AgResearch Ltd Summer Intern Scheme AgResearch Invermay 2012-2013 Summer Intern Scheme The AgResearch Summer Intern scheme has now been running for some years. In that time it has had success in introducing 3rd and 4th year tertiary science students who intend returning to University for further study in 2013 to the rigours and demands of research in a working science environment. The aim of the scheme is to provide a link between the tertiary and research campus. The scheme involves students completing a specific science project drawn from AgResearch’s local programmes. The projects must be completed over a ten week period over the University summer vacation (40 hours per week) - the Intern salary is for a taxable total of $6,200 paid on an hours-worked basis every fortnight ($15.50 per hour). At the end of the period the students complete a written report and present a short talk on the project, its results, and its implications in a Summer Interns’ Seminar held in February. The scheme will give a group of talented, potential science graduates exposure to research in the real world, while giving both students and AgResearch a view of future employment opportunities. The projects available this year are: PROJECT/S Quantitative genetics of sheep (AGR-SIS-IVY-01) The project will focus on data-analysis related to quantitative genetics and bioinformatics. An overarching aim is to gain insight into the genetic structure that forms the sheep population in New Zealand, and to develop tools to better achieve this. A number of sub-projects are available and will be chosen from as best suits the intern’s skills and interest. Data resources include millions of individually recorded sheep and thousands of genotypes from many thousands of individual animals. The project areas of interest are: 1.) investigating the necessary infrastructure (e.g. hardware) and fast and reliable software to impute from 50,000 genotypes to up to one million genotypes 2.) Conduct studies on genomic data in sheep to better understand the genetic architectural with respect to linkage disequilibrium between DNA markers in the context of effective population size and the NZ sheep population. 3.) Investigate whether any recorded sheep trait has important Xlinked inheritance patterns that would allow more efficient selection strategies 4) Investigate the influence of the degree of inbreeding on sheep performance (particularly lamb survival) and on the efficacy of selection. 5) Investigate whether lamb and maternal performance to weaning and genetic parameters, differs for shepherded compared with easy care (non-shepherded) flocks. The intern, depending on the project, may be Knowledge Area/s Supervisor & Project location Quantitative Genetics Bioinformatics Statistics Biology Computing Mathematics Michael Lee michael.lee@agresearch.co.nz Ken Dodds Benoit Auvray Sheryl-Anne Newman Invermay AgResearch Ltd Summer Intern Scheme computer literate, have a background in genetics or statistics, and interested in R&D. Data analysis of meat traits (AGR-SIS-IVY-02) The red meat industry is of high value to the New Zealand economy with export earnings of $8 billion annually. In addition to increasing meat yield, quality of meat is paramount. Key productive meat traits have been and are continuing to be developed by the industry. Utilising genetics and genomics it is possible to estimate breeding values for a variety of traits including meat yield and meat quality allowing the industry to make significant genetic gains in these traits. This summer internship involves the collection of meat phenotypes from processing plant, QC of meat trait data and subsequent data analysis. The student is required to have good data analysis skills in a statistical package such as R, SAS or equivalent. Mating allocation in salmon (AGR-SIS-IVY-03) In a breeding programme, pairs of animals are chosen for mating in a way that maximizes genetic gain subject to constraints on immediate and longterm inbreeding. However, for salmon the pool of candidates changes from day to day, depending on the maturation status of the fish. Therefore, preassigned mate allocations fail. This project aims to devise a computational tool that can input information on candidates that are available for selection on a particular day, along with matings that have already been done and possible future matings, and select a near-optimal set of matings to be performed on that day. Novel methods for breed prediction (AGR-SISIVY-04) DNA markers can be used for breed prediction. Some statistical techniques for assigning group membership do not perform well when there are many predictors. This project will investigate novel methods of utilising large datasets of DNA markers for predicting breed. The methods will be trialled using sheep data with 50,000 genotypes per animal. Identification of SNP (single nucleotide polymorphisms) markers in Greenshell mussel (AGR-SIS-IVY-05) Technologies now exist that enable us to quickly and efficiently locate, characterise, and isolate genes linked to traits of economic importance. The application of this information can have far reaching benefits in terms of stock enhancement and the identification and generation of novel commercial products, but has thus far been applied only sparingly to global aquaculture and never in a New Statistics Biology Agriculture Michael Lee michael.lee@agresearch.co.nz Invermay Computing, Mathematics, Genetics Ken Dodds ken.dodds@agresearch.co.nz Invermay Statistics, Mathematics, Genetics Ken Dodds ken.dodds@agresearch.co.nz Invermay Bioinformatics Anar Khan anar.khan@agresearch.co.nz Invermay AgResearch Ltd Summer Intern Scheme Zealand context. We are currently developing a genomic scaffold and genetic markers for GreenshellTM mussel (Perna canaliculus), a species that with export earnings of NZ$202m (2009) is the cornerstone of the NZ aquaculture industry, but which thus far has been the subject of little genetic improvement. Interfacing traditional animal husbandry, aquaculture and new genomic approaches we will develop and apply a suite of genomic tools to rapidly enhance this species through marker based selective breeding. Using this approach we hope to produce a product that has, for example, more appealing colouration and flesh characteristics, enhanced food conversion and growth rates, heightened resistance to disease, improved shelf life, and higher levels of valuable nutraceutical compounds. This summer intern project will involve the QC and analysis of next generation sequencing data to identify SNPs (single nucleotide polymorphisms) in the mussel genome. This project requires a student with good bioinformatics skills. To summarise, the scheme involves: Ten weeks work over the summer vacation, 40 hours per week Based at Invermay Agricultural Centre, Puddle Alley, Mosgiel, Dunedin (no public transport available) A taxable salary of $6,200 Training in research methodology Providing written and oral presentations For any further information or queries please contact the Project Supervisor or email linda.murray@agresearch.co.nz Applications close on Wednesday 14th September 2012 to: Linda Murray AgResearch Private Bag 50034 MOSGIEL 9053 By Email: linda.murray@agresearch.co.nz