John Newman B.Sc (Hons) MSc.
Contact Number
Date of Birth
07792589916
23 January 1950
E-mail
johnjosephnewman1@gmail.com
EDUCATION
University of Manchester Institute of Science and Technology (UMIST)
- Masters Degree (MSc by research) in Chemistry
University of Madurai, Tamilnadu, India – B.Sc. in Mathematics (1 year) .
University of Madurai, Tamilnadu, India – B.Sc (Hons) in Chemistry – First Class.
(1973-1975)
(1971-1972)
(1968-1971)
WORK EXPERIENCE
GlaxoSmithKline / Glaxowellcome / Glaxo:
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(June 1975 – January 2009)
Senior Research Scientist in Isotope Chemistry, (1989-2009). Primarily involved in the synthesis of
isotopically labelled (radio and stable labelled) drug candidates for biological evaluation.
Core team member on a variety of research/development projects within Isotope Chemistry, in a
vast number of therapeutic areas, such as cardiovascular, CNS, antiviral, antifungal, antiinflammatory and anti-allergy.
Utilised carbon-14 and tritium radio isotopes, as well as a variety of stable isotopes.
Synthesised haptens and pet intermediates
Synthesised labelled and unlabelled drug metabolites, either by conventional chemistry or by
biotransformation process.
Ability to handle microgram to multi-gram quantity of materials – For example, preparation of
tritium labelled compounds involve handling of microgram quantity of materials where as
preparation of unlabelled metabolites for clinical studies may involve handling of hundreds of
grams of materials.
Able to carry through a project from inception to completion with minimum supervision - For
example, allocation of project, research into finding the best and quickest route to drug substance
by modifying the current R&D route ensuring that the labelled input materials are available to make
the route viable and meet the deadline.
Research scientist in Dept of Organic Chemistry of Glaxo (1975-1989). Primarily involved in the
synthesis of potential drug candidates for early phase drug metabolism studies.
Co-author in a number of publications in major chemistry journals, such as Journal of Chemical
Society and Journal of Labelled Compounds and Radiopharmaceuticals. (See attached list of key
publications)
LABORATORY RESPONSIBILITIES (GSK)
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Responsible for Stable Isotope Library of Chemicals. Involved in:
 Maintaining stocks of stable labelled commercial reagents and in-house stable labelled drug
candidates prepared for biological studies within Isotope Chemistry Department.
 Logging of all incoming and outgoing stable labelled materials using excel spreadsheet and
carrying out monthly inventory with the help of technicians.
 Supervising routine dispensing of labelled drug substances by technicians for biological studies.
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Responsible for disposal of radioactive waste and maintenance of Radioactive Waste Tank Room.
 Contributed to the section of Radiochemistry Local Rules in Isotope Chemistry governing the
disposal and maintenance of Radioactive Waste Tank Room.
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Responsible for transfer of stable labelled and radioactive materials between GSK sites and their
customers worldwide.
 Liaison with the specialist couriers and the customers to ensure safe and secure transfer of
materials.
SPECIALIST SKILLS
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Thirty years of experience using various analytical techniques such as TLC, HPLC, MS, LC-MS
and NMR for routine analysis, identification and structure assignment of drug candidates.
 Hands on experience in use and routine maintenance of Radio TLC and HPLC equipments.
Twenty years of experience handling:
 Radioisotopes such as carbon-14 and tritium for drug metabolism studies.
 Stable isotopes such as deuterium, carbon-13 and nitrogen-15 used for preparation of drug
candidates for bio-analytical studies.
TUTORING SKILLS
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More than 5 years of experience in coaching/mentoring chemistry students up to degree level.
Highly experienced in coaching AS/A level students (OCR/Salters, AQA, EDEXEL).
Very good feedback from students and parents.
KEY PUBLICATIONS
1. Syntheses of isotopically labelled angiotensin II receptor antagonist GR138950X Journal of Labelled
Compounds and Radiopharmaceuticals. Volume 38, Issue 5, May 1996, Pages: 453–470, Richard M.
Carr, Karl M. Cable, John J. Newman and Derek R. Sutherland
2. Synthesis of isotopically labelled versions of adenosine agonist GR79236 . Journal of Labelled
Compounds and Radiopharmaceuticals.Volume 43, Issue 1, January 2000, Pages: 11–28, Alan H.
Wadsworth, John J. Newman, Mark D. Wipperman, Ian Fellows and Derek R. Sutherland
3. Synthesis of isotopically labelled pyridoindolone 5-HT3 receptor antagonists (1) . Journal of
Labelled Compounds and Radiopharmaceuticals, Volume 36, Issue 10, October 1995, Pages: 993–
1007, Shimoga R Prakash, Karl M Cable, Itzela D Correa, Lan Fellows, Stephen Montgomery, John
J Newman, Lan Waterhouse, Guy N Wells and Derek R Sutherland
4. ChemInform Abstract: Synthesis of Some Glaxo Wellcome Compounds Labeled with Isotopes
of Carbon. Karl M. Cable, Richard M. Carr, Ian Fellows, Christopher Hughes, J Stephen
Montgomery, John J. Newman, Peter W. Scott, Alan H. Wadsworth, Ian Waterhouse, Guy N.
Wells, etal
5. Ene reactions of allenes. Part 5. Regio- and stereo-selective ene reactions of a trialkylallene. J.
Chem. Soc., Perkin Trans. 1, 1978, 1161 - 1168, Chan Boo Lee, R. John J. Newman and David R.
Taylor
References available on request