PhenX Toolkit Supplemental Information Domain: Sickle Cell Disease: Cardiovascular, Pulmonary, and Renal Release Date: TBD Brain Morphology–Computed Tomography About the Measure Domain Sickle Cell Disease – Neurology, Quality of Life, and Health Services Measure Brain Morphology Definition Medical imaging to determine anatomic features of the brain. About the Protocol Description of Protocol Noncontrast Computed Tomography (CT) of the brain is a noninvasive radiological assessment that produces cross-sectional images due to X-ray absorption by specific tissues. The American College of Radiology–American Society of Radiology (ACR–ASNR) Practice Parameter for the Performance of Computed Tomography of the Brain (Amended 2014, Resolution 39) outlines principles for performing high-quality CT imaging of the brains of adult and pediatric participants. Topics covered include indications for CT of the brain, qualifications and responsibilities of personnel, specifications of the examination, documentation, equipment specifications, radiation safety, and quality control and improvement, safety, infection control, and patient education. Protocol text Noncontrast Computed Tomography (CT) of the Brain The American College of Radiology–American Society of Radiology (ACR–ASNR) Practice Parameter for the Performance of Computed Tomography of the Brain (Amended 2014, Resolution 39) can be found on the American College of Radiology website: http://www.acr.org/~/media/ACR/Documents/PGTS/guidelines/CT_Br ain.pdf Participant All ages Source American College of Radiology–American Society of Radiology (ACR–ASNR). (2014). ACR-ASNR Practice Parameter for the Performance of Computed Tomography of the Brain (Amended 2014, Resolution 39). Available from http://www.acr.org/~/media/ACR/Documents/PGTS/guidelines/CT_Br ain.pdf Language of Source English Personnel and Training Required See the American College of Radiology–American Society of Radiology (ACR–ASNR) Practice Parameter for Performing and Interpreting Diagnostic Computed Tomography (CT) available from PhenX Toolkit Supplemental Information Brain Morphology–Computed Tomography PhenX Toolkit Supplemental Information Domain: Sickle Cell Disease: Cardiovascular, Pulmonary, and Renal Release Date: TBD Brain Morphology–Computed Tomography http://www.acr.org/~/media/ADECC9E11A904B4D8F7E0F0BCF8001 24.pdf Equipment Needs See Section VI. Equipment Specifications in the American College of Radiology–American Society of Radiology (ACR–ASNR) Practice Parameter for the Performance of Computed Tomography of the Brain available from http://www.acr.org/~/media/ACR/Documents/PGTS/guidelines/CT_Br ain.pdf Protocol Type Noninvasive radiologic assessment General References Audebert, H. J., & Fiebach, J. B. (2015). Brain imaging in acute ischemic stroke—MRI or CT? Current Neurology and Neuroscience Reports, 15(3), 526. Howlett, D. C., Hatrick, A. G., Jarosz, J. M., Bingham, J. B., Cox, T. C., & Irvine, A. T. (1997). The role of CT and MR in imaging the complications of sickle cell disease. Clinical Radiology, 52(11), 821– 829. Wasserman, J. K., Perry, J. J., Sivilotti, M. L., Sutherland, J., Worster, A., Émond, M., Jin, A.Y., Oczkowski, W.J., Sahlas, D.J., Murray, H., MacKey, A., Verreault, S., Wells, G.A., Dowlatshahi, D., Stotts, G., Stiell, I.G., & Sharma, M. Computed tomography identifies patients at high risk for stroke after transient ischemic attack/nondisabling stroke: prospective, multicenter cohort study. Stroke, 46(1), 114–119. PhenX Toolkit Supplemental Information Brain Morphology–Computed Tomography