Influence of Ozone Treatment in Sportsmedicine J. Jakl MD, Sportsmedicine, A - 1150, Wien, Akkonpl. 10/15, Date: 1995 Summary: According to the well known effects of ozone treatment and its influence on fatty acids in the eryrtocytic membrane as well as in 2,3 DPG, we took interest in possible effects in endurance tests. 30 sports students had to undertake bicycle ergometrics as vita maxima tests. Aerobic and anaerobic threshold, heartrate O2 utilisation and lactatekinetic were compared before and after different ozone treatments such as intramuscular application, IV O3 blood treatment and rectal insufflation. Especially in the IV blood treatment and in the rectal insufflation group aerobic performance was improved, when no influence on anaerobic workout in lactate concentrations over 4 mmol/l showed up. Those effects and the relative economisation in aerobic training seems to base on ozone effects in intracellular metabolism as well as a better utilisation of free fatty acids. Especially endurance sports and athletes who need a high level of O2 turn-over could probably take some profit of ozone treatment without side effects that could occur with other therapies. In general it showed up, that the positive influence in a very well trained person was less than in those who had lower endurance levels. That probably depends on the just optimized intracellular metabolism which develops after several years of training. Effect of ozone therapy on muscle oxygenation. Journal of Alternative and Complementary Medicine 9: 251-256, 2003. Abstract Clavo B, Pérez JL, López L, Suárez G, Lloret M, Rodríguez V, Macías D, Santana M, Morera J, Fiuza D, Robaina F, Günderoth M. Radiation Oncology Department, Research Unit, Dr. Negrín University Hospital, Canary Islands, Spain. bernardinoclavo@terra.es BACKGROUND AND OBJECTIVE: Ozone therapy is being used to treat ischemic disorders. However, the underlying mechanisms for the success are unknown and the therapy has not been accepted fully within conventional medicine. This study sought to assess the effect of ozone therapy on resting muscle oxygenation. PATIENTS AND DESIGN: Twenty-three (23) patients and 3 volunteers were recruited for this prospective study. Systemic ozone therapy was administered by autohemotransfusion on three alternate days over 1 week. Tissue oxygenation (mmHg) was directly measured in the tibialis anterior muscle using polarographic needle electrodes before and after the first and the third ozone therapy session. RESULTS: Globally, the differences in oxygenation were not statistically significant but there was a significant decrease in the percentage of low-oxygenated values (pO(2) < 5 mmHg) following ozone sessions (p < 0.02). The change in muscle oxygenation following ozone therapy was inversely correlated with age (r = 0.398; p = 0.044) and with the initial (baseline pretherapy) muscle oxygenation values (r = -0.644; p < 0.001), indicating that the more poorly oxygenated muscles benefited most from the therapy. A significant (p = 0.031) higher oxygenation in these tissues was observed 48 hours after the second session. CONCLUSIONS: Ozone therapy can modify oxygenation in resting muscles, particularly of those that are most hypoxic. Our results suggest that ozone therapy could be used effectively as a complementary treatment of hypoxic and ischemic syndromes and that the therapy warrants further investigation for possible application in other clinical conditions. Oxygen-Ozone Therapy and Physical Activity in Humans Riva Sanseverino E., Castellacci P, Institute of Human Physiology, University of Bologna, Bologna, Italy. Date: 1995 Abstract: On the basis of the circulatory and biochemical positive effects of the oxygen-ozone therapy, a study was programmed in order to check if physical activity in humans is improved by treatment with medical ozone administered by means of the major autohemoinfusion (AHT). Preliminary observations indicate that physical activity, performed 12-24 hours after one or several administrations of medical ozone, is improved by 8-12%. Long term performances for a better effectiveness are in progress. Study on Gymnasts, University of Cairo, Prof Mawsouf & team Average Lactic Acid Level Before & After Exertion and Following Rest and Following Single Session Ozone 12 10 8 6 Lactic Acid 4 2 0 Before Exer Rest Ozone Average Lactic Acid Level Before & After Exertion and Following Rest and Ozone 12 10 8 Single 6 Six Sess. 4 2 0 Before Exert. Rest Ozone Average Performance Score Before and After Ozone in the Study Group Compared to the Control Group 10 9 8 7 6 5 4 3 2 1 0 Study Control Before After