(a) Conditional likelihood Let , , where and is the parameter vector of interest is a vector of nuisance parameters. The conditional likelihood can be obtained as follows: S . 1. Find the complete sufficient statistic 2. Construct the conditional log-likelihood lc log f Y |S where f Y |S Y Y1 , is the conditional distribution of the response Y2 occur. One is that for fixed Yn t given 0 , S 0 S 0 S other is that S . Two cases might depends on is independent of 0 . The 0 .The following examples illustrate the use of conditional likelihood. Example 1: Y1 , Y2 ,, Yn i.i.d N , 2 f y 1 2 2 n n 2 n yi 1 exp i 1 2 2 2 2 n n 2 yi yi 2 n i 1 i 1 exp 2 2 2 2 2 1 S , S 2 statistics for interest and n n Yi , Yi 2 are complete sufficient i 1 i 1 , . Therefore, if 2 2 is the parameter of is the nuisance parameter, the conditional density n function Y1 , Y2 ,, Yn given S Yi is f Y |S i 1 fY y f S t n 2 n y n y i i 2 1 n i 1 i 1 exp 2 2 2 2 2 2 2 2 t n 1 exp 2 2n 2 2n n 2 2 yi t n exp i 1 2 2 2 2 2 2 2 C 2 2 t t n exp 2 2 2 2 2 n 1 n 2 t 2 2 exp y 2 i 2 n i 1 C C C2 C2 2 n yi 1 n 2 i 1 exp yi 2 2 i 1 n n 2 yi y exp i 1 2 2 2 n 2 2 1 2n 2 1 Therefore, the conditional log-likelihood is n lc 2 log C 2 which only depends on inference for 2 2. yi i 1 y 2 2 2 , Thus, we can conduct statistical based on the conditional log-likelihood. Note that the sufficient statistic for , S n Y i 1 i , is independent of 2. Example 2: Y1 ~ N 1 ,1, Y2 ~ N 2 ,1 are independent. Suppose 2 1 is the parameter of interest and 2 is the nuisance parameter. Then, the sufficient statistic for the nuisance parameter given 0 is 12 22 2 S 0 Y1 0Y2 ~ N , 1 0 . 1 The conditional density is 3 y1 1 2 y2 2 2 1 exp 2 2 2 12 22 y1 0 y2 1 1 exp 2 1 02 2 1 02 2 fY | S y2 0 y1 0 1 2 c 0 exp 2 2 1 0 where c 0 1 02 . Thus, 2 y2 0 y1 0 1 lc , 1 , 0 log c 0 . 2 2 1 0 Thus, we can make statistical inference for based on lc , 1, 0 . For example, to find the maximum conditional likelihood estimate, we can solve the score function l , 1 , 0 U c 0 1 y 0 y1 0 1 1 2 1 2 2 2 1 0 0 1 y2 y1 1 2 0 4 ˆ y2 y1 ◆ (intuitively, it is a sensible estimate) General Conditional Likelihood Approach: (I) S 0 S independent of 0 , the conditional For log-likelihood (which only depends on ) can be obtained, . lc log fY | S log fY y log f S y Then, ̂ c lc is the maximum conditional maximizing likelihood estimate. To estimate the variance of ̂ c , the conditional Fisher’s information can be used, I | S Note that both ̂ c and 2lc E t . I | S are, in general, different from those derived from the full likelihood. (II) For S 0 dependent on 0 , the conditional log-likelihood (which only depends on , , 0 ) can be obtained, . lc , , 0 log fY | S 0 log fY y log f S 0 y Then, ̂ c is the solution of l , , 0 U c 0 . 0 , ˆ 5 The asymptotic variance of ̂ c is the inverse of 2lc E t 0 , ˆ . Note: lc , , l , is not the logarithm of a density and does not ordinarily have the properties of a log-likelihood function. 6