SCIENTIFIC PROGRAMME
Friday, September 12
17:00
Registration
21:00
Opening Addresses – NATARAJAN, PANTELIAS
Welcome cocktail
Saturday, September 13
9:00 – 10:30 Session 1: From DNA breaks to the formation of chromosomal aberrations
MFISH VERSUS WCP: A RETROSPECTIVE COMPARISON OF GENOME-EQUIVALENT
CHROMOSOME DAMAGE. (M. Cornforth)
THE PROTECTIVE EFFECT OF HYPOTHERMIA ON RADIATION-INDUCED CHROMOSOMAL
DAMAGE (A. Wojcik)
CYCLE STRUCTURE ANALYSIS PROVIDS EVIDENCE FOR HZE PARTICLE TRACK
INTERACTION IN THE FORMATION OF COMPLEX CHROMOSOME EXCHANGES (B. Loukas)
HOMOLOGOUS RECOMBINATION REPAIR PLAYS A CENTRAL ROLE IN THE PROCESSING
OF G2-CHROMOSOMAL BREAKS (A. Soni)
10:30 – 10:50
Coffee break
10:50 – 12:20 Session 2: High LET / THz Radiation and induction of chromosomal aberrations.
LINKING CHROMOSOME ABERRATIONS AND MUTATIONS IN EPITHELIUM EXPOSED TO
HEAVY IONS OF IMPORTANCE IN SPACE FLIGHT (A. Kronenberg)
45 MEV LITHIUM IONS FOCUSED TO SUB-MICROMETER SHOW ENHANCED
RADIOBIOLOGICAL EFFECTIVENESS IN THE INDUCTION OF CHROMOSOME
ABERRATIONS (T. Schmid)
CHROMOSOME ABERRATIONS INDUCED BY THE AUGER EMITTER I-125 (S. Schmitz)
BIOLOGICAL EFFECTS OF IN VITRO THZ RADIATION EXPOSURE IN HUMAN FETAL
FIBROBLASTS (A. De Amicis)
12:30 – 14:30
Lunch break
14:30 – 15:30
Poster Session
15:30 – 17:00 Session 3: Modeling of chromosome aberration formation, Cytogenetic analysis
in cancer therapy
LOCAL COMPLEXITY AND REGIONAL CLUSTERING OF DNA DAMAGE IN DICENTRICS
FORMATION: MODELLING STUDIES ON FOCUSED PROTON BUNCHES MIMICKING
SINGLE HIGH-LET IONS (W. Friedland)
SIMULATION OF THE FORMATION OF DNA DOUBLE STRAND BREAKS AND
CHROMOSOME ABERRATIONS IN IRRADIATED CELLS (L. Plante)
CYTOGENETIC ANALYSIS OF LYMPHOCYTES FROM PATIENTS UNDERGOING RADON
THERAPY* (N. Paz)
COMPARISON OF CHROMOSOME ABERRATIONS OUTCOME IN CANCER PATIENTS WITH
DIFFERENT TUMOR LOCALIZATIONS UNDERGONE 60CO RADIOTHERAPY (N. Maznyk)
17:00 – 17:20
Coffee break
17:20 – 19:00 Session 4: Chromosomal Instability and Cancer
FANCONI ANEMIA AND CHROMOSOME INSTABILITY: FROM GENE DISCOVERY TO NOVEL
THERAPIES (J. Surrales)
TELOMERE MAINTENANCE, CHROMOSOMAL INSTABILITY AND TELOMERE REPLICATION
(L. Sabatier)
RADIATION-INDUCED CHROMOSOMAL INSTABILITY IN AQUATIC BIOTA WITHIN THE
CHERNOBYL EXCLUSION ZONE (D. Gudkov)
THE DNA DAMAGE RESPONSE IS DIFFERENT IN HUMAN HEMATOPOIETIC STEM AND
PROGENITOR COMPARED TO DIFFERENTIATED CELLS FROM PERIPHERAL BLOOD. (C.
Fournier)
THE VALUE OF CYTOGENETICS AS A DIAGNOSTIC AND RESEARCH TOOL IN ACUTE
MYELOID LEUKEMIA (K. Manola)
19:00 – 20:00
20:00
Poster Session
Dinner
Sunday, September 14
9:00 – 10:40 Session 5: Radiation Biodosimetry, Biomonitoring, Health risk evaluation
QUANTIFYING MURINE BONE MARROW AND BLOOD RADIATION DOSE RESPONSE
FOLLOWING 18F-FDG PET WITH BIOMARKERS (C. Badie)
ABSORBED DOSE ESTIMATION USING CENTROMERIC / TELOMERIC PNA PROBES FOR
CHROMOSOMAL ABERRATION ANALYSIS DIRECTLY IN NON-STIMULATED LYMPHOCYTE
PREMATURELY CONDENSED CHROMOSOMES (G. Terzoudi)
RENEB – STATUS QUO OF THE BIODOSIMETRY NETWORK (U. Kulka)
EVOLUTION OF HEALTH CANADA’S ASTRONAUT BIODOSIMETRY PROGRAM (L. BeatonGreen)
STANDARDS IN BIOLOGICAL DOSIMETRY: A REQUIREMENT TO PERFORM AN
APPROPRIATE RISK ASSESSMENT (P. Voisin)
10:40 – 11:00
Coffee break
11:00 – 12:00 Session 6: Role of Telomeres in chromosomal instability
CHROMOSOME INSTABILITY INDUCED BY THE LOSS OF A SINGLE TELOMERE AND
CHROMOSOME ORGANIZATION IN HUMAN EPITHELIAL CANCER CELLS (L. Sabatier)
TELOMERES, TELOMERASE AND DNA REPAIR: AT THE CROSS-ROADS OF AGEING AND
CANCER (P. Hande)
CHROMOSOMAL INSTABILITY AND CANCER CELL STEMNESS UNDER EXTREME
TELOMERE DYSFUNCTION (S. Gagos)
12:00 – 14:00
Lunch break
14:00 – 15:30 Session 7: Micronuclei formation, Chromatin dynamics and Chromothripsis
THE RELATIVE BIOLOGICAL EFFECTIVENESS AND OXYGEN ENHANCEMENT RATIO OF
LOW-AND HIGH-LET RADIATIONS FOR MICRONUCLEUS FORMATION IN SOLID TUMORS
(R. Hirayama)
THE MICRONUCLEOUS ASSAY IN MAMMALIAN CELLS IN VITRO OR IN VIVO TO ASSES
HEALTH BENEFITS OF FUNCTIONAL FOODS. (F. Palitti)
EFFECT OF MODULATION OF CHROMATIN STRUCTURE ON X-RAY INDUCED DNA
DAMAGE IN ATAXIA TELANGIECTASIA CELL LINES (R. Meschini)
CHROMOTHRIPSIS: HOW CHROMOSOMES CAN GET LOCALLY SHATTERED IN A SINGLE
CATASTROPHIC EVENT? (G. Pantelias)
15:30 – 16:30 Session 8: New technologies for chromosome aberration detection, Automation
CYTOGENETICS GOES NEXT-GEN (S. Bailey)
AUTOMATION OF CHROMOSOMAL ABERRATIONS AND MICRONUCLEI (P. Prasanna)
AUTOMATIC DETECTION OF DICENTRIC CHROMOSOME: AN ACTUAL OPTION FOR
BIOLOGICAL DOSIMETRY. (G. Gruel)
16:30 – 17:00
Conclusions, Closing ceremony