Electronic Supplementary Material 2: Dataset and corresponding references used in the comparative analysis. Species Scientific name Camel Camelus bactrianus Felis silvestris Pan troglodytes Bos taurus Canis familiaris Mustela putorius Vulpes vulpes Capra aegragus Cavia porcellus Equus caballus Homo sapiens Mus musculus Sus scrofa Setonix brachyurus Oryctolagus cunniculus Procyon lotor Rattus norvegicus Macaca mulatta Ovis aries Cat Chimpanzee Cow Dog Ferret Fox Goat Guinea pig Horse Human Mice Pig Quokka Rabbit Racoon Norway rat Rhesus macaque Sheep Longevity (years) 35.4 IgG halflife (days) 16.3 Reference half life [1] BMR (watts) Reference BMR 30 59.4 15 17 [2] [4] 12.92 28.18 [3] [5] 20 24 11.1 17.4 9.7 9.43 [6] [8] [9] 306.8 39.8 [7] [7] 21 20.8 9.34 12 [10] [11] 13.6 38.19 [7] [3] 12 57 54.1 4 27 13.8 5.4 27.9 21 7 13.8 8.5 [12] [14] [15] [16] [17] [18] 2.25 380.7 82.78 0.2 104.2 4.52 [13] [7] [13] [7] [7] [13] 9 5.575 [19] 8.6 [7] 21 4 10.55 7.3 [20] [22] 8.59 1 [21] [7] 40 18.445 [23] 11.23 [5] 20.6 13.7 [24] 56.95 [3] References cited 1. Hüselbusch C.G. 2000 Immunoglobulin-G status of camels during six months post-natum. Revue d'Elevage et de Médecine Vétérinaire en Pays Tropicaux 53, 105-110. 2. Johnson R.P., Povey R.C. 1983 Transfer and decline of maternal antibody to feline calicivirus. Canadian Veterinary Journal 24, 6-9. 3. Lesku J.A., Roth II T.C., Rattenborg N.C., Amlaner C.J., Lima S.L. 2008 Phylogenetics and the correlates of mammalian sleep: a reappraisal. Sleep Medicine Reviews 12, 229-244. 4. Cummins L.M., Weinhold K.J., Matthews T.J., Langlois A.J., Perno C.F., Condie R.M., Allain J.P. 1991 Preparation and characterization of an intravenous solution of IgG from human immunodeficiency virus-seropositive donors. Blood 77, 1111-1117. 5. Snodgrass J.J., Leonard W.R., Robertson M.L. 2007 Primate bioenergetics: an evolutionary perspective. In Primate origins: adaptations and evolution (eds. Ravosa M.J., Dagosto M.), pp. 703737, Springer, New York. 6. Nielsen K., Sheppard J., Holmes W., Tizard I. 1978 Changes in the catabolism of serum immunoglobulins and complement components in infected cattle. Immunology 35, 811-816. 7. Valencak T.G., Ruf T. 2007 N-3 polyunsaturated fatty acids impair lifespan but have no role for metabolism. Aging Cell 6, 15-25. 8. Pollock R.V., Carmichael L.E. 1982 Maternally derived immunity to canine parvovirus infection: transfer, decline, and interference with vaccination. J Am Vet Med Assoc 180, 37-42. 9. Appel M.J., Harris W.V. 1988 Antibody titers in domestic ferret jills and their kits to canine distemper virus vaccine. J Am Vet Med Assoc 193, 332-333. 10. Müller T., Selhorst T., Schuster P., Vos A., Wenzel U., Neubert A. 2002 Kinetics of maternal immunity against rabies in fox cubs (Vulpes vulpes). BMC Infectious Diseases 2, 10. 11. Matthews J.G. 2009 Diseases of the goat. Third ed, Blackwell Publishing. 12. Humphrey J.H., Turk J.L. 1961 Immunological unresponsiveness in Guinea pigs. I. Immunological unresponsiveness to heterologous serum proteins. Immunology 4, 301-309. 13. Heusner A.A. 1991 Size and power in mammals. Journal of Experimental Biology 160, 25-54. 14. Wilson W.D., Mihalyi J.E., Hussey S., Lunn D.P. 2001 Passive transfer of maternal immunoglobulin isotype antibodies against tetanus and influenza and their effect on the response of foals to vaccination. Equine Veterinary Journal 33, 644-650. 15. Mix E., Goertsches R., Zettl U.K. 2006 Immunoglobulins - Basic considerations. J Neurol 253, V/9-V/17. 16. Vieira P., Rajewsky K. 1988 The half-lives of serum immunoglobulins in adult mice. Eur J Immunol 18, 313-316. 17. Curtis J., Bourne F.J. 1973 Half-lives of immunoglobulins IgG, IgA and IgM in the serum of new-born pigs. Immunology 24, 147-155. 18. Yadav M. 1971 The transmission of antibodies across the gut of pouch-young marsupials. Immunology 21, 839-851. 19. Watanabe N., Goodwin D.A., Meares C.F., McTigue M., Chaopavang W., Ransone C.M., Renn O. 1994 Immunogenicity in rabbits and mice of antibody-chelate conjugage: comparison of (S) and (R) macrocyclic enantiomers and an acyclic chelating agent. Cancer Research 54, 1049-1054. 20. Paré J.A., Barker I.K., Crawshaw G.J., McEwen S.A., Carman P.S., Johnson R.P. 1999 Humoral response and protection from experimental challenge following vaccination of raccoon pups with a modified-live canine distemper virus vaccine. Journal of Wildlife Diseases 35, 430-439. 21. Muñoz-Garcia A., Williams J.B. 2005 Basal metabolic rate in Carnivores is associated with diet after controlling for phylogeny. Physiological and Biochemical Zoology 78. 22. Williams J.E., Eisenberg Jr. G.H.G., Cavanaugh D.C. 1977 Decline of maternal antibodies to plague in Norway rats. Journal of Hygiene 78, 27-31. 23. Van Rompay K.A.K., Berardi C.J., Dillard-Telm S., Tarara R.P., Canfield D.R., Valverde C.R., Montefiori D.C., Cole K.S., Montelaro R.C., Miller C.J., et al. 1998 Passive immunization of newborn Rhesus macaques prevents oral simian immunodeficiency virus infection. Journal of Infectious Diseases 177, 1247-1259. 24. Smith W.D., Wells P.W., Burrells C., Dawson A.M. 1976 Maternal immunoglobulins and parainfluenza 3 virus inhibitors in the nasal and lachrymal secretions of newborn lambs. Clin Exp Immunol 23, 544-553.