Supplemental Tables
Supplemental Table 1. Demographic and background data. Note: “Age’’ refers to age at the time of Phase 3
evaluation. ‘‘Sex’’ refers to the percentage of male veterans. ‘‘Years of education’’ refers to the total number of
years of education the veterans completed.
Demographic Data
Patient Group
Age (in years)
58.13
Sex (% male)
100.00
Years of education
15.00
Total percent volume loss (cm3)
3.19
Architecture of Fluid Intelligence and Working Memory
Supplemental Table 2. Description of the employed neuropsychological tests of working memory.
Neuropsychological Test
Description
Cognitive Function
Matrix Reasoning
Patient selects from an array of pictured items the abstract
shape that completes the visual-spatial pattern
Fluid Intelligence
Block Design
Picture Completion
1-Back
Participant arranges multicolored blocks to match a model
design
Participant identifies the missing element in a series of
pictures
Patient receives a sequence of visually presented letters
and indicates whether each letter matches the stimulus that
appeared 1 trial previously
Fluid Intelligence
Fluid Intelligence
Monitoring Information in
Working Memory
2-Back
Patient receives a sequence of visually presented letters
and indicates whether each letter matches the stimulus that
appeared 2 trials previously
Monitoring Information in
Working Memory
3-Back
Patient receives a sequence of visually presented letters
and indicates whether each letter matches the stimulus that
appeared 3 trials previously
Monitoring Information in
Working Memory
Arithmetic
Patient hears numerical problems in story format, performs
mental arithmetic, and responds orally
Manipulating Information in
Working Memory
Letter-Number Sequencing
Patient hears a sequence of alternating digits and letters
and then rearranges the items, first repeating the digits in
numerical order, followed by the letters in alphabetical
order
Manipulating Information in
Working Memory
Digit Span Forward
Patient hears a sequence of digits and repeats them in
order
Verbal/Numeric Working
Memory
Patient hears a sequence of digits and repeats them in
reverse order
Patient watches the examiner tap a sequence of locations
on a board and attempts to repeat the tapping sequence in
order
Patient watches the examiner tap a sequence of locations
on a board and attempts to repeat the tapping sequence in
reverse order
Verbal/Numeric Working
Memory
Digit Span Backward
Spatial Span Forward
Spatial Span Backward
Spatial Working Memory
Spatial Working Memory
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Architecture of Fluid Intelligence and Working Memory
Supplemental Figures
Supplemental Figure 1. Structural equation modeling of fluid intelligence and components of working
memory (n = 158).
.72
Gf
.83
Matrix reasoning
Block design
.64
Picture completion
.45
1 back
-.16
.63
Process specific:
monitoring
.75
.85
3 back
-.39
.60
.67
2 back
-.42
Process specific:
manipulation
.80
Arithmetic
.80
Letter number
.59
Digit span forward
.70
Digit span backward
.62
Spatial span forward
.77
Spatial span backward
.94
-.35
Content specific:
numerical
.52
.55
Content specific:
spatial
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Architecture of Fluid Intelligence and Working Memory
Supplemental Figure 2. Lesion overlap map illustrating the number of patients with brain lesions to a particular
voxel. In each axial slice, the right hemisphere is on the reader’s left.
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