个人简历 【学习经历】: 博士后,美国哈佛大学(1990-1993 年) 硕博,日本名古屋大学(硕博连读,1985-1990 年),导师:后藤俊夫 (国际天 然产物化学权威) 学士,南京大学化学系(1979-1983 年) 【工作经历】: 2011 年 1 月—现在 江南大学太湖学者,特聘教授 2008 年 6 月—现在 董事长兼总经理;Alpha Biopharmaceuticals,Inc., Burlingame, CA, USA 2002 年 6 月—2008 年 6 月 高级研究员,项目经理;Genentech, Inc., South San Francisco, CA, USA 2000 年 1 月—2002 年 6 月 高级研究员,项目经理;Cytokinetics, Inc., South San Francisco, CA, USA 1998 年 2 月—2000 年 1 月 化学业务总监,RepliGen Co., Needam, MA, USA 1993 年 5 月—1998 年 2 月 研究员,项目经理,Novartis(Chiron), Seattle, WA, USA 【主讲课程】 药物化学、药物分析、新药设计、药品质量管理 【指导硕、博士生研究方向】 专业方向 药物化学与药物分析 研究方向 新药分子设计与合成 【研究领域】 天然物化学(天然物分离、结构鉴定、全合成、生物合成),心血管疾病药物、 抗感染药物、免疫性疾病以及抗肿瘤靶向性药物的研发。 【主要论著】 1. Fan, Weizheng; Su, Jiapeng; Shi, Dongyang; Feng, Bainian. An efficient one-pot, three-component synthesis of vinyl sulfones via iodide-catalyzed radical alkenylation[J]. Tetrahedron, 2015, 71(38): 6740-6743. 2. Fan, Weizheng; Su, Jiapeng; Feng, Bainian. Palladium(II)-Catalyzed C-H Acylation with Arylglycine Derivatives[J]. Synlett, 2015, 26(14): 2033-2036 3. Fan, Weizheng; Shi, Dongyang; Feng, Bainian. TBAI-catalyzed synthesis of a-ketoamides via sp3 C-H radical/radical cross-coupling and domino aerobic oxidation[J]. Tetrahedron Letters, 2015, 56(31): 4638-4641 4. Fan, Weizheng; Jiang, Shan; Feng, Bainian. Rh(I)-catalyzed decarbonylation synthesis of carbazoles via C-N cleavage[J]. Tetrahedron, 2015, 71(23): 4035-4038. 5. Fan, Weizheng; Liu, Faming; Feng, Bainian. Palladium-Catalyzed Heck-Type Coupling via C-N Cleavage[J]. Synlett, 2015, 26(9): 1253-1257 6. Chunlei Tang, Desheng Xie, Bainian Feng. Zebrafish as a New Model for Phenotype-based Screening of Positive Inotropic Agents[J]. Chemical biology & drug design, 2015, 85(3): 253-258. 7. Wang, W-L., Huang, C., Gao, L-X., Tang, C-L., Wang, J-Q., Wu, M-C., Sheng, L., Chen,H-J., Nan, F-J., Li, J-Y., Li, J., Feng, B., Synthesis and biological evaluation of novel bis-aromatic amides as novelPTP1B inhibitors[J], Bioorganic & Medicinal Chemistry Letters,2014, 24(8): 1889-1894. 8. Wen-Long Wang , Dong-Lin Yang , Li-Xin Gao , Chun-Lan Tang , Wei-Ping Ma ,Hui-Hua Ye , Si-Qi Zhang , Ya-Nan Zhao , Hao-Jie Xu , Zhao Hu , Xia Chen ,Wen-Hua Fan , Hai-Jun Chen , Jing-Ya Li , Fa-Jun Nan , Jia Li , Bainian Feng. 1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors. Molecules 2014, 19, 102-121 9. Wang, Wenlong,Song, Lijun, Wang, Guping, Fan, Wenhua,Yin, Xurenc Yu, Chuanxin, Feng, Bainian. Synthesis and Evaluation of the Antischistosomal Activity against S.japonicum of 1-Methyl-1,2,3,4-tetrahydroisoquinoline Derivatives.Chin. J. Org. Chem. 2013, 33, 2588~2595 10. Wang W L, Song L J, Chen X, et al. Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum[J]. Molecules, 2013, 18(8): 9163-9178. 11. 王文龙, 宋丽君, 王古平, 等. 1-甲基-1, 2, 3, 4-四氢异喹啉衍生物的合成 及抗日本血吸虫活性评价[J]. 有机化学, 2013: 0-0. 12. Wang, W. L.; Chen, H. J.; Ma, W. P.; Gu, M.; Fan, M. Z.; Li, J. Y.; Feng, B. N.*; Nan, F. J. Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A. Molecules 2012, 17, 14522-14530. 13. Flygare, J. A.; Beresini, M.; Budha, N.; Chan, H.; Chan, I. T.; Cheeti, S.; Cohen, F.; Deshayes, K.; Doerner, K.; Eckhardt, S. G.; Elliott, L. O.; Feng, B. N.; Franklin, M. C.; Reisner, S. F.; Gazzard, L.; Halladay, J.; Hymowitz, S. G.; La, H.; LoRusso, P.; Maurer, B.; Murray, L.; Plise, E.; Quan, C.; Stephan, J. P.; Young, S. G.; Tom, J.; Tsui, V.; Um, J.; Varfolomeev, E.; Vucic, D.; Wagner, A. J.; Wallweber, H. J. A.; Wang, L.; Ware, J.; Wen, Z. Y.; Wong, H.; Wong, J. M.; Wong, M.; Wong, S.; Yu, R.; Zobel, K.; Fairbrother, W. J. Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152). Journal of Medicinal Chemistry 2012, 55, 4101-4113. 14. Zhang, Y.; Feng, B. N.*; Zhu, C. J. Au(III)-catalyzed intermolecular amidation of benzylic C-H bonds. Org. Biomol. Chem., 10, 9137-9141, 2012. 15. Zhang, Y.; Luo, S.; Feng, B. N.*; Zhu, C. J. Gold-catalyzed direct indolation of tetrahydroisoquinolines. Chin. J. Chem. 30, 2741-2746, 2012. 16. Tang, C. L.; Xie, D. S.; Feng, B. N*. Vismodegib, A New Drug for The Treatment of Basal Cell Carcinoma. Chinese Jourunal of New Drugs 2013, 22, 1111-1114. 17. Tang, C. L.; Xie, D. S.; Feng, B. N*. A Novel Therapeutic Approach for Systolic Heart Failure: Cardiac Myosin Activators. Chinese Jourunal of New Drugs. 2013, 22(016): 1916-1920