Cylindroma Deba P Sarma, MD Omaha F 37, scalp Cylindroma Clinical: Sex: F>M. Location: Mostly scalp. Slow-growing, painful solitary pink or red dermal nodule about 1 cm in size. Familial cases associated with multiple tumors. May be associated with facial trichoepitheliomas, and eccrine spiradenomas, called autosomal dominant Brooke-Spiegler syndrome (familial cylindromatosis or turban tumor syndrome). Pathology: Presence of numerous scalp lesions called ‘turban tumor’. Non-encapsulated dermal tumor not connected to the overlying epidermis. Composed of lobules of epithelial cells arranged in a jigsaw or mosaic pattern. Prominent red basement membrane-like structure encircles the tumor lobules. Each lobule shows a peripheral lining by dark basaloid cells and an inner larger and paler zone of cells. Nodular deposits of red material within the lobules and focal well-formed ducts. Common adnexal tumor of eccrine origin.