Development of spectroscopic and heat balance methods and instrumentation for non-invasive multi-parameter diagnostics of a blood and biological tissue
Topics: HEALTH-2007-1.2-2, HEALTH-2007-1.2-3
The project is aimed to develop methods and instrumentation which can be used for prototype of
Personal Health System including non invasive multi parameter blood monitoring sensor, data acquisition and communication for connectivity to Health Information Systems.
We have found that spectroscopic measurements of NIR diffuse scattered radiation from a cutaneous tissue and a dynamics of it?s own mid IR radiation can give sufficient information to evaluate non-invasive concentrations of blood components and tissue parameters [1-5]. The idea of the approach under development is to combine spectroscopic information obtained noninvasive from biological tissue with data of heat balance of human body (thermal generation, blood flow rate etc.) to improve a precision of non-invasive blood components and tissue parameters evaluation. Some prototypes of sensor and measuring instrumentation have been developed. Clinical testing of developed equipment is under development now. However accuracy and sensitivity of such methods are not yet enough to displace standard chemometric techniques. This factor as well as tedious calibration procedure which should be based on a database from standard chemometric measurements are the main reasons of limitation for wide use of such a technique in practice.
The aims of the project are:
? To develop methods for non-invasive multi-parameter express monitoring of a blood and biological tissue based on optical spectroscopy and thermal dynamics of the human body.
? To develop improved algorithms and methods of data processing to evaluate with increased reliability physiological and biochemical parameters of a human tissue and blood.
? To develop a compact integrated spectroscopic and thermal biomedical sensors for noninvasive multi-parameter monitoring of blood and biological tissue which are incorporated into microcomputer-based medical instrumentation.
? To perform a systematic investigation of thermal and optical response of human tissue by developed sensor depending on patient group, skin features etc. to simplify and unify a calibration procedure for evaluation noninvasive concentrations of blood components.
? To develop recommendations on optimal sensor configuration and data processing for non-invasive multi-parameter diagnostics of blood and biological tissues.
Results of the intended project can be used by producers of the equipment for non-invasive medical diagnostics. For example, multi-parameter monitoring of blood and tissue of cardiologic patients including newborn pathological child, monitoring glucose concentration in blood of diabetic patients, vascular and dermatology diagnostics, cancer diagnostics.
Recent publications
1. V.A.Saetchnikov and E.A.Tcherniavskaia, G.Schiffner. Fiber optical sensor for noninvasive temperature modulated localized reflectance measurements of blood components in cutaneous tissue. Optical Fibers: Applications, 2005, Proceedings of the SPIE. Volume 5952-33, p 221-229.
2. V.A.Saetchnikov, E.A.Tcherniavskaia, G.Schiffner. Review: Methods of analysis and identification of allocated influence in fibre optical sensors and heterogeneous bio systems // J.
Electronics - INFO. 2006, ?12, PP. 61-66.
3. V.A.Saetchnikov, E.A.Tcherniavskaia, G.Schiffner. Noninvasive analysis of hemoglobin and it?s derivatives concentration in blood. // J. Electronics - INFO, 2006, ?10, PP. 64-66.
4. Saetchnikov V.A., Tcherniavskaia E.A., G.Schiffner Fiber optical sensor for noninvasive optical reflective and thermal emission spectroscopic measurements of blood content in cutaneous tissue// Proceedings SPIE. 2006. Vol. 6191-37. P. 317-326.

5. V.A.Saetchnikov, E.A.Tcherniavskaia, G.Schiffner. Integrated fiber optical and thermal sensor for noninvasive monitoring of blood and human tissue. Approved for SPIE Europe
International Congress on Optics and Optoelectronics, 15-19 April 2007, Prague, Paper: 6585-43.
Contacts:
Prof., Dr. Vladimir A. Saetchnikov
Faculty of Radio Physics and Electronics Belarusian State University Kurchatov Str. 5
220108 Minsk Belarus
Tel. +375 17 209 5833
Fax. +375 17 278 7742 e-mail: saetchnikov@bsu.by