Origins and Benefits of Biologically Active Components of Human Milk July 19-24, 2015 Big Sky, Montana Organizers: Lars Bode, PhD University of California, San Diego La Jolla, California Michelle (Shelley) McGuire, PhD Washington State University Pullman, Washington Sunday, July 19, 2015 4:00 p.m. – 9:00 p.m. Conference Registration 6:00 p.m. – 7:00 p.m. Welcome Reception 7:00 p.m. – 8:00 p.m. DINNER 8:00 p.m. – 8:15 p.m. Welcome and Opening Remarks Lars Bode, PhD (confirmed), University of California, San Diego, CA 8:15 p.m. – 9:00 p.m. Keynote Speaker “Origins and benefits of human milk research – Where do we go from here?” W. Allan Walker, MD (confirmed), Harvard Medical School, Boston, MA 6 February 2016 Monday, July 20, 2015 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m Conference Registration 9:00 a.m. – 12:00 p.m. General session: “Oligosaccharides – Introduction and metabolism” Chair: Lars Bode, PhD (confirmed), University of California, San Diego, CA 9:00 a.m. – 9:30 a.m. “An introduction to human milk oligosaccharides (HMO)” Lars Bode, PhD (confirmed), University of California, San Diego, CA 9:30 a.m. – 10:00 a.m. “In vivo 13C-labelling of milk oligosaccharides in lactating mothers and metabolism in their infants” Clemens Kunz, PhD (confirmed), Justus-Liebig-University Giessen, Germany 10:00 a.m. – 10:30 a.m. MORNING COFFEE BREAK 10:30 a.m. – 11:00 a.m. “HMO in the infant’s feces – Appearance and disappearance over the course of lactation” Henk Schols, PhD (confirmed), Wageningen University, The Netherlands 11:00 a.m. – 11:30 a.m. “A milk-oriented microbiota (MOM) in infants: How HMO help babies find their ‘other’ MOM” David Mills, PhD (confirmed), University of California, Davis, CA 11:30 a.m. – 11:45 a.m. Short talk selected from submitted abstracts 11:45 a.m. – 12:00 p.m. Short talk selected from submitted abstracts 12:00 p.m. – 1:00 p.m. LUNCH and MEET THE SPEAKERS 1:00 p.m. – 4:00 p.m. Free time 4:00 p.m. – 6:00 p.m. General session: “Oligosaccharides – Potential benefits for the breastfed infant” Chair: David Mills, PhD (confirmed), University of California, Davis, CA 4:00 p.m. – 4:30 p.m. “The role of oligosaccharides in host-microbial interactions” Jonathan Lane, PhD (confirmed), Teagasc Food Research Center, Cork, Ireland 4:30 p.m. – 5:00 p.m. “Anti-infective effects of HMO: Potential for public health impact” Ardythe L. Morrow, PhD (confirmed), Cincinnati Children’s Hospital, Cincinnati, OH 5:00 p.m. – 5:30 p.m. “HMO as modulators of intestinal and systemic immunity” Sharon Donovan, PhD, RD (confirmed), University of Illinois at UrbanaChampaign, Urbana, IL 5:30 p.m. – 6:00 p.m. “Novel Approaches to the Elucidation of HMO Biological Effects” Rachael H. Buck, PhD (confirmed), Abbott Nutrition, Columbus, OH 6:00 p.m. – 7:00 p.m. Conference Registration 6:00 p.m. – 7:00 p.m. DINNER 7:00 p.m. – 9:00 p.m. Poster Session 6 February 2016 Tuesday, July 21, 2015 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m. Conference Registration 9:00 a.m. – 12:00 p.m. General session: “Oligosaccharides – Challenges and future opportunities” Chair: Sharon Donovan, PhD, RD (confirmed) University of Illinois at UrbanaChampaign, Urbana, IL 9:00 a.m. – 9:20 a.m. “Do HMO really work? Challenges and opportunities for designing a human intervention study” Nikhat Contractor, PhD (confirmed), Metagenics, Inc. 9:20 a.m. – 9:40 a.m. “Processing strategies for the purification of HMO from donors' milk” Daniela Barile, PhD (confirmed), University of California, Davis, CA 9:40 a.m. – 10:00 a.m. “Challenges in the automated chemical synthesis of HMO and their analogs” Nicola Pohl, PhD (confirmed), Indiana University, Bloomington, IN 10:00 a.m. – 10:30 a.m. MORNING COFFEE BREAK and GROUP PHOTO 10:30 a.m. – 10:50 a.m. “Unraveling functions of milk oligosaccharides using chemo-enzymatic synthesis” Geert-Jan Boons, PhD (confirmed), University of Georgia, Athens, GA 10:50 a.m. – 11:10 a.m. “Metabolic engineering as an approach to produce HMO” Yong-Su Jin, PhD (confirmed), University of Illinois at Urbana-Champaign, Urbana, IL 11:10 a.m. – 11:25 a.m. Short talk selected from submitted abstracts 11:25 a.m. – 11:40 a.m. Short talk selected from submitted abstracts 11:40 a.m. – 12:00 p.m. Panel Discussion on Challenges and Future Opportunities 12:00 p.m. – 1:00 p.m. LUNCH 1:00 p.m. – 4:00 p.m. Free time and ORGANIZED ACTIVITIES/EVENTS 4:00 p.m. – 6:00 p.m. Special session: “Bridging Academia and Industry” Chairs: Nikhat Contractor, PhD (confirmed), Metagenics, Inc. Lars Bode, PhD (confirmed), University of California, San Diego, CA Expert Panel Discussion (all panelists confirmed) Academia Sharon Donovan, PhD, University of Illinois, Urbana, IL Bruce German, PhD, University of California, Davis, CA Josef Neu, MD, University of Florida, Gainesville, FL Industry Carol Berseth, PhD, Director Medical Affairs, Mead Johnson Nutritionals Keith Garleb, PhD, Director Global Discovery R&D, Abbott Nutrition Laurent Fay, PhD, Head R&D Head Infant Formula, Nestle Nutrition 6:00 p.m. – 7:00 p.m. Conference Registration 6:00 p.m. – 7:00 p.m. DINNER 7:00 p.m. – 9:00 p.m. Poster Session 6 February 2016 Wednesday, July 22, 2015 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m. Conference Registration 9:00 a.m. – 12:00 p.m. General session: “Bacteria in Human Milk – Introduction, History, Methodology, Origin(s)” Chair: Juan M. Rodriguez, PhD (confirmed), Universidad Complutense de Madrid, Spain 9:00 a.m. – 9:30 a.m. “Bacteria in human milk – Historical perspective” Mark A. McGuire, PhD (confirmed), University of Idaho, Moscow, ID 9:30 a.m. – 10:00 a.m. “From the human milk microbiota to the human milk metagenome: evolution of methods to study human milk diversity” Esther Jimenez, PhD (confirmed), Complutense University of Madrid, Spain 10:00 a.m. – 10:30 a.m. MORNING COFFEE BREAK 10:30 a.m. – 11:00 a.m. “Computational approaches to inferring ecological information from microbial genomic fingerprints” James A. Foster, PhD (confirmed), University of Idaho, Moscow, ID 11:00 a.m. – 11:30 a.m. “Origin of human milk bacteria – The conquest of the “far breast”?” Rocío Martín, PhD (confirmed), Danone Research Center for Specialized Nutrition, Utrecht, The Netherlands 11:30 a.m. – 11:45 a.m. Short talk selected from submitted abstracts 11:45 a.m. – 12:00 p.m. Short talk selected from submitted abstracts 12:00 p.m. – 12:30 p.m. BUSINESS MEETING 12:30 p.m. – 1:30 p.m. LUNCH and MEET THE SPEAKERS 1:30 p.m. – 4:00 p.m. Free time 4:00 p.m. – 6:00 p.m. General session: “Bacteria in Human Milk – Potential Effects on Mothers and Infants” Chair: Mark McGuire, PhD (confirmed), University of Idaho, Moscow, ID 4:00 p.m. – 4:30 p.m. “Milk microbes and HMO – An evolutionary, sociocultural perspective” Shelley McGuire, PhD (confirmed), Washington State University, Pullman, WA 4:30 p.m. – 5:00 p.m. “Infectious mastitis during lactation: a mammary dysbiosis model” Juan M. Rodriguez, PhD (confirmed), Universidad Complutense de Madrid, Spain 5:00 p.m. – 5:30 p.m. “Relationship of milk microbiota and infant gastrointestinal microbiota” Christophe Lacroix, PhD (confirmed), Institute of Food, Nutrition and Health, ETH Zurich, Switzerland 5:30 p.m. – 6:00 p.m. “Probiotic consumption during lactation – State of the science concerning effects on maternal and infant health” Seppo Salminen, PhD (confirmed), University of Turku, Turku, Finland 6:00 p.m. – 7:00 p.m. Conference Registration 6:00 p.m. – 7:00 p.m. DINNER 7:00 p.m. – 9:00 p.m. Poster Session 6 February 2016 Thursday, July 23, 2015 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m. Conference Registration 9:00 a.m. – 12:00 p.m. General session: “Maternal Cells and Immune Modulators in Human Milk: Historical Perspective, Origin, and Potential Functions” Chair: Shelley McGuire, PhD (confirmed), Washington State University, Pullman, WA 9:00 a.m. – 9:30 a.m. “Overview of immune cells in human milk – What are they and what are they doing there?” Peter Hartmann, PhD (confirmed), University of Western Australia, Perth, Australia 9:30 a.m. – 10:00 a.m. “Update on presence and potential functions of stem cells in human milk” Foteini Hassiotou, PhD (confirmed), University of Western Australia, Perth, Australia 10:00 a.m. – 10:30 a.m. MORNING COFFEE BREAK 10:30 a.m. – 11:00 a.m. “Protective effects of milk and their species-specificity for the preterm newborn” Per Torp Sangild, PhD (confirmed), University of Copenhagen, Denmark 11:00 a.m. – 11:30 a.m. "Role of human milk bioactives in the development of food allergy in infants" Kirsi Jarvinen-Seppo, MD PhD (confirmed), University of Rochester Medical Center, Rochester, NY 11:30 a.m. – 11:45 a.m. Short talk selected from submitted abstracts 11:45 a.m. – 12:00 p.m. Short talk selected from submitted abstracts 12:00 p.m. – 1:00 p.m. LUNCH and MEET THE SPEAKERS 1:00 p.m. – 4:00 p.m. Free time 4:00 p.m. – 6:00 p.m. Special session: “Hot Topics and Data Blitz” Chair: Lars Bode, PhD (confirmed), University of California, San Diego, CA 4:00 p.m. – 4:30 p.m. “The Breast Milk, Microbiome and Immunity Project (First Results from the Gates Foundation Project)” Jeffrey Gordon, MD (not confirmed), Washington University in St. Louis, MO 4:30 p.m. – 5:00 p.m. TBD 5:00 p.m. – 5:15 p.m. Short talk selected from submitted abstracts 5:15 p.m. – 5:30 p.m. Short talk selected from submitted abstracts 5:30 p.m. – 5:45 p.m. Short talk selected from submitted abstracts 5: 45 p.m. – 6:00 p.m. Short talk selected from submitted abstracts 6:00 p.m. – 7:00 p.m. Conference Registration 6:00 p.m. – 9:00 p.m. DINNER and SPECIAL EVENT 6 February 2016 Friday, July 24, 2015 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m. Conference Registration 9:00 a.m. – 11:45 a.m. General session: “Gene Expression in Human Mammary Secretory Epithelial Cells – Evolution of Methods and Current Knowledge” Chair: Kirsi Jarvinen-Seppo, MD PhD (confirmed), University of Rochester Medical Center, Rochester, NY 9:00 a.m. – 9:30 a.m. “Comparative milk genomics: What makes us human?” Danielle Lemay, PhD (confirmed), University of California, Davis, CA 9:30 a.m. – 10:15 a.m. “Gene expression patterns in the human mammary secretory cell, epigenetics, and relevance to milk production and lactation success” Monique Rijnkels, PhD (confirmed), Texas A&M University, Houston, TX 10:15 a.m. – 10:45 a.m. MORNING COFFEE BREAK 10:45 a.m. – 11:15 a.m. “MicroRNAs in human milk – regulation by maternal diet and putative functions in the neonate” Kjersti Aagaard, MD PhD (confirmed), Baylor College of Medicine, Houston, TX 11:15 a.m. – 11:30 a.m. “International Milk Genomics Consortium – Overview and opportunities” Bruce German, PhD (confirmed), University of California, Davis, CA 11:30 a.m. – 11:45 a.m. Short talk selected from submitted abstracts 11:45 a.m. – 12:00 p.m. Closing Remarks Shelley McGuire, PhD (confirmed), Washington State University, Pullman, WA 12:00 p.m. – 1:00 p.m. LUNCH to go and DEPARTURES END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD 20814 www.faseb.org/src 6 February 2016