Rabbit anti-Cortisol polyclonal antibody
Catalog Number: CSB-DMA001BRN
Synonym Names
Hydrocortisone, 11beta-hydroxycortisone, 17alpha-hydroxycorticosterone, dihydrocostisone
Product type
Primary antibodies
Description
Rabbit polyclonal to Cortisol
Clonality
Polyclonal
Isotype
IgG
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Storage buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage
Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Form
Liquid
Raised in
Rabbit
Tested applications
ELISA, Not yet tested in other applications.
Cortisol (hydrocortisone) is the main glucocorticoid secreted by the adrenal cortex., and its production is stimulated
by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). It is
Function
released in response to stress and a low level of blood glucocorticoids. And its primary functions are to increase
blood sugar through glycogenolysis; suppress the immune system; and aid in fat, protein and carbohydrate
metabolism. The synthetic counterpart of cortisol are used to treat a variety of diseases.
[1] Aditya Dubey and Arthur J. Boujoukos. Free cortisol levels should not be used to determine adrenal
responsiveness. Critical Care 2004, 9: E2.
[2] Kirschbaum, Clemens, Hellhammer and Dirk H. Salivary cortisol in psychobiological research: An overview.
Neuropsychobiology, Vol 22(3), 1989, 150-169
[3] HENRY J. RUDER, ROBERT L. GUY and
MORTIMER B. LIPSETT. A Radioimmunoassay for Cortisol in Plasma and Urine. The Journal of Clinical
Endocrinology & Metabolism August 1, 1972 vol. 35 no. 2 219-224
[4] Shimada M, Takahashi K, Ohkawa T, Segawa M, Higurashi M. Determination of Salivary Cortisol by ELISA and
Its Application to the Assessment of the Circadian Rhythm in Children. Horm Res 1995, 44:213–217
[5] John
G.
Lewis , Laurette
immunosorbent
Manley,
J. Crispin
Townsend
assay (ELISA) for urinary free cortisol. Clinica
and
Peter A.
Elder. An enzyme-linked
Chimica Acta, 159 (1986) 205-209
[6] J.G. Lewis, P.A. Elder. An enzyme-linked immunosorbent assay (ELISA) for plasma cortisol. Volume 22, Issue 5,
References
May 1985, Pages 673–676
[7] John G. Lewis, Laurette Manley, Joanna C. Whitlow, Peter A. Elder. Production of a monoclonal antibody to
cortisol: Application to a direct enzyme-linked immunosorbent assay of plasma. Steroids,Volume 57, Issue 2,
February 1992, Pages 82–85
[8]Teresa Cascella, Stefano Palomba, Libuse Tauchmanovà, Francesco Manguso, Sebastiano Di Biase, Donato
Labella,Francesco Giallauria, Carlo Vigorito, Annamaria Colao, Gaetano Lombardi and Francesco Orio. Serum
Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovarian Syndrome. The Journal of
Clinical Endocrinology & Metabolism November 1, 2006 vol. 91 no. 11 4395-4400
[9] E Van Cauter, R Leproult and D J Kupfer.
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. The Journal of Clinical
Endocrinology & Metabolism July 1, 1996 vol. 81 no. 7 2468-2473
[10] Rachel Yehuda, Martin H. Teicher, Robert L. Trestman, Robert A. Levengood , Larry J. Siever. Cortisol
regulation in posttraumatic stress disorder and major depression: A chronobiological analysis. Biological Psychiatry.
Volume 40, Issue 2 , Pages 79-88, 15 July 1996