Refresh the appearance of your lower face with natural-looking
results from RADIESSE® and BELOTERO BALANCE®1-4
By treating wrinkles and folds at different depths of the skin, the effects of RADIESSE
and BELOTERO BALANCE can be complementary.1,2
RADIESSE- The Lift You Need
RADIESSE is beneficial for immediately filling deeper wrinkles and folds and adding lift
to areas experiencing volume loss for a more youthful appearance. 1,3,5
BELOTERO BALANCE- The Finish You Want
BELOTERO BALANCE is an ideal choice to soften and smooth moderate-to-severe
etched-in lines and wrinkles for more of a finishing touch.1,
Although not approved to treat the same wrinkle or fold at the same time, RADIESSE
and BELOTERO BALANCE can each provide immediate correction for natural-looking
results. 1,2
RADIESSE®
When a loss of facial volume causes folds and wrinkles to form, RADIESSE, a
volumizing filler, offers a unique option—it adds an instant lift, smoothing out these signs
of aging for a more youthful, natural-looking appearance that lasts. 1,3,5,7
Treatments: RADIESSE is FDA-approved for subdermal implementation for the
correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.1
RADIESSE refreshes your look after just one treatment, immediately correcting facial
folds and wrinkles. This unique filler also stimulates natural collagen production, which
helps extend the initial effect of RADIESSE for a year or more in many patients. 1,3,5
It's ideal for correcting the following facial areas1
 Smile lines*, also called nasolabial folds, which run from the sides of the nose to
the corners of the mouth
*

Marionette lines*, which begin at the corners of the mouth and extend down
toward the chin

Corners of the mouth* can begin to turn downward, giving the look of a constant
frown

Pre-jowls* that form along the jaw-line

Chin wrinkles* lines across your chin
When wrinkle or fold is treated to full correction. Individual results may vary.
Just a single treatment of RADIESSE can be all you need to correct facial folds and
wrinkles.1
The Benefits of RADIESSE®
Natural collagen is what gives skin a smooth, supple, youthful appearance. As you age,
natural collagen breaks down, resulting in wrinkles and loss of facial volume.
RADIESSE, a volumizing filler, provides an instant lift, filling wrinkles and folds to help
restore a more youthful look to your skin. And it continues to work with your body,
stimulating the natural production of collagen for a more refreshed appearance that can
last up to a year or more in many patients.1,3,5,7
BELOTERO BALANCE®
Restore your natural, finished look with BELOTERO BALANCE injectable gel. This
hyaluronic acid (HA) smoothes moderate-to-severe etched-in lines and wrinkles such as
vertical lip lines above and around the lips. By integrating within in your skin’s tissue,
BELOTERO BALANCE maintains natural movement and facial expressions for a look
that feels natural to the touch.2,4,6
Help take your wrinkles all the way to smooth with BELOTERO BALANCE.2
Treatments: BELOTERO BALANCE is FDA-approved for injection into the mid to deep
dermis to temporarily smooth out and fill in moderate-to-severe facial wrinkles and folds,
such as nasolabial folds (the folds that go from the side of the nose to the corner of the
mouth).2
BELOTERO BALANCE specifically treats highly visible areas around the mouth,
improving the appearance of stubborn, etched-in facial lines and wrinkles. Treatment
areas include2:
 Vertical lip lines†
 Smiles lines†
 Corner lines†
 Moderate nasolabial folds
 Chin wrinkle†
†When wrinkle or fold is treated to full correction. Individual results may vary.
BELOTERO BALANCE integrates directly into the skin, enhancing your appearance with
minimal downtime.2
The Benefits of Belotero Balance®
Discover how to help take your wrinkles all the way to smooth with BELOTERO
BALANCE. Only BELOTERO BALANCE is created using the Cohesive Polydensified
Matrix (CPM) process. With this proprietary technology, BELOTERO BALANCE
injectable gel evenly and completely blends into your skin, providing a natural, finished
look. While some fillers are designed to rebuild facial structure and volume, BELOTERO
BALANCE takes a more targeted approach, specifically treating moderate-to-severe
etched-in lines and wrinkles, such as vertical lip lines. 1,4,6,8
What to Expect
RADIESSE and BELOTERO BALANCE treatments are a quick in-office procedure.
Treatments are usually completed in about 30 minutes. Because little to no downtime is
required, it's likely you'll be free to return to your regular daily routine right afterwards.
And because the results are immediate, you can leave the office looking more
refreshed.1
For detailed information visit www.radiesse.com and www.belotero.com.
Important Safety Information for RADIESSE® and BELOTERO
BALANCE®
RADIESSE should not be used in patients with bleeding disorders or in patients with
severe allergies manifested by a history of anaphylaxis, with a history or presence of
multiple severe allergies or with a history of hypersensitivity to the components of
RADIESSE.
BELOTERO BALANCE should not be used in patients with a history of allergic reactions,
including allergies to gram positive bacterial protein.
Neither RADIESSE nor BELOTERO BALANCE should be injected into blood vessels.
As with all skin-injection procedures, there is a risk of infection with RADIESSE, as
well as BELOTERO BALANCE. Use of RADIESSE or BELOTERO BALANCE in any
person with active skin inflammation or infection in or near the treatment area should
be deferred until the inflammatory or infectious process has been controlled.
The safety and effectiveness of neither RADIESSE, nor BELOTERO BALANCE, during
pregnancy or breastfeeding has been established.
The safety and effectiveness of RADIESSE use in the lips, periorbital area, in patients
under 18, or in patients with a susceptibility to keloid formation and hypertrophic
scarring has not been established. Radiesse patients with a history of previous
herpetic eruption may experience reactivation of the herpes.
The safety or effectiveness of BELOTERO BALANCE for the treatment of dermal
contour defects other than nasolabial folds, such as use in the lips, or in patients
under 21 years has not been established.
Injection site responses to BELOTERO BALANCE have been observed, consisting
mainly of short-term inflammatory symptoms starting early after treatment and with 7
days duration or less.
Laser treatment, chemical peeling, or any other procedure based on active dermal
response performed after treatment with BELOTERO BALANCE may increase the
risk of an inflammatory reaction at the injection site.
Patients using medications that prolong bleeding, such as aspirin or warfarin, may
experience increased bruising and bleeding at the injection site. Exposure of the
treated area to excessive sun, UV lamp exposure, and extreme cold weather should
be minimized until any initial swelling and redness have resolved and puncture sites
have healed.
For full safety information, please visit WWW.RADIESSE.COM and
WWW.BELOTERO.COM
References: 1. RADIESSE [instructions for use]. Franksville, WI: Merz North America,
Inc.; 2013. 2. BELOTERO BALANCE® [instructions for use/patient guide]. Greensboro,
NC: Merz Pharmaceuticals, LLC; 2012. 3. Moers-Carpi M, Vogt S, Santos BM, Planas J,
Vallve SR, Howell DJ. A multicenter, randomized trial comparing calcium hydroxylapatite
to two hyaluronic acids for treatment of nasolabial folds. Dermatol Surg. 2007;33(Suppl
2):S144-S151. 4. Lorenc ZP, Fagien S, Flynn TC, Waldorf HA. Review of key Belotero
Balance safety and efficacy trials. Plast Reconstr Surg. 2013;132(4 suppl 2):33S-40S. 5.
Berlin AL, Hussain M, Goldberg DJ. Calcium hydroxylapatite filler for facial rejuvenation:
a histologic and immunohistochemical analysis. Dermatol Surg. 2008;34(Suppl 1):S64S67. 6. Tran C, Carraux P, Micheels P, Kaya G, Salomon D. In vivo bio-integration of
three hyaluronic acid fillers in human skin: a histological study. Dermatology.
2014;228(1):47-54. 7. Sundaram H, Voigts B, Beer K, Meland M. Comparison of the
rheological properties of viscosity and elasticity in two categories of soft tissue fillers:
calcium hydroxylapatite and hyaluronic acid. Dermatol Surg. 2010;36 (Suppl 3):18591865. 8. Micheels P, Besse S, Flynn TC, Sarazin D, Elbaz Y. Superficial dermal
injection of hyaluronic acid soft tissue fillers: comparative ultrasound study. Dermatol
Surg. 2012;38(7 Pt 2):1162-1169.
Copyright © 2015 Merz North America, Inc. All rights reserved. MERZ AESTHETICS
and the MERZ AESTHETICS logo are trademarks of Merz Pharma GmbH & Co. KGaA.
RADIESSE is a registered trademark of Merz North America, Inc.
BELOTERO and BELOTERO BALANCE are registered trademarks of Merz Pharma
GmbH & Co. KGaA. RADIESSE is a registered trademark of Merz North America, Inc.
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