Diseases Presumed to be Associated with
Agent Orange Exposure
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Acute and Subacute Peripheral Neuropathy
A nervous system condition that causes numbness, tingling, and motor weakness. Under
VA's rating regulations, it must be at least 10% disabling within 1 year of exposure to
herbicides and resolve within 2 years after the date it began.
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Adult Fibrosarcoma
A tumor formed as an adult derived from connective tissue
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AL Amyloidosis
A rare disease caused when an abnormal protein, amyloid, enters tissues or organs.
Occurs when a plasma cell in the bone marrow spontaneously overproduces a protein
portion of an antibody called the light chain. It causes the accumulation of protein
deposits in and around organs.
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Alveolar Soft Part Sarcoma
A sarcoma found in the alveolus, the sack-like ducts in the lung.
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Angiosarcoma
A tumor occurring in the breast and skin, and believed to originate from blood vessels.
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Birth Defects
An abnormal structure, function, or metabolism of the fetus, whether genetically
determined or as the result of an environmental influence during embryonic or fetal life.
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Cancer of the Bronchus
A malignant tumor found in a bronchus, an extension of the trachea (windpipe)
connecting it to the lungs.
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Cancer of the Larynx, Lung, Prostate, Trachea
Malignant tumor.
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Chloracne (or Similar Acneform Disease)
A skin condition that occurs soon after exposure to chemicals and looks like common
forms of acne seen in teenagers. Under VA's rating regulations, chloracne (or other
acneform disease similar to chloracne) must be at least 10% disabling within 1 year of.
exposure to herbicides.
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Chronic B-cell Leukemias
A type of cancer which affects white blood cells.
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Clear Cell Sarcoma of Aponeuroses
A sarcoma found at the end of a muscle where it becomes a tendon.
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Clear Cell Sarcoma of Tendons
A sarcoma found in the tendons.
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Congenital Fibrosarcoma
A malignant tumor formed before birth and derived from connective tissue.
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Dermatofibrosarcoma
A relatively slow growing benign skin tumor consisting of one or more firm nodules.
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Diabetes Mellitus (Type 2)
A disease characterized by high blood sugar levels resulting from the body’s inability to
respond properly to the hormone insulin.
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Ectomesenchymoma
A tumor found in a certain part of the skin.
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Epithelioid Malignant Leiomyosarcoma
A malignant tumor derived from smooth muscle fund in the layer covering the muscle.
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Epithelioid Malignant Schwannoma
A moderately firm, benign, tumor found in the layers of membrane covering surfaces
inside the body, caused by too many Schwann cells growing in a disorderly manner.
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Epithelioid Sarcoma
A tumor found in the membrane covering surfaces inside the body.
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Extraskeletal Ewing’s Sarcoma
A tumor outside the bone consisting of small, rounded cells.
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Harry-cell Leukemia
A slow-growing blood cancer in which bone marrow makes too many B cells
(lymphocytes), a type of white blood cell that fights infection. The excess B cells are
abnormal and look “hairy” under a microscope.
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Hemangiosarcoma
A tumor in the lymph nodes characterized by the increasing enlargement of the lymph
nodes, liver and spleen and by progressive anemia.
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Hodgkin’s Disease
A malignant lymphoma (cancer) characterized by progressive enlargement of the lymph
nodes, liver, and spleen, and by progressive anemia.
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Infantile Fibrosarcoma
A tumor formed as a child derived from fibrous connective tissue.
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Ischemic Heart Disease
A disease characterized by a reduced supply of blood to the heart that leads to chest pain.
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Leiomyosarcoma
A tumor derived from smooth muscle.
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Liposarcoma
A tumor that may occur in any site in the body consisting of irregular fat cells.
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Lymphangiosarcoma
A tumor derived from blood vessels.
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Lymphoma
A malignant tumor of lymph nodes.
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Malignant Fibrous Histiocytoma
A type of tumor present in connective tissue.
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Malignant Giant Cell Tumor of the Tendon Sheath
A tumor found in the membrane of the tendon.
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Malignant Glandular Schwannoma
A moderately firm, malignant tumor in the glands caused by too many Schwann cells
growing in a disorder pattern.
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Malignant Glomus Tumor
A tumor found in the glomus, the tiny nodes found in the nailed, pads of fingers and toes,
ears, hands, feet and many other organs of the body.
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Malignant Hemangiopericytoma
A tumor characterized by rapidly growing fat cells formed in blood vessels and lining
blood filled spaces.
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Malignant Mesenchymoma
A malignant tumor in the embryonic tissue or fluid.
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Malignant Schwannoma with Rhabdomyoblastic
A moderately firm, malignant tumor found in skeletal muscle resulting from the rapid
growth of Schwann cells in a disorderly pattern.
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Multiple Myeloma
A cancer of plasma cells, a type of white blood cell in bone marrow.
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Non-Hodgkin’s Lymphoma
A group of cancers that affect the lymph glands and other lymphatic tissue.
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Parkinson’s Disease
A progressive disorder of the nervous system that affects muscle movement.
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Porphyria Cutanea Tarda
A disorder characterized by liver dysfunction and by thinning and blistering of the skin in
sun-exposed areas. Under VA's rating regulations, it must be at least 10% disabling
within 1 year of exposure to herbicides.
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Prostate Cancer
Cancer of the prostate; one of the most common cancers among men.
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Respiratory Cancers
Cancers of the lung, larynx, trachea, and bronchus.
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Soft Tissue Sarcoma (other than Osteosarcoma, Chondrosarcoma, Kaposi’s
sarcoma, or Mesothelioma)
A group of different types of cancers in body tissues such as muscle, fat, blood and
lymph vessels, and connective tissues.