Registry of Toxic Effects of Chemical Substances

IBUPROFEN

RTECS NUMBER : MU6640000

CHEMICAL NAME : Hydratropic acid, p-isobutyl-

CAS REGISTRY NUMBER : 15687-27-1

BEILSTEIN REFERENCE NO. : 2049713

LAST UPDATED : 199801

DATA ITEMS CITED : 47

MOLECULAR FORMULA : C13-H18-O2

MOLECULAR WEIGHT : 206.31

WISWESSER LINE NOTATION : QVY&R DIY

COMPOUND DESCRIPTOR : Drug

Mutagen

Reproductive Effector

Human

SYNONYMS/TRADE NAMES :

* Acide (isobutyl-4 phenyl)-2 propionique

* Adran

* Advil

* Anflagen

* Artril 300

* Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-

* Bluton

* Brufanic

* Brufen

* Buburone

* Butylenin

* Dolgin

* Epobron

* Ibufen

* Ibuprocin

* Ibuprofen

* IP-82

* p-Isobutylhydratropic acid

* 4-Isobutylhydratropic acid

* 2-(4-Isobutylphenyl)propanoic acid

* alpha-p-Isobutylphenylpropionic acid

* alpha-(4-Isobutylphenyl)propionic acid

* 2-(p-Isobutylphenyl)propionic acid

* Lamidon

* Liptan

* Motrin

* Mynosedin

* Napacetin

* Nobfelon

* Nobfen

* Nobgen

* Nuprin

* Nurofen

* Paduden

* Proflex

* RD 13621

* Rebugen

* Roidenin

* Rufin

* Unipron

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - man

DOSE/DURATION : 180 mg/kg/3W-I

TOXIC EFFECTS :

Liver - jaundice, cholestatic

REFERENCE :

AJGAAR American Journal of Gastroenterology. (American College of

Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-

1954- Volume(issue)/page/year: 91,1626,1996




DOSE/DURATION : 800 mg/kg

TOXIC EFFECTS :

Behavioral - coma

Behavioral - somnolence (general depressed activity)

Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :

PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd.,

POB

88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 69,575,1993





TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,

acute tubular necrosis)

Nutritional and Gross Metabolic - changes in potassium


REFERENCE :

AJEMEN American Journal of Emergency Medicine. (WB Saunders,

Philadelphia,

PA) V.1- 1983- Volume(issue)/page/year: 13,375,1995



SPECIES OBSERVED : Human - woman


TOXIC EFFECTS :

Behavioral - headache

Nutritional and Gross Metabolic - body temperature increase

REFERENCE :

JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.

Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:

239,1062,1978




DOSE/DURATION : 120 mg/kg/W-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

Skin and Appendages - dermatitis, other (after systemic exposure)


REFERENCE :

NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of

New York, POB 5405, Lake Success, NY 11042) V.1- 1901-

Volume(issue)/page/year: 78,1239,1978



SPECIES OBSERVED : Human - child

DOSE/DURATION : 480 mg/kg/17D-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse

Immunological Including Allergic - uncharacterized


REFERENCE :

JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial

Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year:

90,657,1977

TYPE OF TEST : LDLo - Lowest published lethal dose




TOXIC EFFECTS :

Behavioral - general anesthetic

Vascular - BP lowering not characterized in autonomic section

REFERENCE :

BMJOAE British Medical Journal. (British Medical Assoc., BMA House,

Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-

Volume(issue)/page/year:

281,1458,1980





TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

AEMED3 Annals of Emergency Medicine. (American College of Emergency

Physicians, 1125 Executive Circle, Irving, TX 75038)






TOXIC EFFECTS :

Lungs, Thorax, or Respiration - respiratory obstruction




REFERENCE :

JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270

Madison Ave., New York, NY 10016) V.19- 1982-


32,315,1994





TOXIC EFFECTS :

Blood - thrombocytopenia

REFERENCE :

BJCPAT British Journal of Clinical Practice. (Medical News Group, 1

Bedford

St., London WC2E 9HD, UK) V.10(10)- 1956- Volume(issue)/page/year:

48,51,1994


ROUTE OF EXPOSURE : Unreported



TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - diplopia

REFERENCE :



248,649,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill


SPECIES OBSERVED : Rodent - rat


TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,

Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-



ROUTE OF EXPOSURE : Intraperitoneal



TOXIC EFFECTS :

Behavioral - analgesia

Biochemical - Metabolism (Intermediary) - effect on inflammation or

mediation of inflammation

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :





ROUTE OF EXPOSURE : Subcutaneous



TOXIC EFFECTS :


REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,415,1982


ROUTE OF EXPOSURE : Rectal



TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex)

Behavioral - changes in motor activity (specific assay)

Gastrointestinal - hypermotility, diarrhea

REFERENCE :





SPECIES OBSERVED : Rodent - mouse


TOXIC EFFECTS :

Behavioral - analgesia

REFERENCE :

PCJOAU Pharmaceutical Chemistry Journal (English Translation).

Translation

of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-






TOXIC EFFECTS :


Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

15,310,1969





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :




REFERENCE :





SPECIES OBSERVED : Rodent - guinea pig


TOXIC EFFECTS :


REFERENCE :

ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,

Inc.,

Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-




SPECIES OBSERVED : Rodent - hamster


TOXIC EFFECTS :


REFERENCE :


Inc.,





SPECIES OBSERVED : Mammal - species unspecified

DOSE/DURATION : 1 gm/kg

TOXIC EFFECTS :


REFERENCE :

APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR.

(Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937-


** OTHER MULTIPLE DOSE TOXICITY DATA **




DOSE/DURATION : 12 gm/kg/30D-C

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - changes in thymus weight

Blood - hemorrhage

REFERENCE :

IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho

Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-

1970-






TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from large intestine

Kidney, Ureter, Bladder - changes in bladder weight

Blood - normocytic anemia

REFERENCE :



15,310,1969





TOXIC EFFECTS :


REFERENCE :



52,454,1980





TOXIC EFFECTS :

Gastrointestinal - other changes


Related to Chronic Data - death

REFERENCE :

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda

Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-






TOXIC EFFECTS :

Liver - other changes



REFERENCE :

TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,

Warner-Lambert

Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)

V.6(3/4)-




SPECIES OBSERVED : Mammal - dog


TOXIC EFFECTS :


REFERENCE :



15,310,1969




DOSE/DURATION : 9 gm/kg/90D-I

TOXIC EFFECTS :


Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :

TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,

Warner-Lambert

Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)

V.6(3/4)-


** REPRODUCTIVE DATA **




DOSE : 8 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO

63132) V.3- 1969- Volume(issue)/page/year: 28,592,1983




DOSE : 840 mg/kg

SEX/DURATION : female 8-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight

gain)

REFERENCE :







DOSE : 10 mg/kg

SEX/DURATION : female 21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :







DOSE : 600 mg/kg


TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora lutea)

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured

before birth)

REFERENCE :

IJEBA6 Indian Journal of Experimental Biology. (Publications &

Information

Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-



ROUTE OF EXPOSURE : Intrauterine


DOSE : 2 mg/kg


TOXIC EFFECTS :



REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-





DOSE : 270 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition

Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :






DOSE : 891 mg/kg


lactating female 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - weaning or lactation index (e.g., #

alive at weaning per # alive at day 4)

REFERENCE :






DOSE : 1 gm/kg



TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day

4

per # born alive)

REFERENCE :






DOSE : 810 mg/kg

SEX/DURATION : male 60 day(s) pre-mating

female 2 week(s) pre-mating - 7 day(s) after

conception

TOXIC EFFECTS :



REFERENCE :






DOSE : 8100 mg/kg


female 2 week(s) pre-mating - 7 day(s) after

conception

TOXIC EFFECTS :




before birth)

REFERENCE :






DOSE : 420 mg/kg


TOXIC EFFECTS :




before birth)

REFERENCE :







DOSE : 1260 mg/kg


TOXIC EFFECTS :



Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :




** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis


TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 1470 mg/kg/7D

REFERENCE :

CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,

Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year:

55,722,1986

TYPE OF TEST : Sister chromatid exchange




REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

393,123,1997





REFERENCE :



393,123,1997

*** REVIEWS ***

TOXICOLOGY REVIEW

JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270

Madison Ave., New York, NY 10016) V.19- 1982-


30,23,1992

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X4905

No. of Facilities: 82 (estimated)

No. of Industries: 1

No. of Occupations: 1

No. of Employees: 2249 (estimated)

No. of Female Employees: 1246 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

IBUPROFEN SODIUM

RTECS NUMBER : MU6641000

CHEMICAL NAME : Hydratropic acid, p-isobutyl-, sodium salt




MOLECULAR FORMULA : C13-H17-O2.Na





* Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, sodium salt

* Ibuprofen sodium

* p-Isobutylhydratropic acid sodium salt

* Sodium ibuprofen




ROUTE OF EXPOSURE : Intramuscular



TOXIC EFFECTS :


REFERENCE :

PHSCFB Pharmaceutical Sciences. (Royal Pharmaceutical Society of Great

Braitain, 1 Lambeth High St., London SE1 7JN, UK) V.1 1995-





SPECIES OBSERVED : Rodent - rabbit

DOSE : 1 gm/kg


TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

REFERENCE :

FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave.

S,

Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 38,238,1982

IMIDAZOLE

RTECS NUMBER : NI3325000

CHEMICAL NAME : Imidazole



REFERENCE : 5-23-04-00191 (Beilstein Handbook Reference)



MOLECULAR FORMULA : C3-H4-N2


WISWESSER LINE NOTATION : T5M CNJ

COMPOUND DESCRIPTOR : Agricultural Chemical

Mutagen



* 1,3-Diaza-2,4-cyclopentadiene

* 1,3-Diazole

* Formamidine, N,N'-vinylene-

* Glioksal

* Glyoxalin

* Glyoxaline

* Imidazol

* Iminazole

* Imutex

* Miazole

* Pyrro(b)monazole

* USAF EK-4733







TOXIC EFFECTS :


REFERENCE :

PREPAB Przeglad Epidemiologiczny. (Panstwowy Zaklad Wydawnictw

Lekarskich,

ul. Dluga 38-40, 00-238 Warsaw, Poland) V.1- 1947-






TOXIC EFFECTS :


REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-






TOXIC EFFECTS :


REFERENCE :

GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and

Trademark Office, Foreign Patents, Washington, DC 20231)

Volume(issue)/page/year: #3046325





TOXIC EFFECTS :


REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: AD277-689





TOXIC EFFECTS :


REFERENCE :


&




ROUTE OF EXPOSURE : Intravenous



TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Lekarskich,





SPECIES OBSERVED : Mammal - cat


TOXIC EFFECTS :

Behavioral - food intake (animal)

Behavioral - rigidity (including catalepsy)


REFERENCE :

AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.

(Leipzig,

Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see

NSAPCC.






TOXIC EFFECTS :


REFERENCE :


Lekarskich,







TOXIC EFFECTS :


REFERENCE :

PCOC** Pesticide Chemicals Official Compendium, Association of the

American

Pesticide Control Officials, Inc., 1966. (Topeka, KS)

Volume(issue)/page/year: -,608,1966





DOSE : 150 mg/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - impotence

REFERENCE :

NLETDU Neuroendocrinology Letters. (Brain Research Promotion, D-7400,

Tubingen, Germany) V.1- 1979- Volume(issue)/page/year: 12,69,1990

** MUTATION DATA **

TYPE OF TEST : DNA inhibition

TEST SYSTEM : Human Cells - not otherwise specified

DOSE/DURATION : 1 mmol/L

REFERENCE :

JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co.,

428

E. Preston St., Baltimore, MD 21202) V.1- 1938-


65,400,1975



NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - M1601






NOES Hazard Code - M1601








EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

IMIDAZOLECARBOXYLIC ACID (4-)


CHEMICAL NAME : Imidazole-4-carboxylic acid




MOLECULAR FORMULA : C4-H4-N2-O2


WISWESSER LINE NOTATION : T5M CNJ DVQ



* 4-Carboxyimidazole

* 1H-Imidazole-4-carboxylic acid







TOXIC EFFECTS :


REFERENCE :

PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach

CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year:

1,542,1965

IMIDAZOLIDINETHIONE (2-)


CHEMICAL NAME : 2-Imidazolidinethione


OTHER CAS REGISTRY NOS. : 96-46-8



MOLECULAR FORMULA : C3-H6-N2-S


WISWESSER LINE NOTATION : T5MYMTJ BUS


Tumorigen

Mutagen


Primary Irritant


* Akrochem etu-22

* 4,5-Dihydroimidazole-2(3H)-thione

* Ethylene thiourea

* 1,3-Ethylenethiourea

* N,N'-Ethylenethiourea

* 1,3-Ethylene-2-thiourea

* ETU

* Imidazole-2(3H)-thione, 4,5-dihydro-

* Imidazoline, 2-mercapto-

* Imidazoline-2-thiol

* 2-Imadazoline-2-thiol

* Ethylene thiouree

* 2-Mercaptoimidazoline

* 2-Merkaptoimidazolin

* NA-22

* NA-22-D

* NCI-C03372

* Pennac CRA

* RCRA waste number U116

* Robac 22

* Rodanin S-62

* Sanceller 22

* Sodium-22 neoprene accelerator

* 2-Thiol-dihydroglyoxaline

* Urea, 1,3-ethylene-2-thio-

* USAF EL-62

* Vulkacit npv/C2

* Warecure C


** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye


DOSE/DURATION : 500 mg/24H

REACTION SEVERITY : Mild

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,988,1986






TOXIC EFFECTS :


REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ






TOXIC EFFECTS :


REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and

Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

V.1-36, 1957-1992. For publisher information, see MTPEEI

Volume(issue)/page/year: 30(5),59,1986





DOSE/DURATION : 297 mg/kg/28D-C

TOXIC EFFECTS :

Endocrine - other changes


REFERENCE :


Inc.,







TOXIC EFFECTS :


Endocrine - changes in thyroid weight


REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.





DOSE/DURATION : 220 mg/kg/7W-C

TOXIC EFFECTS :



Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :



67,264,1983





TOXIC EFFECTS :




REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.


NJ


** TUMORIGENIC DATA **




DOSE/DURATION : 10920 mg/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Endocrine - thyroid tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-388,1992





TOXIC EFFECTS :


Lungs, Thorax, or Respiration - tumors


REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC)

V.1-60,

1940-78. For publisher information, see JJIND8.


49,583,1972





TOXIC EFFECTS :


Liver - tumors


REFERENCE :



NTP-TR-388,1992




DOSE/DURATION : 77 gm/kg/82W-C

TOXIC EFFECTS :


Liver - tumors

Blood - lymphoma, including Hodgkin's disease

REFERENCE :


V.1-60,



42,1101,1969

TYPE OF TEST : TD - Toxic dose (other than lowest)




TOXIC EFFECTS :



REFERENCE :

JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)

V.61-79, 1978-87. For publisher information, see JNCIEQ.





DOSE/DURATION : 44 gm/kg/2Y-C

TOXIC EFFECTS :



Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :

EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,

France) V.7-9, 1974-76. For publisher information, see TOERD9.





DOSE/DURATION : 146 gm/kg/2Y-C

TOXIC EFFECTS :



REFERENCE :

EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,

France) V.7-9, 1974-76. For publisher information, see TOERD9.






TOXIC EFFECTS :


Endocrine - tumors


REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

publisher information, see FCTOD7. Volume(issue)/page/year: 13,493,1975





TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

REFERENCE :









DOSE : 60 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :


(Alan






DOSE : 100 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - gastrointestinal

system

REFERENCE :

SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o

Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,

Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher

information, see CGANE7. Volume(issue)/page/year: 18,241,1978




DOSE : 60 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

REFERENCE :

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell

House,

Fairview Park, Elmsford, NY 10523) V.20- 1982-


20,273,1982




DOSE : 10 mg/kg


TOXIC EFFECTS :


4

per # born alive)



REFERENCE :


Inc.,






DOSE : 50 mg/kg


TOXIC EFFECTS :



Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :








DOSE : 30 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System



REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,

see TOSCF2 Volume(issue)/page/year: 9,415,1987

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation


DOSE : 120 mg/m3/3H


TOXIC EFFECTS :




REFERENCE :



Volume(issue)/page/year: PB277-077




DOSE : 27200 ug/m3/3H


TOXIC EFFECTS :


REFERENCE :



Volume(issue)/page/year: PB277-077


ROUTE OF EXPOSURE : Administration onto the skin


DOSE : 100 mg/kg


TOXIC EFFECTS :


System




REFERENCE :



41,35,1977




DOSE : 2800 mg/kg


female 1-21 day(s) after conception

TOXIC EFFECTS :


Reproductive - Effects on Newborn - stillbirth


gain)

REFERENCE :

TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,

Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,102,1992




DOSE : 30 mg/kg


TOXIC EFFECTS :


System



REFERENCE :


(Alan






DOSE : 30 mg/kg


TOXIC EFFECTS :


4

per # born alive)

REFERENCE :


(Alan






DOSE : 30 mg/kg


TOXIC EFFECTS :


before birth)


System


4

per # born alive)

REFERENCE :

CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2

Ono-higashi,

Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-


30,121,1990




DOSE : 30 mg/kg


TOXIC EFFECTS :


gain)

REFERENCE :

CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2

Ono-higashi,

Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-


30,121,1990




DOSE : 80 mg/kg


TOXIC EFFECTS :




System



REFERENCE :



48,229,1979




DOSE : 80 mg/kg


TOXIC EFFECTS :


Reproductive - Specific Developmental Abnormalities - homeostasis

REFERENCE :



48,229,1979




DOSE : 300 mg/kg


TOXIC EFFECTS :


System




REFERENCE :

AHEMA5 Anatomia, Histologia, Embryologia. (Paul Parey Scientific Pub.,

35

W. 38th St., Suite 3W, New York, NY 10018) V.2- 1973-





DOSE : 1600 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - sex ratio

REFERENCE :

JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,

1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-





DOSE : 2 gm/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 2 gm/kg


TOXIC EFFECTS :



REFERENCE :


(Alan






DOSE : 2 gm/kg


TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)



REFERENCE :


(Alan


Volume(issue)/page/year: 27,57A,1983




DOSE : 2400 mg/kg


TOXIC EFFECTS :



REFERENCE :


(Alan


Volume(issue)/page/year: 27,57A,1983




DOSE : 600 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear

Reproductive - Specific Developmental Abnormalities - body wall



REFERENCE :


(Alan






DOSE : 1120 mg/kg


TOXIC EFFECTS :



REFERENCE :


(Alan






DOSE : 140 mg/kg


TOXIC EFFECTS :


System

REFERENCE :


(Alan






DOSE : 600 mg/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 6480 mg/kg


TOXIC EFFECTS :





system

REFERENCE :








DOSE : 2400 mg/kg


TOXIC EFFECTS :




REFERENCE :







DOSE : 2160 mg/kg


TOXIC EFFECTS :



REFERENCE :








DOSE : 1200 mg/kg


TOXIC EFFECTS :


System



REFERENCE :




** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium


REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,

Switzerland) V.1- 1945- Volume(issue)/page/year: 31,214,1975



DOSE/DURATION : 20 ug/plate

REFERENCE :

BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,

Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-


37,873,1978

TYPE OF TEST : DNA repair


DOSE/DURATION : 20 mg/plate

REFERENCE :



38,122,1976


TEST SYSTEM : Bacteria - Escherichia coli

DOSE/DURATION : 200 mg/L

REFERENCE :

PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,

52

Vanderbilt Ave., New York, NY 10017) V.1- 1981-


1,396,1981




REFERENCE :


52



1,195,1981

TYPE OF TEST : Phage inhibition capacity


DOSE/DURATION : 10 gm/L

REFERENCE :


52



1,224,1981

TYPE OF TEST : DNA damage

TEST SYSTEM : Bacteria - Bacillus subtilis

DOSE/DURATION : 2 mg/disc

REFERENCE :


52



1,175,1981

TYPE OF TEST : Specific locus test

ROUTE OF EXPOSURE : Multiple routes

TEST SYSTEM : Insect - Drosophila melanogaster

DOSE/DURATION : 500 umol/L

REFERENCE :



395,229,1997


TEST SYSTEM : Yeast - Saccharomyces cerevisiae


REFERENCE :

MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger

Pl.

3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-





REFERENCE :


52



1,502,1981

TYPE OF TEST : Gene conversion and mitotic recombination



REFERENCE :


52



1,491,1981

TYPE OF TEST : Sex chromosome loss and nondisjunction



REFERENCE :


52



1,468,1981


TEST SYSTEM : Mold - Aspergillus nidulans


REFERENCE :



172,139,1986


ROUTE OF EXPOSURE : Parenteral

TEST SYSTEM : Rodent - rat


REFERENCE :



38,349,1976





REFERENCE :

CSHCAL Cold Spring Harbor Conferences on Cell Proliferation. (Cold

Spring

Harbor, NY) V.1-10, 1974-83. Volume(issue)/page/year: 4,267,1977


TEST SYSTEM : Rodent - mouse Lymphocyte


REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41

E.

11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:

12,85,1988





REFERENCE :



391,201,1997

TYPE OF TEST : Host-mediated assay

TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium


REFERENCE :



56,111,1977

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - hamster Kidney

DOSE/DURATION : 80 ug/L

REFERENCE :




37,873,1978

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

V.1- 1972- Volume(issue)/page/year: 7,45,1974

IARC Cancer Review:Human Inadequate Evidence

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-


7,207,1987

IARC Cancer Review:Group 2B




7,207,1987

TOXICOLOGY REVIEW

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 7,243,1974

TOXICOLOGY REVIEW

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf

Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:

39(6),A34,1978

TOXICOLOGY REVIEW

85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer

Congress," Chicago, Year Book Medical Pub., 1971


5,250,1970

TOXICOLOGY REVIEW

CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du

Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year:

14,49,1979

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-FINLAND:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Carcinogen JAN 1993

OEL-SWEDEN;Carcinogen JAN 1993


NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :

NIOSH REL TO ETHYLENE THIOUREA-air:CA lowest feasible concentration

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of

Health, Education, and Welfare, Reports and Memoranda.

Volume(issue)/page/year: DHHS #92-100,1992



NOHS Hazard Code - 82079






NOES Hazard Code - 82079







EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Rodent

dominant lethal

EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Histidine

reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; Sperm

morphology-mouse

EPA GENETOX PROGRAM 1988, Negative: TRP reversion

EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus



On EPA IRIS database


NIOSH CURRENT INTELLIGENCE BULLETIN 22, 1978

NIOSH Analytical Method, 1994: Ethylene thiourea, 5011

NTP Carcinogenesis Studies (feed);clear evidence:mouse,rat



NTP-TR-388,1992

NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be

Human Carcinogen

IMINOBISPROPYLAMINE (3,3'-)

RTECS NUMBER : JL9450000

CHEMICAL NAME : Dipropylamine, 3,3'-diamino-








WISWESSER LINE NOTATION : Z3M3Z

COMPOUND DESCRIPTOR : Primary Irritant


* Aminobis(propylamine)

* Bis-(3-aminopropyl)amine

* 3,3-Diaminodipropylamine

* 3,3'-Diaminodipropylamine

* Dipropylenetriamine

* Dipropylentriamin

* Iminobis(propylamine)

* 3,3'-Iminobis(propylamine)

* 1,3-Propanediamine, N-(3-aminopropyl)-

* Propylamine, 3,3'-iminobis-



TYPE OF TEST : Open irritation test



DOSE/DURATION : 470 mg

REACTION SEVERITY : Moderate

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/13/1968





REACTION SEVERITY : Severe

REFERENCE :








TOXIC EFFECTS :


REFERENCE :

ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB

Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.

Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : 110 uL/kg

TOXIC EFFECTS :

Skin and Appendages - primary irritation (after topical exposure)

REFERENCE :







TOXIC EFFECTS :


REFERENCE :







NOES Hazard Code - T0646










IMINODIACETIC ACID

RTECS NUMBER : AI2975000

CHEMICAL NAME : Acetic acid, iminodi-






MOLECULAR FORMULA : C4-H7-N-O4


WISWESSER LINE NOTATION : QV1M1VQ


* Aminodiacetic acid

* N-(Carboxymethyl)glycine

* Diglycin

* Diglycine

* Diglykokoll

* Glycine, N-(carboxymethyl)-

* Hampshire

* IDA

* Iminobis(acetic acid)

* Iminodiacetic acid

* 2,2'-Iminodiacetic acid

* Iminodiethanoic acid

* USAF DO-55







TOXIC EFFECTS :


REFERENCE :
















IMINODIACETIC ACID

RTECS NUMBER : MT6550000

CHEMICAL NAME : Humic acid, sodium salt




COMPOUND DESCRIPTOR : Reproductive Effector


* CH 02

* CHA 02

* Dolaflux

* Huminsaure natrium

* Natrium-humat

* Sodium humate







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International

Book

Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88.

For

publisher information, see ZYZAEU. Volume(issue)/page/year: 18,180,1983





TOXIC EFFECTS :


REFERENCE :








DOSE : 250 mg/kg


TOXIC EFFECTS :



REFERENCE :

AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag,

Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-












IMINODIACETONITRILE

RTECS NUMBER : AM0650000

CHEMICAL NAME : Acetonitrile, iminodi-








WISWESSER LINE NOTATION : NC1M1CN



* Acetonitrile, 2,2'-iminobis-

* Di(cianometil)ammina

* 1,1'-Imidodiacetonitrile

* 2,2'-Iminobisacetonitrile

* Iminodiacetonitrile

* 2406 I.S.







TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :



Volume(issue)/page/year: OTS0536765





TOXIC EFFECTS :


REFERENCE :

FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,

Italy) V.8-43 1953-88 For publisher information, see FRMCE8






TOXIC EFFECTS :




REFERENCE :







IMINODIBENZYL

RTECS NUMBER : HN8950000

CHEMICAL NAME : 5H-Dibenz(b,f)azepine, 10,11-dihydro-






MOLECULAR FORMULA : C14-H13-N


WISWESSER LINE NOTATION : T C676 BM&T&J



* 10,11-Dihydro-5-dibenz(b,f)azepine

* 2,2'-Iminobibenzyl

* Iminodibenzyl

* 2,2'-Iminodibenzyl








REFERENCE :


House,



20,573,1982






TOXIC EFFECTS :


REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical

Systems

Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD

21010)

Volume(issue)/page/year: NX#01352




IMIPRAMINE HYDROCHLORIDE

RTECS NUMBER : HO1925000

CHEMICAL NAME : 5H-Dibenz(b,f)azepine,

5-(3-(dimethylamino)propyl)-10,11-dihydro-,

monohydrochloride




MOLECULAR FORMULA : C19-H24-N2.Cl-H


WISWESSER LINE NOTATION : T C676 BN&T&J B3N1&1 &GH


Mutagen


Human


* Antideprin hydrochloride

* Chimoreptin

* Chrytemin

* Co cap imipramine 25

* Deprinol

* 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-,

hydrochloride

* 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-,

monohydrochloride

* 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz(b,f)azepine

hydrochloride

* N-(gamma-Dimethylaminopropyl)iminodibenzyl hydrochloride

* N-(3-Dimethylaminopropyl)iminodibenzyl hydrochloride

* N-(gamma-Dimetilaminopropil)-iminodibenzile cloridrato

* Dynazina

* Efuranol

* Feinalmin

* Fujisawa

* G 22355

* IA-Pram

* Imavate

* Imidol

* Imilanyle

* Imipramine hydrochloride

* Imipramine monohydrochloride

* Iprogen

* Janimine

* Melipramine hydrochloride

* NSC 114900

* Persamine

* Pertofram

* Presamine

* Pryleugan

* SK-Pramine hydrochloride

* Teperine

* Tofranil

* Tofranile






DOSE/DURATION : 2143 ug/kg/2D-I

TOXIC EFFECTS :

Behavioral - tremor

REFERENCE :

JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press,

Inc., POB 240008, Memphis, TN 38124) V.39- 1978-






TOXIC EFFECTS :

Behavioral - sleep



REFERENCE :



179,456,1962





TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)

Cardiac - other changes

Kidney, Ureter, Bladder - other changes

REFERENCE :




1,261,1974





TOXIC EFFECTS :


Behavioral - muscle contraction or spasticity


REFERENCE :



230,1405,1974





TOXIC EFFECTS :


Cardiac - pulse rate increase, without fall in BP


REFERENCE :

AJEMEN American Journal of Emergency Medicine. (WB Saunders,

Philadelphia,

PA) V.1- 1983- Volume(issue)/page/year: 12,456,1994





TOXIC EFFECTS :

Peripheral Nerve and Sensation - paresthesis


REFERENCE :




2,1458,1959





TOXIC EFFECTS :


REFERENCE :



18,185,1971





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,

1954-74.

For publisher information, see ARTODN. Volume(issue)/page/year:

21,30,1965





TOXIC EFFECTS :


REFERENCE :

THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,

France) V.1- 1946- Volume(issue)/page/year: 20,67,1965





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia,

Italy)

V.8-43 1953-88 For publisher information, see FRMCE8






TOXIC EFFECTS :


REFERENCE :






SPECIES OBSERVED : Primate - monkey


TOXIC EFFECTS :




REFERENCE :


Information







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,

Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year:

38,749,1983





TOXIC EFFECTS :


REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.

(Heymans

Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Brain and Coverings - changes in brain weight

Lungs, Thorax, or Respiration - other changes

Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :

DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,

New

York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 6,135,1983





DOSE : 285 mg/kg

SEX/DURATION : female 14 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76.

For

publisher information, see PSCHDL. Volume(issue)/page/year: 41,237,1975




DOSE : 200 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 800 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 1 gm/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 180 mg/kg



TOXIC EFFECTS :



REFERENCE :


For





DOSE : 225 mg/kg



TOXIC EFFECTS :





REFERENCE :


For





DOSE : 210 mg/kg


TOXIC EFFECTS :



gain)

REFERENCE :

DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub.,

Inc.,

79 Fifth Ave., New York, NY 10003) V.1- 1980-


8,17,1985




DOSE : 65 mg/kg


TOXIC EFFECTS :


System

Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,

Inc.,

41 E. 11th St., New York, NY 10003) V.1- 1980-


6,173,1986




DOSE : 130 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular

(circulatory) system

REFERENCE :

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,

Inc.,

41 E. 11th St., New York, NY 10003) V.1- 1980-


6,173,1986




DOSE : 65 mg/kg


TOXIC EFFECTS :


Reproductive - Effects on Newborn - behavioral

REFERENCE :

NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR





DOSE : 9700 mg/kg



TOXIC EFFECTS :



4

per # born alive)


gain)

REFERENCE :

RCOCB8 Research Communications in Chemical Pathology and Pharmacology.

(PJD

Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-





DOSE : 9200 mg/kg

SEX/DURATION : female 10 week(s) pre-mating


TOXIC EFFECTS :



REFERENCE :


(PJD






DOSE : 125 mg/kg


TOXIC EFFECTS :





System

REFERENCE :

DGDFA5 Development, Growth & Differentiation. (Japan Pub. Trading Co.

(USA), 1255 Howard St., San Francisco, CA 94103) V.11- 1969-





DOSE : 165 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - physical


4

per # born alive)

REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:

20,186,1963




DOSE : 35 mg/kg


TOXIC EFFECTS :


System



REFERENCE :

RCPBDC Research Communications in Psychology, Psychiatry and Behavior.

(PJD



** MUTATION DATA **



TEST SYSTEM : Insect - Drosophila melanogaster


REFERENCE :



260,99,1991



TEST SYSTEM : Insect - not otherwise specified


REFERENCE :

JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York

Ave.,

New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,182a,1970



TEST SYSTEM : Insect - not otherwise specified


REFERENCE :

JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York

Ave.,

New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,182a,1970

*** REVIEWS ***

TOXICOLOGY REVIEW

IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79.

Discontinued. Volume(issue)/page/year: 2,209,1975












INDANDIONE (1,3-)

RTECS NUMBER : NK5070000

CHEMICAL NAME : 1,3-Indandione








WISWESSER LINE NOTATION : L56 BV DV CHJ



* 1,3-Diketohydrindene

* 1H-Indene-1,3(2H)-dione







TOXIC EFFECTS :


REFERENCE :

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,

D-1000

Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:

33,191,1975





DOSE : 25 mg/kg


TOXIC EFFECTS :




REFERENCE :


D-1000


33,191,1975



INDAZOLE


CHEMICAL NAME : 1H-Indazole






WISWESSER LINE NOTATION : T56 BMNJ



* 2-Azaindole

* 1H-Benzopyrazole

* 1,2-Diazaindene

* Indazole

* Isoindazole







TOXIC EFFECTS :


REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,

Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,

DC


INDENE


CHEMICAL NAME : Indene




MOLECULAR FORMULA : C9-H8


WISWESSER LINE NOTATION : L56 BHJ


* Inden

* Indene

* 1H-Indene

* Indonaphthene



TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill



DOSE/DURATION : 14 gm/m3

TOXIC EFFECTS :


REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : >5 gm/kg

TOXIC EFFECTS :


REFERENCE :








DOSE/DURATION : 3 mg/m3/24H/15W-C

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - true cholinesterase


levels - catalases

REFERENCE :




*** REVIEWS ***

ACGIH TLV-TWA 48 mg/m3 (10 ppm)

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 10 ppm (45 mg/m3)




3,134,1971

OSHA PEL (Construc):8H TWA 10 ppm (45 mg/m3)

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 10 ppm (45 mg/m3)


Supt.


29,1915.1000,1993


OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3) JAN 1993

OEL-BELGIUM:TWA 10 ppm (48 mg/m3) JAN 1993

OEL-DENMARK: TWA 10 ppm (45 mg/m3), JAN1999

OEL-FINLAND:TWA 10 ppm (47 mg/m3);STEL 20 ppm (95 mg/m3) JAN 1993

OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3) JAN 1993

OEL-SWITZERLAND:TWA 10 ppm (45 mg/m3) JAN 1993

OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3);STEL 15 ppm (70 mg/m3) JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV



NIOSH REL TO INDENE-air:10H TWA 10 ppm

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.

of





















INDIGO

RTECS NUMBER : DU2988400

CHEMICAL NAME : (delta(sup 2,2')-Biindoline)-3,3'-dione








COMPOUND DESCRIPTOR : Mutagen


* delta(sup 2,2')-Bipseudoindoxyl

* 11669 Blue

* Blue No. 201

* C.I. 73000

* C.I. Vat Blue 1

* Cystoceva

* D&C Blue No. 6

* D and C Blue No. 6

* Diindogen

* (2,2'-Biindoline)-3,3'-dione

* Indigo

* Indigo Blue

* Indigo Ciba

* Indigo Ciba SL

* Indigo J

* Indigo N

* Indigo NAC

* Indigo nacco

* Indigo P

* Indigo PLN

* Indigo powder W

* Indigo Pure BASF

* Indigo Pure BASF Powder K

* Indigo synthetic

* Indigotin

* Indigo VS

* 3H-Indol-3-one, 2(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-

* Lithosol Deep Blue V

* Mitsui indigo paste

* Mitsui Indigo Pure

* Modr Kypova 1

* Monolite Fast Navy Blue BV

* NCI-C61392

* Synthetic indigo

* Synthetic indigo TS

* Vat Blue 1

* Vulcafix Blue R

* Vulcafor Blue A

* Vulcanosine Dark Blue L

* Vynamon Blue A







TOXIC EFFECTS :


REFERENCE :

85PEAG "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai

Science/Technology Publisher, Peop. Rep. China, 1994






TOXIC EFFECTS :


REFERENCE :

85PEAG "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai

Science/Technology Publisher, Peop. Rep. China, 1994


** MUTATION DATA **



DOSE/DURATION : 500 nmol/plate

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-





NOHS Hazard Code - T0884















INDIGO CARMINE

RTECS NUMBER : DU3000000

CHEMICAL NAME : (delta(sup 2,2')-Biindoline)-5,5'-disulfonic acid,

3,3'-dioxo-, disodium salt




MOLECULAR FORMULA : C16-H8-N2-O8-S2.2Na


WISWESSER LINE NOTATION : T56 BMYVJ GSWO CU- CT56 BMYVJ GSWO &-NA- 2

COMPOUND DESCRIPTOR : Tumorigen

Drug

Mutagen


* Acid Blue W

* Acid Leather Blue IC

* A.F. Blue No. 2

* Airedale Blue IN

* Amacid Brilliant Blue

* Aniline Carmine powder

* Atul Indigo Carmine

* 1311 Blue

* 12070 Blue

* Bucacid indigotine B

* Canacert Indigo Carmine

* Carmine Blue (biological stain)

* C.I. 73015

* C.I. 75781

* C.I. Acid Blue 74

* C.I. Food Blue 1

* C.I. Food Blue 1, disodium salt

* Cilefa Blue R

* C.I. Natural Blue 2

* Disodium indigo-5,5-disulfonate

* Disodium salt of 1-indigotin-S,S'-disulphonic acid

* Dolkwal Indigo Carmine

* E 132

* Edicol Supra Blue X

* FD and C Blue No. 2

* Food Blue 2

* Grape Blue A Geigy

* HD Indigo Carmine

* HD Indigo Carmine Supra

* Hexacert Blue No. 2

* Hexacol Indigo Carmine Supra

* Indigo Carmine

* Indigo Carmine A

* Indigo Carmine AC

* Indigo Carmine (biological stain)

* Indigo Carmine BP

* Indigo Carmine Conc. FQ

* Indigo Carmine disodium salt

* Indigo Carmine powder

* Indigo Carmine X

* Indigo disulfonate (biological stain)

* Indigo extract

* Indigo-karmin

* Indigotin I

* 5,5'-Indigotindisulfonic acid

* Indigotin-5,5'-disulfonic acid disodium salt

* Indigotine

* Indigotine B

* Indigotine Blue LZ

* Indigotine conc. powder

* Indigotine disodium salt

* Indigotine Extra Pure A

* Indigotine I

* Indigotine Lake

* Indigotine N

* Indocarmine F

* Intense Blue

* L-Blau 2

* Maple Indigo Carmine

* Mitsui Indigo Carmine

* Modr Kysela 74

* Modr Pigment 63

* Modr Potravinarska 1

* Murabba

* Sachsischblau

* San-ei Indigo Carmine

* Schultz Nr. 1309

* Sodium indigotindisulfonate

* Sodium 5,5'-indigotidisulfonate

* Soluble indigo

* Sumitomo Wool Blue SBC

* Usacert Blue No. 2







TOXIC EFFECTS :


REFERENCE :

SCPHA4 Scientia Pharmaceutica. (Oesterreichische

Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9,

Austria)






TOXIC EFFECTS :


REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,83,1982





TOXIC EFFECTS :


REFERENCE :



Austria)






TOXIC EFFECTS :


REFERENCE :



Austria)






DOSE/DURATION : 9 gm/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Tumorigenic - tumors at site of application

REFERENCE :



8,29,1966

** MUTATION DATA **




DOSE/DURATION : 5400 mg/kg/90D (Continuous)

REFERENCE :

CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1-

1969-






REFERENCE :

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.

Ireland

Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:

30,315,1986





REFERENCE :


Ireland


52,33,1990


TEST SYSTEM : Rodent - hamster Fibroblast


REFERENCE :


House,



22,623,1984


TEST SYSTEM : Rodent - hamster Ovary

DOSE/DURATION : 20 umol/L/5H (Continuous)

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979

















EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion

EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay


INDIUM

RTECS NUMBER : NL1050000

CHEMICAL NAME : Indium




MOLECULAR FORMULA : In


WISWESSER LINE NOTATION : IN


* Indium







TOXIC EFFECTS :


REFERENCE :

28ZLA8 "Toxicity of Industrial Metals," Browning, E., London,

Butterworths,

1961 Volume(issue)/page/year: -,144,1961

*** REVIEWS ***

TOXICOLOGY REVIEW

ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.

Discontinued. Volume(issue)/page/year: 5,51,1972


MSHA STANDARD-air:TWA 0.1 mg/m3




3,134,1971

OSHA PEL (Construc):8H TWA 0.1 mg/m3


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.1 mg(In)/m3


Supt.


29,1915.1000,1993


OEL-AUSTRALIA:TWA 0.1 mg/m3 JAN 1993

OEL-BELGIUM:TWA 0.1 mg/m3 JAN 1993

OEL-DENMARK: TWA 0.1 mg(In)/m3, JAN1999

OEL-FINLAND:TWA 0.1 mg/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 0.1 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 0.1 mg/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 0.1 mg/m3;STEL 0.3 mg/m3 JAN 1993





NIOSH REL TO INDIUM AND COMPOUNDS (as I)-air:10H TWA 0.1 mg/m3

REFERENCE :















INDIUM(III) CHLORIDE


CHEMICAL NAME : Indium chloride




MOLECULAR FORMULA : Cl3-In


WISWESSER LINE NOTATION : IN G3




* Indium trichloride






DOSE/DURATION : 2370 ug/kg

TOXIC EFFECTS :


REFERENCE :


Japan) Volume(issue)/page/year: -,136,1990





TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise

specified

Skin and Appendages - hair

REFERENCE :

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)

V.18-31, 1936-49. For publisher information, see AEHLAU.






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.

(Paris, France) V.1-261, 1835-1965. For publisher information, see

CRASEV.






TOXIC EFFECTS :


REFERENCE :

EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.

Rep.

Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Rep.






DOSE : 2500 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects





REFERENCE :




** MUTATION DATA **


TEST SYSTEM : Mammal - species unspecified Lymphocyte


REFERENCE :

JCHODP Journal of Clinical Hematology and Oncology. (Cancer Center at

Wadley Institutes, POB 35988, Dallas, TX 75235) V.5(3)- 1975-



OSHA PEL (Construc):8H TWA 0.1 mg(In)/m3


Supt.


29,1926.55,1994











INDOLE


CHEMICAL NAME : Indole






WISWESSER LINE NOTATION : T56 BMJ


Primary Irritant


* 1-Azaindene

* 1-Benzazole

* Benzopyrrole

* 2,3-Benzopyrrole

* Indol

* Ketole






DOSE/DURATION : 750 ug/24H


REFERENCE :



-,820,1986






TOXIC EFFECTS :


REFERENCE :



23,95,1962





TOXIC EFFECTS :


REFERENCE :

AECTCV Archives of Environmental Contamination and Toxicology.


NJ






TOXIC EFFECTS :


REFERENCE :

YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,

2-12-15

Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-






TOXIC EFFECTS :


REFERENCE :

KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3,

D-1000


35,504,1957





TOXIC EFFECTS :


REFERENCE :



23,95,1962




SPECIES OBSERVED : Mammal - domestic


TOXIC EFFECTS :

Blood - other changes

REFERENCE :

FEPRA7 Federation Proceedings, Federation of American Societies for

Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.







TOXIC EFFECTS :


Blood - leukemia

REFERENCE :


D-1000


35,504,1957





TOXIC EFFECTS :


Tumorigenic - tumor types after systemic administration not seen

spontaneously

REFERENCE :

AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium)

V.1-20,

1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year:

19,660,1963





TOXIC EFFECTS :


Blood - leukemia

REFERENCE :

VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,

see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,

1928-37; V.1- 1955- Volume(issue)/page/year: 10(9),70,1964





TOXIC EFFECTS :



Blood - leukemia

REFERENCE :

VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,

see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,

1928-37; V.1- 1955- Volume(issue)/page/year: 20(8),75,1974



















INDOLEALDEHYDE (3-)


CHEMICAL NAME : Indole-3-carboxaldehyde






MOLECULAR FORMULA : C9-H7-N-O


WISWESSER LINE NOTATION : T56 BMJ DVH



* 3-Formylindole

* Indole-3-aldehyde

* Indole-3-carbaldehyde

* 1H-Indole-3-carboxaldehyde

* beta-Indolylaldehyde







TOXIC EFFECTS :

Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,

spasmolytic)

Behavioral - anticonvulsant


REFERENCE :


Translation





INDOLEBUTYRIC ACID


CHEMICAL NAME : 1H-Indole-3-butanoic acid









WISWESSER LINE NOTATION : T56 BMJ D3VQ


Mutagen


* Butyric acid, 4-(indolyl)-

* Hormex rooting powder

* Hormodin

* IBA

* Indole butyric acid

* beta-Indolebutyric acid

* gamma-(Indole-3)-butyric acid

* 3-Indolebutyric acid

* 3-Indolyl-gamma-butyric acid

* gamma-(3-Indolyl)butyric acid

* gamma-(Indol-3-yl)butyric acid

* Indolyl-3-butyric acid

* 4-(Indol-3-yl)butyric acid

* 4-(3-Indolyl)butyric acid

* Jiffy grow

* Kyselina 4-indol-3-ylmaselina

* Rhizopon AA

* Seradix

* Seradix 2

* Seradix 3

* Seradix B 2

* Seradix B 3



TYPE OF TEST : LD - Lethal dose



DOSE/DURATION : >500 mg/kg

TOXIC EFFECTS :


REFERENCE :

NCNSA6 National Academy of Sciences, National Research Council,

Chemical-Biological Coordination Center, Review. (Washington, DC)






TOXIC EFFECTS :


REFERENCE :

85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA,

Thomson

Publications, 1976/77 revision Volume(issue)/page/year: 3,76,1976/1977





TOXIC EFFECTS :


REFERENCE :

85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,

eds., Nottingham, Royal Soc. of Chemistry, 1983-86


A231,1983

** MUTATION DATA **




REFERENCE :







REFERENCE :




TYPE OF TEST : Mutation test systems - not otherwise specified

TEST SYSTEM : Human Leukocyte

DOSE/DURATION : 100 nmol/L

REFERENCE :




EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of

Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:

54,7740,1989











INDOLEPROPIONIC ACID (3-)

RTECS NUMBER : NM1329000

CHEMICAL NAME : 1H-Indole-3-propionic acid










* Indolepropionic acid

* beta-Indolepropionic acid

* 3-(3-Indolyl)propanoic acid







TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema


REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-




INDOLEPYRUVIC ACID (3-)


CHEMICAL NAME : Indole-3-pyruvic acid








WISWESSER LINE NOTATION : T56 BMJ D1VVQ



* 1H-Indole-3-propanoic acid, alpha-oxo-

* Indole-3-pyruvate

* beta-Indolepyruvic acid

* 3-Indolylpyroracemic acid

* Indolyl-3-pyruvate

* beta-Indolylpyruvic acid

* 3-Indolylpyruvic acid


** MUTATION DATA **




REFERENCE :


V.1-60,



57,921,1976

INDOLYLACETIC ACID (3-)


CHEMICAL NAME : 1H-Indole-3-acetic acid








Tumorigen

Mutagen



* Indol-3-ylacetic acid

* Acetic acid, indolyl-

* Heteroauxin

* Hexteroauxin

* IAA

* 3-Iaa

* beta-Indoleacetic acid

* beta-Indole-3-acetic acid

* 3-Indoleacetic acid

* alpha-Indol-3-yl-acetic acid

* beta-Indolylacetic acid

* Indolyl-3-acetic acid

* 3-Indolylacetic acid

* Kyselina 3-indolyloctova

* Rhizopin

* Rhizopon A

* omega-Skatole carboxylic acid







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


Tumorigenic - tumor types after systemic administration not seen

spontaneously

REFERENCE :


V.1-20,


19,660,1963





DOSE : 4500 mg/kg


TOXIC EFFECTS :



REFERENCE :


(Alan






DOSE : 450 mg/kg


TOXIC EFFECTS :


REFERENCE :


(Alan






DOSE : 4500 mg/kg


TOXIC EFFECTS :





System

REFERENCE :


(Alan






DOSE : 4500 mg/kg


TOXIC EFFECTS :





REFERENCE :


(Alan



** MUTATION DATA **




REFERENCE :







REFERENCE :





TEST SYSTEM : Fish - salmon Sperm


REFERENCE :

PYTCAS Phytochemistry. An International Journal of Plant Biochemistry.

(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523)

V.1-





REFERENCE :




TEST SYSTEM : Human Lymphocyte


REFERENCE :



241,109,1990




REFERENCE :

PYTCAS Phytochemistry. An International Journal of Plant Biochemistry.

(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523)

V.1-













INDOMETHACIN


CHEMICAL NAME : Indole-3-acetic acid,

1-(p-chlorobenzoyl)-5-methoxy-2-methyl-






MOLECULAR FORMULA : C19-H16-Cl-N-O4


WISWESSER LINE NOTATION : T56 BNJ BVR CG& C1 D1VQ GO1


Drug

Mutagen


Human


* Amuno

* Artracin

* Artrinovo

* Artrivia

* N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid

* 1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure

* 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid

* (1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid

* 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid

* 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indole-acetic acid

* alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid

* 1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico

* Confortid

* Dolovin

* Idomethine

* Imbrilon

* Inacid

* Indacin

* Indocid

* Indomecol

* Indomed

* Indomee

* Indometacin

* Indometacine

* Indometacyna

* Indomethacin

* Indomethacine

* Indometicina

* Indoptic

* Indo-rectolmin

* Indo-tablinen

* Inflazon

* Infrocin

* Inteban SP

* Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy

* Lausit

* Metacen

* Metartril

* Methazine

* Metindol

* Mezolin

* Mikametan

* Mobilan

* NCI-C56144

* Reumacide

* Sadoreum

* Tannex







TOXIC EFFECTS :


REFERENCE :


POB






TOXIC EFFECTS :

Blood - aplastic anemia

REFERENCE :

IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,

Israel) V.1- 1965- Volume(issue)/page/year: 17,433,1981



SPECIES OBSERVED : Human - infant


TOXIC EFFECTS :

Gastrointestinal - necrotic changes

REFERENCE :



107,484,1985





TOXIC EFFECTS :



Kidney, Ureter, Bladder - urine volume decreased

REFERENCE :

SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,

Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year:

78,1390,1985




DOSE/DURATION : 22500 ug/kg/3W-I

TOXIC EFFECTS :

Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)


REFERENCE :




3,155,1967




DOSE/DURATION : 22500 ug/kg/3W-I

TOXIC EFFECTS :


REFERENCE :

APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696,

Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year:

29,883,1994



SPECIES OBSERVED : Human


TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :

Blood - hemorrhage

REFERENCE :



107,312,1985





TOXIC EFFECTS :

Behavioral - stiffness

Kidney, Ureter, Bladder - hematuria

REFERENCE :

ARHEAW Arthritis and Rheumatism. (Arthritis Foundation, 1314 Spring St.,

NW, Atlanta, GA 30309) V.1- 1958- Volume(issue)/page/year:

20,917,1977




DOSE/DURATION : 2586 mg/kg/3.5Y-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - retinal changes (pigmentary

depositions, retinitis, other)

REFERENCE :

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.

Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-





DOSE/DURATION : 3557 mg/kg/5Y-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - retinal changes (pigmentary

depositions, retinitis, other)

REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu

Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-






TOXIC EFFECTS :


REFERENCE :



38,127,1976





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and

Trademark Office, Foreign Patents, Washington, DC 20231)

Volume(issue)/page/year: #3005827





TOXIC EFFECTS :


REFERENCE :

AFTOD7 Archivos de Farmacologia y Toxicologia. (Universidad Complutense,

Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad

Universitaria, Madrid 3, Spain) V.1- 1975- Volume(issue)/page/year:

8,201,1982





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :

Behavioral - excitement

REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil,

France)






TOXIC EFFECTS :


REFERENCE :


Inc.,







TOXIC EFFECTS :


REFERENCE :

IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical

Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-







TOXIC EFFECTS :


Gastrointestinal - ulceration or bleeding from duodenum


REFERENCE :








TOXIC EFFECTS :

Lungs, Thorax, or Respiration - changes in lung weight

Endocrine - changes in spleen weight


REFERENCE :








TOXIC EFFECTS :


Biochemical - Metabolism (Intermediary) - other proteins


REFERENCE :








TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from small intestine



REFERENCE :







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



Related to Chronic Data - changes in ovarian weight

REFERENCE :








TOXIC EFFECTS :


REFERENCE :



52,454,1980





TOXIC EFFECTS :


Blood - changes in spleen


REFERENCE :








TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



Blood - changes in leukocyte (WBC) count

REFERENCE :







TOXIC EFFECTS :



Nutritional and Gross Metabolic - changes in chlorine

REFERENCE :









TOXIC EFFECTS :


Skin and Appendages - tumors

REFERENCE :








DOSE : 1500 ug/kg

SEX/DURATION : female 36 week(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - respiratory system

Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :



92,478,1978




DOSE : 1500 mg/kg


TOXIC EFFECTS :



REFERENCE :

NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10

Shattuck St., Boston, MA 02115) V.198- 1928-


319,327,1988




DOSE : 12 mg/kg

SEX/DURATION : female 33-34 week(s) after conception

TOXIC EFFECTS :


REFERENCE :






DOSE : 525 mg/kg


TOXIC EFFECTS :




REFERENCE :

AJMGDA American Journal of Medical Genetics. (John Wiley & Sons Ltd.,

605

Third Ave., New York, NY 10158) V.1- 1977- Volume(issue)/page/year:

39,252,1991




DOSE : 18 mg/kg


TOXIC EFFECTS :


REFERENCE :

AOGSAE Acta Obstetricia et Gynecologica Scandinavica. (Box 443, S-90109

Umeaa, Sweden) V.1- 1921- Volume(issue)/page/year: 61,183,1982




DOSE : 6 mg/kg


TOXIC EFFECTS :


REFERENCE :

JMFMEC Journal of Maternal - Fetal Medicine. (John Wiley & Sons, 605

Third

Ave., New York, NY 10158) V.1- 1992- Volume(issue)/page/year:

4,65,1995




DOSE : 4 mg/kg


TOXIC EFFECTS :


REFERENCE :

MIPEA5 Minerva Pediatrica. (Edizioni Minerva Medica, Casella Postale

491,

I-10126 Turin, Italy) V.1- 1949- Volume(issue)/page/year: 27,675,1975




DOSE : 2 mg/kg


TOXIC EFFECTS :



REFERENCE :

PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,

Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 24,644,1988




DOSE : 12 mg/kg


TOXIC EFFECTS :


REFERENCE :






DOSE : 14 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :






DOSE : 22 mg/kg


TOXIC EFFECTS :


System

Reproductive - Effects on Newborn - Apgar score (human only)

REFERENCE :

RFDEEH Reproduction, Fertility and Development. (Reproduction, Fertility

and Development, 314 Albert Street, East Melbourne, Victoria 3002

Australia)





DOSE : 12 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - blood and lymphatic

systems (including spleen and marrow)


system


REFERENCE :



113,738,1988




DOSE : 1 mg/kg


TOXIC EFFECTS :



REFERENCE :






DOSE : 300 ug/kg


TOXIC EFFECTS :



Reproductive - Effects on Newborn - live birth index (measured after

birth)

REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)





DOSE : 10 mg/kg


TOXIC EFFECTS :




REFERENCE :

PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,

Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 15,147,1981




DOSE : 12 mg/kg


TOXIC EFFECTS :



REFERENCE :


(PJD






DOSE : 20 mg/kg


TOXIC EFFECTS :




Reproductive - Specific Developmental Abnormalities - other developmental

abnormalities

REFERENCE :

IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK)

V.3-11,

1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year:

3,300,1975




DOSE : 2500 ug/kg


TOXIC EFFECTS :


REFERENCE :

PROMDL Prostaglandins and Medicine. (Edinburgh, Scotland, UK) V.1-7,

1978-81. For publisher information, see PLMEDD.


7,29,1981




DOSE : 28 mg/kg


TOXIC EFFECTS :

Reproductive - Fertility - male fertility index (e.g. # males impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-





DOSE : 4150 ug/kg


TOXIC EFFECTS :


REFERENCE :

PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA

94022)





DOSE : 5 mg/kg


TOXIC EFFECTS :



REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

16,286,1977




DOSE : 2500 ug/kg


TOXIC EFFECTS :


REFERENCE :


94022)





DOSE : 12 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina



REFERENCE :


Depot,






DOSE : 9 mg/kg


TOXIC EFFECTS :


REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E,

DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

78,343,1975




DOSE : 3 mg/kg


TOXIC EFFECTS :




REFERENCE :

ERJOEI European Respiratory Journal. (Munksgaard International

Publishers,

238 Main St., Cambridge, MA 02142) V.1- 1988-


8,209,1995




DOSE : 3 mg/kg


TOXIC EFFECTS :



REFERENCE :


(Alan


Volume(issue)/page/year: 30(1),20A,1984




DOSE : 500 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-



ROUTE OF EXPOSURE : Intravaginal


DOSE : 125 mg/kg


TOXIC EFFECTS :




before birth)


REFERENCE :

RDCNBM Reproduccion. (Madrid, Spain) V.1-7, 1974-83. Discontinued.





DOSE : 10 mg/kg


TOXIC EFFECTS :




System


REFERENCE :








DOSE : 10 mg/kg


TOXIC EFFECTS :




REFERENCE :








DOSE : 4 mg/kg


TOXIC EFFECTS :



REFERENCE :

JCGBDF Journal of Craniofacial Genetics and Developmental Biology. (Alan

R.

Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-





DOSE : 9 mg/kg


TOXIC EFFECTS :



REFERENCE :


94022)





DOSE : 40 mg/kg


TOXIC EFFECTS :





REFERENCE :

ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,

Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886- Volume(issue)/page/year:

136,349,1974




DOSE : 40 mg/kg


TOXIC EFFECTS :


REFERENCE :

ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,

Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886- Volume(issue)/page/year:

136,349,1974




DOSE : 8 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina


REFERENCE :


S,





DOSE : 8 mg/kg


TOXIC EFFECTS :


REFERENCE :


Depot,






DOSE : 496 mg/kg


TOXIC EFFECTS :



gain)


REFERENCE :


S,





DOSE : 747 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - extra-embryonic structures

(e.g., placenta, umbilical cord)

REFERENCE :

AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,

11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-





DOSE : 6 mg/kg


TOXIC EFFECTS :


REFERENCE :


V.1-





DOSE : 96 mg/kg


TOXIC EFFECTS :


REFERENCE :


W.


15,551,1976




DOSE : 10 mg/kg


TOXIC EFFECTS :



REFERENCE :


94022)





DOSE : 6 mg/kg


TOXIC EFFECTS :


REFERENCE :

JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,

c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,

Kyoto

606, Japan) V.1- 1951- Volume(issue)/page/year: 28,909,1978




DOSE : 1590 ug/kg


TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

REFERENCE :


W.


29,833,1983




DOSE : 48 mg/kg


TOXIC EFFECTS :


REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-





DOSE : 32 mg/kg


TOXIC EFFECTS :




before birth)

REFERENCE :


94022)





DOSE : 24 mg/kg


TOXIC EFFECTS :


Reproductive - Effects on Embryo or Fetus - extra-embryonic structures

(e.g., placenta, umbilical cord)



REFERENCE :


W.


18,148,1978




DOSE : 64 mg/kg


TOXIC EFFECTS :


before birth)

REFERENCE :


W.


18,148,1978




DOSE : 20 mg/kg


TOXIC EFFECTS :




REFERENCE :

CJPPA3 Canadian Journal of Physiology and Pharmacology. (National

Research

Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,

Canada) V.42- 1964- Volume(issue)/page/year: 58,212,1980




DOSE : 148 mg/kg


TOXIC EFFECTS :




before birth)

REFERENCE :


Depot,






DOSE : 20 mg/kg


TOXIC EFFECTS :


REFERENCE :


S,





DOSE : 20 mg/kg


TOXIC EFFECTS :


REFERENCE :


94022)





DOSE : 7500 ug/kg


TOXIC EFFECTS :


REFERENCE :


W.


19,552,1978




DOSE : 5500 ug/kg


TOXIC EFFECTS :



REFERENCE :


W.


14,451,1976




DOSE : 30 mg/kg


TOXIC EFFECTS :



REFERENCE :

JPEMAO Journal of Perinatal Medicine. (Walter de Gruyter, Inc., 200 Saw

Mill River Rd., Hawthorne, NY 10532) V.1- 1973-


6,240,1978




DOSE : 2500 ng/kg


TOXIC EFFECTS :


REFERENCE :

LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview

Park,

Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-


14,129,1974



SPECIES OBSERVED : Mammal - pig

DOSE : 160 mg/kg


TOXIC EFFECTS :


REFERENCE :


W.


32,105,1985




DOSE : 240 mg/kg


TOXIC EFFECTS :


REFERENCE :

BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd.,

Houndmills,



49,98,1973




DOSE : 66640 ug/kg


TOXIC EFFECTS :


REFERENCE :

BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd.,

Houndmills,



49,98,1973




DOSE : 144 mg/kg


TOXIC EFFECTS :


REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E,

DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

78,343,1975



SPECIES OBSERVED : Mammal - cattle

DOSE : 40 ug/kg


TOXIC EFFECTS :


REFERENCE :


Depot,






DOSE : 1 mg/kg


TOXIC EFFECTS :



REFERENCE :


(Alan



** MUTATION DATA **



DOSE/DURATION : 100 ug/disc

REFERENCE :

JNUDAT Journal of Nihon University School of Dentistry. (Nihon

University

School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101,

Japan)





REFERENCE :

BOAEBM Berichte der Oesterreichischen Studiengesellschaft fuer

Atomenergie.

(Vienna, Austria) SGAE 2001-SGAE 4032, 1972-80. Volume(issue)/page/year:

SGAE-2261,1974





REFERENCE :

REXMAS Research in Experimental Medicine. (Springer-Verlag, Heidelberger

Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.157- 1972-



TEST SYSTEM : Rodent - rat Cells - not otherwise specified


REFERENCE :

REXMAS Research in Experimental Medicine. (Springer-Verlag, Heidelberger

Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.157- 1972-


TYPE OF TEST : Dominant lethal test



DOSE/DURATION : 17 mg/kg/13W (Continuous)

REFERENCE :

BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia.

(V/O






REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,



24,219,1975

TYPE OF TEST : Micronucleus test



DOSE/DURATION : 72 mg/kg/24H

REFERENCE :



188,343,1987




DOSE/DURATION : 72 mg/kg/24H

REFERENCE :



188,343,1987




DOSE/DURATION : 44 umol/kg

REFERENCE :


(PJD




TEST SYSTEM : Rodent - mouse Cells - not otherwise specified


REFERENCE :

BOAEBM Berichte der Oesterreichischen Studiengesellschaft fuer

Atomenergie.

(Vienna, Austria) SGAE 2001-SGAE 4032, 1972-80. Volume(issue)/page/year:

SGAE-2261,1974





REFERENCE :



188,343,1987

TYPE OF TEST : Sperm Morphology




REFERENCE :



188,343,1987





REFERENCE :



188,343,1987

*** REVIEWS ***

TOXICOLOGY REVIEW

CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher

information, see JTCTDW. Volume(issue)/page/year: 17,85,1980

TOXICOLOGY REVIEW

REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,



9,7,1995












INOSINE


CHEMICAL NAME : Inosine






WISWESSER LINE NOTATION : T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q


Mutagen


* Atorel

* HXR

* Hypoxanthine nucleoside

* Hypoxanthine ribonucleoside

* Hypoxanthine riboside

* Hypoxanthine D-riboside

* Hypoxanthosine

* INO

* beta-Inosine

* Oxiamin

* Pantholic-L

* Ribonosine

* Selfer

* Trophicardyl







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :


Translation







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Endocrine - changes in thymus weight



REFERENCE :



** MUTATION DATA **




REFERENCE :

PNASA6 Proceedings of the National Academy of Sciences of the United

States

of America. (National Academy of Sciences, Printing & Pub. Office, 2101

Constitution Ave., Washington, DC 20418) V.1- 1915-













INOSITOL


CHEMICAL NAME : myo-Inositol








* Dambose

* Inosital

* Inositene

* Inositina

* Inositol

* Inositol, myo-

* i-Inositol

* iso-Inositol

* meso-Inositol

* Meat sugar

* Mesoinosit

* Mesoinosite

* Mesoinositol

* Mesol

* Mesovit

* MI

* Myoinosite

* Myoinositol

* Nucite

* Phaseomannite

* Phaseomannitol

* Scyllite







TOXIC EFFECTS :


REFERENCE :

JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark

Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year:

#92-9328





TOXIC EFFECTS :


REFERENCE :

JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark

Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year:

#92-9328





TOXIC EFFECTS :


REFERENCE :

TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,

101479,

Russia) History Unknown Volume(issue)/page/year: (2),25,1994



IODINE

RTECS NUMBER : NN1575000

CHEMICAL NAME : Iodine




MOLECULAR FORMULA : I2


WISWESSER LINE NOTATION : I2


Human


* IODE

* Iodine

* Iodine crystals

* Iodine sublimed

* Iodio

* Jod

* Jood







TOXIC EFFECTS :



REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,

Academic Press, Inc., 1969 Volume(issue)/page/year: -,330,1969




DOSE/DURATION : 26 mg/kg/1Y-I

TOXIC EFFECTS :

Endocrine - evidence of thyroid hyperfunction

REFERENCE :


POB






TOXIC EFFECTS :


REFERENCE :

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,

J.M.,

Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970





TOXIC EFFECTS :


REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,

08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:

4,876,1979

TYPE OF TEST : LCLo - Lowest published lethal concentration



DOSE/DURATION : 137 ppm/1H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation



REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :



4,876,1979





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."

(Leipzig,

Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935





TOXIC EFFECTS :


REFERENCE :

HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders

Co.,

1956-59 Volume(issue)/page/year: 5,76,1959





TOXIC EFFECTS :


REFERENCE :



4,876,1979





TOXIC EFFECTS :


REFERENCE :

HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders

Co.,







TOXIC EFFECTS :


REFERENCE :








DOSE : 1100 mg/kg


TOXIC EFFECTS :


4

per # born alive)

REFERENCE :

JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,

Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 84,107,1964




DOSE : 2750 mg/kg


TOXIC EFFECTS :


gain)

REFERENCE :






DOSE : 15 mg/kg


TOXIC EFFECTS :


4

per # born alive)


gain)

REFERENCE :



*** REVIEWS ***

ACGIH TLV-CL 1.0 mg/m3 (0.1 ppm)




TLV/BEI,1997

TOXICOLOGY REVIEW

FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher

information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942

TOXICOLOGY REVIEW

KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control.

(Kogai

Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka,

Minato-ku,

Tokyo 107, Japan) V.1- 1965- Volume(issue)/page/year: 11,1300,1975





54,7740,1989

MSHA STANDARD:air-CL 0.1 ppm (1 mg/m3)




3,135,1971

OSHA PEL (Gen Indu):CL 0.1 ppm (1 mg/m3)


Supt.


29,1910.1000,1994

OSHA PEL (Construc):CL 0.1 ppm (1 mg/m3)


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):CL 0.1 ppm (1 mg/m3)


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):CL 0.1 ppm (1 mg/m3)


Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 0.1 ppm (0.1 mg/m3) JAN 1993

OEL-AUSTRIA: MAK 0.1 ppm (1 mg/m3), JAN1999

OEL-AUSTRALIA:TWA 0.1 ppm (1 mg/m3) JAN 1993

OEL-BELGIUM:STEL 0.1 ppm (1 mg/m3) JAN 1993

OEL-DENMARK: TWA 0.1 ppm (1 mg/m3), JAN1999

OEL-FINLAND:STEL 0.1 ppm (1 mg/m3);Skin JAN 1993

OEL-JAPAN: OEL 0.1 ppm (1 mg/m3), JAN1999

OEL-GERMANY:TWA 0.1 ppm (1 mg/m3) JAN 1993

OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993

OEL-JAPAN:TWA 0.1 ppm (1 mg/m3);STEL 1 mg/m3 JAN 1993

OEL-POLAND: MAC(TWA) 1 mg/m3, JAN1999

OEL-THE NETHERLANDS:TWA 0.1 ppm (1 mg/m3) JAN 1993

OEL-THE PHILIPPINES:TWA 0.1 ppm (1 mg/m3) JAN 1993

OEL-RUSSIA:TWA 0.1 ppm;STEL 1 mg/m3;Skin JAN 1993

OEL-SWEDEN:STEL 0.1 ppm (1 mg/m3) JAN 1993

OEL-SWITZERLAND:TWA 0.1 ppm (1 mg/m3);STEL 0.2 ppm (2 mg/m3) JAN 1993

OEL-THAILAND:TWA 0.1 ppm (1 mg/m3) JAN 1993

OEL-TURKEY:TWA 0.1 ppm (1 mg/m3) JAN 1993

OEL-UNITED KINGDOM:STEL 0.1 ppm (1 mg/m3) JAN 1993





NIOSH REL TO IODINE-air:CL 0.1 ppm

REFERENCE :






















NIOSH Analytical Method, 1994: Iodine, 6005

OSHA ANALYTICAL METHOD #ID-177

IODINE MONOCHLORIDE

RTECS NUMBER : NN1650000

CHEMICAL NAME : Iodine chloride




MOLECULAR FORMULA : Cl-I


WISWESSER LINE NOTATION : I G


* Protochlorure d'iode

* Wijs' chloride







TOXIC EFFECTS :


REFERENCE :

KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)

Volume(issue)/page/year: 21MAY1971





TOXIC EFFECTS :


REFERENCE :






NOHS Hazard Code - A1150






NOES Hazard Code - A1150








IODOACETAMIDE

RTECS NUMBER : AC4200000

CHEMICAL NAME : Acetamide, 2-iodo-






MOLECULAR FORMULA : C2-H4-I-N-O


WISWESSER LINE NOTATION : ZV1I


Mutagen


* Iodoacetamide

* alpha-Iodoacetamide

* 2-Iodoacetamide

* Monoiodoacetamide

* Surauto

* USAF D-1







TOXIC EFFECTS :


REFERENCE :


D-1000


47,179,1981





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Systems


21010)







TOXIC EFFECTS :




REFERENCE :




7,482,1953

** MUTATION DATA **



DOSE/DURATION : 20 ppm

REFERENCE :



24,365,1974




REFERENCE :

STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin

DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year:

50,97,1975










EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast


IODOACETIC ACID


CHEMICAL NAME : Acetic acid, iodo-






MOLECULAR FORMULA : C2-H3-I-O2


WISWESSER LINE NOTATION : QV1I


Mutagen



* Iodoacetate

* Iodoacetic acid

* Kyselina jodoctova

* MIA

* Monoiodoacetate

* Monoiodoacetic acid






DOSE/DURATION : 94 gm/m3/30M

TOXIC EFFECTS :


REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation).

Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,

Surrey,

UK) V.30- 1967- Volume(issue)/page/year: 41,113,1978





TOXIC EFFECTS :


REFERENCE :



Surrey,






TOXIC EFFECTS :

Behavioral - fluid intake



REFERENCE :



26,93,1973





TOXIC EFFECTS :



Nutritional and Gross Metabolic - other changes

REFERENCE :


V.1-60,



31,297,1963





TOXIC EFFECTS :



REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

York, NY 10022) V.1- 1878- Volume(issue)/page/year: 80,360,1934






TOXIC EFFECTS :




REFERENCE :




7,482,1953





TOXIC EFFECTS :



REFERENCE :

GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)

V.1-75,

1907-84. For publisher information, see JJCREP.


45,601,1954





TOXIC EFFECTS :




REFERENCE :


V.1-20,


11,699,1955





DOSE : 40 mg/kg


TOXIC EFFECTS :


REFERENCE :

NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing

Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-





DOSE : 20 mg/kg


TOXIC EFFECTS :



REFERENCE :


(Alan



** MUTATION DATA **




REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)



TEST SYSTEM : Human HeLa cell


REFERENCE :

RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St.,

Duluth,

MN 55802) V.1- 1954- Volume(issue)/page/year: 37,334,1969


TEST SYSTEM : Rodent - mouse Ascites tumor


REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical

Assoc.,

2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-





REFERENCE :




*** REVIEWS ***

TOXICOLOGY REVIEW

CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000

Corporate

Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:

1(1),93,1971

TOXICOLOGY REVIEW


V.1-59,


11,13,1955





IODOANILINE (4-)

RTECS NUMBER : BY3850000

CHEMICAL NAME : Aniline, p-iodo-




MOLECULAR FORMULA : C6-H6-I-N


WISWESSER LINE NOTATION : ZR DI



* p-Aminophenyl iodide

* Aniline, 4-iodo-

* Benzenamine, 4-iodo-

* p-Iodoaniline

* 4-Iodoaniline

* 4-Iodobenzenamine







TOXIC EFFECTS :


REFERENCE :

CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. (PNS-Ustredni

Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1-






TOXIC EFFECTS :


REFERENCE :

BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)

V.1-33, 1946-68. For publisher information, see BJPCBM.




SPECIES OBSERVED : Bird - wild bird species


TOXIC EFFECTS :


REFERENCE :



21,315,1972


EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse


IODOBENZENE

RTECS NUMBER : DA3390000

CHEMICAL NAME : Benzene, iodo-




MOLECULAR FORMULA : C6-H5-I


WISWESSER LINE NOTATION : IR


* Benzene iodide

* Iodinebenzol

* Iodobenzene

* Phenyl iodide







TOXIC EFFECTS :


REFERENCE :








DOSE/DURATION : 16320 mg/m3

TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :







IODOBENZOIC ACID (4-)

RTECS NUMBER : DH2976000

CHEMICAL NAME : Benzoic acid, p-iodo-










* Benzoic acid, 4-iodo-

* p-Iodobenzenecarboxylic acid

* p-Iodobenzoic acid

* 4-Iodobenzoic acid

* 4-Jodbenzoesaeure







TOXIC EFFECTS :


REFERENCE :



12,415,1957



IODOBENZOIC ACID (ORTHO-)


CHEMICAL NAME : Benzoic acid, o-iodo-








WISWESSER LINE NOTATION : QVR BI


* Benzoic acid, 2-iodo-

* o-Iodobenzoic acid

* 2-Iodobenzoic acid

* Kyselina o-jodbenzoova

* USAF EK-572







TOXIC EFFECTS :


REFERENCE :



12,415,1957





TOXIC EFFECTS :


REFERENCE :






IODOBENZYL ALCOHOL (4-)

RTECS NUMBER : DO8318020

CHEMICAL NAME : Benzyl alcohol, p-iodo-






MOLECULAR FORMULA : C7-H7-I-O


WISWESSER LINE NOTATION : Q1R DI


* Benzenemethanol, 4-iodo-

* p-Iodobenzyl alcohol

* 4-Iodobenzyl alcohol







TOXIC EFFECTS :


REFERENCE :


Assoc.,



IODOBUTANE (1-)

RTECS NUMBER : EK4400000

CHEMICAL NAME : Butane, 1-iodo-








Mutagen


* Butyl iodide

* n-Butyl iodide

* 1-Iodobutane

* 1-Jodbutan






DOSE/DURATION : 6100 mg/m3/4H

TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under

Single

Exposure," Izmerov, N.F., et al., Moscow, Centre of International

Projects,

GKNT, 1982 Volume(issue)/page/year: -,30,1982





TOXIC EFFECTS :


REFERENCE :


Single


Projects,







TOXIC EFFECTS :



REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

35,1411,1975











EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9




IODOETHANE

RTECS NUMBER : KI4750000

CHEMICAL NAME : Ethane, iodo-









* Ethyl iodide

* Ethyljodid

* Hydriodic ether

* Iodoethane

* Jodethan

* Monoiodoethane







TOXIC EFFECTS :


REFERENCE :

FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active

Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-






TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia

(usually neuromuscular blockage)

Lungs, Thorax, or Respiration - respiratory stimulation


REFERENCE :

JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,

c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,

Kyoto

606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954





TOXIC EFFECTS :


REFERENCE :

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,

Clayton,

G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.

Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.

Volume(issue)/page/year: 2B,3487,1981





TOXIC EFFECTS :


REFERENCE :


Single


Projects,


** MUTATION DATA **




REFERENCE :


D-1000


46,277,1980




REFERENCE :


D-1000


46,277,1980



















IODOETHANOL (2-)

RTECS NUMBER : KL3820000

CHEMICAL NAME : Ethanol, 2-iodo-








WISWESSER LINE NOTATION : Q2I



* Ethylene iodohydrin

* Iodoethanol

* 2-Iodoethanol







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :








TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :








TOXIC EFFECTS :

Blood - hemorrhage


REFERENCE :




** MUTATION DATA **



DOSE/DURATION : 2 umol/plate

REFERENCE :



26,367,1974



DOSE/DURATION : 1 umol/plate

REFERENCE :



26,367,1974


TEST SYSTEM : Bacteria - Klebsiella pneumoniae


REFERENCE :




EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine

reversion-Ames test




IODOFORM

RTECS NUMBER : PB7000000

CHEMICAL NAME : Methane, triiodo-




MOLECULAR FORMULA : C-H-I3


WISWESSER LINE NOTATION : IYII


Drug

Mutagen


* Carbon triiodide

* Dezinfekt V

* Iodoform

* Jodoform

* NCI-C04568

* Triiodomethane

* Trijodmethane







TOXIC EFFECTS :




REFERENCE :

ZDTUAB Zdravookhranenie Turkmenistana. Public Health of Turkmenistan.

(V/O







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :


(V/O







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Behavioral - antipsychotic

Vascular - other changes


REFERENCE :



4,354,1962





TOXIC EFFECTS :

Behavioral - tremor



REFERENCE :

ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,

Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.






TOXIC EFFECTS :




REFERENCE :


(V/O







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :


(V/O





SPECIES OBSERVED : Amphibian - frog


TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :


(Leipzig,







TOXIC EFFECTS :


Blood - changes in erythrocyte (RBC) count


levels - multiple enzyme effects

REFERENCE :








TOXIC EFFECTS :


REFERENCE :


(V/O



** MUTATION DATA **




REFERENCE :


publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl

1),3,1983


TEST SYSTEM : Rodent - hamster Embryo


REFERENCE :

SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20

Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-


TYPE OF TEST : Unscheduled DNA synthesis



REFERENCE :







REFERENCE :




*** REVIEWS ***

ACGIH TLV-TWA 10 mg/m3 (0.6 ppm)




TLV/BEI,1997


OEL-AUSTRALIA:TWA 0.6 ppm (10 mg/m3) JAN 1993

OEL-BELGIUM:TWA 0.6 ppm (10 mg/m3) JAN 1993

OEL-DENMARK: TWA 0.2 ppm (3 mg/m3), JAN1999

OEL-FINLAND:TWA 0.2 ppm (3 mg/m3);STEL 0.6 ppm (10 mg/m3);Skin JAN 1993

OEL-THE NETHERLANDS:TWA 0.2 ppm (3 mg/m3) JAN 1993

OEL-SWITZERLAND:TWA 0.6 ppm (10 mg/m3) JAN 1993

OEL-UNITED KINGDOM:TWA 0.6 ppm (10 mg/m3);STEL 1 ppm (20 mg/m3) JAN 1993





NIOSH REL TO IODOFORM-air:10H TWA 0.6 ppm

REFERENCE :




















NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,rat

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-110,1978

IODOMETHANE

RTECS NUMBER : PA9450000

CHEMICAL NAME : Methane, iodo-




MOLECULAR FORMULA : C-H3-I




Mutagen

Primary Irritant


* Halon 10001

* Iodometano

* Iodomethane

* Iodure de methyle

* Jod-methan

* Joodmethaan

* Methyl iodide

* Methyljodid

* Methyljodide

* Metylu jodek

* Monoioduro di metile







DOSE/DURATION : 1 gm/10M


REFERENCE :

BJIMAG British Journal of Industrial Medicine. (British Medical Journal,

Box 560B, Kennebunkport, ME 04046) V.1- 1944-


7,122,1950




DOSE/DURATION : 1 gm/30M


REFERENCE :




7,122,1950






REFERENCE :









REFERENCE :









TOXIC EFFECTS :


REFERENCE :

BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,

Commerce

Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-


98,38,1966





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :

ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)

V.1-75,

1903-71. For publisher information, see JCROD7.


74,241,1970




DOSE/DURATION : 5 gm/m3/57M-C

TOXIC EFFECTS :


REFERENCE :




7,122,1950





TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :



4,354,1962





TOXIC EFFECTS :


REFERENCE :


Clayton,



Volume(issue)/page/year: 2B,3447,1981





TOXIC EFFECTS :



Blood - hemorrhage

REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :


Single


Projects,







TOXIC EFFECTS :


Gastrointestinal - colon tumors


REFERENCE :

ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)

V.1-75,

1903-71. For publisher information, see JCROD7.


74,241,1970





TOXIC EFFECTS :



REFERENCE :



35,1411,1975

** MUTATION DATA **



DOSE/DURATION : 2 uL/plate

REFERENCE :







REFERENCE :


D-1000


46,277,1980



DOSE/DURATION : 10 ug/disc

REFERENCE :







REFERENCE :


D-1000


46,277,1980




REFERENCE :






DOSE/DURATION : 50 mg/L/4H

REFERENCE :



59,61,1979

TYPE OF TEST : Mutation in mammalian somatic cells



REFERENCE :


publisher information, see EMMUEG. Volume(issue)/page/year: 7,523,1985




REFERENCE :

IJCNAW International Journal of Cancer. (International Union Against

Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1-

1966-





REFERENCE :



136,137,1984

*** REVIEWS ***

ACGIH TLV-TWA 12 mg/m3 (2 ppm) (skin)




TLV/BEI,1997

IARC Cancer Review:Animal Limited Evidence


Chemicals


12210)


IARC Cancer Review:Human No Adequate Data


Chemicals


12210)


IARC Cancer Review:Group 3




7,56,1987


MSHA STANDARD-air:TWA 5 ppm (28 mg/m3) (skin)




3,166,1971

OSHA PEL (Gen Indu):8H TWA 5 ppm (28 mg/m3) (skin)


Supt.


29,1910.1000,1994

OSHA PEL (Construc):8H TWA 5 ppm (28 mg/m3) (skin)


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 5 ppm (28 mg/m3) (skin)


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 5 ppm (28 mg/m3) (skin)


Supt.


41,50-204.50,1994


OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3);Skin;Carcinogen JAN 1993

OEL-AUSTRIA: Skin, Carcinogen, JAN1999

OEL-BELGIUM:TWA 2 ppm (12 mg/m3);Skin;Carcinogen JAN 1993

OEL-DENMARK: TWA 1 ppm (5.6 mg/m3), Skin, JAN1999

OEL-FINLAND:TWA 5 ppm (28 mg/m3);STEL 10 ppm (56 mg/m3);Skin JAN 1993

OEL-GERMANY;Carcinogen JAN 1993

OEL-THE NETHERLANDS:TWA 2 ppm (10 mg/m3);Skin JAN 1993

OEL-THE PHILIPPINES:TWA 5 ppm (28 mg/m3);Skin JAN 1993

OEL-POLAND: MAC(TWA) 10 mg/m3, MAC(STEL) 30 mg/m3, JAN1999

OEL-SWEDEN:TWA 1 ppm (6 mg/m3);STEL 5 ppm (30 mg/m3);Skin;Carcinogen JAN

1993

OEL-SWEDEN: NGV 1 ppm (6 mg/m3), KTV 5 ppm (30 mg/m3), Skin, Carginogen,

JAN1999

OEL-SWITZERLAND:TWA 2 ppm (12 mg/m3);Skin JAN 1993

OEL-UNITED KINGDOM:TWA 5 ppm (28 mg/m3);STEL 10 ppm;Skin JAN 1993





NIOSH REL TO METHYL IODIDE-air:10H CA TWA 2 ppm (Sk) (1.7 ppm LOQ)

REFERENCE :






NOHS Hazard Code - M0422






NOES Hazard Code - M0422







EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal

assay

EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; E coli

polA without S9

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis





NIOSH CURRENT INTELLIGENCE BULLETIN 43, 1984

NIOSH Analytical Method, 1994: Methyl iodide, 1014

NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be

Human Carcinogen

IODOMETHYLPROPANE (1,2-)

RTECS NUMBER : TZ4250000

CHEMICAL NAME : Propane, 1-iodo-2-methyl-








WISWESSER LINE NOTATION : I1Y1&1



* 1-Iodo-2-methylpropane

* Isobutyl iodide

* Isobutyljodid

* 1-Jod-2-methylpropan

* 2-Methylpropyl iodide

* Primary isobutyl iodide







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :




EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9


IODOOCTANE (1-)

RTECS NUMBER : RG9700100

CHEMICAL NAME : Octane, 1-iodo-










* 1-Iodooctane

* 1-Jodoktan

* Octyl iodide

* n-Octyl iodide

* 1-Octyl iodide

* 1-n-Octyl iodide







TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :


Single


Projects,




IODOPHENOL (2-)

RTECS NUMBER : SL5500000

CHEMICAL NAME : Phenol, o-iodo-








WISWESSER LINE NOTATION : QR BI


* o-Iodophenol

* 2-Iodophenol

* o-Jodfenol

* 2-Jodfenol







TOXIC EFFECTS :



Behavioral - muscle weakness

REFERENCE :

RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La

Suisse

Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-




IODOPHENOL (3-)


CHEMICAL NAME : Phenol, m-iodo-










* m-Hydroxyiodobenzene

* m-Iodophenol

* 3-Iodophenol

* 3-Jodphenol

* Phenol, 3-iodo-







TOXIC EFFECTS :


REFERENCE :



18,642,1963



IODOPHENOL (4-)


CHEMICAL NAME : Phenol, p-iodo-






WISWESSER LINE NOTATION : QR DI



* p-Hydroxyiodobenzene

* 4-Hydroxyiodobenzene

* 4-Hydroxyphenyl iodide

* p-Iodophenol

* 4-Iodophenol

* Phenol, 4-iodo-







TOXIC EFFECTS :


REFERENCE :


Assoc.,








TOXIC EFFECTS :



REFERENCE :



19,413,1959



IODOPROPANE (1-)


CHEMICAL NAME : Propane, 1-iodo-









* 1-Iodopropane

* 1-Jodpropan

* Propyl iodide

* n-Propyl iodide







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :


Single


Projects,







TOXIC EFFECTS :



REFERENCE :



35,1411,1975



IODOPROPANE (2-)


CHEMICAL NAME : Propane, 2-iodo-






WISWESSER LINE NOTATION : IY1&1



* 2-Iodopropane

* Isopropyl iodide

* 2-Jodpropan

* sec-Propyl iodide

* 2-Propyl iodide







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :



REFERENCE :



35,1411,1975












IODOPROPIONIC ACID (3-)

RTECS NUMBER : UF4900000

CHEMICAL NAME : Propionic acid, 3-iodo-








WISWESSER LINE NOTATION : QV2I


Mutagen


* 3-Iodopropanoic acid

* beta-Iodopropionic acid

* 3-Iodopropionic acid

* Propanoic acid, 3-iodo-







TOXIC EFFECTS :


REFERENCE :



28,653,1968






TOXIC EFFECTS :



REFERENCE :



28,653,1968

** MUTATION DATA **




REFERENCE :

DHEFDK HEW Publication (FDA. United States). (Washington, DC)

?-1979(?).

For publisher information, see HPFSDS. Volume(issue)/page/year:

FDA-78-1046,1978



IODOSOBENZOIC ACID (2-)


CHEMICAL NAME : Benzoic acid, o-iodoso-










* Benzoic acid, 2-iodosyl-

* o-Iodosobenzoic acid

* 2-Iodosobenzoic acid

* o-Iodosylbenzoic acid

* 2-Iodosylbenzoic acid







TOXIC EFFECTS :




REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE


45,289,1989

IODOSUCCINIMIDE

RTECS NUMBER : WN2817000

CHEMICAL NAME : Succinimide, N-iodo-






MOLECULAR FORMULA : C4-H4-I-N-O2


WISWESSER LINE NOTATION : T5VNVTJ BI


* N-Iodosuccinimide

* 2,5-Pyrrolidinedione, 1-iodo-

* Succiniodimide







TOXIC EFFECTS :


REFERENCE :


Systems


21010)


IRON (III) CHLORIDE TETRAHYDRATE

RTECS NUMBER : NO5600000

CHEMICAL NAME : Iron(2+) chloride, tetrahydrate




MOLECULAR FORMULA : Cl2-Fe.4H2-O


WISWESSER LINE NOTATION : FE G2


* Ferrous chloride, tetrahydrate

* Iron chloride tetrahydrate

* Iron (II) chloride, tetrahydrate

* Iron dichloride tetrahydrate







TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und

Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher

information, see NSAPCC. Volume(issue)/page/year: 244,17,1962





TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.



MSHA STANDARD-air:TWA 1 mg(Fe)/m3




3,138,1971


OEL-FINLAND:TWA 1 mg(Fe)/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JAN 1993

OEL-SWITZERLAND:TWA 1 mg(Fe)/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JAN 1993










IRON(II) ACETATE


CHEMICAL NAME : Acetic acid, iron(2+) salt




MOLECULAR FORMULA : C4-H6-O4.Fe


WISWESSER LINE NOTATION : OV1 2 &-FE-


* Ferrous acetate

* Iron(2+) acetate

* Iron (II) acetate

* Iron diacetate






3,138,1971









NOES Hazard Code - E0218








IRON(II) SULFATE

RTECS NUMBER : NO8510000

CHEMICAL NAME : Iron(II) sulfate (1:1), heptahydrate




MOLECULAR FORMULA : O4-S.Fe.7H2-O


WISWESSER LINE NOTATION : .FE..S-O4 .QH7


Mutagen


* Ferrous sulfate heptahydrate

* Fesofor

* Fesotyme

* Green vitrol

* Haemofort

* Ironate

* Iron protosulfate

* Iron sulfate heptahydrate

* Irosul

* Mol-iron

* Presfersul







TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :

AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove

Rd., Thorofare, NJ 08086) New series: V.1- 1841-


230,491,1955





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :



Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove

Rd., Thorofare, NJ 08086) New series: V.1- 1841-


230,491,1955





TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.


** MUTATION DATA **




REFERENCE :

CIWYAO Year Book--Carnegie Instition of Washington. (Carnegie

Institution

of Washington, 1530 P St., NW, Washington, DC 20005) V.1- 1902-



TEST SYSTEM : Rodent - mouse Cells - not otherwise specified


REFERENCE :



244,337,1990

*** REVIEWS ***

TOXICOLOGY REVIEW

CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher

information, see JTCTDW. Volume(issue)/page/year: 4,615,1971





54,7740,1989





3,138,1971















ISATIN


CHEMICAL NAME : Indole-2,3-dione









WISWESSER LINE NOTATION : T56 BMVVJ




* o-Aminobenzoylformic anhydride

* 2,3-Diketoindoline

* 2,3-Dioxoindoline

* 2,3-Indolinedione

* Isatic acid lactam

* Isatin

* Isatinic acid anhydride

* 2,3-Ketoindoline

* Pseudoisatin

* Tribulin







TOXIC EFFECTS :




REFERENCE :

IJPPAZ Indian Journal of Physiology and Pharmacology. (All India

Institute

of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110

029,

India) V.1- 1957- Volume(issue)/page/year: 6,145,1962





TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :

IJPPAZ Indian Journal of Physiology and Pharmacology. (All India

Institute

of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110

029,

India) V.1- 1957- Volume(issue)/page/year: 6,145,1962





TOXIC EFFECTS :


REFERENCE :



Surrey,






TOXIC EFFECTS :


REFERENCE :

NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.

(Nippon

Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,

Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-


55,1514,1959






TOXIC EFFECTS :

Blood - pigmented or nucleated red blood cells


Blood - changes in erythrocyte (RBC) count

REFERENCE :









DOSE : 200 mg/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - other effects on male

REFERENCE :

IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical

Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-













ISATOIC ANHYDRIDE

RTECS NUMBER : DM3100000

CHEMICAL NAME : 2H-3,1-Benzoxazine-2,4(1H)-dione








WISWESSER LINE NOTATION : T66 BMVOVJ



* Isatoic acid anhydride

* Isatoic anhydride






DOSE : 34800 mg/kg


female 21 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant

per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland)

V.12-17, 1965-67. For publisher information, see PHMGBN.




ISOAMYL ACETATE

RTECS NUMBER : NS9800000

CHEMICAL NAME : Isopentyl alcohol, acetate








WISWESSER LINE NOTATION : 1Y1&2OV1


* Acetic acid, isopentyl ester

* Banana oil

* Isoamyl acetate

* Isoamylester kyseliny octove

* Isoamyl ethanoate

* Isopentyl acetate

* 3-Methyl-1-butanol acetate

* 3-Methylbutyl acetate

* 3-Methyl-1-butyl acetate

* 3-Methylbutyl ethanoate

* Pear oil







TOXIC EFFECTS :


REFERENCE :

YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,

Tokyo,

Japan) V.1- 1950- Volume(issue)/page/year: 32,1241,1981





TOXIC EFFECTS :



Kidney, Ureter, Bladder - proteinuria

REFERENCE :

AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)

V.1-18, 1930-61. For publisher information, see IAEHDW.






TOXIC EFFECTS :


REFERENCE :

IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,

1949-73.

For publisher information, see IOHSA5. Volume(issue)/page/year:

41,31,1972





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory

change


REFERENCE :

AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)

V.1-18, 1930-61. For publisher information, see IAEHDW.


*** REVIEWS ***





TLV/BEI,1997






3,138,1971

OSHA PEL (Gen Indu):8H TWA 100 ppm (525 mg/m3)


Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 100 ppm (525 mg/m3)


Supt.


41,50-204.50,1994





OEL-JAPAN:TWA 100 ppm (530 mg/m3) JAN 1993


OEL-JAPAN: OEL 100 ppm (530 mg/m3), JAN1999

OEL-THE PHILIPPINES:TWA 100 ppm (525 mg/m3) JAN 1993

OEL-RUSSIA:TWA 100 ppm JAN 1993

OEL-UNITED KINGDOM:TWA 100 ppm (525 mg/m3);STEL 125 ppm JAN 1993





NIOSH REL TO ISOAMYL ACETATE-air:10H TWA 100 ppm

REFERENCE :





















NIOSH Analytical Method, 1994: Esters I, 1450

ISOAMYL NITRITE

RTECS NUMBER : NT0187500

CHEMICAL NAME : Isopentyl alcohol, nitrite








WISWESSER LINE NOTATION : ONO2Y



* Amyl nitrite

* Aspiral

* Isoamyl nitrite

* Isopentyl nitrite

* 3-Methylbutanol nitrite

* 3-Methylbutyl nitrite

* Nitramyl

* Nitrous acid, 3-methylbutyl ester

* Vaporole







TOXIC EFFECTS :


REFERENCE :

FEPRA7 Federation Proceedings, Federation of American Societies for

Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.






TOXIC EFFECTS :



Lungs, Thorax, or Respiration - cyanosis

REFERENCE :







DOSE/DURATION : 1430 ppm/30M

TOXIC EFFECTS :


REFERENCE :

NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)

V.3-8,

1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:

8,139,1986





TOXIC EFFECTS :


REFERENCE :


(PJD







TOXIC EFFECTS :


REFERENCE :


(PJD







TOXIC EFFECTS :


REFERENCE :


(PJD



** MUTATION DATA **




REFERENCE :


publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl

7),1,1986




REFERENCE :


E.


14,115,1989




REFERENCE :


E.


10(Suppl 10),1,1987




REFERENCE :


E.


10(Suppl 10),1,1987











ISOASCORBIC ACID (D-)

RTECS NUMBER : KF3015000

CHEMICAL NAME : D-erythro-Hex-2-enonic acid, gamma-lactone










* Araboascorbic acid

* D-Araboascorbic acid

* Erycorbin

* Erythorbic acid

* D-Erythorbic acid

* Glucosaccharonic acid

* Isoascorbic acid

* D-Isoascorbic acid

* Isovitamin C

* Mercate 5

* Neo-cebicure

* Saccharosonic acid


** MUTATION DATA **




REFERENCE :


House,



22,623,1984




REFERENCE :

JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center

for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)

V.19-





















ISOBUTANOL

RTECS NUMBER : NP9625000

CHEMICAL NAME : Isobutyl alcohol






MOLECULAR FORMULA : C4-H10-O


WISWESSER LINE NOTATION : Q1Y1&1


Mutagen


* Alcool isobutylique

* Fermentation butyl alcohol

* 1-Hydroxymethylpropane

* Isobutyl alcohol

* Isobutylalkohol

* Isopropylcarbinol

* 2-Methyl propanol

* 2-Methyl-1-propanol

* 2-Methylpropan-1-ol

* 2-Methylpropyl alcohol

* 1-Propanol, 2-methyl-








TOXIC EFFECTS :


REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.

(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


(PJD







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :

JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,

11830

Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-






TOXIC EFFECTS :


REFERENCE :

NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.

(National

Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair

Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








DOSE/DURATION : 93 gm/kg/13W-I

TOXIC EFFECTS :


Nutritional and Gross Metabolic - changes in potassium


REFERENCE :









TOXIC EFFECTS :



Blood - leukemia

REFERENCE :

ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit

Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-






TOXIC EFFECTS :


Gastrointestinal - tumors

Liver - tumors

REFERENCE :

ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit

Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-


** MUTATION DATA **




REFERENCE :

ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)

V.1-41,

1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:

23,843,1969

*** REVIEWS ***





TLV/BEI,1997






3,140,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994



OEL-AUSTRIA: MAK 50 ppm (150 mg/m3), JAN1999

OEL-AUSTRIA:TWA 100 ppm (300 mg/m3) JAN 1993


OEL-DENMARK: TWA 50 ppm (150 mg/m3), Skin, JAN1999

OEL-GERMANY:TWA 100 ppm (300 mg/m3) JAN 1993

OEL-JAPAN: OEL 50 ppm (150 mg/m3), JAN1999

OEL-JAPAN:TWA 50 ppm (150 mg/m3) JAN 1993




OEL-RUSSIA:TWA 50 ppm;STEL 10 mg/m3;Skin JAN 1993

OEL-SWITZERLAND:TWA 50 ppm (150 mg/m3);STEL 100 ppm (300 mg/m3) JAN 1993






NIOSH REL TO ISOBUTYL ALCOHOL-air:10H TWA 50 ppm

REFERENCE :























NIOSH Analytical Method, 1994: Alcohols II, 1401

ISOBUTYL ACETATE


CHEMICAL NAME : Acetic acid, isobutyl ester








WISWESSER LINE NOTATION : 1Y1&1OV1



* Acetate d'isobutyle

* Acetic acid, 2-methylpropyl ester

* Isobutyl acetate

* Isobutylester kyseliny octove

* 2-Methylpropyl acetate

* 2-Methyl-1-propyl acetate

* beta-Methylpropyl ethanoate








REFERENCE :








REFERENCE :


For







REFERENCE :


For







TOXIC EFFECTS :


REFERENCE :


(National








TOXIC EFFECTS :


REFERENCE :



23,95,1962





TOXIC EFFECTS :


REFERENCE :


1949-73.


41,31,1972





TOXIC EFFECTS :


REFERENCE :


(National




*** REVIEWS ***





TLV/BEI,1997






3,139,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994


OEL-AUSTRALIA:TWA 150 ppm (700 mg/m3);STEL 187 ppm (875 mg/m3) JAN 1993


OEL-BELGIUM:TWA 150 ppm (713 mg/m3);STEL 187 ppm (888 mg/m3) JAN 1993





OEL-SWITZERLAND:TWA 150 ppm (700 mg/m3);STEL 300 ppm JAN 1993






NIOSH REL TO ISOBUTYL ACETATE-air:10H TWA 150 ppm

REFERENCE :






















NIOSH Analytical Method, 1994: Esters I, 1450

ISOBUTYL METHYLXANTHINE (3:1-)

RTECS NUMBER : ZD8500000

CHEMICAL NAME : Xanthine, 3-isobutyl-1-methyl-






WISWESSER LINE NOTATION : T56 BM DN FNVNVJ F1Y1&1 H1



* IBMX

* 3-Isobutyl-1-methylxanthine

* 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-







TOXIC EFFECTS :


REFERENCE :

EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.

(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)


** MUTATION DATA **




REFERENCE :

BIOJAU Biophysical Journal. (Rockefeller Univ. Press, 1230 York Ave.,

New





REFERENCE :

BIOJAU Biophysical Journal. (Rockefeller Univ. Press, 1230 York Ave.,

New





REFERENCE :

ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)

V.1-41,

1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:

41,1171,1982


TEST SYSTEM : Rodent - mouse Embryo


REFERENCE :


(Alan







REFERENCE :


(PJD












ISOBUTYLAMINE

RTECS NUMBER : NP9900000

CHEMICAL NAME : Isobutylamine






WISWESSER LINE NOTATION : Z1Y1&1


* 1-Amino-2-methylpropane

* Monoisobutylamine

* NSC 8028

* 1-Propanamine, 2-methyl-

* Valamine







TOXIC EFFECTS :


Behavioral - ataxia

Behavioral - antipsychotic

REFERENCE :



63,150,1982


OEL-AUSTRIA: MAK 5 ppm (15 mg/m3), Skin, JAN1999

OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993


OEL-DENMARK: TWA 5 ppm (15 mg/m3), Skin, JAN1999



ISOBUTYLENE OXIDE


CHEMICAL NAME : Propane, 1,2-epoxy-2-methyl-








WISWESSER LINE NOTATION : T3OTJ B1 B1



* 1,1-Dimethylethylene oxide

* 2,2-Dimethyloxirane

* 1,2-Epoxyisobutane

* Isobutene oxide

* Isobutylene epoxide

* Isobutyleneoxide

* 1,2-Isobutylene oxide

* 2-Methyl-1,2-epoxypropane

* Oxirane, 2,2-dimethyl-


** MUTATION DATA **




REFERENCE :



271,213,1992


TEST SYSTEM : Bacteria - Klebsiella pneumoniae


REFERENCE :



89,269,1981





ISOBUTYRALDEHYDE

RTECS NUMBER : NQ4025000

CHEMICAL NAME : Isobutyraldehyde






WISWESSER LINE NOTATION : VHY1&1


Primary Irritant


* Isobutaldehyde

* Isobutanal

* Isobutyral

* Isobutyraldehyd

* Isobutyric aldehyde

* Isobutyryl aldehyde

* Isopropyl aldehyde

* Isopropyl formaldehyde

* Methyl propanal

* 2-Methylpropanal

* 2-Methyl-1-propanal

* alpha-Methylpropionaldehyde

* 2-Methylpropionaldehyde

* NCI-C60968

* Propanal, 2-methyl-

* Propionaldehyde, 2-methyl-

* Valine aldehyde








REFERENCE :








TOXIC EFFECTS :



Blood - hemorrhage

REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :



Lungs, Thorax, or Respiration - pleural thickening

REFERENCE :








TOXIC EFFECTS :


REFERENCE :








DOSE/DURATION : 500 ppm/6H/2Y-I

TOXIC EFFECTS :


specified

REFERENCE :

TOSCF2 Toxicological Sciences. (Academic Press, 6277 Sea Harbor Dr.,

Orlando, FL 32887) V.41- 1998- Volume(issue)/page/year: 42,136,1998




DOSE/DURATION : 4000 ppm/6H/13W-I

TOXIC EFFECTS :


specified



REFERENCE :






DOSE/DURATION : 1000 ppm/6H/2Y-I

TOXIC EFFECTS :


specified


REFERENCE :







TOXIC EFFECTS :


specified



REFERENCE :




OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993

OEL-POLAND: MAC(TWA) 100 mg.m3, JAN1999




















NIOSH Analytical Method, 1994: Aldehydes, screening, 2539

NTP Carcinogenesis Studies (inhalation):no evidence:mouse,rat



NTP-TR-472,1998

ISOBUTYRIC ACID

RTECS NUMBER : NQ4375000

CHEMICAL NAME : Isobutyric acid








WISWESSER LINE NOTATION : QVY1&1



* Acetic acid, dimethyl-

* Dimethylacetic acid

* Isopropylformic acid

* Kyselina isomaselna

* alpha-Methylpropionic acid

* 2-Methylpropanoic acid

* 2-Methylpropionic acid

* Propionic acid, 2-methyl-






DOSE/DURATION : 139 ug/24H

REFERENCE :



23,95,1962






TOXIC EFFECTS :


REFERENCE :



23,95,1962





TOXIC EFFECTS :


REFERENCE :



23,95,1962

*** REVIEWS ***

TOXICOLOGY REVIEW

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,

1955-60.

For publisher information, see AEHLAU. Volume(issue)/page/year:

21,100,1960













ISOBUTYRONITRILE


CHEMICAL NAME : Propanenitrile, 2-methyl-








WISWESSER LINE NOTATION : NCY1&1



* 2-Cyanopropane

* Dimethylacetonitrile

* Isopropyl cyanide

* Isopropylkyanid

* Isopropyl nitrile

* alpha-Methylpropanenitrile

* 2-Methylpropanenitrile

* 2-Methylpropionitrile








REFERENCE :








TOXIC EFFECTS :



Vascular - regional or general arteriolar or venous dilation

REFERENCE :


Clayton,



Volume(issue)/page/year: 2C,4874,1982





TOXIC EFFECTS :


REFERENCE :



23,95,1962





TOXIC EFFECTS :


REFERENCE :


D-1000


55,47,1984





TOXIC EFFECTS :




REFERENCE :

ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt,

Fed.

Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969





TOXIC EFFECTS :




REFERENCE :


Fed.






TOXIC EFFECTS :


REFERENCE :


Fed.






TOXIC EFFECTS :


change



REFERENCE :


(Heymans







TOXIC EFFECTS :


REFERENCE :


Clayton,



Volume(issue)/page/year: 2C,4874,1982





TOXIC EFFECTS :


change

Behavioral - tremor


REFERENCE :


(Heymans





NIOSH REL TO ISOBUTYRONITRILE-air:10H TWA 8 ppm

REFERENCE :






ISOBUTYRYL CHLORIDE

RTECS NUMBER : UC3944000

CHEMICAL NAME : Propanoyl chloride, 2-methyl-




MOLECULAR FORMULA : C4-H7-Cl-O




* Chloro isopropyl ketone

* Dimethylacetyl chloride

* Isobutanoyl chloride

* Isobutyric acid chloride

* Isobutyroyl chloride

* Isobutyryl chloride

* 2-Methylpropanoyl chloride

* alpha-Methylpropionyl chloride

* 2-Methylpropionyl chloride






DOSE/DURATION : 100 uL/24H


REFERENCE :









TOXIC EFFECTS :

Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)

Lungs, Thorax, or Respiration - acute pulmonary edema


REFERENCE :






ISOFLURANE

RTECS NUMBER : KN6799000

CHEMICAL NAME : Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl





MOLECULAR FORMULA : C3-H2-Cl-F5-O



Drug

Mutagen


Human


* 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

* Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-

* Forane

* Isoflurane

* (+-)-Isoflurane

* R-E 235dal







TOXIC EFFECTS :

Brain and Coverings - changes in surface EEG



REFERENCE :

NLJMAV Netherlands Journal of Medicine. (Elsevier Science, POB 211, 1000

AE

Amsterdam. Netherlands) V.16- 1973- Volume(issue)/page/year:

33,74,1988





TOXIC EFFECTS :

Behavioral - ataxia



REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :

Behavioral - ataxia



REFERENCE :








TOXIC EFFECTS :

Behavioral - ataxia



REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :

Behavioral - ataxia



REFERENCE :









TOXIC EFFECTS :

Endocrine - changes in adrenal weight



REFERENCE :







DOSE/DURATION : 150 ppm/24H/5W-C

TOXIC EFFECTS :


REFERENCE :

ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,

2350

Virginia Ave., Hagerstown, MD 21740) V.1- 1940-


42,408,1975




DOSE/DURATION : 1500 ppm/24H/5W-C

TOXIC EFFECTS :


REFERENCE :


2350



42,408,1975





DOSE : 10500 ppm/6H


TOXIC EFFECTS :



REFERENCE :


2350



64,339,1986




DOSE : 4000 ppm/3H


TOXIC EFFECTS :



REFERENCE :







DOSE : 12000 ppm/3H



TOXIC EFFECTS :


REFERENCE :







DOSE : 6000 ppm/4H


TOXIC EFFECTS :





REFERENCE :


(Alan



** MUTATION DATA **




DOSE/DURATION : 4 mmol/kg

REFERENCE :



413,1,1998

*** REVIEWS ***

IARC Cancer Review:Animal Inadequate Evidence




7,93,1987


OEL-SWEDEN: TWA 10 ppm (80 mg/m3), STEL 20 ppm (150 mg/m3), JAN1999












EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

ISOLEUCINE (L-)

RTECS NUMBER : NR4705000

CHEMICAL NAME : Isoleucine, L-







WISWESSER LINE NOTATION : QVYZY2&1 -L



* Acetic acid, amino-sec-butyl-

* 2-Amino-3-methylpentanoic acid, (S-(R*,R*))-

* (2S,3S)-2-Amino-3-methylpentanoic acid

* (S-(R*,R*))-2-Amino-3-methylpentanoic acid

* alpha-Amino-beta-methylvaleric acid

* 2-Amino-3-methylvaleric acid

* (2S,3S)-alpha-Amino-beta-merthylvaleric acid

* (2S,3S)-alpha-Amino-beta-methyl-n-valeric acid

* (2S,3S)-alpha-Amino-beta-merthyl-n-valeric acid

* Isoleucine

* 2S,3S-Isoleucine

* erythro-L-Isoleucine

* L-Isoleucine

* L-(+)-Isoleucine

* erythro-L-Isoleucine

* (S)-Isoleucine

* (S,S)-Isoleucine

* 2S,3S-Isoleucine

* L-Norvaline, 3-methyl-, erythro-

* Pentanoic acid, 2-amino-3-methyl-, (S-(R*,R))-

* Valeric acid, 2-amino-3-methyl-







TOXIC EFFECTS :



REFERENCE :

ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1

E.


58,253,1955






TOXIC EFFECTS :

Kidney, Ureter, Bladder - urine volume increased

Nutritional and Gross Metabolic - changes in sodium


levels - transaminases

REFERENCE :




** MUTATION DATA **




REFERENCE :



372,75,1996


OEL-RUSSIA:STEL 5 mg/m3 JAN 1993


















ISONICOTINAMIDE

RTECS NUMBER : NR9500000

CHEMICAL NAME : Isonicotinamide






MOLECULAR FORMULA : C6-H6-N2-O


WISWESSER LINE NOTATION : T6NJ DVZ



* 4-Carbamoylpyridine

* Isonicotinic acid amide

* gamma-Pyridinecarboxamide

* 4-Pyridinecarboxamide


** MUTATION DATA **


TEST SYSTEM : Rodent - rat Liver


REFERENCE :






ISONICOTINIC ACID


CHEMICAL NAME : Isonicotinic acid






WISWESSER LINE NOTATION : T6NJ DVQ



* Acide iso-nicotinique

* 4-Carboxypyridine

* gamma-Picolinic acid

* 4-Picolinic acid

* gamma-Pyridinecarboxylic acid

* p-Pyridinecarboxylic acid

* 4-Pyridinecarboxylic acid







TOXIC EFFECTS :



REFERENCE :


Translation







TOXIC EFFECTS :



REFERENCE :


Translation







TOXIC EFFECTS :



REFERENCE :


Translation







TOXIC EFFECTS :


REFERENCE :














ISONICOTINIC ACID HYDRAZIDE


CHEMICAL NAME : Isonicotinic acid hydrazide



62229-51-0

37271-10-6

41466-07-3



MOLECULAR FORMULA : C6-H7-N3-O


WISWESSER LINE NOTATION : T6NJ DVMZ


Drug

Mutagen


Human

Primary Irritant


* Andrazide

* Antimicina

* Antituberkulosum

* Armazide

* Atcotibine

* Azuren

* BP 5015

* Cedin

* Cemidon

* Chemiazid

* Chemidon

* Cotinazin

* Defonin

* Dibutin

* Diforin

* Dinacrin

* Ditubin

* Ebidene

* Eralon

* Ertuban

* Eutizon

* Evalon

* Fimalene

* FSR 3

* GInk

* HIA

* Hidranizil

* Hidrasonil

* Hidrulta

* Hidrun

* Hycozid

* Hydrazid

* 4-(Hydrazinocarbonyl)pyridine

* Hyozid

* Hyzyd

* I.A.I.

* Ido-tebin

* Idrazide dell'acido isonicotinico

* Idrazil

* IN-73

* INAH

* INH

* Inizid

* Iscotin

* Isidrina

* Ismazide

* Isobicina

* Isocid

* Isocidene

* Isocotin

* Isolyn

* Isonerit

* Isonex

* Isoniazid

* Isoniazide

* Isonicazide

* Isonicid

* Isonico

* Isonicotan

* Isonicotil

* Isonicotinhydrazid

* Isonicotinoyl hydrazide

* Isonicotinoylhydrazine

* Isonicotinsaeurehydrazid

* Isonicotinyl hydrazide

* Isonide

* Isonidrin

* Isonikazid

* Isonilex

* Isonin

* Isonindon

* Isonirit

* Isoniton

* Isonizide

* Isotebe

* Isotebezid

* Isotinyl

* Isozide

* Isozyd

* L 1945

* Laniazid

* Mybasan

* Neoteben

* Neo-tizide

* Neoxin

* Neumandin

* Nevin

* Niadrin

* Nicazide

* Nicetal

* Nicizina

* Niconyl

* Nicotibina

* Nicozide

* Nidaton

* Nidrazid

* Nikozid

* Niplen

* Nitadon

* Niteban

* NSC 9659

* Nydrazid

* Pelazid

* Phthisen

* Preparation 6424

* Pycazide

* 4-Pyridinecarboxylic acid, hydrazide

* 4-Pyridinecarboxylic hydrazide

* Pyrizidin

* Raumanon

* Razide

* Retozide

* Rifamate

* Rimicid

* Rimifon

* Rimitsid

* Robisellin

* Roxifen

* 5015 RP

* RU-EF-TB

* Sanohidrazina

* Sauterazid

* Stanozide

* TB-Phlogin

* TB-Razide

* TB-Vis

* Tebecid

* Tebenic

* Tebexin

* Tebilon

* Tebos

* Teebaconin

* Tekazin

* Tibazide

* Tibinide

* Tibison

* Tibivis

* Tibizide

* Tibusan

* Tisin

* Tisiodrazida

* Tizide

* Tubazid

* Tubazide

* Tubeco

* Tubercid

* Tuberian

* Tubicon

* Tubomel

* Tyvid

* Unicozyde

* USAF CB-2

* Vazadrine

* Vederon

* Zinadon

* Zonazide








REFERENCE :



4,44,1962






TOXIC EFFECTS :


Behavioral - headache

Cardiac - EKG changes not diagnostic of specified effects

REFERENCE :

PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,

Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 97,782,1996





TOXIC EFFECTS :

Behavioral - hallucinations, distorted perceptions


Gastrointestinal - nausea or vomiting

REFERENCE :







TOXIC EFFECTS :


Behavioral - tremor

Behavioral - ataxia

REFERENCE :

CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc.,

POB

8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-


148,49,1993





TOXIC EFFECTS :

Behavioral - tremor


REFERENCE :







TOXIC EFFECTS :


Behavioral - coma


REFERENCE :

AEMED3 Annals of Emergency Medicine. (American College of Emergency

Physicians, 1125 Executive Circle, Irving, TX 75038)






TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse


REFERENCE :



176,877,1961





TOXIC EFFECTS :

Behavioral - toxic psychosis

Behavioral - ataxia

REFERENCE :

NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth,

MN






TOXIC EFFECTS :

Peripheral Nerve and Sensation - structural change in nerve or sheath

REFERENCE :

ARDSBL American Review of Respiratory Disease. (American Lung Assoc.,

1740

Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:

105,206,1972





TOXIC EFFECTS :



REFERENCE :

NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth,

MN






TOXIC EFFECTS :


REFERENCE :

SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,






TOXIC EFFECTS :

Behavioral - anorexia (human)

Skin and Appendages - sweating


REFERENCE :

ARDSBL American Review of Respiratory Disease. (American Lung Assoc.,

1740

Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:

106,849,1972





TOXIC EFFECTS :



Lungs, Thorax, or Respiration - emphysema

REFERENCE :

JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312,

Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 16,57,1992





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :

SZTPA5 Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie.

(Basel, Switzerland) V.1-18, 1944-61. Volume(issue)/page/year:

9,226,1952





TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :



REFERENCE :

ARTUA4 American Review of Tuberculosis. (New York, NY) V.1-70, 1917-54.

For publisher information, see ARDSBL. Volume(issue)/page/year:

65,376,1952





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,

2-12-15

Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-






TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :



REFERENCE :



65,376,1952





TOXIC EFFECTS :


REFERENCE :



65,392,1952





TOXIC EFFECTS :


change



REFERENCE :


D-1000


30,959,1952





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :



9,226,1952





TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :



9,226,1952





TOXIC EFFECTS :


REFERENCE :



65,376,1952





TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :



9,226,1952


ROUTE OF EXPOSURE : Intracerebral



TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :



9,226,1952





TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :



9,226,1952





TOXIC EFFECTS :


change



REFERENCE :


D-1000


30,959,1952





TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :



9,226,1952





TOXIC EFFECTS :


REFERENCE :

ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,

1954-74.

For publisher information, see ARTODN. Volume(issue)/page/year:

22,80,1966





TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :



9,226,1952






TOXIC EFFECTS :


REFERENCE :



8,325,1966





TOXIC EFFECTS :

Peripheral Nerve and Sensation - structural change in nerve or sheath

Blood - changes in platelet count


levels - other transferases

REFERENCE :

JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,

Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.

Discontinued.






TOXIC EFFECTS :

Liver - change in gall bladder structure or function


levels - phosphatases



REFERENCE :

AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and

Medical

Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

V.30-V.32,






TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

REFERENCE :



10,183,1967





TOXIC EFFECTS :




REFERENCE :



65,392,1952





TOXIC EFFECTS :


REFERENCE :



65,376,1952






TOXIC EFFECTS :




REFERENCE :


V.1-60,



41,331,1968





multigenerations

TOXIC EFFECTS :


Reproductive - Tumorigenic effects - transplacental tumorigenesis


REFERENCE :

JCROD7 Journal of Cancer Research and Clinical Oncology.

(Springer-Verlag

New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93-






TOXIC EFFECTS :



REFERENCE :


(Springer-Verlag







TOXIC EFFECTS :


Blood - leukemia

Blood - lymphoma, including Hodgkin's disease

REFERENCE :

UICMAI UICC Monograph Series. International Union Against Cancer.

(Secaucus, NJ) V.1-12, 1967-69(?). Volume(issue)/page/year: 7,180,1967





TOXIC EFFECTS :



REFERENCE :


V.1-75,



51,83,1960





TOXIC EFFECTS :


Lungs, Thorax, or Respiration - bronchiogenic carcinoma

REFERENCE :

PAPOAC Patologia Polska. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)






TOXIC EFFECTS :



Liver - tumors

REFERENCE :



26,1473,1966





TOXIC EFFECTS :



REFERENCE :


V.1-75,



51,83,1960





TOXIC EFFECTS :



Liver - tumors

REFERENCE :


V.1-60,



41,331,1968





TOXIC EFFECTS :



REFERENCE :

TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,

Italy) V.1- 1911- Volume(issue)/page/year: 56,315,1970





TOXIC EFFECTS :




REFERENCE :


V.1-75,



50,107,1959





TOXIC EFFECTS :


Lungs, Thorax, or Respiration - bronchiogenic carcinoma

Liver - tumors

REFERENCE :


(Springer-Verlag







TOXIC EFFECTS :



Liver - tumors

REFERENCE :

IJCNAW International Journal of Cancer. (International Union Against

Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1-

1966-






TOXIC EFFECTS :



Liver - tumors

REFERENCE :




18,543,1964





TOXIC EFFECTS :



REFERENCE :


11830







TOXIC EFFECTS :



REFERENCE :


11830







DOSE : 2790 ug/kg


TOXIC EFFECTS :




before birth)

REFERENCE :

DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw,

Poland)

V.18-24, 1966-72. For publisher information, see PJPPAA.





DOSE : 27900 ug/kg


TOXIC EFFECTS :


System


REFERENCE :


Poland)






DOSE : 1848 mg/kg


TOXIC EFFECTS :


Reproductive - Effects on Newborn - delayed effects

REFERENCE :


Information






DOSE : 160 mg/kg


TOXIC EFFECTS :




before birth)


REFERENCE :

GJMSA7 Gunma Journal of Medical Sciences. (Maebashi, Japan) V.1-17,

1952-69. Discontinued. Volume(issue)/page/year: 14,233,1965




DOSE : 40 mg/kg


TOXIC EFFECTS :




before birth)

REFERENCE :


Poland)



** MUTATION DATA **




REFERENCE :







REFERENCE :

BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946,

Leipzig


97,137,1978



DOSE/DURATION : 187 ug/well

REFERENCE :



133,161,1984


TEST SYSTEM : Bacteria - Bacillus subtilis


REFERENCE :



5,343,1968


TEST SYSTEM : Microorganism - not otherwise specified


REFERENCE :



173,233,1986




REFERENCE :



173,233,1986




REFERENCE :

BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946,

Leipzig


95,463,1976




REFERENCE :



91,215,1981


TEST SYSTEM : Human Liver


REFERENCE :


Ireland


30,103,1986


TEST SYSTEM : Human HeLa cell


REFERENCE :

JOUOD4 Journal of UOEH (University of Occupational and Environmental

Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka,

Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979-

Volume(issue)/page/year: 8(Suppl),291,1986


TEST SYSTEM : Human Fibroblast


REFERENCE :


Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,9,1981




REFERENCE :



50,251,1978




REFERENCE :

HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center,

44

Hartz Way, Secaucus, NJ 07094) V.31- 1976- Volume(issue)/page/year:

52,309,1979




REFERENCE :




TEST SYSTEM : Human Bone marrow


REFERENCE :

CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses

Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-


TYPE OF TEST : Body fluid assay

TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium


REFERENCE :



56,289,1978




DOSE/DURATION : 900 mg/kg/12W (Intermittent)

REFERENCE :


44


42,9,1978





REFERENCE :

LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-



TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium


REFERENCE :



41,89,1976





REFERENCE :

PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB

1001,

00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see

PJPAE3 Volume(issue)/page/year: 31,689,1979




DOSE/DURATION : 960 umol/kg

REFERENCE :



41,1469,1981

TYPE OF TEST : DNA adduct




REFERENCE :

HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,

Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,153,1987





REFERENCE :


Information







REFERENCE :

NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in

Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,

Calcutta

700 019, India) V.1- 1958- Volume(issue)/page/year: 22,96,1979





REFERENCE :



Calcutta



TEST SYSTEM : Rodent - mouse Ascites tumor


REFERENCE :



32,178,1977


TEST SYSTEM : Rodent - mouse Mammary gland

DOSE/DURATION : 3200 umol/L/24H (Continuous)

REFERENCE :

JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of

Toxicological

Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,

Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 5,141,1980





REFERENCE :



Calcutta



TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium


REFERENCE :



41,89,1976


TEST SYSTEM : Rodent - mouse Bacteria - Escherichia coli


REFERENCE :



164,19,1986





REFERENCE :

REBPAT Radiation and Environmental Biophysics. (Springer-Verlag New

York,

Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11- 1974-





REFERENCE :



50,251,1978



TEST SYSTEM : Rodent - hamster

DOSE/DURATION : 10 mg/kg/2W (Intermittent)

REFERENCE :


44


42,9,1978


TEST SYSTEM : Rodent - hamster Lung


REFERENCE :

AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52



3,253,1980




REFERENCE :

ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic

Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,

Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:

(96),55,1978




REFERENCE :



68,351,1979




REFERENCE :


44


54,155,1980


TEST SYSTEM : Rodent - hamster Bacteria - Salmonella typhimurium


REFERENCE :



41,89,1976


TEST SYSTEM : Rodent - guinea pig Bacteria - Salmonella typhimurium


REFERENCE :



41,89,1976

*** REVIEWS ***

IARC Cancer Review:Animal Limited Evidence


Chemicals


12210)






7,227,1987

IARC Cancer Review:Group 3




7,227,1987

TOXICOLOGY REVIEW

AJHPA9 American Journal of Hospital Pharmacy. (American Soc. of Hospital

Pharmacists, 4630 Montgomery Ave., Bethesda, MD 20814) V.15- 1958-


TOXICOLOGY REVIEW

CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000

Corporate

Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:

2,365,1973

TOXICOLOGY REVIEW

MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)

V.33-115, 1886-1973. Volume(issue)/page/year: 115,1685,1973

TOXICOLOGY REVIEW



39,111,1977




NOHS Hazard Code - A1139













EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay

EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte

EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm

morphology-mouse

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-rabbit

EPA GENETOX PROGRAM 1988, Inconclusive: Body fluid assay;

Cytogenetics-male

germ cell

EPA GENETOX PROGRAM 1988, Inconclusive: Mouse spot test; Mouse specific

locus


ISONIPECOTIC ACID


CHEMICAL NAME : Isonipecotic acid










* Acide isonipecotique

* Acide piperidine-carboxylique-4

* 4-Carboxypiperidine

* 4-Hexahydroisonicotinic acid

* 4-Piperidinecarboxylic acid







TOXIC EFFECTS :


REFERENCE :





ISONUTROSOACETIOPHENONE (2-)

RTECS NUMBER : MD3325000

CHEMICAL NAME : Glyoxal, 1-phenyl-, 2-oxime








WISWESSER LINE NOTATION : QNU1VR


Drug


* Acetophenone, 2-hydroxyimino-

* Benzeneacetaldehyde, alpha-oxo-, aldoxime

* Benzoylformaldoxime

* 2-Hydroxyiminoacetophenone

* Isonitrosoacetophenone

* 2-Isonitrosoacetophenone

* Phenylglyoxal aldoxime

* Phenylglyoxal monoxime

* Phenylglyoxal 2-oxime







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Behavioral - coma

REFERENCE :


&





ISOPENTYL BENZOATE


CHEMICAL NAME : Benzoic acid, isopentyl ester








WISWESSER LINE NOTATION : 1Y1&2OVR

COMPOUND DESCRIPTOR : Natural Product

Primary Irritant


* Benzoic acid, 1-(3-methyl)butyl ester

* 1-Butanol, 3-methyl-, benzoate

* Isoamyl benzoate

* Isopentyl alcohol, benzoate

* Isopentyl benzoate

* 3-Methylbutyl benzoate








REFERENCE :


For







TOXIC EFFECTS :


REFERENCE :


For






TOXIC EFFECTS :


REFERENCE :


For





ISOPHORONE

RTECS NUMBER : GW7700000

CHEMICAL NAME : 2-Cyclohexen-1-one, 3,5,5-trimethyl-








WISWESSER LINE NOTATION : L6V BUTJ C1 D1 D1


Mutagen

Human

Primary Irritant


* Isoacetophorone

* Isoforon

* Isoforone

* Isophoron

* Isophorone

* Izoforon

* NCI-C55618

* 1,1,3-Trimethyl-3-cyclohexene-5-one

* 3,3,5-Trimethyl-5-cyclohexen-1-one

* 3,5,5-Trimethyl-2-cyclohexene-1-one

* 3,5,5-Trimethyl-2-cyclohexen-1-on

* 3,5,5-Trimetil-2-cicloesen-1-one







REFERENCE :









REFERENCE :

JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72.

For publisher information, see TOERD9. Volume(issue)/page/year:

5,31,1972




DOSE/DURATION : 920 ug


REFERENCE :








REFERENCE :



-,290,1986






REFERENCE :









TOXIC EFFECTS :


specified

Sense Organs and Special Senses (Eye) - conjunctive irritation


REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :



17,498,1970

TYPE OF TEST : LC - Lethal concentration



DOSE/DURATION : >3500 mg/kg/6H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :








TOXIC EFFECTS :


Cardiac - pulse rate


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :



-,290,1986






TOXIC EFFECTS :


REFERENCE :



NTP-TR-291,1986





TOXIC EFFECTS :


REFERENCE :



NTP-TR-291,1986





TOXIC EFFECTS :


Kidney, Ureter, Bladder - changes in both tubules and glomeruli


REFERENCE :








TOXIC EFFECTS :




REFERENCE :







DOSE/DURATION : 208 mg/m3/6H/4W-I

TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


REFERENCE :



NTP-TR-291,1986





TOXIC EFFECTS :


REFERENCE :



NTP-TR-291,1986





TOXIC EFFECTS :


Kidney, Ureter, Bladder - changes in both tubules and glomeruli


REFERENCE :








TOXIC EFFECTS :




Blood - changes in other cell count (unspecified)

REFERENCE :









TOXIC EFFECTS :


Kidney, Ureter, Bladder - tumors

REFERENCE :








TOXIC EFFECTS :


Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 39,207,1986

** MUTATION DATA **


TEST SYSTEM : Rodent - rat Liver


REFERENCE :



315,147,1994




REFERENCE :


E.


12,85,1988




REFERENCE :



369,243,1996




REFERENCE :



NTP-TR-291,1986

*** REVIEWS ***

ACGIH TLV-Animal carcinogen




TLV/BEI,1997

ACGIH TLV-CL 28 mg/m3 (5 ppm)




TLV/BEI,1997






3,140,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994




OEL-BELGIUM:STEL 5 ppm (28 mg/m3) JAN 1993


OEL-FINLAND:TWA 5 ppm (28 mg/m3);STEL 10 ppm (56 mg/m3) JAN 1993




OEL-POLAND: MAC(TWA) 5 mg/m3, MAC(C) 25 mg/m3, JAN1999


OEL-SWEDEN:STEL 5 ppm (30 mg/m3) JAN 1993


OEL-TURKEY:TWA 25 ppm (149 mg/m3) JAN 1993

OEL-UNITED KINGDOM:TWA 5 ppm (25 mg/m3);STEL 5 ppm (25 mg/m3) JAN 1993





NIOSH REL TO ISOPHORONE-air:10H TWA 4 ppm

REFERENCE :



















ATSDR TOXICOLOGY PROFILE



Volume(issue)/page/year: PB/90/180225/AS


EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE



47,26992,82




NIOSH Analytical Method, 1994: Isophorone, 2508

NTP Carcinogenesis Studies (gavage);some evidence:rat



NTP-TR-291,1986

NTP Carcinogenesis Studies (gavage);equivocal evidence:mouse



NTP-TR-291,1986

ISOPHTHALOYL DICHLORIDE


CHEMICAL NAME : Isophthaloyl chloride






MOLECULAR FORMULA : C8-H4-Cl2-O2


WISWESSER LINE NOTATION : GVR CVG



* 1,3-Benzenedicarbonyl chloride

* Dichlorid kyseliny isoftalove

* Isophthalic acid chloride

* Isophthalic acid dichloride

* Isophthaloyl dichloride

* Isophthalyl chloride

* Isophthalyl dichloride

* m-Phthalic dichloride

* m-Phthaloyl chloride








REFERENCE :








REFERENCE :








TOXIC EFFECTS :


REFERENCE :



TYPE OF TEST : LC - Lethal concentration



DOSE/DURATION : >31 gm/m3/4H

TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :



28,313,1974






TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :

Gastrointestinal - alteration in gastric secretion


REFERENCE :
















ISOPRENE


CHEMICAL NAME : Isoprene







WISWESSER LINE NOTATION : 1UY1&1U1


Mutagen


* 1,3-Butadiene, 2-methyl-

* beta-Methylbivinyl

* 2-Methylbutadiene

* 2-Methyl-1,3-butadiene

* NSC 9237






DOSE/DURATION : 180 gm/m3/4H

TOXIC EFFECTS :



REFERENCE :



Surrey,





DOSE/DURATION : 139 gm/m3/2H

TOXIC EFFECTS :


REFERENCE :










TOXIC EFFECTS :

Behavioral - alteration of classical conditioning

REFERENCE :







DOSE/DURATION : 3400 mg/m3/22W-I

TOXIC EFFECTS :

Brain and Coverings - changes in brain weight

Lungs, Thorax, or Respiration - changes in lung weight

Kidney, Ureter, Bladder - changes in kidney weight

REFERENCE :









TOXIC EFFECTS :

Behavioral - changes in psychophysiological tests

REFERENCE :









TOXIC EFFECTS :

Behavioral - alteration of classical conditioning


REFERENCE :





** MUTATION DATA **




DOSE/DURATION : 438 ppm/6H/12D (Continuous)

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

3,141,1988




DOSE/DURATION : 438 ppm/6H/12D (Continuous)

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

3,141,1988

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence


Chemicals


12210)




Chemicals


12210)


IARC Cancer Review:Group 2B


Chemicals


12210)






















EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8707


NTP Toxicity studies, RPT# TOX-31, May 1999

NTP Carcinogenesis studies; test completed (camera copy in progress), May

1999

ISOPROPENYL ACETATE

RTECS NUMBER : UD4200000

CHEMICAL NAME : 1-Propen-2-ol, acetate








WISWESSER LINE NOTATION : 1VOY1&U1



* Acetic acid, isopropenyl ester

* Isopropenylester kyseliny octove

* Methylvinyl acetate

* 1-Propen-2-yl acetate








REFERENCE :



-,355,1986






REFERENCE :









REFERENCE :



-,355,1986






TOXIC EFFECTS :


REFERENCE :








ISOPROPYL ACETATE


CHEMICAL NAME : Acetic acid, isopropyl ester








WISWESSER LINE NOTATION : 1Y1&OV1

COMPOUND DESCRIPTOR : Human

Primary Irritant


* Acetate d'isopropyle

* Acetic acid, 1-methylethyl ester

* 2-Acetoxypropane

* Isopropile (acetato di)

* Isopropylacetaat

* Isopropylacetat

* Isopropyl acetate

* Isopropyl (acetate d')

* Isopropylester kyseliny octove

* 2-Propyl acetate







REFERENCE :









REFERENCE :



-,354,1986






TOXIC EFFECTS :


REFERENCE :


1955-60.


21,28,1960





TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - conjunctive irritation

REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :



20,364,1959





TOXIC EFFECTS :


REFERENCE :

JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First

St.,






TOXIC EFFECTS :


REFERENCE :

JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First

St.,






TOXIC EFFECTS :


REFERENCE :


1949-73.


41,31,1972




DOSE/DURATION : >20 mL/kg

TOXIC EFFECTS :


REFERENCE :




*** REVIEWS ***

ACGIH TLV-STEL 1290 mg/m3 (310 ppm)




TLV/BEI,1997





TLV/BEI,1997

TOXICOLOGY REVIEW


1955-60.


21,28,1960






3,141,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994







OEL-HUNGARY:TWA 400 mg/m3;STEL 800 mg/m3 JAN 1993



OEL-SWITZERLAND:TWA 200 ppm (840 mg/m3);STEL 400 ppm JAN 1993























NIOSH Analytical Method, 1994: Isopropyl acetate, 1454

ISOPROPYL CHLORIDE

RTECS NUMBER : TX4410000

CHEMICAL NAME : Propane, 2-chloro-






MOLECULAR FORMULA : C3-H7-Cl




* Chlorodimethylmethane

* Isoprid

* Isopropylchloride

* Narcosop

* sec-Propyl chloride

* 2-Propyl chloride







TOXIC EFFECTS :

Autonomic Nervous System - other (direct) parasympathomimetic



REFERENCE :








TOXIC EFFECTS :



levels - true cholinesterase



REFERENCE :








TOXIC EFFECTS :

Autonomic Nervous System - other (direct) parasympathomimetic



REFERENCE :








TOXIC EFFECTS :


REFERENCE :








DOSE/DURATION : 236 gm/m3/30M/1W-I

TOXIC EFFECTS :


REFERENCE :


&



** MUTATION DATA **



DOSE/DURATION : 1 gm/plate

REFERENCE :

DTESD7 Developments in Toxicology and Environtal Science. (Elsevier

Science, New York, NY) V.1-15, 1977-87. Discontinued












EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis




ISOPROPYL ETHER


CHEMICAL NAME : Propane, 2,2'-oxybis-






WISWESSER LINE NOTATION : 1Y1&OY1&1


Primary Irritant


* Diisopropyl oxide

* Ether, isopropyl

* Ether isopropylique

* 2-Isopropoxypropane

* Isopropyl ether

* Izopropylowy eter








REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :


REFERENCE :

SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon

Rd.,

San Romon, CA 94583) Volume(issue)/page/year: -,5,1961





TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :








DOSE/DURATION : 20 mL/kg

TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :










TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS


REFERENCE :









TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


Liver - liver function tests impaired

REFERENCE :









DOSE : 3095 ppm/6H


TOXIC EFFECTS :



REFERENCE :




*** REVIEWS ***





TLV/BEI,1997





TLV/BEI,1997






3,142,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994


















NIOSH REL TO ISOPROPYL ETHER-air:10H TWA 500 ppm

REFERENCE :






















NIOSH Analytical Method, 1994: Isopropyl ether, 1618

ISOPROPYL PIPERAZINE

RTECS NUMBER : TM0860000

CHEMICAL NAME : Piperazine, 1-isopropyl-








WISWESSER LINE NOTATION : T6M DNTJ DY1&1


* Isopropyl piperazine

* N-Isopropylpiperazine

* 1-(1-Methylethyl)piperazine

* Piperazine, 1-(1-methylethyl)-







TOXIC EFFECTS :


REFERENCE :



30,470,1969





TOXIC EFFECTS :


REFERENCE :



30,470,1969

ISOPROPYLACRYLAMIDE (N-)

RTECS NUMBER : AS3675000

CHEMICAL NAME : Acrylamide, N-isopropyl-






MOLECULAR FORMULA : C6-H11-N-O


WISWESSER LINE NOTATION : 1Y1&MV1U1



Primary Irritant


* Isopropyl acrylamide

* N-Isopropylacrylamide

* Isopropylamid kyseliny akrylove

* N-(1-Methylethyl)-2-propenamide

* Nipam

* 2-Propenamide, N-(1-methylethyl)-








REFERENCE :









TOXIC EFFECTS :


change


Blood - hemorrhage

REFERENCE :








TOXIC EFFECTS :


REFERENCE :


D-1000


47,179,1981





TOXIC EFFECTS :


REFERENCE :

CBCCT* "Summary Tables of Biological Tests," National Research Council

Chemical-Biological Coordination Center. (National Academy of Science

Library, 2101 Constitution Ave., NW, Washington, DC 20418)






TOXIC EFFECTS :


change


Blood - hemorrhage

REFERENCE :









TOXIC EFFECTS :

Related to Chronic Data - changes in testicular weight

REFERENCE :


D-1000


47,179,1981





DOSE : 2235 mg/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :


D-1000


47,179,1981




DOSE : 238 gm/kg

SEX/DURATION : male 5 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,

sperm morphology, motility, and count)

Reproductive - Fertility - male fertility index (e.g. # males impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :


D-1000


59,201,1986




DOSE : 158 gm/kg

SEX/DURATION : male 5 week(s) pre-mating

TOXIC EFFECTS :



REFERENCE :


D-1000


59,201,1986

** MUTATION DATA **





REFERENCE :


D-1000


59,201,1986



EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8852


ISOPROPYLAMINE


CHEMICAL NAME : Isopropylamine






WISWESSER LINE NOTATION : ZY1&1


Primary Irritant


* 2-Amino-propaan

* 2-Aminopropan

* 2-Aminopropane

* 2-Amino-propano

* Isopropilamina

* Isopropylamine

* 1-Methylethylamine

* Monoisopropylamine

* 2-Propanamine

* Propane, 2-amino-

* sec-Propylamine

* 2-Propylamine








REFERENCE :








REFERENCE :









TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,

National Cancer Institute, Memorandum, June 17, 1974

Volume(issue)/page/year: 17JUN1974





TOXIC EFFECTS :


REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see

PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon

Rd.,

San Romon, CA 94583) Volume(issue)/page/year: -,7,1961





TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :

IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,

National Cancer Institute, Memorandum, June 17, 1974

Volume(issue)/page/year: 17JUN1974





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.

Toxicology of New Industrial Chemical Substances. For English translation,

see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-






TOXIC EFFECTS :


REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.

Toxicology of New Industrial Chemical Substances. For English translation,

see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-


*** REVIEWS ***





TLV/BEI,1997





TLV/BEI,1997

TOXICOLOGY REVIEW

CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office

Dept.

223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-







3,141,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994













OEL-SWEDEN: TWA 5 ppm (12 mg/m3), STEL 10 ppm (25 mg/m3), JAN1999





















NTP Carcinogenesis studies; selected, May 1999

ISOPROPYLBENZALDEHYDE (4-)

RTECS NUMBER : CU7000000

CHEMICAL NAME : Benzaldehyde, p-isopropyl-








WISWESSER LINE NOTATION : VHR DY1&1


Primary Irritant


* Benzaldehyde, 4-(1-methylethyl)-

* Cumaldehyde

* Cumic aldehyde

* p-Cumic aldehyde

* Cuminal

* Cuminaldehyde

* Cuminic aldehyde

* Cuminyl aldehyde

* p-Isopropylbenzaldehyde

* 4-Isopropylbenzaldehyde

* p-Isopropylbenzenecarboxaldehyde

* 4-(1-Methylethyl)benzaldehyde







REFERENCE :


For







TOXIC EFFECTS :




REFERENCE :


For






TOXIC EFFECTS :

Tumorigenic - active as anti-cancer agent

REFERENCE :

BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,

Commerce

Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-


34,1196,1940





TOXIC EFFECTS :


REFERENCE :


For













ISOPROPYLBENZOIC ACID (4-)


CHEMICAL NAME : Benzoic acid, 4-(1-methylethyl)-










* Benzoic acid, p-isopropyl-

* Cumic acid

* Cuminic acid

* p-Isopropylbenzoic acid

* 4-Isopropylbenzoic acid

* 4-(1-Methylethyl)benzoic acid







TOXIC EFFECTS :


REFERENCE :

CBCCT* "Summary Tables of Biological Tests," National Research Council

Chemical-Biological Coordination Center. (National Academy of Science

Library, 2101 Constitution Ave., NW, Washington, DC 20418)




ISOPROPYLCYCLOHEXYLAMINE (N-)

RTECS NUMBER : GX1450000

CHEMICAL NAME : Cyclohexylamine, N-isopropyl-








WISWESSER LINE NOTATION : L6TJ AMY1&1


* N-Isopropylcyclohexylamine







TOXIC EFFECTS :


REFERENCE :

USXXAM United States Patent Document. (U.S. Patent Office, Box 9,

Washington, DC 20231) Volume(issue)/page/year: #3816470





TOXIC EFFECTS :


REFERENCE :


Systems


21010)


ISOPROPYLTOLUENE (4-)

RTECS NUMBER : GZ5950000

CHEMICAL NAME : p-Cymene






WISWESSER LINE NOTATION : 1Y1&R D1


Primary Irritant


* Benzene, 1-isopropyl-4-methyl-

* Camphogen

* Cumene, p-methyl-

* Cymene

* Cymol

* Dolcymene

* p-Isopropylmethylbenzene

* 4-Isopropyl-1-methylbenzene

* p-Isopropyltoluene

* p-Methylisopropyl benzene

* 1-Methyl-4-isopropylbenzene

* Paracymene

* Paracymol








REFERENCE :


For







TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - chromodacryorrhea



REFERENCE :


For



OEL-RUSSIA:STEL 10 mg/m3;Skin JAN 1993

OEL-SWEDEN:TWA 25 ppm (140 mg/m3);STEL 35 ppm (190 mg/m3) JAN 1993















ISOQUINOLINE

RTECS NUMBER : NW6825000

CHEMICAL NAME : Isoquinoline






WISWESSER LINE NOTATION : T66 CNJ


Primary Irritant


* 2-Azanaphthalene

* 2-Benzazine

* Benzo(c)pyridine

* Isochinolin

* Leucoline

* beta-Quinoline








REFERENCE :



-,848,1986






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du

Systeme

Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,

1948






TOXIC EFFECTS :


REFERENCE :

85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du

Systeme

Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,

1948


















EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test




ISOQUINOLINESULFONYLMETHYLPIPERAZINE (1:5,2-)

RTECS NUMBER : TL9305000

CHEMICAL NAME : Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-





MOLECULAR FORMULA : C14-H17-N3-O2-S




* H 7

* 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine







TOXIC EFFECTS :


REFERENCE :

EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier

Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992-

Volume(issue)/page/year: 30A,525,1994

ISOVALERALDEHYDE

RTECS NUMBER : ES3450000

CHEMICAL NAME : Butyraldehyde, 3-methyl-








WISWESSER LINE NOTATION : VH1Y1&1



* Aldehyde isovalerianique

* 1-Butanal, 3-methyl-

* Isoamyl aldehyde

* Isopentaldehyde

* Isovaleral

* Isovaleraldehyde

* Isovaleric aldehyde

* 2-Methylbutanal-4

* 3-Methylbutanal

* 3-Methylbutyraldehyde








REFERENCE :



-,271,1986






REFERENCE :



-,271,1986






TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :








TOXIC EFFECTS :


REFERENCE :

CSCIAE Clinical Science. (Biochemical Society Book Depot, POB 32,

Commerce

Way Colchester, Essex CO2 8HP, UK) V.1-44, 1933-73; V.56- 1979-






TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :


REFERENCE :

APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353

Vineuil,






TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :


House,



26,379,1988







NIOSH Analytical Method, 1994: Aldehydes, screening, 2539

ISOVALERIC ACID

RTECS NUMBER : NY1400000

CHEMICAL NAME : Isovaleric acid








WISWESSER LINE NOTATION : QV1Y1&1



* Acetic acid, isopropyl-

* Butyric acid, 3-methyl-

* Delphinic acid

* Isopentanoic acid

* Isopropylacetic acid

* Isovalerianic

* Isovalerianic acid

* Kyselina isovalerova

* 3-Methylbutanoic acid

* 3-Methylbutyrate

* beta-Methylbutyric acid

* 3-Methylbutyric acid








REFERENCE :








REFERENCE :


For





DOSE/DURATION : 940 ug


REFERENCE :







DOSE/DURATION : 2 mL/kg

TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :


V.1-59,


18,141,1961





TOXIC EFFECTS :


REFERENCE :



*** REVIEWS ***

TOXICOLOGY REVIEW


1955-60.


21,100,1960




















ISOVANILLIN

RTECS NUMBER : CU6540000

CHEMICAL NAME : Benzaldehyde, 3-hydroxy-4-methoxy-








WISWESSER LINE NOTATION : VHR CQ DO1



* p-Anisaldehyde, 3-hydroxy-

* 5-Formylguaiacol

* 3-Hydroxy-p-anisaldehyde

* Isovanillin

* Isovanilline

* Oxy-3 methoxy-4 benzaldehyde







TOXIC EFFECTS :


REFERENCE :

COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.

(Paris, France) V.1-261, 1835-1965. For publisher information, see

CRASEV.






TOXIC EFFECTS :


REFERENCE :

APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353

Vineuil,


** MUTATION DATA **




REFERENCE :



206,17,1988



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