文献名称 Food & nutrition research 摘要 出处 In the test groups the hepatic ASKIM levels of MK-4 and MK-4O GADEHOLT G.Dietary intake of reflected the dietary intake of menaquinone-4 MK-4.; hepatic CONCLUSION: The M, menaquinone-4 good bone resistance [J].Food supplements of K(3) in the feed, may and chickens were in good health with without HAUG A, determine pancreatic in chickens & nutrition research,2012,56 but at least a natural content of 23 ng MK-4/g feed. Liver and pancreas appears to use MK-4 in different ways. Hepatology (Baltimore, Md) CONCLUSION: Efficacy of YOSHIDA H, SHIRATORI Y, vitamin K2 in suppressing HCC KUDO M, et al.Effect of vitamin recurrence was not confirmed in K2 this hepatocellular carcinoma [J].Hepatology (Baltimore, double-blind, randomized, placebo-controlled Copyright study. 2011 American on the recurrence of Md),2011,54(2):532-540. Association for the Study of Liver Diseases. Hepatology Research Conclusions: Serum DCP levels YAMASHIKI N, SUGAWARA Y, may be raised in end-stage liver TAMURA disease patients without HCC, and accuracy of .alpha.-fetoprotein and cannot be used as a reliable des-.gamma.-carboxy prothrombin marker for HCC among liver in screening for hepatocellular transplant candidates. carcinoma S, in candidates et al.Diagnostic liver transplant [J].Hepatology Research,2011,41(12):1199-1207. Liver International Des-.gamma.-carboxyprothrombin INAGAKI (DCP) is known as a tumor MAKUUCHI M, et al.Clinical and marker molecular for hepatocellular Y, insights TANG into W, the carcinoma (HCC). Various tumor hepatocellular carcinoma tumour markers have been developed for marker serol. des-.gamma.-carboxyprothrombin diagnosis including HCC, of in cancers, order to increase the survival rate of cancer patients. The currently recommended combined testing of DCP (AFP) and or .alpha.-fetoprotein Lens culinaris agglutinin-reactive fraction alpha.-fetoprotein has established to diagnose HCC. of been [J].Liver International,2011,31(1):22-35. Bone After the one-month experimental IWAMOTO J, SEKI A, SATO Y, period, et al.Effect of vitamin K2 on histomorphometric analysis was performed on cortical and cancellous bone mass cortical and cancellous bone from and hepatic lipids in rats with the tibial diaphysis and proximal combined metaphysis, respectively, while deficiency histological examination of the [J].Bone,2011,48(5):1015-1021. methionine-choline liver was performed after staining with hematoxylin and eosin and Oil Red 0. Science (Washington DC) Whether vitamin K-2 exerts a VOS similar in EDIRISINGHE J N, et al.Vitamin eukaryotic cells is unknown. We K-2 Is a Mitochondrial Electron identified Carrier carrier function Drosophila M, That UBIAD1/Heix as a modifier of Deficiency pink1, (Washington a gene mutated in Parkinson's disease that affects ESPOSITO Rescues G, Pink1 [J].Science D C),2012,336(6086):1306-1310. mitochondrial function. We found that vitamin K-2 was necessary and sufficient to transfer electrons in Drosophila mitochondria. Heix mutants showed severe mitochondrial defects that were rescued by vitamin K-2, and, similar to ubiquinone, vitamin K-2 transferred electrons Drosophila in mitochondria, resulting in more adenosine triphosphate efficient (ATP) production. Thus, mitochondrial dysfunction was rescued by vitamin K-2 that serves as a mitochondrial electron carrier, helping to maintain normal ATP production. Science (New York, NY) Human UBIAD1 mitochondria localizes VOS M, ESPOSITO G, converts EDIRISINGHE J N, et al.Vitamin vitamin K(1) to vitamin K(2). K2 is a mitochondrial electron Vitamin K(2) is best known as a carrier cofactor in blood coagulation, but deficiency [J].Science (New York, in NY),2012,336(6086):1306-1310. bacteria and to it is a membrane-bound electron carrier. Whether vitamin K(2) exerts a similar carrier function in that rescues pink1 eukaryotic cells is unknown. We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial function. We found that vitamin K(2) was necessary and sufficient to transfer electrons in Drosophila mitochondria. Heix mutants showed severe mitochondrial defects that were rescued by vitamin K(2), and similar to ubiquinone, vitamin K(2) transferred electrons Drosophila in mitochondria, resulting in more efficient adenosine triphosphate (ATP) production. Clinical drug investigation Patients with diseases such neurological IWAMOTO J, MATSUMOTO H, Alzheimer's TAKEDA as disease, stroke and Parkinson's menatetrenone disease have been reported to against have fractures vitamin K deficiency T.Efficacy of (vitamin K2) non-vertebral in and patients hip with secondary to malnutrition, which neurological diseases: increases the risk of non-vertebral meta-analysis of three randomized, and hip fractures. The purpose of controlled trials [J].Clinical drug the present study was to clarify investigation,2009,29(7):471-479. the efficacy of menatetrenone (vitamin K(2)) against non-vertebral and hip fractures in patients with neurological diseases. Alternative review medicine This article covers in vitro, in PLAZA vivo, and human data on the W.Vitamin K2 in bone metabolism positive effect of vitamin K2 on and osteoporosis. Data is available on medicine review : a journal of vitamin clinical K2 for osteoporosis caused by a number of conditions, including postmenopausal osteoporosis, Parkinson's disease, biliary cirrhosis, stroke, and drug-induced osteoporosis. The activity of vitamin K2 involves both an increase in the S M, osteoporosis LAMSON D [J].Alternative therapeutic,2005,10(1):24-35. bone-building process and a separate decrease in the bone-loss process. Vitamin K2 exerts a more powerful influence on bone than vitamin K1, considered and for treatment in known to osteoporosis. should be prevention or those conditions contribute to