Professor Albert Moyano
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Albert Moyano was born (1955) and educated in Barcelona. He graduated in Chemistry at the University
of Barcelona (1978), where he also obtained a PhD in Organic Chemistry, under the guidance of
Professor Félix Serratosa. After a postdoctoral stage at the “Joseph Fourier” University in Grenoble
(1985-1986) in the laboratory of Professor Andrew E. Greene, working in asymmetric cycloadditions, he
came back to the University of Barcelona, where he is Full Professor of Organic Chemistry since 2003.
His scientific activity over the years has involved work in theoretical organic chemistry (localized
molecular orbitals, theory of aromaticity), in the application of organometallic chemistry to organic
synthesis (development of enantioselective versions of the Pauson-Khand reaction), and in the
asymmetric synthesis of biologically active compounds. His present research interests are centered in the
enantioselective synthesis of metallocenes, in the development of new methods of catalytic asymmetric
organic synthesis, and in the study of asymmetric autocatalysis and of spontaneous symmetry-breaking
processes. Albert Moyano is the head of the research project AYA2009-13920-C02-02, Experimental and
theoretical models for the abiotic emergence of chirality and its detection as the signature for evolutive systems in
extraterrestrial materials, coordinates the Research Group on Chirality Emergence, Amplification and
Transfer (2009 SGR 881), and is Scientific Advisor to ENANTIA (www.enantia.com), a company
devoted to chemical research and development, custom synthesis and crystal engineering, with a strong
focus on asymmetric chemistry and co-crystallization technologies. Albert Moyano has authored or coauthored more than 180 scientific papers, several patents, and book chapters, and has an h-index (Hirsch
index) of 37.
Selected Publications
“Novel Peptidyl Aryl Vinyl Sulfones as Highly Potent and Selective Inhibitors of Cathepsins L and B”, L.
Mendieta, A. Picó, T. Tarragó, M. Teixidó, M. Castillo, L. Rafecas, A. Moyano, E. Giralt,
ChemMedChem 2010, 5, 1556-1567.
“Enantioselective Organocatalytic Addition of Azlactones to Maleimides: A Highly Stereocontrolled
Entry to 2,2-Disubstituted-2H-oxazol-5-ones”, A.-N. R. Alba, G. Valero, T. Calbet, M. Font-Bardía, A.
Moyano, R. Rios, Chem. Eur. J. 2010, 16, 9884-9889.
“Searching for Untrodden Paths in the Organocatalysis Territory”, G. Valero, X. Companyó, N. Bravo,
A.-N. R. Alba, A. Moyano, R. Rios, Synlett 2010, 1883-1908.
“Bifunctional Thiourea-Catalyzed Asymmetric Addition of Anthrones to Maleimides”, A. Zea, G. Valero,
A.-N. R. Alba, A. Moyano, R. Rios, Adv. Synth. Catal. 2010, 352, 1102-1106.
“Asymmetric Organocatalytic Rearrangement Reactions”, A. Moyano, N. El-Hamdouni, A. Atlamsani,
Chem. Eur. J. 2010, 16, 5260-5273.
“Substrate-dependent Nonlinear Effects in Proline-Thiourea Catalyzed Aldol Reactions. Unraveling the
Role of the Thiourea Co-catalyst”, N. El-Hamdouni, X. Companyó, A.-N. Alba, R. Rios, A. Moyano,
Chem. Eur. J. 2010, 16, 1123-1134.
“Frank Model and Spontaneous Emergence of Chirality in Closed Systems”, J. Crusats, D. Hochberg, A.
Moyano, J. M. Ribó, ChemPhysChem 2009, 10, 2123-2131.
“En route to new chiral ferrocene derivatives: dead ends, detours, and avenues”, A. Moyano, R. Rios,
Synlett 2009, 1863-1886.
“Formal highly enantioselective organocatalytic addition of alkyl anions to a,ß-unsaturated aldehydes.
Aplication to the synthesis of isotope-enantiomers”. A.-N. Alba, X. Companyó, A. Moyano, R. Rios.
Chem. Eur. J. 2009, 15, 11095-11099.
“Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl anion to alpha,betaunsaturated Aldehydes”. A.-N. Alba, X. Companyó, A. Moyano, R. Rios. Chem Eur. J. 2009, 15, 70357038.
“Highly Enantio- and Diastereoselective Organocatalytic Desymmetrization of Prochiral
Cyclohexanones by Simple Direct Aldol Reaction Catalyzed by Proline”. X. Companyó, G. Valero, L.
Crovetto, A. Moyano, R. Rios. Chem. Eur. J. 2009, 15, 6556-6558.
“Organocatalytic kinetic resolution of a planar-chiral ferrocenecarbaldehyde”, A. N. Alba, P. GómezSal, R. Rios, A. Moyano, Tetrahedron: Asymmetry 2009, 20, 1314-1318.
“A highly stereocontrolled route to 2-(2'-oxiranyl)piperidines and pyrrolidines: enantioselective synthesis
of (+)--conhydrine”, Tetrahedron Lett. 2008, 49, 6866-6869.
“Enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde”, G. Valero, A.-N.
Balaguer, A. Moyano, R. Rios, Tetrahedron Lett. 2008, 49, 6659-6652.
“Enantiocontrolled Preparation of the First Stable alpha-Ferrocenylalanine Derivatives”, R. M. Moreno,
M. Catasús, C. López, A. Moyano, Eur. J. Org. Chem. 2008, 2388-2396.
“Diastereoselective addition of organozinc and organomagnesium reagents to 2-(2’pyrimidyl)ferrocenecarbaldehyde”, M. Omedes, P. Gómez-Sal, J. Andriès, A. Moyano, Tetrahedron
2008, 64, 3953-3959.
“An efficient, general synthesis of racemic 2-substituted ferrocenecarboxaldehydes”, J. García, A.
Moyano, M. Rosol, Tetrahedron 2007, 63, 1907-1912.
“Asymmetric Dihydroxylation of 2-Substituted 1-Vinylferrocenes: The First Non-Enzymatic Kinetic
Resolution of Planar-Chiral Ferrocenes”, A. Bueno, M. Rosol, J. García, A. Moyano, Adv. Synth. Catal.
2006, 348, 2590-2596.
“Catalytic Asymmetric Dihydroxylation of 1-Substituted-1-ferrocenylethenes. An Enantioselective Entry
to Chiral Tertiary Ferrocenylcarbinols and Ferrocenylalkylamines”, R. M. Moreno, A. Bueno, A.
Moyano, J. Org. Chem. 2006, 71, 2528-2531.
“Oxazoline-mediated interannular cyclopalladation of ferrocene: Chiral palladium(II) catalysts for
enantioselective aza-Claisen rearrangement”, A. Moyano, M. Rosol, R. M. Moreno, C. López, M. A.
Maestro, Angew. Chem. Int. Ed. 2005, 44, 1865-1869.
“Enantiodivergent, Catalytic Asymmetric Synthesis of gamma-Amino Vinyl Sulfones”, A. Picó, A.
Moyano, M. A. Pericàs, J. Org. Chem. 2003, 68, 5075-5083.
“Sulphur ylide-mediated stereoselective synthesis of a stable ferrocenyl epoxide”, M. Catasús, A.
Moyano, V. K. Aggarwal, Tetrahedron Lett. 2002, 43, 3475-3479.
“Reversing the Stereoselectivity of the Intermolecular Pauson-Khand Reaction: Formation of endo-Fused
Norbornadiene Adducts”, R. Rios, M. A. Pericàs, A. Moyano, M. A. Maestro, J. Mahía, Org. Lett. 2002,
4, 1205-1208.
“-Ferrocenyl--amino alcohols: a new class of central chiral ferrocene derivatives”, M. Catasús, A.
Bueno, A. Moyano, M. A. Maestro, J. Mahía, J. Organomet. Chem. 2002, 642, 212-226.
“A New Chiral Bidentate (P,S) Ligand for the Asymmetric Intermolecular Pauson-Khand Reaction”, X.
Verdaguer, A. Moyano, M. A. Pericàs, A. Riera, M. A. Maestro, J. Mahía, J. J. Am. Chem. Soc. 2000,
122, 10242-10243.
“Acetylene-Dicobaltcarbonyl Complexes with Chiral Phosphinooxazoline Ligands: Synthesis, Structural
Characterization, and Application to Enantioselective Intermolecular Pauson-Khand Reactions”, J.
Castro, A. Moyano, M. A. Pericàs, A. Riera, A. Alvarez-Larena, J. F. Piniella, J. Am. Chem. Soc. 2000,
122, 7944-7952.
“Tris(pyrrolyl)phosphine-Substituted Acetylene-Dicobalt carbonyl Complexes: Syntheses, Structural
Characterization, and Reactivity Studies”, J. Castro, A. Moyano, M. A. Pericàs, A.Riera, M. A. Maestro,
J. Mahia, Organometallics 2000, 19, 1704-1712.
“A superior, readily available enantiopure ligand for the catalytic enantioselective addition of diethylzinc
to -substituted aldehydes”, L. Solà, K. S. Reddy, A. Vidal-Ferran, A. Moyano, M. A. Pericàs, A. Riera,
A. Alvarez-Larena, J. F. Piniella, J. Org. Chem. 1998, 63, 7078-7082.
“A General, Catalytic and Enantioselective Synthesis of (S)--[(S)-1-Aminoalkyl]--lactones”, N.
Aguilar, A. Moyano, M. A. Pericàs, A. Riera, J. Org. Chem. 1998, 63, 3560-3567.
“Ready access to bicyclo[5.3.0]decan-1-ones and to bicyclo[6.3.0]undecan-1-ones by intramolecular
Pauson-Khand reactions using a temporary sulfur bridge”, J. Castro, A. Moyano, M. A. Pericàs, A.
Riera, J. Org. Chem. 1998, 63, 3346-3351.
“Totally Stereocontrolled Intermolecular Pauson-Khand Reactions of N-(2-Alkynoyl) Sultams”, S.
Fonquerna, A. Moyano, M. A. Pericàs, A. Riera, J. Am. Chem. Soc. 1997, 119, 10225-10226.
“Enantioselective Construction of Angular Triquinanes through an Asymmetric Intramolecular PausonKhand Reaction. Synthesis of (+)-15-nor-Pentalenene”, J. Tormo, A. Moyano, M. A. Pericàs, A. Riera,
J. Org. Chem. 1997, 62, 4851-5854.
“Distortive Properties of - and -electrons and Aromaticity: A Semiempirical Localized Molecular
Orbital Approach”, A. Moyano, J. C. Paniagua, Theochem-J. Mol. Struct. 1996, 369, 39-52.
“Asymmetric Approach to (+)--Cuparenone by Intramolecular Pauson-Khand Reaction”, J. Castro, A.
Moyano, M. A. Pericàs, A.Riera, A. E. Greene, A. Alvarez-Larena, J. F. Piniella, J. Org.Chem. 1996, 61,
2016-2020.
“A Straightforward, Highly Stereoselective Synthesis of Protected Isostatine Derivatives”, P. Castejón,
A. Moyano, M. A. Pericàs, A. Riera, Chem. Eur. J. 1996, 2, 189-194.
“A Dual-Function, Highly Efficient Chiral Controller for Stereoselective Intermolecular Pauson-Khand
Reactions”, X. Verdaguer, A. Moyano, M. A. Pericàs, A. Riera, V. Bernardes, A. E. Greene, A. AlvarezLarena, J. F. Piniella, J. Am. Chem. Soc. 1994, 116, 2153-2154.
“Divergent Stereoselective Synthesis of (E) and (Z) O-Alkyl Enol Ethers”, L. Solà, J. Castro, A. Moyano,
M. A. Pericàs, A. Riera, Tetrahedron Lett. 1992, 33, 2863-2866.
“A simple approach for the evaluation of local aromaticities”, A. Moyano, J. C. Paniagua, J. Org. Chem.
1991, 56, 1858-1866.
“Asymmetric Approach to Pauson-Khand Bicyclization. Enantioselective Formal Synthesis of Hirsutene”,
J. Castro, H. Sörensen, A. Riera, C. Morin, A. Moyano, M. A. Pericàs, A. E. Greene, J. Am. Chem. Soc.
1990, 112, 9388-9389.
“A Theoretical Study on Ketene-Olefin Cycloadditions. Part I: Intermolecular Reactions”, E. Valentí, M.
A. Pericàs, A. Moyano, J. Org. Chem. 1990, 55, 3582-3593.
“A Theoretical Study on the Mechanism of the Thermal and the Acid-catalyzed Decarboxylation of 2Oxetanones (-lactones)”, A. Moyano, M. A. Pericàs, E. Valentí, J. Org. Chem. 1989, 54, 573-582.
“Enantioselective ring construction through asymmetric olefin-ketene cycloaddition. A highly
enantiocontrolled approach to (-)--Cuparenone and (+)--Cuparenone”, A. E. Greene, F. Charbonnier,
M. J. Luche, A. Moyano, J. Am. Chem. Soc. 1987, 109, 4752-4753.
“A simple preparation of chiral acetylenic ethers”, A. Moyano, F. Charbonnier, A. E. Greene, J. Org.
Chem. 1987, 52, 2919-2922.
“A facile preparation of chiral O-alkyl enol ethers”, A. E. Greene, F. Charbonnier, A. Moyano, J. Org.
Chem. 1987, 52, 2303-2306.
“Localized molecular orbitals of acyclic polyenes as a basis for a new approach to resonance energies”,
A. Moyano, J. C. Paniagua, J. Org. Chem. 1986, 51, 2250-2257.
“Synthesis of triquinacene derivatives. New approach towards the synthesis of dodecahedrane”, E.
Carceller, M. L. García, A. Moyano, M. A. Pericás, F. Serratosa, Tetrahedron 1986, 42, 1831-1839.