Essay B, Student 6, Expert Marker Describe the Mechanisms Regulating Blood Flow to the Diverse Organs of Vertebrates Blood is an important liquid tissue in vertebrates and it makes up the cardiovascular system alongside the heart and blood vessels. The main components of blood are blood cells; both red and white, platelets, hormones and plasma containing nutrients and ions such as K+ and Na+. Blood plays an important role in the transport of substances to all body organs. The main transport material is oxygen. Red blood cells contain haemoglobins and each can carry 4 molecules of oxygen. To make sure that substances reach the desired organ destinations there are a few mechanisms that regulate the blood flow which involves the pump, blood vessels and muscles. Vertebrates have a closed circulatory system. This has several advantages over open circulations in arthropods and molluscs; closed systems can control the direction of blood to specific tissues by changing the resistance in the vessels, rapid transport of nutrients and wastes to and from cells and also molecules and specialised cells that help in the transport of materials are contained in the vessels (K.PURVES et al., 2004). The heart’s function is to pump blood. The hearts of vertebrates consist of two or more chambers. The main chambers are the atria and ventricles, which is further divided in vertebrates with more than two chambers, to make up the left and right atria and ventricles. The walls of the heart are made up of cardiac muscles. These muscles contract spontaneously making up the heartbeat. The ventricles have thicker muscles as they pump blood out of the heart to the rest of the body. The atria on the other hand, receive blood from other parts of the body. For instance, the unusual feature in a reptilian heart, they have the ability to control the amount of blood going to the lungs and other parts of the body. Reptiles can bypass their blood flow to the lungs and direct all their blood to the rest of their body when not breathing (K.PURVES et al., 2004). This is possible with an additional aorta. This is of course logical since there’s no need for blood to go through the pulmonary circuit if there’s no breathing hence saving energy. Essay B, Student 6, Expert Marker Blood vessels also play a part in regulating blood flow. The major vessels are the arteries, veins and capillaries. The arteries have the thickest walls to withstand the high pressure of rapid flowing blood pumped out of the heart. The walls contain a lot of elastic fibres and collagen for that specific function. Arteries and arterioles are also known as resistance vessels as their resistance can vary (K.PURVES et al., 2004). Smooth muscles in the arterial walls allows the vessels to be dilated or constricted which then changes their resistance to blood flow and hence changes the amount of blood that passes through. They also posses precapillary sphincters (smooth muscle “cuffs”) which can block blood supply to the capillary bed. These changes are controlled by neuronal and hormonal mechanisms. “Most arteries and arterioles are innervated by the autonomic nervous system, especially the sympathetic division” (K.PURVES et al., 2004). Norepinephrine are released by most sympathetic neurone, which causes smooth muscle cells to contract, constricting the vessels and hence reducing blood flow. Some specialized sypathetic neurones in skeletal muscle however releases acetylcholine which does the exact opposite to what norepinephrine does.Other hormones can also affect the vessels such as epinephrine which is released during the fight-or-flight response, angiotensin which is produced when blood pressure in the kidney falls and vasopressin which is released by the posterior pituitary when blood pressure falls. Hormone secretions can also be caused by changes in emotions. These hormones affect the arterioles in the extremities or in tissues that do not need continuous maintenance. They increase the central blood pressure and blood flow to important organs , the heart, brain and kidneys. The blood then goes back to the heart via the veins. Veins have a larger lumen but a thinner wall compared to arteries. The large lumen allows larger volumes of blood to flow back towards the heart. Furthermore, veins are the only blood vessel that possesses valves. These valves are there to prevent the backflow of blood and make sure that blood flow in one direction. Furthermore, veins have thinner walls so they do not have adequate muscles, they then depend on neighbouring muscles which helps to push blood upwards while doing movements and even by breathing. As observed in the venules of the bat wing, peristaltic contractions of the smooth muscle of venules (the vessel connecting capillaries and Essay B, Student 6, Expert Marker veins) can also help to promote venous flow towards the heart (RANDAL et al., 2002). To sum up, there are a lot of mechanisms at work to keep and control the blood flow towards all the organs in a vertebrates’ body. A healthy body system could sense if there was something in error (autoregulation) and produce a correcting mechanism such as the negative feedback mechanism or by secreting hormones to the desired area of the body and keep the blood pressure in check. The cardiovascular system is an effective transport system for blood to reach every part of the body. The highly branched vessels played a major role in regulating blood flow as well. The heart keeps the motion going so without the heart there’s no point in having all these mechanisms as they will not work. The flow of blood toward organs below the heart is also helped by the gravity force. On the other hand, the blood flowing upwards is made possible with valves and movements of muscles around the body. And lastly, these regulations are important to supply enough nutrients and oxygen and remove waste products to and from cells to keep a vertebrate alive. Bibliography Essay B, Student 6, Expert Marker K.PURVES, William, David SADAVA, Gordon H. ORIANS, and H. Craig HELLER. 2004. Circulatory systems. In: Sinauer ASSOCIATES, (ed). Life: The Science of Biology, U.S.A: W. H. Freeman and Company, pp.940-960. RANDAL, David, Warren BURGGREN, and Kathleen FRENCH. 2002. Circulation. In: Jason NOE, Morgan RYAN, and Jane O'NEILL, (eds). Eckert Animal Physiology Mechanisms and Adaptations, New York: W. H. Freeman and Company, pp.473-522.