Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 1 Rabies in Southeast Asia Francesca Fung and Sam Therrien Northeastern University Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 2 Abstract Rabies is a disease of public health and economic importance in Southeast Asia, affecting many lives of the general population. Dog bites account for a large percentage of rabies cases in the Southeast Asia region. This article explains what steps need to be taken to prevent rabies and eventually eliminate it. Innovative tools and techniques including vaccinations, population management, and education are used to control the disease in dogs. Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 3 Rabies is a virus that has long been recognized throughout history. It is present in many animal species such as dogs and bats. There are two forms of rabies, furious and paralytic rabies, both of these forms are fatal. The disease is commonly spread to humans through the bite of an infected animal. The virus infects the central nervous system and can progress quickly causing neurological disorders and eventually death in all mammals, including humans. Canine rabies is the cause of the majority of human rabies deaths globally, especially in developing countries like those in Southeast Asia. 1 Recent studies show, more than 1.4 billion people are at risk of contracting rabies infections in Southeast Asia. The outbreak of rabies in this region has started to increase and the epidemic has claimed many human lives this past year. Each year 23,000 to 25,000 people die from rabies in Southeast Asia, this accounts for over 45% of the world's deaths from rabies. 1 The majority of the rabies cases are in children in the 5 to 15 year old age group. These children make up 40% of the people exposed and infected to dog bites in Southeast Asia. More likely than not, these bites go unreported and the exposed children do not get the proper post exposure treatment in a timely manner. Thus, there is the possibility of a disproportionately high number of young children contracting and dying of undiagnosed rabies. 1 There is no certain cure for rabies as of right now but the virus can be prevented by vaccinations. Rabies vaccine is given to both canine and human as preventive measures. It is also given to victims who have been exposed to the infection as soon as possible. Most countries in the world require domestic puppies to be vaccinated against rabies by law. However many developing countries lack the education of and financial resources for rabies control, and therefore do not prioritize the importance of obtaining these vaccinations. This is one main reason to why rabies is known as a disease of poverty. 2 Due to the absence of successful medical treatment for rabies and because of the severity of the disease, most rabies victims die at home instead of being admitted to a hospital. The lack of reported hospitalizations creates image that rabies is a rare disease resulting from the bite of a neglected dogs and Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 4 does not receive the priority or attention it deserves. There is no national rabies control program as such in most countries and the ever-increasing dog population is a big challenge to prevent human exposure and to achieve the desired level of dog vaccination coverage. The only way the rabies outbreak in Southeast Asia is going to decrease is if people are educated about proper medical procedure and get their vaccinations. This is not a case of people in Southeast Asia choosing not to get vaccinated but a case of people either not being educated or not having the means to get vaccinated. There is a lack of organizations like the World health Organization (WHO) and local government programs in place in Southeast Asia. These programs need to communicate and share resources in order to spread awareness and eliminate rabies from the region. 3 Cost of rabies vaccine may be a huge factor to why population in developing countries such as South East Asia is neglecting to have their dogs or themselves vaccinated. Vaccinations for dogs can range from $20 to $150 USD and vaccinations for human is much more expensive. However many organizations such as the World Health Organization have started to administer low-cost vaccinations for impoverished regions in Southeast Asia like Sri Lanka and Thailand to encourage the population to take precaution. Massive decreases in rabies related deaths through mass dog vaccination movements, improved accessibility of vaccines and more effective vaccine delivery systems have been seen in both countries since they have adopted cost-effective intradermal rabies vaccination to control human rabies. 4 In India, intradermal rabies vaccination schedule has been supported at the individual state level. Animal welfare and non-government organizations (NGOs), like The Rabies in Asia Foundation and the Animal Welfare Board of India, carry out animal birth control and anti-rabies vaccinations for dogs. Unfortunately, the rest of Southeast Asia does not have access to these resources due to the fact they cannot financial support local or national programs to control and prevent rabies. That is why, larger world organizations need to supplement Southeast Asia’s programs already in place. 5 Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 5 A huge issue that has been persisting in Southeast Asia is the lack of dog population management. This has led to an increase in the number of stray dogs in the region. Stray dogs have pose human health and animal welfare problems throughout the years. Studies have shown that rate of rabies infection is directly proportional to the increase in the number of strays; and controlling this population has successfully minimized the spread of the virus. Monitoring dog populations is currently one of the most effective tools for the prevention of rabies in man and animals. Use of cruel methods of dog population such as poisoning and drowning are practiced in some underdeveloped countries, therefore organizations such as the World Organization for Animal Health (OIE) has provided ways to combat stray dogs by humane means. This includes reproductive control through the promotion of sterilization of dogs, animal birth control, and the control of trade and movement of dogs. 6 Another issue with the increase in rabies transmission is that the responsibility of dog ownership at the community level is not promoted in Southeast Asia. Legislation for responsible ownership could also help reduce the number of stray dogs. Registered dogs are often linked to animal health societies which encourage mandatory rabies vaccination. However, many dogs in the region are not treated as part of the family like how we treat our beloved companion here in the United States. The concept of spending money on registering a dog and providing preventative care for their domestic pet is not a priority, which is also a reason to why many dogs do not get vaccinated. This problem may be tackled by lowering costs and educating the community on health care not only for their dogs but for themselves as well. 7 On the topic of education, public health education on rabies in the region is one strategy that could absolutely reduce the spread of the virus. It could be as simple as promoting proper care of dog bite wounds or educate children to take caution while handling domestic or stray dogs. The Global Alliance for Rabies Control have started a global movement called World Rabies Day to spread awareness on rabies prevention and reduce transmission. It promotes education in classrooms, teaching children how to be safe around animals and the importance of taking care of them as well. This knowledge is encouraged Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 6 to be reinforced and passed on to the community. Making sure people understand this information helps save many lives lost to the disease every year. 8 Rabies has created a major problem in Southeast Asia due to the numerous stray dogs and the lack of human education and government program regarding rabies. Plans to control and eventually eliminate this epidemic need to be put in place in this region. Southeast Asian countries must establish national programs to control rabies, so they can develop a strategic plan of action. This plan should include a vaccination schedule for humans and dogs, and emergency medical procedures for infected patients. In order to complete these tasks there must be improved rabies surveillance and data collection. This will provide better records to that better treatment can be administered. This information can be used to promote rational use of TCVs for PEP and encourage the introduction of cost-effective intradermal (I/D) human rabies vaccination schedule in major rabies vaccination centers. This is only part of the solution. The dog population has to be controlled. There must be the appropriate measures for the regulation of dog movements around the region. The biggest part of the control and eventual elimination of rabies in Southeast Asia is the community participation. The people of the region need to be educated and need to make a conscience effort to get medical attention if bitten, get their dogs vaccinated and get themselves vaccinated. This is the only way to eliminate the risk of rabies from billions of people. 9 Unfortunately the majority of cases for rabies in Southeast Asia is in children, and goes unreported and untreated until it is too late, and over 10,000 children between the ages of 5 and 15 years old die from it. Overall, rabies can be easily prevented and eliminated throughout the world, if individual countries perform the correct preventive measures, educate their people about rabies, and take swift action when people are infected. Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 7 **Sam Therrien Reflective Note: Seeing as I am not a medical sciences major, I have to relate this to supply chain, specifically global supply chain. Seeing is most supply chains are global, many raw materials are produced or manufactured in Southeast Asia. This rabies epidemic and restrictions on transportation of livestock and good between Southeast Asian countries could be affected. This drives costs up on the financial side of the supply chain with in turn drives costs up for the consumers. Having a good understanding of how epidemics affect the supply chain is key to understanding my concentration. Rabies in Southeast Asia: Veterinarian Sciences and Medical Vaccines 8 References 1. Rabies In The South-East Asia Region. 1st ed. India: India, 2012. Web. 15 June 2015. 2. Strategic Framework For Elimination Of Human Rabies Transmitted By Dogs In The South-East Asia Region. 1st ed. New Delhi, India: WHO, 2012. Web. 15 June 2015. 3. The South-East Asia Dog Rabies Elimination Strategy. 1st ed. Web. 15 June 2015. 4. 1.4. What is rabies and why is it important to control it? (2014, September 1). Retrieved June 15, 2015, from http://caninerabiesblueprint.org/1-4-What-is-rabies-and-why-is-it?lang=en 5. Rabies. (2014, September 1). Retrieved June 15, 2015, from http://www.who.int/mediacentre/factsheets/fs099/en/ 6. Dodet, B., & Bureau, T. A. R. E. (2006). Preventing the incurable: Asian rabies experts advocate rabies control. Vaccine, 24(16), 3045-3049. 7. Bahnemann, H. G. (1985). Rabies in South East Asia. In Rabies in the Tropics(pp. 541-544). Springer Berlin Heidelberg. 8. Gongal, G., & Wright, A. E. (2011). Human rabies in the WHO Southeast Asia Region: forward steps for elimination. Advances in preventive medicine, 2011. 9. Cleaveland, S., Kaare, M., Tiringa, P., Mlengeya, T., & Barrat, J. (2003). A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries. Vaccine, 21(17), 1965-1973.