CALL FOR PAPERS Special Issue on Bioinformatics and Computational Biology IEEE Tsinghua Science and Technology was started publication in 1996. It is an international academic journal sponsored by Tsinghua University and is published bimonthly. This journal aims at presenting the up-to-date scientific achievements in computer science, electronic engineering, and other IT fields. It is indexed by EI and other abstracting indexes. From 2012,the journal enters into IEEE Xplore Digital Library and all papers published there are freely downloadable. This special issue is devoted to new research addressing the challenges in the areas of bioinformatics and computational biology. Biological and medical science is one of the fastest developing research fields in the last two decades. High throughput biological data that are used to provide information at molecular and genetic level are rapidly generated. Almost all research problems in biological and medical sciences nowadays are computationally hard. Computational techniques have become an indispensable tool to discover new biological insights. It has already enabled unprecedented advances in biological and medical sciences, and will continue to be a vibrant research area with broadening of computational techniques and new emerging challenges. The goal of this special issue is to gather recent advances addressing computational methods related to, or with application in, bioinformatics. It aims to publish high quality, original, unpublished research papers covering all issues in bioinformatics and computational biology. Specific topics for this special issue include but are not limited to: Systems biology Data mining and visualization Structural biology Computational proteomics Software tools and applications Computational genetic epidemiology Pattern discovery and classification Comparative genomics Molecular modeling and simulation Bio-ontologies Biological data integration Biomolecular imaging Molecular sequence alignment and analysis Biomedical databases High-throughput sequencing data analysis Population genetics High-performance bio-computing RNA and protein folding and structure prediction Genome analysis Molecular evolution and phylogenetics Gene expression analysis Medical imaging and pattern recognition SUBMISSION GUIDELINES Papers submitted to this journal for possible publication must be original and must not be under consideration for publication in any other journals. Prospective authors should submit an electronic copy of their complete manuscript, in PDF format, to the lead guest editor (yipan@gsu.edu) with the email subject "Tsinghua Science and Technology Special Issue on Bioinformatics —Paper Submission". Tsinghua Science and Technology has published two Special Issues on Bioinformatics and Computational Biology in Vol. 17 , Issue 6, 2012 and Vol. 18 , Issue http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=5971803. IMPORTANT DATES Manuscript Due: April 15, 2014 First Round of Reviews: May 15, 2014 Camera Ready: June 15, 2014 Publication Date: October 15, 2014 GUEST EDITOR Yi Pan, Georgia State University, USA 5, 2013 . They are available at