Table S5 Dothistromin gene orthologs and flanking genes in Leptosphaeria maculans
(supercontig 13).
ASD
orthologa
PksA
Nor1
(HexA)d
AflR
HypC
HexB
(HexA)d
AflJ
a
Lepma
Protein IDb
Supercontig 13 CDS
coordinates (strand)
2889
2891
2892
2893
2894
2895
2896
1415843-1416552 (-)
1418093-1424481 (-)
1424869-1426310 (+)
1426780-1428165 (+)
1428596-1429536 (-)
1430732-1431163 (+)
1431699-1432295 (-)
2897
2898
2899
2900
2901
2902
2904
2905
2906
2907
2908
2909
2910
1438204-1439836 (+)
1440856-1441392 (+)
1441845-1442615 (+)
1444412-1445637 (-)
1446238-1447610 (+)
1448479-1449713 (-)
1451035-1454379 (-)
1454775-1456091 (+)
1456563-1457867 (+)
1458273-1459031 (-)
1459766-1465599 (-)
1465862-1467212 (+)
1468951-1470209 (-)
Predicted function
hypothetical protein
polyketide synthase
salicylate hydroxylase
aminotransferase
NAD(P) reductase
stress-responsive A/B barrel domainc
hypothetical protein
~5.8kb repeat region
oxidoreductase
hypothetical protein
oxidoreductase
oxidoreductase
methyltransferase
dioxygenase
fatty acid synthase (partial; 1115 aa)
regulatory protein
monooxygenase
hypothetical/anthrone oxidase
fatty acid synthase (1884 aa)
HexA Acyl transferase domain (434 aa)
regulatory protein
~164 kb repeat region to contig ende
Only the seven genes listed are ASD orthologs, although others clearly have similarity to other ASD
genes.
b
Protein identification (accession) numbers refer to those at http://genome.jgipsf.org/Lepmu1/Lepmu1.home.html for Cochliobolus heterostrophus (Coche1).
c
A stress-responsive A/B barrel domain protein is also seen in other ASD clusters: between estA (stcI)
and avnA (stcF) in A. nidulans, and between AdhA and VerB in D. septosporum (not shown in Fig. 1).
d
Incomplete HexA genes.
e
There are three dispersed genes in the 164 kb telomeric region: 1 kinase and 2 hypothetical protein genes.