
Dr Glen LICHTWARK g.lichtwark@uq.edu.au
Muscle mechanics and function in Cerebral Palsy. In the past it has been assumed that the main
limitation for normal movement in children with cerebral palsy (CP) is muscle spasticity. We have
been developing highly innovative ultrasound imaging and force measuring techniques to
characterise how the structural and mechanical properties of affected CP muscles differ from typically
developed muscle. Opportunities exist to use these techniques to assess the effectiveness of
interventions such as Botulinum toxin A, strength training or serial casting.
For general information about the Queensland Cerebral Palsy and Rehabilitation Research
Centre, contact: Admin Officer: Sabina Scott; Phone: 07 3636 5542
The Prince Charles Hospital
Peter DEVADASON Geriatric Psychiatrist Peter_Devadason@health.qld.gov.au
A project is available in this area;
The Prince Charles Hospital has a strong shared care model between the Geriatric Physicians and
Geriatric Psychiatrists, in particular with regards to patients with dementia who suffer from severe
BPSD(Behavioural and Psychological Symptoms of Dementia), i.e. patient with dementia who are
severely agitated, pose a risk to themselves and others, and whose cares cannot be safely managed
in the community. While this arrangement may exist in other hospitals, TPCH is rather unique
(nationally and internationally), because of our use of Electroconvulsive Therapy (ECT) as a
treatment for severe BPSD.
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Psychiatry:
A/Prof Gerard BYRNE gerard.byrne@uq.edu.au
 Do certain personality traits mitigate the impact of stressful life events on depression and
anxiety (using a population-based cohort of older women)?
 Does the disability associated with mental disorders vary by age (using national survey data)?
Do older people with mental disorders have access to appropriate health services (using
national survey data)?
Prof Graham MARTIN g.martin@uq.edu.au
 Self-injury in students – what are the links to academic performance
 Self-injury in young people – dietetic, fMRI, cognitive correlates, or management and therapy
 Self-injury in young people – what works to help them give self-injury up
 Self-injury and suicidality in young people
A/Prof Jane Turner jane.turner@uq.edu.au
 Communication in oncology-communication skills training, barriers, implementation
 Delivery of brief tailored psychosocial therapies to reduce depression in patients with cancer
(RCT recruiting from Jan 2011)
 Supporting couples coping with cancer
 Impact of parental cancer on children
Dr Helen Stallman h.stallman@uq.edu.au
 The role of student expectations on the working alliance with their FP
 Predictors of uptake of low intensity interventions in a university health service
 A comparison of the mental health of tertiary students compared with age-matched peers
(using national survey data
 Has the prevalence of mental health problems in university students increased over time?
Dr Mark Daglish m.daglish@uq.edu.au
 Use of an inpatient self-help handbook and relationship to early relapse to alcohol use
 Mood change profile during inpatient detoxification
 Medical and allied health perceptions of medication as a treatment for mental health disorders
Perinatal Research Centre, RBWH and UQCCR.
Professor Paul COLDITZ, Director p.colditz@uq.edu.au
Early brain development in infants at risk of cerebral palsy. New Opportunities exist for medical and
allied health researchers for would be scholars in the area of very early brain development in infants
born preterm and/or at high risk of CP the RBWH and UQCCR work closely with the QCPPRC.
Research methods include (i) natural history models to study for example the effects of brain blood
flow on white matter injury and (ii) RCT interventional models to study the effect/s of physical or
nutritional interventions on brain development, injury and plasticity.
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Discipline of General Practice
Professor Claire Jackson c.jackson@uq.edu.au
 APHCRI Centre of Excellence in Research in Primary Health Care Research - Quality,
Governance, Performance and Sustainability: A Clinical Microsystems Approach
 NHMRC Centre of Research Excellence in improving quality and safety at the interface
between primary and secondary level care
 Reform initiatives- health professionals and community engagement in healthcare reforms,
facilitating reform process
 Innovative primary health care models of care
Dr Margaret KAY m.kay1@uq.edu.au
 Doctor’s health
 Refugee health
Dr David KING d.king@uq.edu.au
 Cochrane Reviews
 Structured problem solving in general practice using physician directed patient workbook
 Predictors of recurrence of major depression: A thematic systematic review
 Audit of prophylactic anticoagulation prior to lower limb surgery, and measurement of DVT
incidence in the following 3 months
 Health intervention/program development, implementation, and evaluation
 Health service provision- improving interface between primary and secondary care
 Complementary and alternative medicine (CAM) education and research in primary care
 Does Post-coital voiding prevent UTI in high risk young women
 Predictors of Recurrence of Major Depression: A thematic systematic review
 Brief structured problem solving in general practice using physician directed patient workbook
approach
Dr Tina JANAMIAN t.janamian1@uq.edu.au
 Health service provision- improving interface between primary and secondary care (SOPD
project)
 Primary health intervention/program development, implementation, and evaluation
 Research and evaluation of medical education- improving quality of medical education
through assessment and evaluation
Prof Geoff MITCHELL g.mitchell@uq.edu.au
 What happens to people with Traumatic Brain Injury on stimulants when they become adult
 Exploring the Relationship Between Quality of Life and Clinical Outcomes
A/Prof Jared DART j.dart@uq.edu.au
 Complex care needs of general practice patients and the potential role of GP Super Clinics
 eHealth as a means of enhancing primary care
 Health literacy, eHealth and health information strategies for primary care
Dr Jane NIKLES uqjnikle@uq.edu.au
 Research into the use of melatonin in children and adults - qualitative research, a
randomised controlled trial and safety study Thanks Jane
Dr Pamela DOUGLAS pameladouglas@uq.edu.au
 Qualitative research concerning unsettled babies and their mothers
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UQ Thoracic Research Centre, The Prince Charles Hospital, Northside Clinical School
A/Prof Ian YANG, Prof Kwun FONG, A/Prof Rayleen BOWMAN Ian_Yang@health.qld.gov.au
 Projects in lung health, investigating lung cancer, mesothelioma, chronic obstructive
pulmonary disease and other respiratory conditions
UQ Centre for Clinical Research (CCR)
Prof Murray MITCHELL murray.mitchel@uq.edu.au
 Foetal/placental growth/development, implantation of the embryo and pregnancy and parturition
 Epigenetic regulation of implantation of the embryo
 Epigenetic regulation of parturition
 The role of myostatin on placental glucose transport
 Adverse effects of endocrine disruptors in human reproductive health
 Transfer/actions of endocrine disruptors in human placenta using placental perfusion methods
 Role of endocannabinoids in implantation and preterm labour
 Role of arachidonic acid metabolism in pregnancy and parturition
Centre for Medical Education Research and Scholarship (CMEDRS)
A/Prof Diann ELEY d.eley@uq.edu.au
Student well being, internationalisation of medical education, interprofessional learning in medical
education and early career choice, for example;
 ways to monitor and support student well being
 learning objectives for international electives
 personal traits in medical students
 intentions and the decision making process around career choice in medical students
 interprofessional learning models for medical and health science curricula
 e-learning
Workforce & Rural Health
 Integration of overseas Trained Doctors (OTD) into rural communities
 Rural preceptor needs: Professional/social issues in relation to teaching/mentoring students
 Indigenous Health Workers: Status of training opportunities and career structure
 Bonded Medical Scholarships: what is the influence on intentions for rural practice?
 Rural Health Clubs: do they foster commitments to rural medicine?
Dr Jenny ZHANG jenny.zhang@uq.edu.au
Student selection, progression and professionalism
 Patterns of student performance from year 1 to year 4
 Differences in student characteristics and performance
 Personal professional development (PPD) assessment
Work based assessment
 Interns confidence and competence, Mini-CEX evaluation and methods
Methodology and data analysis
 Research design and statistical data analysis methods, instrument validation
Health care and the underserved population
 Medical Students’ Knowledge and Attitudes Towards Providing Care For The Underserved
 Socioeconomic position and health services utilisation
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Medical Ethics
A/Prof Malcolm PARKER m.parker@uq.edu.au; Dr Sarah Winch sarah.winch@uq.edu.au
 Medical ethics, clinical ethics, medical law, futile treatment, medical professionalism
Centre of National Research on Disability and Rehabilitation Medicine (CONROD)
Prof Justin KENARDY j.kenardy@uq.edu.au
 Impact of PICU admission on child and parent psychological health
 Preventing postconcussion syndrome in children with mild traumatic brain injury
 e-Health intervention for child traumatic stress
 Burn injuries in pre-school children: psychological impact
 Long-term outcomes of traumatic brain injury in children
 Cochrane reviews
A/Prof Michele STERLING: m.sterling@uq.edu.au
 Prevention of chronic pain and disability following musculoskeletal injury
 Exploration of nociceptive processing using psychophysical methods and fMRI in
musculoskeletal conditions
 Immune and stress responses following whiplash injury
 Predicting outcome following whiplash injury
 Development of clinical methods for the assessment and management of musculoskeletal
pain
Developmental Paediatrics - Mater Children's Hospital
Dr Honey HEUSSLER h.heussler@mater.org.au
 Projects available in Developmental Paediatrics
 Paediatric sleep medicine
 Hypersomnolence
 Retts syndrome
 A number of projects relating to sleep and specific syndromes
Medicine – Mater Health Services and Mater Medical Research Institute
Prof Timothy FLORIN t.florin@uq.edu.au
 Personalised medicine
 Better use of thiopurines in Inflammatory Bowel Diseases through therapeutic drug monitoring
 Preventing off-target effects
 Drug therapy for Endoplasmic Reticulum Stress Disorder in Inflammatory Bowel Diseases
 Intestinal epithelial cell communication with the gut immune system
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Lung & Allergy Research Centre, Respiratory Medicine – Princess Alexandra Hospital
Prof John UPHAM j.upham@uq.edu.au, Michelle MURPHY: Michelle_A_Murphy@health.qld.gov.au
 Virus infections in patients with lung disease
 Lung cancer – improving the patient journey through diagnosis and treatment
Janet DAVIES j.davies2@uq.edu.au
 Grass pollen allergy in asthma & allergic rhinitis
The UQ Diamantina Institute (UQDI)
Professor Ian FRAZER i.frazer@uq.edu.au
 Investigations in cancer immunology and immunotherapy.
Professor Ranjeny THOMAS ranjeny.thomas@uq.edu.au
 Suppression of autoimmune disease using nanoparticles
 Does atherosclerotic risk precede onset of rheumatoid arthritis? Analysis of a regional
population-based data collection in Norway.
Dr Gethin THOMAS g.thomas1@uq.edu.au
 Functional studies in ankylosing spondylitis to elucidate the roles of candidate genes
identified through genomewide association studies.
A/Professor Melissa BROWN Melissa.brown@uq.edu.au
 Identification of biomarkers of breast cancer predisposition and progression
Paediatrics & Child Health
A/Prof Mark COULTHARD m.coulthard@uq.edu.au
 Telemedicine in PICU,
 Pharmacological approaches to vascular leak
Ipswich Hospital / Ipswich Clinical School
Kassam MAHOMED Kassam_Mahomed@health.qld.gov.au
Women’s health and related to pregnancy such as;
 Satisfaction with use of MIRENA for menorrhagia and need for further surgery
 Maternal an perinatal morbidity associated with failed attempt at vaginal birth after 1 previous
c/section - a case controlled study
 pregnancy outcome in women with hyperemesis gravidarum
 experience with the use of foetal fibronection at Ipswich hospital
 5.GP survey re training in insertion of MIRENA - facilitators and barriers to insertion in general
practice
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NHMRC National Centre of Research Excellence for Peripheral Artery Disease
Jonathon GOLLEDGE jonathan.golledge@jcu.edu.au and Philip WALKER p.walker@uq.edu.au
An NHMRC Centre of Research Excellence for Peripheral Arterial Disease (PAD) has recently been
established by group of leading clinicians and scientists from throughout Australia, led by Prof
Jonathon Golledge and A/Prof Philip Walker. The centre facilitates research studies designed to
improve the management of PAD through a variety of research initiatives including: pre-clinical
studies in rodent models and human samples, clinical trials and guideline development and
implementation. Examples of studies readily available for student projects include;
 Biomarkers in PAD: Currently diagnostic or prognostic information which enables
individualisation of management of PAD is limited. Using human samples and rodent models
the group is carrying out a range of studies to identify novel markers of disease presence and
progression which identify new disease mechanisms and potential diagnostic aids.
 Development of novel therapies for PAD: Using human samples and rodent models the
group is carrying out a range of studies to identify novel therapies for PAD. By contrast to
heart disease there is a current lack of specific medication designed for PAD patients. For
example there is currently no medical management for patients with small aortic aneurysms.
 Clinical prospective studies: The group is carrying out a range of studies in patients with PAD
to identify better markers of outcome to help rationalise risk stratification and outcome
prediction. Examples include: clinical, imaging and circulating markers of cardiovascular
events and prognostic markers for durable outcomes after surgery.
 Clinical Trials: The group is currently carrying out a range of clinical trials such as medication
trials in patients with small aortic aneurysms and exercise trials in patients with intermittent
claudication designed to identify better therapeutic options.
 Guideline development and implementation: Currently there are no national guidelines for
many of the conditions suffered by PAD patients. Such guidelines need development by
carrying out appropriate systematic reviewers and appropriate consultation. Furthermore we
urgently need methods to assist patients to adopt better health behaviours. A motivational
interviewing method to encourage exercise for example may provide a means to improve
secondary prevention.
Top up scholarships to high class applicants attached to university scholarships also possible
Dermatology Research Centre
Prof H. Peter SOYER p.soyer@uq.edu.au
 Phenotypic characterisation of naevi in high risk melanoma patients and controls
 In-vivo imaging of SCC precursor lesions and surrounding normal skin (“field effect”) using
reflectance confocal microscopy
 Non-invasive assessment of solar elastosis using multi-photon microscopy
 Teledermoscopy of naevi using cutting edge mobile imaging devices
 An integrated teledermatology service for A&E departments as well as rural and remote
locations
Prof Helmut SCHAIDER h.schaider@uq.edu.au
 Epithelial-mesenchymal transition in early melanomagenesis
 Lineage specific expression of target genes in melanocytic cells
 Epigenetic changes in atypical melanocytic lesions
 Genetic profiles of atypical melanocytic lesions
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Queensland Centre for Intellectual and Developmental Disability
Prof Nick LENNOX n.lennox@uq.edu.au
 Investigating the effects of health screening tools and hand held health records in adolescents
with intellectual disability
 A qualitative assessment of the acceptability of health screening tools to adults with
intellectual disability, their carer and their GP
 The health status of prisoners with intellectual disability
 Factors associated with non-adherence to examination for people with intellectual disability
visiting their GP
Discipline of General Practice
Lisa CROSSLAND l.crossland1@uq.edu.au
Diabetic retinopathy screening and monitoring of early stage disease in general practice
Diabetic retinopathy (DR) is the leading cause of preventable blindness in Australians younger than
60 years, mainly from the development of diabetic macular oedema (DME) and the sequelae of
advanced proliferative DR. This study aims to test the accuracy, acceptability and cost-effectiveness
of general practice based DR screening integrated into the diabetes annual cycle of care compared
to conventional methods of DR screening. Secondly, this project aims to test the accuracy,
acceptability and cost-effectiveness of routine monitoring by the GP of mild to moderate DR levels
with ophthalmic support and education through videoconferencing.
Discipline of General Practice
Nancy STURMAN n.sturman1@uq.edu.au
A project tracking use of and referrals within, health care services by homeless men living in inner
city Brisbane. This mapping will be used to inform the development of a primary care homelessness
service, through the application of a ‘Lean Thinking’ approach to health care.
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Clinical School Southside, Princess Alexandra Hospital
Jennifer MARTIN j.martin4@uq.edu.au
 Drug induced liver injury project
 Drug doses in morbidly obese people
 Drug dosing in renal failure
 Patterns of Care (chart review/data analysis) focusing on a particular research question or a
specific cancer group
 Qualitative research, interviewing health professionals and/or patients:
o Explore health care professionals’ perspectives around Indigenous & non-Indigenous
patients who commenced treatment to examine their clinical decision-making, in the
context of co morbidity, culture and geographical isolation from cancer care services;
o Explore those who did not commence treatment and reasons for non-uptake or noncompletion
o Explore the patients’ perspective about their treatment: their experiences and
understanding of cancer and treatment choices
Patricia VALERY patricia.valery@qimr.edu.au
 Use of cancer medications in indigenous people
Paul KUBLER paul.kubler@healthg.qld.gov.au
 looking at quality use of medicines in tertiary hospital setting
Sandro PORCEDDU Sandro_Porceddu@health.qld.gov.au
 head and neck cancer research.
Oncology - Princess Alexandra Hospital
Sandro V PORCEDDU - Senior Radiation Oncologist Sandro_Porceddu@health.qld.gov.au
The following projects are suitable for Honours Projects. Students will be offered either first of 2nd
authorship on publications depending on the amount of work.
1) "The Utility of the 12 week PET scan in the detection of metastatic disease in head and neck
cancer"
Ethics approved. Data will be extracted from an existing data base - will require updating of some
patients. Aim to write a paper to be published in a peer-reviewed journal. Student will be offered
authorship on the manuscript.
2) "Is tumour spill an indication for post-operative radiotherapy"
This project will be a review of the published literature of the problem of operative tumour spill of
head and neck cancers and whether there is evidence that post-operative radiotherapy is required.
Controversial topic and this report is likely to be published in a peer-reviewed journal. Student will be
offered second or possibly first authorship depending on the amount of work performed.
3) "The impact of PET in the management of the neck in node positive head and neck cancer treated
with radiotherapy with or without chemotherapy: An international survey of clinical practice in major
cancer centres"
Exciting project. The student will produce an e-survey and approach major head and neck cancer
centres to determine the current practice and variation in the management of the neck in head and
neck cancer. This study will have a high level of interest throughout the international head and neck
community. It will compliment other publications from this unit which has looked at the utility of PET in
head and neck cancer and cost-effectiveness of PET.
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Queensland Cerebral Palsy Research and Rehabilitation Centre
Roslyn BOYD r.boyd@uq.edu.au
Website: www.som.uq.edu.au/cerebralpalsy
The QCPRRC is a multidisciplinary Research centre in the SOM with six NHMRC funded clinical
trials (3 current) and 1 NIH funded study. The QCPRRC has nine key research themes reflecting the
key areas of need for investigation in infants and children with cerebral palsy. The key research
themes include:
1) Early brain development and the impact of early interventions.
2) Novel therapies – including the potential of Stem cells and Neuroprotection strategies.
3) Neuroscience – brain structure and the link to outcomes.
4) Neuro-rehabilitation & the impact on gross, fine motor abilities & musculoskeletal outcomes.
5) Genetic factors and the relationship to severity of CP.
6) Growth, Nutrition, Physical Activity and Physical Fitness.
7) Parenting interventions to assist environmental enrichment.
8) Translational research: the implementation of science applications to clinical practice.
9) Evidence and Education; training the next generation of clinical researchers.
The QCPPRC has close collaborations with Orthopaedics, Neurology, and research groups such as
the UQ Perinatal Research Centre, Children’s Nutrition Research Centre, Centre for Magnetic
Resonance Imaging in the UQCCRE, the School of Rehabilitation science (Schools of Occupational
and Physiotherapy) Genetics group at QBI among other national and international collaborations. All
honours students can be involved in our annual training course on systematic reviews and meta
analysis (8 sessions), which will assist them in developing skills for their literature search and
systematic review of the literature or the psychometric properties of measures that they will use. The
following topics are some of those available for Honours or MPhil Students commencing in 2011.
(1) Longitudinal Cerebral Palsy Child Study- NHMRC 465128
Early Longitudinal Hip development status and relationship to Motor status in young children with
cerebral palsy:
(ii) Relationship between Brain Structure and early Gait Patterns in young children with cerebral
palsy
(iii) Relationship between Brain Structure and Community Performance in young children with
cerebral palsy
(iv) Relationship between Gross and Fine Motor functional abilities and community performance in
young children with cerebral palsy
(v) Cost and Consequences of management of children with cerebral palsy related to functional
severity
(2) Longitudinal Growth, Nutrition and Physical Activity (NHMRC funded, 569605)
This study is in collaboration with the UQ Children’s Nutrition Research Centre (Prof Peter
Davies).
(i)
Relationship between Levels of Physical Activity, community Motor Performance and
Brain Structure in young children with Cerebral Palsy
(ii)
Relationship between brain metrics and longitudinal growth
(i)
In addition to the above specific topics the following researchers and collaborators with QCPRRC can
be contacted about Honours/MPhil projects. The Senior Investigators and topics for study include:
Queensland Cerebral Palsy Research and Rehabilitation Centre
A/Professor Roslyn BOYD, Director r.boyd@uq.edu.au
New intervention studies for infants at risk of and children with Cerebral Palsy. Opportunities exist for
students (Medical, PT, OT and Psychology) to be involved in two RCT’s of intervention. A very early
rehabilitation trial for your children/ infants at high risk of cerebral palsy (AVERT CP) (MiiTii Australia,
Move it to improve it).
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