POISEUILLE'S LAW Constant Pressure (1) Decreasing the radius of a tube by 1/2 reduces the gas flow to 1/16 of its original flow. ex. If the radius of a bronchial tube through which gas flows at a rate of 50 L/min is reduced to one half its original size, the flow through the bronchial tube would change to: 50 = 3.13 L/min 16 (2) Decreasing the radius of a tube by 1/16 (16%) reduces the gas flow to 1/2 of its original flow. ex. If the radius of a bronchial tube through which gas flows at a rate of 50 L/min is reduced by 16%, the flow through the bronchial tube would change to: 50 = 25 L/min 2 Constant Flow (1) If the radius of a tube is reduced by 1/2, the driving pressure would have to increase 16 times its original level to maintain the same flow. ex. If the radius of a bronchial tube with a driving pressure of 10 cmH20 is reduced to 1/2 its original size, the driving pressure would have to change to: 10 x 16 = 160 cmH20 (2) If the radius of a tube is reduced by 1/16 (16%), the driving pressure would have to increase 2 times its original level to maintain the same flow. ex. If the radius of a bronchial tube with a driving pressure of 10 cmH20 is reduced by 16% , the driving pressure would have to change to 10 x 2 = 20 cmH20 Practice Problems: Poiseuille's Law 1. Assuming the pressure remains constant, if the radius of a bronchial tube through which gas flows at a rate of 400 L/min is reduced to one half of its original size, the flow through the bronchial tube would change to: a. 800 L/min b. 200 L/min c. 50 L/min d. 25 L/min 2. Assuming the pressure remains constant, if the radius of a bronchial tube through which gas flows at a rate of 40 L/min is reduced by 16%, the flow through the bronchial tube would change to: a. 2.5 L/min b. 20 L/min c. 80 L/min d. 640 L/min 3. Assuming the flow remains constant, if the radius of a bronchial tube with a driving pressure of 15 cmH20 is reduced to 1/2 its original size, the driving pressure would have to change to: a. 240 cmH20 b. 30 cmH20 c. 7.5 cmH20 d. 0.94 cmH20 4. Assuming the flow remains constant, if the radius of a bronchial tube with a driving pressure of 20 cmH20 is reduced by 16%, the driving pressure would have to change to: a. 1.25 cmH20 b. 10 cmH20 c. 40 cmH20 d. 320 cmH20 5. Assuming the pressure remains constant, if the radius of a bronchial tube through which gas flows at a rate of 35 L/min is reduced to one half of its original size, the flow through the bronchial tube would change to: a. 560 L/min b. 70 L/min c. 17.5L/min d. 2.19 L/min 6. Assuming the pressure remains constant, if the radius of a bronchial tube through which gas flows at a rate of 70 L/min is reduced by 16%, the flow through the bronchial tube would change to: a. 4.4 L/min b. 35 L/min c. 140 L/min d. 1120 L/min 7. Assuming the flow remains constant, if the radius of a bronchial tube with a driving pressure of 30 cmH20 is reduced to 1/2 its original size, the driving pressure would have to change to: a. 480 cmH20 b. 60 cmH20 c. 15 cmH20 d. 1.88 cmH20 8. Assuming the flow remains constant, if the radius of a bronchial tube with a driving pressure of 40 cmH20 is reduced by 16%, the driving pressure would have to change to: a. 2.5 cmH20 b. 20 cmH20 c. 80 cmH20 d. 640 cmH20 9. Assuming the pressure remains constant, if the radius of a bronchial tube through which gas flows at a rate of 200 L/min is reduced to one half of its original size, the flow through the bronchial tube would change to: a. 400 L/min b. 100 L/min c. 12.5L/min d. 3200 L/min 10. Assuming the flow remains constant, if the radius of a bronchial tube with a driving pressure of 25 cmH20 is reduced to 1/2 its original size, the driving pressure would have to change to: a. 400 cmH20 b. 25 cmH20 c. 12.5 cmH20 d. 1.56 cmH20 Poiseuille's Law Answers to practice problems: 1. d 2. b 3. a 4. c 5. d 6. b 7. a 8. c 9. c 10. a 400 / 16 = 25 L/min 40 / 2 = 20 L/min 15 x 16 = 240 cmH2O 20 x 2 = 40 cmH2O 35 / 16 = 2.19 L/min 70 / 2 = 35 L/min 30x 16 = 480 cmH2O 40 x 2 = 80 cmH2O 200 / 16 = 2.5 L/min 25 x 16 = 400 cmH2O