Allan Bradley PhD FRS FMedSci
Director
The Wellcome Trust Sanger Institute
Hinxton, Cambridge CB10 1SA UK
Phone: +44 (0) 1223 494 881
FAX +44(0)1223 494 714
Personal
Date of Birth
Place of Birth
Citizenship
February 15 1960
Wolverhampton, England
British
Education & Fellowships
BA with Honors, 1981. MA, 1986. Natural Science Tripos, Part II Genetics.
University of Cambridge
Cambridge, England
Ph.D., 1981-1984.
Department of Genetics, University of Cambridge, Cambridge, England
Mentor: Dr. Martin Evans.
Thesis: Isolation and Developmental Potential of Murine Embryonic Stem Cells
Postdoctoral Research Fellow, 1984 - 1987
Department of Genetics, University of Cambridge
Mentor: Dr. Martin Evans
Positions Held
The Wellcome Trust Sanger Institute
Director Emeritus (March 2010 – present)
Director (Nov 2000 – March 2010)
Howard Hughes Medical Institute
Investigator (June 1997 – Oct 2000)
Howard Hughes Medical Institute
Associate Investigator (1993 - August 1997)
Department of Molecular & Human Genetics, Baylor College of Medicine
Professor (January 1995 – October 2000)
Associate Professor (April 1992 - January 1995)
Assistant Professor (June 1987 - March 1992)
Honors and Awards
Beit Memorial Trust Postdoctoral Research Fellow position, (1984 - 1987)
Searle Scholar 1988-1991
Leukemia Society Scholar 1992-1997
Michael E. DeBakey, M.D. Excellence in Research Award, 1994
Cullen Endowed Chair, 1996
Allan Bradley, Ph.D.
Curriculum Vitae
Page 2
Fellow of the Royal Society 2002
Fellow of the Academy of Medical Sciences 2002
Editorial Advisory Boards
Molecular and Cellular Biology, 1994-present
Developmental Biology, 1995-present
Molecular Biotechnology, 1995-present
Mechanisms of Development, 1995-1999
Cell & Differentiation, 1996-present
Publications
1.
Robertson EJ, Kaufman MH, Bradley A, and Evans MJ (1983). Isolation, properties and
karyotype analysis of pluripotential (EK) cell lines from normal and parthenogenetic
embryos. In Teratocarcinoma Stem Cells (eds. Silver LM, Martin, GR, and Strickland S).
Cold Spring Harbor Conferences on Cell Proliferation, Vol. 10, p. 647. Cold Spring Harbor,
New York.
2.
Evans M, Robertson E, Bradley A, and Kaufman MH (1983). The relationship between
embryonal carcinoma cells and embryos. In Current Problems in Germ Cell Differentiation
(eds. McLaren A and Wylie CC), p. 139. Cambridge University Press.
3.
Kaufman MH, Evans MJ, Robertson EJ, and Bradley A (1984). Influence of injected
pluripotential (EK) cells on haploid and diploid parthenogenetic development. J. Embrol.
Exp. Morph., 80, 75.
4.
Bradley A, Evans M, Kaufman MH, and Robertson EJ (1984). Formation of germ line
chimaeras from embryo-derived teratocarcinoma cell lines. Nature, 309, 255-256.
5.
Evans M, Bradley A, and Robertson EJ (1985). EK cell contribution to chimaeric mice;
from tissue culture to sperm. In Genetic Manipulation of the Early Mammalian Embryo.
Banbury Report 20, p. 93. Cold Spring Harbor, New York.
6.
Evans MJ, Bradley A, Kuehn MR, and Robertson EJ (1985). The ability of EK cells to
form chimaeras after selection of clones in G418 and some
observations on the
integration of retroviral vector proviral DNA into EK cells. In Molecular Biology of
Development. Cold Spring Harbor Symposia on Quantitative Biology, Vol. 50, p. 685.
Cold Spring Harbor, New York.
7.
Lovell-Badge RH, Bygrave A, Bradley A, Robertson EJ and Cheah KSE (1986).
Transformation of embryonic stem cells with a human type II collagen gene and its
expression in chimaeric mice. In Molecular Biology of Development. Cold Spring Harbor
Symposia on Quantitative Biology, Vol. 50, p. 707. Cold Spring Harbor, New York.
8.
Robertson EJ and Bradley A (1986). The fate of cultured mouse embryonic stem cells on
reintroduction into the embryo. In Germ Cell Tumours II, (eds. Jones WG, Milford-Ward A,
and Anderson CK). Advances in the Biosciences, Vol. 55. Pergamon Press.
9.
Bradley A, Robertson EJ (1986). Embryo-derived stem cells: A tool for elucidating the
developmental genetics of the mouse. In Current Topics in Developmental Biology, Vol.
20, p 357. Academic Press.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 3
10.
Robertson EJ, Bradley A, Kuehn MR, and Evans MJ (1986). Germ-line transmission of
genes introduced into cultured pluripotential cells by retroviral vector. Nature, 323, 445448.
11.
Robertson EJ and Bradley A (1987). The production of permanent cell lines from early
embryos and their use in studying developmental problems. In Experimental Approaches
to Mammalian Embryonic Development, p 475 (eds. Rossant J and Pedersen R).
Cambridge University Press.
12.
Bradley A (1987). Production and analysis of chimaeric mice. In Teratocarcinomas and
Embryonic Stem Cells - A Practical Approach, p. 113 (ed. Robertson EJ). IRL Press 1987.
13.
Kuehn MR, Bradley A, Robertson EJ, and Evans MJ (1987). A potential animal model
for Lesch-Nyhan syndrome through the introduction of HPRT mutations into mice. Nature
326, 295-298.
14.
Lovell-Badge RH, Bygrave A, Bradley A, Robertson EJ, Tilly R and Cheah KSE (1987).
Tissue specific expression of the human type II collagen gene in mice. Proc. Natl. Acad.
Sci. U.S.A., 84, 2803-2807.
15.
Graham A, Papalopulu N, Hunt P, Sham MH, Simmoneau L, Cook M, Bradley A, and
Krumlauf R (1989). The murine and Drosophila homeoboxes are derived from a common
ancestor based on similarities in structure and expression. In Molecular Genetics of Early
Drosophila and Mouse Development (eds. Capecchi MR). Cold Spring Harbor Press.
16.
McMahon AP, and Bradley A (1990). The Wnt-1 (Int-1) proto-oncogene is required for
the development of a large region of the mouse brain. Cell, 62, 1073-1085.
17.
Bradley A (1990). Embryonic stem cells: Proliferation and differentiation. Current
Opinion in Cell Biology, 2, 1013-1017.
18.
Hasty P, Ramirez-Solis R, Krumlauf R, and Bradley A (1991). Introduction of a subtle
mutation into the Hox-2.6 locus in embryonic stem cells. Nature, 350, 243-246.
19.
Soriano P, Montgomery C, Geske R, and Bradley A (1991). Targeted disruption of the csrc proto-oncogene leads to osteopetrosis in mice. Cell, 64, 693-702.
20.
Hasty P, Rivera-Perez J, Chang C, and Bradley A (1991). Target frequency and
integration pattern for insertion and replacement vectors in embryonic stem cells. Mol.
Cell. Biol., 11, 4509-4517.
21.
Zheng H, Hasty P, Brenneman M, Grompe M, Gibbs R, Wilson J and Bradley A (1991).
Fidelity of targeted recombination in human fibroblasts and murine embryonic stem cells.
Proc. Nat. Acad. Sci. U.S.A., 88, 8067-8071.
22.
Hasty P, Rivera-Perez J, and Bradley A (1991). The length of homology required for
gene targeting in embryonic stem cells. Mol. Cell, Biol., 11, 5586-5591.
23.
Bradley A (1991). Modifying the mammalian genome by gene targeting. Current
Opinion in Biotechnology, 2, 823-829.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 4
24.
Bradley A (1991). Developmental potential of murine pluripotential stem cells. In
Boundaries Between Promotion and Progression During Carcinogenesis, p. 83-99 (ed.
Sudilovsky O.) Plenum Publishing
Corporation, New York.
25.
Bradley A, Ramirez-Solis R, Zheng H, Hasty P, Davis A (1992).Genetic manipulation of
the mouse via gene targeting in embryonic stem cells. In Postimplantation development of
the mouse. (Ciba Foundation Symposium 165) p. 256-276, Wiley, Chichester.
26.
Ramirez-Solis R, Rivera-Perez J, Wallace JD, Wims M, Zheng H, and Bradley A (1992).
Genomic DNA microextraction, a method to screen numerous samples. Analytical
Biochemistry, 201, 331-335.
27.
McMahon AP, Gavin BJ, Parr B, Bradley A, and McMahon JA. (1992). The wnt family of
cell signaling molecules in post implantation development of the mouse. In: Post
implantation development of the mouse. (Ciba Foundation Symposium 165), p. 199-218,
Wiley, Chichester.
28.
Davis A, Wims M, and Bradley A (1992). Investigation of coelectroporation as a method
for introducing small mutations into embryonic stem cells. Mol.
Cell. Biol., 12, 27692776.
29.
Donehower LA, Harvey M, Slagle B, McArthur MJ, Montgomery CA, Butel JS, and
Bradley A (1992). Mice deficient for p53 are developmentally normal but susceptible to
spontaneous tumours. Nature, 356, 215-221.
30.
Matzuk M and Bradley A (1992). Cloning of the human activin receptor cDNA reveals high
evolutionary conservation. Biochimica et Biophysica Acta, 1130, 105-108.
31.
Bradley A, Hasty P, Davis A, and Ramirez-Solis R (1992). Modifying the mouse: Design
and desire. Biotechnology, 10, 534-539.
32.
Hasty P, Rivera-Perez J, and Bradley A (1992). The role and fate of DNA ends for
homologous recombination in ES cells. Mol. Cell. Biol., 12, 2464-2474.
33.
Matzuk M and Bradley A (1992). Structure of the mouse activin receptor type II gene.
Biochem. and Biophys. Res. Commun., 185, 404-413.
34.
McMahon AP, Joyner AL, Bradley A, and McMahon JA (1992).The mid-hind brain
phenotype of wnt-1/wnt-1 mice results from stepwise deletion of engrailed expressing cells
by 9.5 days post coitum. Cell, 69, 581-595.
35.
Lee EY-H, Chang C-Y, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee W-H, and Bradley A
(1992). Mice deficient for RB are nonviable and show defects in neurogenesis and
hematopoiesis. Nature, 359, 288-294.
36.
Matzuk MM, Finegold MJ, Su J-GJ, Hsueh AJW, and Bradley A (1992
-inhibin is
a tumor-suppressor gene with gonadal specificity in mice. Nature, 360, 313-319.
37.
Bradley A (1993). Site directed mutagenesis of the mouse. In Recent Progress in
Hormone Research, 48, 237-251. Academic Press, Inc.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 5
38.
Davis AC, Wims M, Spotts GD, Hann SR, Bradley A (1993). A null c-myc mutation
causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in
heterozygous female mice. Genes and Development, 7, 671-682.
39.
Rudolph U, Brabet P, Hasty P, Bradley A and Birnbaumer L (1993). Targeting of the Gi2a
locus in ES cells with replacement and insertion vectors. J. Receptor Res., 13, 619-637.
40.
Ramirez-Solis R, Zheng H, Whiting J, Krumlauf R and Bradley A (1993). Hoxb-4 (Hox2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the
closure of the sternal rudiments. Cell, 73, 279-294.
41.
Dalton DK, Pitts-Meek S, Keshav-S, Figari IS, Bradley A and Stewart TA (1993). Multiple
defects of immune cell function in mice with disrupted interferon-gamma genes. Science,
259, 1693-1694.
42.
Davis A and Bradley A (1993). Mutation of N-myc in Mice: What does the phenotype tell
us? BioEssays, 15, 273-275.
43.
Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson, EN and Klein WH
(1993). Muscle deficiency and neonatal death in mice with a targeted mutation in the
myogenin gene. Nature, 364, 501-506.
44.
Harvey M, McArthur MJ, Montgomery CA, Bradley A and Donehower LA (1993).
Genetic background alters the spectrum of tumors which develop in p53-deficient mice.
FASEB J, 7, 938-943.
45.
Harvey M, Sands AT, Weiss RS, Wiseman RW, Pantazis P, Giovanella BC, Tainsky
MA, Bradley A and Donehower A (1993). In vitro growth characteristics of embryo
fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457-2467.
46.
Wilson RW, Ballantyne CM, Smith CW, Montgomery C, Bradley A, O'Brien WE and
Beaudet AL (1993). Gene targeting yields a CD18-Mutant mouse for study of
inflammation. J Immunology, 151, 1571-1578.
47.
Hasty P and Bradley A (1993). Gene targeting vectors for mammalian cells. In Gene
Targeting, a Practical Approach, IRL Press, Ed. A. Joyner, 1-31.
48.
Sligh JE, Ballantyne CM, Rich SS, Hawkins HK, Smith CW, Bradley A and Beaudet A
(1993). Inflammatory and immune responses are impaired in
mice deficient in
intercellular adhesion molecule 1. Proc. Natl. Acad.
Sci. USA, 90, 8529-8533.
49.
Donehower LA and Bradley A (1993). The tumor suppressor p53. Biochemica. et
Biophysica Acta, 1155, 181-205.
50.
O'Neal WK, Hasty P, McCray PB, Casey B, Rivera-Perez J, Welsh MJ, Beaudet AL and
Bradley A (1993). A severe phenotype in mice with a duplication of exon 3 in the Cystic
Fibrosis locus. Human Molecular Genetics, 2, 1561-1569.
51.
Ramirez-Solis R, Davis A and Bradley A (1993). Gene targeting in mouse embryonic
stem cells. In: Methods in Enzymology, Guide to Techniques in Mouse Development, (Eds.
Wassarman PM, DePamphilis ML). Vol. 225, p. 855-878.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 6
52.
Kemp CJ, Donehower LA, Bradley A and Balmain A (1993). Reduction of p53 gene
dosage does not increase initiation or promotion but enhances malignant progression of
chemically induced skin tumors. Cell, 74, 813-822.
53.
Rudolph U, Brabet P, Hasty P, Bradley A and Birnbaumer L (1993). Disruption of the
G12a locus in embryonic stem cells and mice: a modified hit and run strategy with
detection by a PCR dependent on gap repair. Transgenic Research, 2, 345-355.
54.
Matzuk MM and Bradley A (1994). Identification and analysis of tumour suppressor genes
using transgenic mouse models. Seminars in Cancer Biology, 5, 37-45.
55.
Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A and Donehower LA
(1994).Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nature
Genetics, 5(3), 225-229.
56.
Zhang H, Hasty P and Bradley A (1994). Targeting frequency for deletion vectors in
embryonic stem cells. Mol. Cell. Biol., 14, 2404-2410.
57.
Wu X, Wakamiya M, Vaishnav S, Geske R, Montgomery C, Jr, Jones P, Bradley A and
Caskey CT (1994). Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.
Proc. Natl. Acad. Sci. USA, 91, 742-746.
58.
Hu N, Gutsmann A, Herbert D, Bradley A, Lee W-H and Lee Y-HP (1994).
Heterozygous Rb-1/+ mice are predisposed to tumors of the pituitary gland with a nearly
complete penetrance. Oncogene, 9, 1021-1027.
59.
Sands A, Donehower LA and Bradley A (1994). Gene targeting and the p53 tumor
suppressor gene. Mutation Res., 307, 557-572.
60.
Shikone T, Matzuk MM, Perlas E, Finegold MJ, Lewis KA, Vale W, Bradley A and Hsueh
AJW (1994). Characterization of gonadal sex cord-stromal tumor cell lines from inhibinand p53-deficient mice: The role of activin as an autocrine growth factor. Molecular
Endocrinology, 8, 983-995.
61.
Lee EY-HP, Hu N, Yuan S-SF, Cox LA, Bradley A, Lee W-H and Herrup K (1994). Dual
roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.
Genes & Dev., 8, 2008-2021.
62.
Matzuk MM, Finegold MJ, Mather JP, Krummen L, Lu H and Bradley A (1994).
Development of cancer cachexia syndrome and adrenal tumors in inhibin-deficient mice.
Proc. Natl. Acad. Sci. USA, 91, 8817-8821.
63.
Ramirez-Solis R and Bradley A (1994). Recent advances in the use of embryonic stem
cell technology. Current Opinion in Biotechnology, 5, 528-533.
64.
Bradley A (1994). Manipulating the mouse genome. In: Proceedings of the 5th World
Congress on Genetics Applied to Livestock Production. Vol. 21 p 354-361. Guelph,
Ontario, Canada.
65.
Hasty P, Crist M, Grompe, M and Bradley A (1994). Efficiency of insertion versus
replacement vector targeting varies at different chromosomal loci. Mol. Cell. Biol., 14,
8385-8390.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 7
66.
Patejunas G, Bradley A, Beaudet AL and O'Brien WE (1994). Generation of a mouse
model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene.
Somatic Cell and Molecular Genetics, 20, 55-60.
67.
Varmus HE, Godley LA, Roy S, Taylor ICA, Yuschenkoff L, Shi Y-P, Pinkel D, Gray J,
Bradley A, Aldaz CM, Pyle R, Medina D and Donehower LA (1994). Defining the steps in
the multi-step mouse model for mammary carcinogenesis. Cold Spring Harbor Symp.
Quanti. Biol., 59, 491-499.
68.
Rudolph U, Bradley A and Birnbaumer L (1994). Targeted inactivation of the Gi2 alpha
gene with replacement and insertion vectors: analysis in a 96-well plate format. Methods
Enzymol, 237, 366-386.
69.
Harvey M, Vogel H, Morris D, Bradley A, Bernstein A and Donehower LA (1995). A
mutant p53 transgene accelerates tumour development in heterozygous but not
nullizygous p53-deficient mice. Nature Genetics, 9, 305-311.
70.
Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Bradley A and
Birnbaumer L (1995). G12α protein deficiency: A model for inflammatory bowel disease.
Journal of Clinical Immunology, 15, 101S-105S
71.
Harvey M, Vogel H, Lee EY-HP, Bradley A and Donehower LA (1995). Mice deficient in
both p53 and Rb develop tumors primarily of endocrine origin. Cancer Research, 55,
1146-1151.
72.
Matzuk MM, Kumar TR, Vassalli A, Bickenbach JR, Roop DR, Jaenisch R and Bradley A
(1995). Functional analysis of activins during mammalian development. Nature, 374, 354356.
73.
Matzuk MM, Lu H, Vogel H, Sellheyer K, Roop DR and Bradley A (1995). Multiple defects
and perinatal death in mice deficient in follistatin. Nature, 374, 360-363.
74.
Matzuk MM, Kumar TR and Bradley A (1995). Different phenotypes for mice deficient in
either activins or activin receptor type II. Nature, 374, 356-374.
75.
Thompson TC, Park SH, Timme TL, Ren C, Eastham JA, Donehower LA, Bradley A,
Kadmon D and Yang G (1995). Loss of p53 function leads to metastasis in ras+mycinitiated mouse prostate cancer, Oncogene, 10, 869-879.
76.
Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi Y-P, Pinkel D, Gray J, Bradley A,
Medina D and Varmus HE (1995). Deficiency of p53 accelerates mammary tumorigenesis
in Wnt-1 transgenic mice and promotes chromosomal instability. Genes & Dev., 9, 882895.
77.
Wakamiya M, Blackburn MR, Jurecic R, McArthur MJ, Geske RS, Cartwright J, Mitani K,
Vaishnav S, Belmont JW, Kellems RE, Finegold MJ, Montgomery CA, Bradley A and
Caskey CT (1995). Disruption of the adenosine deaminase gene causes hepatocellular
impairment and perinatal lethality in mice. Proc. Natl. Acad. Sci. USA, 92, 3673-3677.
78.
Rudolph E, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G,
Bradley A and Birnbaumer L (1995). Ulcerative colitis and adenocarcinoma of the colon in
Gai2-deficient mice. Nature Genetics, 10, 143-150.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 8
79.
Almasan A, Yin Y, Kelly RE, Lee EY-HP, Bradley A, Li W, Bertino JR and Wahl GM
(1995). Deficiency of retinoblastoma protein leads to inappropriate S-phase entry,
activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA, 92, 54365440.
80.
Hasty P, Rivera-Perez J and Bradley A (1995). Gene conversion during vector insertion in
embryonic stem cells. Nucl. Acids. Res., 23, 2058-2064.
81.
Horan GSB, Ramirez-Solis R, Featherstone MS, Wolgemuth DJ, Bradley A and Behringer
RR (1995). Compound mutants for the paralogous hoxa-4, Hoxb-4, and hoxd-4 genes
show more complete homeotic transformations and a dose-dependent increase in the
number of vertebrae transformed. Genes & Dev., 9, 1667-1677.
82.
Hasty P, O'Neal WK, Liu K-O, Morris AP, Bebok Z, Shumyatsky GB, Jilling T, Sorscher EJ,
Bradley A and Beaudet AL (1995). Severe phenotype in mice with a termination mutation
in exon 2 of Cystic Fibrosis gene. Somatic Cell and Molecular Genetics, 21(3), 177-187.
83.
Sands AT, Abuin A, Sanchez A, Conti CJ and Bradley A (1995). Mice deficient for XPC are
highly susceptible to UV-induced carcinogenesis. Nature, 377, 162-165.
84.
Sands AT, Suraokar MB, Sanchez A, Marth JE, Donehower LA and Bradley A (1995). p53
deficiency does not affect the accumulation of point mutations in a transgene target. Proc.
Natl. Acad. Sci. USA 92, 8517-8521.
85.
Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW and
Elledge SJ (1995). p53-Independent expression of p21Cip1 in muscle and other terminally
differentiating cells. Science, 267, 1024-1027.
86.
Martin JF, Bradley A and Olson EN (1995). The paired-like homeo box gene MHox is
required for early events of skeletogenesis in multiple lineages. Genes & Dev., 9, 12371249.
87.
Donehower LA, Harvey M, Vogel H, McArthur MJ, Montgomery CA Jr, Park SH, Thompson
T, Ford RJ and Bradley A (1995). Effects of genetic background on tumorigenesis in p53deficient mice. Molecular Carcinogenesis, 14, 16-22.
88.
Wang N, Finegold MJ, Bradley A, Ou CN, Abdelsayed SV, Wilde MD, Taylor LR, Wilson
DR and Darlington GJ (1995). Impaired energy homeostasis in C/EBPa knockout mice.
Science, 269, 1108-1112.
89.
Matzuk MM, Finegold MJ, Mishina Y, Bradley A and Behringer RR (1995). Synergistic
effects of inhibins and Mullerian-inhibiting substance on testicular tumorigenesis.
Molecular Endocrinology, 9(10), 1337-1345.
90.
Jones SN, Roe AE, Donehower LA and Bradley A (1995). Rescue of embryonic lethality
in mdm-2 deficient mice by absence of p53. Nature, 378, 206-208.
91.
Kumar TR, Donehower LA, Bradley A and Matzuk M (1995). Transgenic mouse models
for tumour-suppressor genes. Journal of Internal Medicine, 238, 233-238.
92.
Sharan SK and Bradley A (1995). Role of transgenic mice in identification and
characterization of tumour suppressor genes. Cancer Surveys, 25, 143-159.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 9
93.
Sharan SK, Wims M and Bradley A (1995). Murine Brca1: Sequence and significance to
human missense mutations. Human Molecular Genetics, 4(12), 2275-2278.
94.
Ramirez-Solis R, Liu P and Bradley A (1995). Chromosome engineering in mice. Nature,
378, 720-724.
95.
Luo G, Hofmann C, Bronckers ALJJ, Sohoki M, Bradley A and Karsenty G (1995). BMP 7
is an inducer of nephrogenesis and is required for eye development and skeletal
patterning. Genes & Dev., 9, 2808-2820.
96.
Jones SN, Donehower LA and Bradley A (1995). Analysis of tumor suppressor genes
using transgenic mice. Methods, 8, 247-258.
97.
Mitani K, Wakamiya M, Hasty P, Graham FL, Bradley A and Caskey CT (1995). Gene
Targeting in mouse embryonic stem cells with an adenoviral vector. Somatic Cell and
Molecular Genetics, 21, 221-231.
98.
Weitzer G, Milner DJ, Kim JU, Bradley A and Capetanaki Y (1995). Cytoskeletal control of
myogenesis: A desmin null mutation blocks the myogenic pathway during embryonic stem
cell differentiation. Developmental Biology, 172, 422-439.
99.
Wilson RW, Ballantyne CM, Smith CW, Montgomery C, Bradley A and O'Brien
WE
(1995). Identification and characterization of tumor suppressor genes. Cancer Surveys,
25, 143-159.
100. Karsenty G, Luo G, Hofmann C & Bradley A. (1995). BMP7 is required for
nephrogenesis, eye development and skeletal patterning. Ann. N. Y. Acad. Sci. 785, 98107.
101. Harriman GR, Bradley A, Das S, Rogers-Fani P and Davis AC (1996). IgA class switch in
of germline transcription in class switch recombination.
Journal of Clinical Investigation, 97, 477-485.
102. Abuin A and Bradley A (1996). Recycling selectable markers in mouse embryonic stem
cells. Mol. Cell. Biol., 16, 1851-1856.
103. Coerver KA, Woodruff TK, Finegold MJ, Mather J, Bradley A and Matzuk MM (1996).
Activin signaling through activin receptor type II causes the Cachexia-like symptoms in
inhibin-deficient mice. Molecular Endocrinology, 10, 534-543.
104. Fidanza V, Melotti P, Yano T, Nakamura T, Bradley A, Canaani E, Calabretta B and Croce
CM (1996). Double knockout of the All-1 gene blocks hematopoietic differentiation.
Cancer Research, 56, 1179-1183.
105. Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie D-M, Monell C,
Arnheim N, Bradley A, Ashley T, and Liskay RM (1996). Involvement of mouse Mlh1 in
DNA mismatch repair and meiotic crossing over. Nature Genetics, 13, 336-342.
106. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein
S, Gundberg C, Bradley A and Karsenty G (1996). Increased bone formation in
osteocalcin-deficient mice. Nature, 382, 448-452.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 10
107. Bradley A and Liu P (1996). Target practice in transgenics. Nature Genetics, 14, 121123.
108. Zhang H and Bradley A (1996). Mice deficient for BMP2 are nonviable and have efects in
amnion/chorion and cardiac development. Development, 122, 2977-2986.
109. Burgess R, Rawls A, Brown D, Bradley A and Olson EN (1996). Requirement of the
paraxis gene for somite formation and musculoskeletal patterning. Nature, 384, 570-573.
110. Jones SN, Ansari-Lari MA, Hancock AR, Jones WJ, Gibbs RA, Donehower LA and
Bradley A (1996). Genomic organization of the mouse double minute 2 gene (Mdm2).
Gene, 175, 209-213.
111. Milner DJ, Weitzer G, Tran D, Bradley A and Capetakaki Y (1996). Disruption of muscle
architecture and myocardial degeneration in mice lacking desmin. The Journal of Cell
Biology, 134, 1255-1270.
112. Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM and
Bradley A (1996). The tumorigenic potential and cell growth characteristics of p53deficient cells are equivalent in the presence or absence of Mdm2. Proc. Natl. Acad. Sci
USA, 93, 14106-14111.
113. Sharan SK and Bradley A (1996). Identification and characterization of a microsatellite
marker within murine Brca2 gene. Mammalian Genome, 8, 79.
114. Prolla TA, Abuin A and Bradley A (1996). DNA mismatch repair deficient mice
cancer research. Seminars in Cancer Biology, Vol. 7, 241-247.
in
115. Bradley A (1996). Introduction: Mutant mice in cancer research. Seminars in Cancer
Biology, 7, 227-228.
116. Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi Y-P, Pinkel D, Gray J, Bradley A,
Medina D and Varmus HE (1996). The role of p53 in genomic instability and tumor
progression in a murine mammary cancer model. In: Progress in Clinical and Biological
Research, (Ed. Wiley-Liss Series), 395, 1-11.
117. Studer M, Lumsden A, Ariza-McNaughton L, Bradley, A and Krumlauf R (1996). Altered
segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1.
Nature, 384, 630-634.
118. Bradley A & Sharan SK (1996). And secreted tumour suppressors (1996). Nature
Genetics 13, 268-269 (discussion)
119. Sharan SK and Bradley A (1997). Murine Brca2: Sequence, map position and expression
pattern. Genomics, 40, 234-241.
120. Sharan SK, Morimatsu M, Albrecht U, Lim D-S, Regel E, Dinh C, Sands A, Eichele G,
Hasty P and Bradley A (1997). Embryonic lethality and radiation hypersensitivity mediated
by Rad51 in mice lacking Brca2. Nature, 386, 804-810.
121. Justice MJ, Zheng B, Woychik RP and Bradley A (1997). Using targeted large deletions
and high-efficiency N-Ethyl-N-nitrosourea mutagenesis for functional analyses of the
mammalian genome. Methods in Enzymology, 13, 423-436.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 11
122. Fritzell JA, Narayanan L, Baker SM, Bronner CE, Andrew SE, Prolla TA, Bradley A, Jirik
FR, Liskay M and Glazer PM (1997). Role of DNA mismatch repair in the cytotoxicity of
ionizing radiation. Cancer Res., 57(22), 5143-5147.
123. Prolla T, Baker SM, Harris AC, Tsao J-L, Yao X, Bronner CE, Zheng B, Gordon M,
Reneker J, Arnheim N, Shibata D, Bradley A and Liskay RM (1998). Tumour susceptibility
and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch
repair. Nature Genetics, 18, 276-279.
124. Bradley A and Liu P (1998). Engineering chromosomes in mice to facilitate the
identification of tumour suppressor genes. In: Novel Systems for the Study of Human
Disease from Basic Research to Application. OECD Proceedings.
125. Biggs P and Bradley A (1998). A step toward genotype-based therapeutic regimens for
breast cancer in patients with BRCA2 mutations? Journal of the National Cancer
Research, 90(13), 951-953.
126. Venkatachalam S, Shi Y-P, Jones SN, Vogel H, Bradley A, Pinkel D and Donehower LA
(1998). Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of
p53 dosage can promote cancer formation. EMBO J., 16, 4657-4667.
127. Luo G, Ivics Z, Izsvak Z and Bradley A (1998). Chromosomal transposition of a
Tc1/mariner-like element in mouse embryonic stem cells. Proc. Natl. Acad. Sci USA, 95,
10769-10773.
128. Bradley A and Medina D (1998). BRCA1 and BRCA2 in mammary gland development
and tumorigenesis. Journal of Mammary Gland Biology and Neoplasia, 3(4), 363-364.
129. Sharan SK and Bradley A (1998). Functional characterization of BRCA1 and BRCA2:
Clues from their interacting proteins, Journal of Mammary Gland Biology and Neoplasia,
3(4), 413-421.
130. Liu P, Zhang H, McLellan A, Vogel H and Bradley A (1998). Embryonic lethality and
tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics,
150, 1155-1168.
131. Bradley A and Luo G (1998). The Ptentative nature of mouse knockouts. Nature
Genetics, 20, 322-323.
132. Bradley A, Zheng B and Liu P (1998). Thirteen years of manipulating the mouse genome:
A personal history. Int. J. Dev. Biol., 42, 943-950.
133. Jones, SN, Hancock AR, Vogel H, Donehower LA and Bradley A (1998). Overexpression
of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc. Natl.
Acad. Sci. USA, 95, 15608-15612.
134. Cai W-W, Reneker J, Chow, C-W, Vaishnav M and Bradley A (1998). An anchored
framework BAC map of mouse chromosome 11 assembled using multiplex oligonucleotide
hybridization. Genomics, 54, 387-397.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 12
135. Yamaguchi TP, Bradley A, McMahon AP and Jones S (1999). A Wnt5a pathway
underlies outgrowth of multiple structures in the vertebrate embryo. Development, 126(6),
1211-1223.
136. Mills AA, Zheng B, Wang X-J, Vogel H, Roop DR and Bradley A (1999). p63, a p53
homologue required for limb and epidermal morphogenesis. Nature, 398, 708-713.
137. Zheng B, Mills AA and Bradley A (1999). A system for rapid generation of coat
color
tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids, 27,
2354-2360.
138. Harriman GR, Bogue M, Rogers P, Finegold M, Pacheco S, Bradley A, Zhang Y and
Mbawuike IN (1999). Targeted deletion of the IgA constant region in mice leads to IgA
deficiency with alterations in expression of other immunoglobulin isotypes. Journal of
Immunology, 162, 2521-2529.
139. Zheng B, Larkin DW, Albrecht U, Sun ZS, Sage M, Eichele G, Lee CL and Bradley A
(1999). The mPer2 gene encodes a functional component of the mammalian circadian
clock. Nature, 400, 169-173.
140. Zheng B, Sage M, Cai W-W, Thompson DM, Tavsanli BC, Cheah, Y-C, and Bradley A
(1999). Engineering a mouse balancer chromosome. Nature Genetics, 22, 375-378.
141. Liu P, Wakamiya M, Shea MJ, Albrecht U, Behringer RR, and Bradley A (1999).
Requirement for Wnt3 in vertebrate axis formation. Nature Genetics, 22, 361-365.
142. Mishina Y, Crombie R, Bradley A, and Behringer RR (1999). Multiple roles for activin-like
kinase-2 signaling during mouse embryogenesis. Developmental Biology, 213, 314-326.
143. Lindsey EA, Botta A, Jurecic V, Carattini-Rivera S, Cheah Y-C, Rosenblatt HM, Bradley A,
and Baldini A (1999). Congenital heart disease in mice deficient for the DiGeorge
syndrome region Nature, 401, 379-383.
144. Justice MJ, Noveroske JK, Weber JS, Zheng B, and Bradley A (1999). Mouse ENU
mutagenesis. Hum. Mol. Genet., 8, 1955-1963.
145. Luo G, Yao MS, Bender CF, Mills M, Bladl AR, Bradley A and Petrini JH (1999).
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic
development and sensitivity to ionizing radiation. Proc. Natl. Acad. Sci. USA, 96, 73767381.
146. Abuin A, Zhang H and Bradley A (2000). Genetic analysis of mouse embryonic stem cells
bearing Msh3 and Msh2 single and compound mutations, Mol. Cell. Biol., 20, 149-157.
147. Klysik J, Cai WW and Bradley A (2000). An integrated gene and SSLP BAC map
framework of mouse chromosome 11. Genomics, 62, 123-128.
148. Zheng B, Sage M, Sheppeard EA, Jurecic V, and Bradley A (2000). Engineering mouse
chromosomes with Cre-loxP: Range, efficiency and somatic applications. Mol. Cell. Biol,
20, 648-655.
149. Su H, Wang X and Bradley A (2000). Nested chromosomal deletions induced with
retroviral vectors in mice. Nature Genetics, 24, 92-95.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 13
150. Hasty P, Abuin A and Bradley A (2000). Gene targeting, principles & practice in
mammalian cells. In Gene Targeting, a Practical Approach, 2nd Edition, IRL Press, Ed. A.
Joyner.
151. Schildmeyer LA, Braun R, Taffet G, Debasi M, Burns AE, Bradley A & Schwartz RJ.
(2000). Impaired vascular contractility and blood pressure homeostasis in the smooth
muscle actin null mouse. FASEB J. 14, 2213-2220.
152. Medina-Martinez O, Bradley A and Ramirez-Solis R (2000). A large targeted deletion of
Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations.
Dev. Biol. 222, 71-83.
153. Suraokar M, and Bradley A (2000). Targeting sheep. Nature, 405, 1004-1005.
154. Luo G, Santoro I, McDaniel LD, Nishijima I, Mills M, Youssoufian H, Vogel H, Schultz RA,
Bradley A (2000) Cancer predisposition caused by elevated mitotic recombination in
Bloom mice. Nature Genetics 26, 424-429.
155. Chen Y-T and Bradley A (2000). A new positive/negative selectable marker, pu∆tk, for
use in embryonic stem cells. Genesis 28, 31-35.
156. Liu Q, Guntuku S, Chi XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S,
DeMayo F, Bradley A, Donehower LA, and Elledge SJ (2000). CHK1 is an essential gene
that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes &
Devel. 14, 1448-1459.
157. Pershouse M, Li J, Yang C, Su H, Brundage E, Di W, Biggs PJ, Bradley A, and Chinault,
AC (2000). BAC contig from a 3 cM region of mouse chromosome 11 surrounding Brca1.
Genomics 69, 139-142.
158. Lindsay EA, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jureic V, Ogunrinu G,
Sutherland H, Scambler PJ, Bradley A & Baldini A (2001). Tbx haploinsufficiency in the
DiGeorge syndrome region causes aortic arch defects in mice. Nature 410 97-101
159. Binhai Zheng, Urs Albrecht, Krista Kaasik, Marijke Sage, Weiqin Lu, Sukeshi Vaishnav, Qiu
Li, Zhong Sheng Sun, Gregor Eichele, Allan Bradley (2001) Nonredundant Roles of the
mPer1 and mPer2 Genes in the Mammalian Circadian Clock. Cell 105(5) 683-694.
160. Binhai Zheng, Alea A Mills and Allan Bradley (2001). Introducing defined chromosomal
rearrangements into the mouse genome. Methods 24(1) 81-94
161. Alea A Mills and Allan Bradley (2001) From mouse to man: generating megabase
chromosome rearrangements. Trends in Genetics 17 (6) 331-339
162. Michele A Cleary, Catherine D van Raamsdonk, John Levorse, Binhai Zheng, Allan
Bradley & Shirley M Tilghman (2001) Disruption of an imprinted gene cluster by a
targeted Chromosomal translocation in mice. Nature Genetics 29 78-82
163. Cai W, Chow C, Damani C and Bradley A (2001). An SSLP marker anchored BAC
framework map of the mouse genome. Nature Genetics 29(2) 133-4
Allan Bradley, Ph.D.
Curriculum Vitae
Page 14
164. Jane Rogers and Allan Bradley (2001) The Mouse Genome Sequence: Status and
Prospects. Genomics 77 (3) 117-8
165. Yeujin Yu and Allan Bradley (2001) Engineering chromosomal rearrangements in mice.
Nature Reviews Genetics 2(10) 780-790
166. Wei-Wen Cai, Rui Chen, Richard A Gibbs and Allan Bradley (2001). A clone-array pooled
shotgun strategy for sequencing large genomes. Genome Research 11 1619-1623
167. David J Adams, Allan Bradley (2002) Induced mitotic recombination: a switch in time
Nature Genetics 30(1) 6-7
168. Stuart D Tyner, Sundaresan Venkatachalam, Jene Choi, Stephen Jones, Nader
Ghebranious, Herbert Igelmann, Xionghbin Lu, Gabrialle Soron, Banjamin Cooper, Cory
Brayton, Sang Hee Park, Timothy Thompson, Gerard Karsenty, Allan Bradley & Lawrence
A Donehower (2002) P53 mutant mice that display early ageing associated phenotypes
Nature 415(3) 45-53
169. Wei-Wen Cai, Jian-Hua Mao, Chi-Wen Chow, Shamsha Damani, Allan Balmain, Allan
Bradley (2002) Genome-wide Detection of Chromosomal Imbalances in Tumors Using
BAC Microarrays. Nature Biotechnology 20 393-396
170. Hong Su, Alea A Mills, Xiaozhong Wang and Allan Bradley (2002) A Targeted X-linked
CMV-Cre Line. Genesis 32 187-188
171. Alea A Mills, Yi Qi and Allan Bradley (2002) Conditional Inactivation of p63 by CreMediated Excision. Genesis 32 138-141
172. XiaozhongWang, Hong Su and Allan Bradley (2002) Molecular Mechanisms Governing
Gene Expression: Evidence for a Multiple Promoters and cis- Alternative Splicing
Model Genes & Development 16 (15)
173. Binhai Zheng, Hannes Vogel, Lawrence A Donehower and Allan Bradley (2002) Visual
Genotyping of a Coat Color Tagged p53 Mutant Mouse Line Cancer Biology and Therapy
1 (4)
174. Xiaozhong Wang, Hong Su, Leslie D Copenhagen, Sukishi Vaishnav, Fredalina Pieri,
Cynthia Do Shope, William E Brownell, Mariella De Biasi, Richard Paylor, and Allan
Bradley (2002). Urocortin deficient mice display normal stress-induced anxiety behavior
and autonomic control but impaired acoustic startle response. Molecular and Cellular
Biology 22 (18) 6605-6610
175. Louise van der Weyden, Jos Jonkers and Allan Bradley (2002) Cancer: Stuck at first
base. Nature 419 127-128
176. Xiaozhong Wang, Joshua A Weiner, Sabine Levi, Ann Marie Craig, Allan Bradley and
Joshua R Sanes (2002) Gamma Protocadherins are required for survival of spinal
Interneurons. Neuron 36 1-20
177. Allan Bradley (2002) Mining the mouse genome Nature 420 512-514
178. Louise van der Weyden, David J Adams and Allan Bradley (2002) Tools for targeted
manipulation of the mouse genome. Physiological Genomics 11 133-164
Allan Bradley, Ph.D.
Curriculum Vitae
Page 15
179. Ana O. Hoff, Philip Catala-Lehnen, Pamela M. Thomas, Matthias Priemel, Johannes
M.Rueger, Igor Nasonkin, Allan Bradley, Mark R. Hughes, Nelson Ordonez, Gilbert J.
Cote, Michael Amling, and Robert F. Gagel (2002) Increased bone mass is an
unexpected phenotype associated with deletion of the calcitonin gene J. Clin. Invest. 110:
1849-1857.
180. Choi J, Nannenga B, Demidov ON, Bulavin DV, Cooney A, Brayton C, Zhang Y, Mbawuike
IN, Bradley A, Appella E, Donehower LA. (2002) Mice deficient for the wild-type p53induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function,
and cell cycle control. Mol Cell Biol. 22(4):1094-105
181. Jan Klysik, Monica Justice and Allan Bradley (2003) Chromosome Engineering and ENU
Mutagenesis: Their Use for Defining Gene Function. Current Genomics 4 37-50
182. Katherina Walz, Sandra Caratini-Rivera, Weimin Bi, Patricia Fonseca, Dena L. Mansouri,
Jennifer Lynch, Hannes Vogel, Jeffrey L. Noebels, Allan Bradley, and James R. Lupski
(2003) Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) Contiguous Gene
Syndromes by Chromosome Engineering in Mice: Phenotypic Consequences of Gene
Dosage Imbalance Molecular and Cellular Biology 23(10) 3646–3655
183. Haydn Prosser and Allan Bradley (2003) Transgenics at breaking-point Cancer Cell 3
411-413
184. Guangwen Cao, Guang Yang, Terry L. Timme, Takashi Saika, Luan D. Truong, Takefumi
Satoh, Alexei Goltsov, Sang Hee Park, Taoyan Men, Nobuyuki Kusaka, Weihua Tian,
Chengzhen Ren, Hongyu Wang, Dov Kadmon, Wei Wen Cai, A. Craig Chinault, Timothy B.
Boone, Allan Bradley and Timothy C. Thompson (2003) Disruption of the Caveolin-1
Gene Impairs Renal Calcium Reabsorption and Leads to Hypercalciuria and Urolithiasis.
American Journal of Pathology 162 (4) 1241-1248
185. P J Biggs, H Vogel, M Sage, L A Martin, L A Donehower, A Bradley (2003) Allelic phasing
of a mouse chromosome 11 deficiency influences p53 tumourigenicity (In press)
Oncogene
186. Ichiko Nishijima, Alea Mills, Yi Qi, Michael Mills and Allan Bradley (2003) Two New
balancer Chromosomes on Mouse Chromosome 4 to Facilitate Functional Annotation of
Human Chromosome 1p Genesis 26 142-148
187. Benjamin T. Kile, Kathryn E. Hentges, Amander T. Clark, Hisashi Nakamura, Andrew P.
Salinger, Bin Liu, Neil Box, David W. Stockton, Randy L. Johnson, Richard R. Behringer,
Allan Bradley & Monica J. Justice (2003) Functional genetic analysis of mouse
chromosome 11. Nature 425 81-86
188. Huiling Liang, Qin Chen, Andrew H. Coles, Stephen J. Anderson, German Pihan, Allan
Bradley, Rachel Gerstein, Roland Jurecic and Stephen N. Jones (2003) Wnt5a inhibits B
cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell
4 (5) 349-360
189. Jiong Yan, Katherina Walz, Hisashi Nakamura, Sandra Carattini-Rivera, Qi Zhao, Hannes
Vogel, Ning Wei, Monica J. Justice, Allan Bradley, and James R. Lupski (2003) COP9
Signalosome Subunit 3 Is Essential for Maintenance of Cell Proliferation in the Mouse
Embryonic Epiblast Mol. Cell. Biol. 23(19) 6798-6808.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 16
190. Cao G, Yang G, Timme TL, Saika T, Truong LD, Satoh T, Goltsov A, Park SH, Men T,
Kusaka N, Tian W, Ren C, Wang H, Kadmon D, Cai WW, Chinault AC, Boone TB, Bradley
A, Thompson TC. (2003) Disruption of the caveolin-1 gene impairs renal calcium
reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol. 162(4) 1241-8.
191. Yeun-Jun Chung, Jos Jonkers, Hannah Kitson, Heike Fiegler Sean Humphray Carol Scott
Sarah Hunt Yuejin Yu, Ichiko Nishijima, Arno Velds, Henne Holstege, Nigel Carter and
Allan Bradley (2004) A Whole-Genome Mouse BAC Microarray With 1-Mb Resolution
for Analysis of DNA Copy Number Changes by Array Comparative Genomic Hybridization.
Genome Research 14:188-196
192. Jan Klysik, Chris Dinh and Allan Bradley. (2004) Two new mouse chromosome 11
balancers. Genomics 83(2) 303-310
193. Ge Guo, Wei Wang & Allan Bradley. (2004) Mismatch repair genes identified using
genetic screens in Blm-deficient embryonic stem cells. Nature 429 891-895
194. Thompson, D. M., van der Weyden, L., Biggs, P. J., Chung, Y.-J., and Bradley, A., (2004)
Mouse models of cancer. Oncogenomics. Molecular approaches to cancer, Brenner, C.,
and Duggan, D., Eds., Wiley-Liss, pp. 199-254.
195. Adams D.J., P.J. Biggs, T. Cox, R. Davies, L. van der Weyden, J. Jonkers, J. Smith, B.
Plumb, R. Taylor, I. Nishijima, Y. Yu, J. Rogers & A. Bradley (2004) Mutagenic Insertion
and Chromosome Engineering Resource (MICER). Nature Genetics 36, 867-71.
196. The Comprehensive Knockout Mouse Project Consortium: Christopher P Austin, James F
Battey, Allan Bradley, Maja Bucan, Mario Capecchi, Francis S Collins, William F Dove,
Geoffrey Duyk, Susan Dymecki, Janan T Eppig, Franziska B Grieder, Nathaniel Heintz,
Geoff Hicks, Thomas R Insel, Alexandra Joyner, Beverly H Koller, K C Kent Lloyd, Terry
Magnuson, Mark W Moore, Andras Nagy, Jonathan D Pollock, Allen D Roses, Arthur T
Sands, Brian Seed, William C Skarnes, Jay Snoddy, Philippe Soriano, David J Stewart,
Francis Stewart, Bruce Stillman, Harold Varmus, Lyuba Varticovski, Inder M Verma,
Thomas F Vogt, Harald von Melchner, Jan Witkowski, Richard P Woychik, Wolfgang
Wurst, George D Yancopoulos, Stephen G Young & Brian Zambrowicz (2004) The
Knockout Mouse Project Nature Genetics 36(9) 921 – 924
197. The European Mouse Mutagenesis Consortium: Johan Auwerx, Phil Avner, Richard
Baldock, Andrea Ballabio, Rudi Balling, Mariano Barbacid, Anton Berns, Allan Bradley,
Steve Brown, Peter Carmeliet, Pierre Chambon, Roger Cox, Duncan Davidson, Kay
Davies, Denis Duboule, Jiri Forejt, Francesca Granucci, Nick Hastie, Martin Hrabé de
Angelis, Ian Jackson, Dimitris Kioussis, George Kollias, Mark Lathrop, Urban Lendahl,
Marcos Malumbres, Harald von Melchner, Werner Müller, Juha Partanen, Paola RicciardiCastagnoli, Peter Rigby, Barry Rosen, Nadia Rosenthal, Bill Skarnes, A Francis Stewart,
Janet Thornton, Glauco Tocchini-Valentini, Erwin Wagner, Walter Wahli & Wolfgang Wurst
(2004) The European dimension for the mouse genome mutagenesis program. Nature
Genetics 36(9) 925-927
198. Jiong Yan, Victoria W. Keener, Weimin Bi1, Katherina Walz, Allan Bradley, Monica J.
Justice and James R. Lupski (2004) Reduced penetrance of craniofacial anomalies as a
function of deletion size and genetic background in a chromosome engineered partial
mouse model for Smith–Magenis syndrome Human Molecular Genetics Vol. 13(21) 26132624
Allan Bradley, Ph.D.
Curriculum Vitae
Page 17
199. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. (2004). Identification of
mammalian microRNA host genes and transcription units. Genome Res.14:1902-10.
200. You-Tzung Chen, Pentao Liu, and Allan Bradley (2004) Inducible Gene Trapping with
Drug-Selectable Markers and Cre/loxP To Identify Developmentally Regulated Genes.
Mol. Cell. Biol. 24(22): 9930-9941
201. You-Tzung Chen, Regis Levasseur, Sukeshi Vaishnav, Gerard Karsenty, and Allan
Bradley (2004) Bigenic Cre/loxP, putk conditional genetic ablation. Nucl. Acids Res. 32:
e161
202. David J Adams, Louise van der Weyden, Fanni V Gergely, Mark J Arends, Bee Ling Ng,
David Tannahill, Roland Kanaar, Andrea Markus, Brian J Morris, Allan Bradley (2005)
‘BRCTx is a novel hRad18 interacting protein’ Molecular & Cellular Biology 25(2) 779-788
203. David J Adams, Emmanouil T Dermitzakis, Tony Cox, James Smith, Rob Davies, Ruby
Banerjee, James Bonfield, James C Mullikin, Yeun Jun Chung, Jane Rogers & Allan
Bradley (2005) Complex haplotypes, copy number polymorphisms and coding variation in
two recently divergent mouse strains. Nature Genetics 37(5), 532 – 536
204. Zhongyou Lia, Paul F. Szureka, Chuantao Jiangb, Annie Paoa, Brian Bundyc, Wei-dong
Leb, Allan Bradley and Y. Eugene Yu (2005) Neuronal differentiation of NTE-deficient
embryonic stem cells. Biochemical and Biophysical Research Communications 330(4)
1103-1109
205. Tomás Vacík, Michael Ort, Sona Gregorová, Petr Strnad, Radek Blatny, Nathalie Conte,
Allan Bradley, Jan Bures, and Jirí Forejt (2005) Segmental trisomy of chromosome 17: A
mouse model of human aneuploidy syndromes. PNAS 102(12) 4500-4505
206. van der Weyden L., D.J. Adams, L.W. Harris, D. Tannahill, M.J. Arends & A. Bradley
(2005): Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT
vector. Genesis 41(4) 171-8
207. van der Weyden L., K.K. Tachibana, M.A. Gonzalez, D.J. Adams, B.L. Ng, R. Petty, A.R.
Venkitaraman, M.J. Arends & A. Bradley (2005) The RASSF1A Isoform of RASSF1
Promotes Microtubule Stability and Suppresses Tumorigenesis. Mol. Cell. Biol. 25(18)
8356-67.
208. Adams, D. J.; Quail, M. A.; Cox, T.; van der Weyden, L.; Gorick, B. D.; Su, Q.; Chan, W. I.;
Davies, R.; Bonfield, J. K.; Law, F.; Humphray, S.; Plumb, B.; Liu, P.; Rogers, J.; Bradley,
A. (2005) A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector
construction. Genomics 86 753-8
209. Loning Fu, Millan S. Patel, Allan Bradley, Erwin F. Wagner, Gerard Karsenty (2005) The
Molecular Clock Mediates Leptin-Regulated Bone Formation. Cell 122 (5) 803-815
210. Louise van der Weyden, Mark J. Arends, Oriane E. Chausiaux, Peter J. Ellis, Ulrike C.
Lange, M. Azim Surani, Nabeel Affara, Yoshinori Murakami, David J. Adams, and Allan
Bradley (2006) Loss of TSLC1 Causes Male Infertility Due to a Defect at the Spermatid
Stage of Spermatogenesis. Mol. Cell. Biol. 26: 3595-3609.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 18
211. Kathryn E. Hentges, Hisashi Nakamura, Yasuhide Furuta, Yuejin Yu, Debrah M.
Thompson, William O’Brien, Allan Bradley and Monica J. Justice (2006) Novel lethal
mouse mutants produced in balancer chromosome screens Gene Expression Patterns 6
653-665
212. Michael C. Zody, Manuel Garber, David J. Adams, Ted Sharpe, Jennifer Harrow, James R.
Lupski, Christine Nicholson, Steven M. Searle, Laurens Wilming, Sarah K. Young, Amr
Abouelleil, Nicole R. Allen, Weimin Bi, Toby Bloom, Mark L. Borowsky, Boris E. Bugalter,
Jonathan Butler, Jean L. Chang, Chao-Kung Chen, April Cook, Benjamin Corum, Christina
A. Cuomo, Pieter J. de Jong, David DeCaprio, Ken Dewar, Michael FitzGerald, James
Gilbert, Richard Gibson, Sante Gnerre, Steven Goldstein, Darren V. Grafham, Russell
Grocock, Nabil Hafez, Daniel S. Hagopian, Elizabeth Hart, Catherine Hosage Norman,
Sean Humphray, David B. Jaffe, Matt Jones, Michael Kamal, Varsha K. Khodiyar, Kurt
LaButti, Gavin Laird, Jessica Lehoczky, Xiaohong Liu, Tashi Lokyitsang, Jane Loveland,
Annie Lui, Pendexter Macdonald, John E. Major, Lucy Matthews, Evan Mauceli, Steven A.
McCarroll, Atanas H. Mihalev, Jonathan Mudge, Cindy Nguyen, Robert Nicol, Sinéad B.
O'Leary, Kazutoyo Osoegawa, David C. Schwartz, Charles Shaw-Smith, Pawel
Stankiewicz, Charles Steward, David Swarbreck, Vijay Venkataraman, Charles A.
Whittaker, Xiaoping Yang, Andrew R. Zimmer, Allan Bradley, Tim Hubbard, Bruce W.
Birren, Jane Rogers, Eric S. Lander and Chad Nusbaum (2006) DNA sequence of human
chromosome 17 and analysis of rearrangement in the human lineage. Nature 440 1045-9
213. Keyes W.M., H. Vogel, M.I. Koster, X. Guo, Y. Qi, K.M. Petherbridge, D.R. Roop, A.
Bradley & A.A. Mills (2006) p63 heterozygous mutant mice are not prone to spontaneous
or chemically induced tumors. PNAS 103 8435-40
214. Yu Y.E., M. Morishima, A. Pao, D.Y. Wang, X.Y. Wen, A. Baldini & A. Bradley (2006): A
deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in
mice. Genetics 173 297-307
215. Michael A. Gonzalez, Kiku-e K. Tachibana, David J. Adams, Louise van der Weyden,
Myriam Hemberger, Nicholas Coleman, Allan Bradley, and Ronald A. Laskey (2006)
Geminin is essential to prevent endoreduplication and to form pluripotent cells during
mammalian development. Genes Dev. 20 1880-1884
216. van der Weyden L., M.J. Arends, O.E. Chausiaux, P.J. Ellis, U.C. Lange, M.A.Surani, N.
Affara, Y. Murakami, D.J. Adams & A. Bradley (2006): Loss of TSLC1 Causes Male
Infertility Due to a Defect at the Spermatid Stage of Spermatogenesis. Molecular and
cellular biology 26 3595-609.
217. Bradley A. & L. van der Weyden (2006) Mouse: Chromosome Engineering for Modeling
Human Disease. Annu Rev Genomics Hum Genet 7 247-276
218. Cunningham F., D. Rios, M. Griffiths, J. Smith, Z. Ning, T. Cox, P. Flicek, P. Marin-Garcin,
J. Herrero, J. Rogers, L. van der Weyden, A. Bradley, E. Birney & D.J. Adams (2006):
TranscriptSNPView: a genome-wide catalog of mouse coding variation Nature Genetics
38 853
219. Ohtoshi A., A. Bradley, R.R. Behringer & I. Nishijima (2006): Generation and maintenance
of Dmbx1 gene-targeted mutant alleles. Mamm Genome 17 744-50
220. van der Weyden L., L. Wei, J. Luo, X. Yang, D.E. Birk, D.J. Adams, A.Bradley & Q. Chen
(2006): Functional knockout of the matrilin-3 gene causes premature chondrocyte
Allan Bradley, Ph.D.
Curriculum Vitae
Page 19
maturation to hypertrophy and increases bone mineral density and osteoarthritis. Am J
Pathol 169 515-27
221. Ichiko Nishijima, Takanori Yamagata, Corinne M. Spencer, Edwin J. Weeber, Olga
Alekseyenko, J. David Sweatt, Mariko Y. Momoi, Masayuki Ito, Dawna L. Armstrong, David
L. Nelson, Richard Paylor, and Allan Bradley (2006) Secretin receptor-deficient mice
exhibit impaired synaptic plasticity and social behavior Hum. Mol. Genet. 15 3241-3250
222. Wang W., M. Warren & A. Bradley (2007) Induced mitotic recombination of p53 in vivo.
PNAS, 104 4501-4505
223. Warren M., W. Wang, S. Spiden, D. Chen-Murchie, D. Tannahill, K.P. Steel & A. Bradley
(2007) A Sall4 mutant mouse model useful for studying the role of Sall4 in early
embryonic development and organogenesis. Genesis 45 51-8
224. Prosser H.M., A. Bradley, J.E. Chesham, F.J. Ebling, M.H. Hastings & E.S. Maywood
(2007): Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior
by the suprachiasmatic nuclei. PNAS 104 648-653
225. Antony Rodriguez, Elena Vigorito, Simon Clare, Madhuri V. Warren, Philippe Couttet,
Dalya R. Soond, Stijn van Dongen, Russell J. Grocock, Partha P. Das, Eric A. Miska, David
Vetrie, Klaus Okkenhaug, Anton J. Enright, Gordon Dougan, Martin Turner, and Allan
Bradley (2007) Requirement of bic/microRNA-155 for Normal Immune Function. Science
316 608-611
226. Wang, W., Bradley, A. A recessive genetic screen for host factors required for retroviral
infection in a library of insertionally mutated Blm-deficient embryonic stem cells Genome
Biology 8(4):R48 (2007)
227. Juan Cadiñanos and Allan Bradley (2007) Generation of an inducible and optimized
piggyBac transposon system Nucleic Acids Research 35: e87
228. Haydn M. Prosser, Allan Bradley, Maeve A. Caldwell (2007) Olfactory bulb hypoplasia in
Prokr2 null mice stems from defective neuronal progenitor migration and differentiation.
European Journal of Neuroscience 26 (12) 3339–3344
229. Chan CS, Levenson JM, Mukhopadhyay PS, Zong L, Bradley A, Sweatt JD, Davis
RL.(2007) Alpha3-integrins are required for hippocampal long-term potentiation and
working memory. Learn Mem. 14(9):606-15.
230. Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska
EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC,
Turner M. (2007) microRNA-155 regulates the generation of immunoglobulin classswitched plasma cells. Immunity 27(6):847-59
231. L. van der Weyden, M. J. Arends, O. M. Dovey, H. L. Harrison, G. Lefebvre, N. Conte, F. V.
Gergely, A. Bradley & D. J. Adams (2008) Loss of Rassf1a cooperates with Apc(Min) to
accelerate intestinal tumourigenesis. Oncogene 27 4503-4508
232. Q. Liang, N. Conte, W. C. Skarnes & A. Bradley (2008): Extensive genomic copy number
variation in embryonic stem cells. Proceedings of the National Academy of Sciences of the
United States of America 105 17453-17456
Allan Bradley, Ph.D.
Curriculum Vitae
Page 20
233. Su, Q., Prosser, H.M., Campos, L.S., Ortiz, M., Nakamura, T., Warren, M., Dupuy, A.J.,
Jenkins, N.A., Copeland, N.G., Bradley, A. & Liu, P. (2008) A DNA transposon-based
approach to validate oncogenic mutations in the mouse. Proceeding of the National
Academy of Science of the United States of America, 105(50) 19904-19909.
234. Wang, W., Lin, C., Lu, D., Ning, Z., Cox, T., Melvin, D., Wang, X., Bradley, A. & Liu, P.
(2008) Chromosomal transposition of PiggyBac in mouse embryonic stem cells.
Proceeding of the National Academy of Science of the United States of America 105(27)
9290-9295.
235. Prosser HM, Rzadzinska AK, Steel KP, Bradley A. (2008) Mosaic complementation
demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell
Biol. 28(5):1702-12.
236. Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A, Surani MA. (2008)
Normal germline establishment in mice carrying a deletion of the Ifitm/Fragilis gene family
cluster. Mol Cell Biol. 28(15) 4688-96
237. Ijuin, T.; Yu, Y. E.; Mizutani, K.; Pao, A.; Tateya, S.; Tamori, Y.; Bradley, A.; Takenawa, T.
(2008) Increased insulin action in SKIP heterozygous knockout mice Molecular and
Cellular Biology. 28(17) 5184-95
238. L. van der Weyden, C. Shaw-Smith & A. Bradley (2009): Chromosome Engineering in ES
Cells. Methods in Molecular Biology 530 1-29.
239. Wang, W., Bradley, A. & Huang, Y. (2009), "A piggyBac transposon-based genome-wide
library of insertionally mutated Blm-deficient murine ES cells", Genome Research 19(4)
667-673
240. Yusa, K., Rad, R., Takeda, J. & Bradley, A. (2009), "Generation of transgene-free induced
pluripotent mouse stem cells by the piggyBac transposon", Nature methods 6 363-369
241. Melissa K Boles, Bonney M Wilkinson, Andrea Maxwell, Lihua Lai, Alea A Mills, Ichiko
Nishijima, Andrew P Salinger, Ivan Moskowitz, Karen K Hirschi, Bin Liu, Allan Bradley,
Monica J Justice (2009) A mouse chromosome 4 balancer ENU-mutagenesis screen
isolates eleven lethal lines BMC Genetics 10:12
242. Liang, Q., Kong, J., Stalker, J. & Bradley, A. (2009) "Chromosomal mobilization and
reintegration of Sleeping Beauty and PiggyBac transposons", Genesis 47(6) 404-408
243. Zoltán Ivics, Meng Amy Li, Lajos Mátés, Jef D Boeke, Andras Nagy, Allan Bradley &
Zsuzsanna Izsvák (2009) Transposon-mediated genome manipulation in vertebrates.
Nature Methods 6(6) 415-422
244. Stephen J. Pettitt, Qi Liang, Xin Y. Rairdan, Jennifer L. Moran, Haydn M. Prosser, David R.
Beier, Kent Lloyd, Allan Bradley & William C. Skarnes (2009) Agouti C57BL/6N embryonic
stem cells – a foundation for mouse genetic resources Nature Methods 6(7) 493-495
245. Nakatani, J., Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., Tomonaga, S.,
Watanabe, Y., Chung, Y.J., BANERJEE, R., Iwamoto, K., Kato, T., Okazawa, M.,
Yamauchi, K., Tanda, K., Takao, K., Miyakawa, T., Bradley, A. & Takumi, T.(2009)
"Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13
Duplication Seen in Autism", Cell, 137(7)1235-1246
Allan Bradley, Ph.D.
Curriculum Vitae
Page 21
246. Jack Favor, Allan Bradley, Nathalie Conte, Dirk Janik, Walter Pretsch, Peter Reitmeir,
Michael Rosemann, Wolfgang Schmahl, Johannes Wienberg, and Irmgard Zaus (2009)
“Analysis of Pax6 Contiguous Gene Deletions in the Mouse, Mus musculus, Identifies
Regions Distinct from Pax6 Responsible for Extreme Small-Eye and Belly-Spotting
Phenotypes” Genetics 2009 182(4) 1077–1088
247. Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ, Harrow J, Grafham D, Hentges
KE, Woodward LP, Maxwell A, Mitchell K, Risley MD, Johnson R, Hirschi K, Lupski JR,
Funato Y, Miki H, Marin-Garcia P, Matthews L, Coffey AJ, Parker A, Hubbard TJ, Rogers J,
Bradley A, Adams DJ, Justice MJ. (2009) Discovery of candidate disease genes in ENUinduced mouse mutants by large-scale sequencing, including a splice-site mutation in
nucleoredoxin. PLoS Genet. 5(12) e1000759
248. Mercedes Pardo, Benjamin Lang, Lu Yu, Haydn Prosser, Allan Bradley, M. Madan Babu,
Jyoti Choudhary (2010) An Expanded Oct4 Interaction Network: Implications for Stem Cell
Biology, Development, and Disease Cell Stem Cell 6(4), 382-395
249. Warren M, Chung YJ, Howat WJ, Harrison H, McGinnis R, Hao X, McCafferty J,
Fredrickson TN, Bradley A, Morse HC 3rd. (2010) Irradiated Blm-deficient mice are a
highly tumor prone model for analysis of a broad spectrum of hematologic malignancies
Leuk Res 34(2):210-20
250. Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB,
Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L. (2010) Butyrate greatly
enhances derivation of human induced pluripotent stem cells by promoting epigenetic
remodeling and the expression of pluripotency-associated genes. Stem Cells 28(4) 71320.
251. Dietrich MF, van der Weyden L, Prosser HM, Bradley A, Herz J, Adams DJ. (2010)
Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage
independent functions in vivo. PLoS 5(4):e9960.
252. Yu T, Li Z, Jia Z, Clapcote SJ, Liu C, Li S, Asrar S, Pao A, Chen R, Fan N, Carattini-Rivera
S, Bechard AR, Spring S, Henkelman RM, Stoica G, Matsui S, Nowak NJ, Roder JC, Chen
C, Bradley A, Yu YE. (2010) A mouse model of Down syndrome trisomic for all human
chromosome 21 syntenic regions. Hum Mol Genet. 19(14):2780-91
253. Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC,
Baldini A, Mobley WC, Bradley A, Yu YE. (2010) Deficiencies in the region syntenic to
human 21q22.3 cause cognitive deficits in mice. Mamm Genome.;21(5-6):258-67
254. Vassiliou G, Rad R, Bradley A. (2010) The use of DNA transposons for cancer gene
discovery in mice. Methods Enzymol. 477:91-106
255. Li MA, Pettitt SJ, Yusa K, Bradley A. (2010) Genome-wide forward genetic screens in
mouse ES cells. Methods Enzymol. 477:217-42.
256. Foster CT, Dovey OM, Lezina L, Luo JL, Gant TW, Barlev N, Bradley A, Cowley SM.
(2010) Lysine Specific Demethylase 1 (LSD1) Regulates the Embryonic Transcriptome
and CoREST Stability. Mol Cell Biol. [Epub ahead of print]
Allan Bradley, Ph.D.
Curriculum Vitae
Page 22
257. Rad, R., Rad, L., Cadinanos, J,. Vassiliou, G,. Rice, S,. Campos, L,. Yusa, K,. Banerjee,
R,. Li, M,. de la Rosa, J,. Lu, D,. Ellis, P,. Conte, N,. Yang, F.T., Liu, P,.Bradley, A,. (2010)
Cancer Gene discovery in mice using PiggyBac transposon mutagenesis Science 330
1104-07
258. Royo, H., Polikiewicz, G., Mahadevaiah, S. K., PROSSER, H., Mitchell, M., BRADLEY, A.,
de Rooij, D. G., Burgoyne, P. S. and Turner, J. M. A. (2010) Evidence that Meiotic Sex
Chromosome Inactivation Is Essential for Male Fertility Current Biology
20(23)21172123
259. Kosuke Yusa, Liqin Zhou, Meng Amy Li, Allan Bradley, and Nancy L. Craig (2011) A
hyperactive piggyBac transposase for mammalian applications. PNAS published ahead of
print January 4
260. Meng Amy Li & Allan Bradley (2011) Crafting rat genomes with zinc fingers.
Nature Biotechnology 29(1) 39-41
261. Su Kit Chew, Roland Rad, P. Andrew Futreal, Allan Bradley, Pentao Liu. (2011) Genetic
screens using the piggyBac transposon Methods in press
-------------------------------------------------------------------------------Issued Patents
1.
Donehower LA, Bradley A, Butel JS, and Slagle B (1996). Transgenic Mice
Containing a Disrupted p53 Gene. US Patent # 5,569,824, Oct 29th 1996.
2.
Bradley A, Hasty P, Davis AC. Methods for the Genetic Modification of
Endogenous Genes in Plants and Animals. US Patent #5,614,396, March 25,
1997.
3.
Beaudet AL, Wilson R, Bradley A, O'Brien WE, Sligh J, Ballantyne C, Bullard
D. Nonhuman animal having predefined allele of a cellular adhesion gene. US
Patent #5,602,307, Feb 11, 1997.
4.
Bradley A and Cai WW. Chemically modified nucleic acids and methods for
coupling nucleic acids to solid support. US Patent #, 6,048,695, April 11, 2000.
5.
Bradley A, Ramirez-Solis R and Lui P. Method for chromosomal rearrangement
by consecutive gene targeting of two recombination substrates to the deletion
endpoints. US Patent #6,077,667. June 20, 2000
6.
Arthur Sands, Alejandro Abuin & Allan Bradley. Xeroderma pigmentosumdeficient mouse. US Patent # 5,948,952 September 7, 1999.
Allan Bradley, Ph.D.
Curriculum Vitae
Page 23
7.
Arthur Sands, Glenn Friedrich, Brian Zambrowicz & Allan Bradley. Indexed
library of cells containing genomic modifications and methods of making and
utilizing the same. US Patent # 6,136,566 March 27th 2001.
8.
Gibbs, Richard; Bradley, Allan; Cai, Wei-Wen Clone-array poolet shotgun
strategy for nucleic acid sequencing. US Patent # 6,975,943 December 13, 2005
Consulting activities
1.
2.
3.
Genentech 1990 - 1992
Life Science Technologies 1991 - 1993
DuPont/Merck 1993 - 1996
Scientific Advisory Boards and Company Founding
1.
2.
3.
4.
5.
6.
7.
8.
9.
GenPharm 1988 - 1996 (Founding member of the SAB)
GeneMedicine 1993 – 1997 (SAB member)
Sequana Therapeutics 1993 - 1997 (Founding member of the SAB )
Lexicon Genetics 1995 - 1998 (Founder of the Company & Chair of SAB)
Spectral Genomics 2000- 2007 (Founder of the Company & SAB chair)
Ceros Pharmaceuticals 2000- 2002 (Co-founder of the company & SAB member)
Roswell Park Cancer Institute 2007-2009 (SAB Member)
RIKEN Yokohama Institute 2008- (SAB Member)
Max Plank Institute for Molecular Genetics 2008- (SAB Member)