Online Appendix 1 for the following January, 29 JACC article
TITLE: Carotid Artery Revascularization in High-Surgical-Risk Patients Using the
Carotid WALLSTENT and FilterWire EX/EZ: 1-Year Outcomes in the BEACH Pivotal
Group
AUTHORS: Sriram S. Iyer, MD, FACC, Christopher J. White, MD, FACC, L. N.
Hopkins, MD, Barry T. Katzen, MD, Robert Safian, MD, FACC, Mark H. Wholey, MD,
William A. Gray, MD, FACC, Rocco Ciocca, MD, William B. Bachinsky, MD, FACC,
Gary Ansel, MD, James D. Joye, DO, FACC, Mary E. Russell, MD, FACC, for the
BEACH Investigators
APPENDIX 1: CORE LABORATORIES
Measurement
Core Laboratory
Angiography
Brigham & Women’s Hospital
Angiographic Core Laboratory
(Boston, MA)
Computerized tomography/
Perceptive Informatics Medical Imaging
magnetic resonance imaging
Services (Waltham, MA)
Ultrasound
Vascular Ultrasound Core Laboratory
(Boston, MA)
ECG
Harvard Clinical Research Institute (HCRI)
ECG Core Laboratory (Boston, MA)
Data management/statistical analysis
Harvard Clinical Research Institute
Measurement
Core Laboratory
(Boston, MA)
APPENDIX 2: REFERENCES USED IN THE OPC CALCULATION
References for OPC Determination
AbuRahma AF, Snodgrass KR, Robinson PA, Wood DJ, Meek RB, Patton DJ. Safety
and durability of redo carotid endarterectomy for recurrent carotid artery stenosis. Am J
Surg 1994;168:175–8.
Das MB, Hertzer NR, Ratliff NB, O’Hara PJ, Beven EG. Recurrent carotid stenosis. A
five year series of 65 operations. Ann Surg 1985;202:28–35.
Francfort JW, Gallagher JF, Penman E, Fairman RM. Surgery for radiation- induced
symptomatic carotid atherosclerosis. Ann Vasc Surg 1989;3:14–9.
Gasecki AP, Eliasziw M, Ferguson GG, Hachinski V, Barnett HJ. Long-term prognosis
and effect of endarterectomy in patients with severe carotid stenosis and contralateral
carotid stenosis or occlusion: results from NASCET. North American Symptomatic
Carotid Endarterectomy Trial (NASCET) group. J Neurosurg 1995;83:778–82.
Goldstein LB, McCrory DB, Landsman PB, et al. Multi-center review of preoperative
risk factors for carotid endarterectomy in patients with ipsilateral symptoms. Stroke
1994;25:1116–21.
References for OPC Determination
Goldstein LB, Samsa GP, Machtar DB, Oddone EZ. Multi-center review of preoperative
risk factors for endarterectomy for asymptomatic carotid artery stenosis. Stroke
1998;29:750–3.
Hamdan AD, Pomposelli FB, Jr., Gibbons GW, Campbell DR, LoGerfo FW. Renal
insufficiency and altered postoperative risk in carotid endarterectomy. J Vasc Surg
1999;29:1006–11.
Hertzer NR, O’Hara PJ, Mascha EJ, Krajewski LP, Sullivan TM, Beven EG. Early
outcome assessment for 2228 carotid endarterectomy procedures: the Cleveland Clinic
experience from 1989 to 1995. J Vasc Surg 1997;26:1–10.
Little NS, Meyer FB. Carotid endarterectomy: indications, techniques, and Mayo Clinic
experience. Neuro Med Chir (Tokyo) 1997;37:227–35.
Magnadottir HB, Lightdale N, Harbaugh RE. Clinical outcomes for patients at high risk
who underwent carotid endarterectomy with regional anesthesia. Neurosurgery
1999;45:786–9.
McCrory DB, Goldstein LB, Samsa GP, Landsman PB, Moore WS, Machtar DB.
Predicting complications of carotid endarterectomy. Stroke 1993;24:1285–91.
Meyer FB, Meissner I, Fode NC, Losasso TJ. Carotid endarterectomy in elderly patients.
Mayo Clin Proc 1991;66:464–9.
References for OPC Determination
O’Hara PJ, Hertzer NR, Mascha EJ, Beven EG, Krajewski LP, Sullivan TM. Carotid
endarterectomy in octogenarians: early results and late outcomes. J Vasc Surg
1998;27:860–71.
Rigdon EE, Monajjem N, Rhodes RS. Is carotid endarterectomy justified in patients with
severe chronic renal insufficiency? Ann Vasc Surg 1997;11:115–9.
Rockman CB, Riles TS, Fisher FS, Adelman MA, Lamprello PJ. The surgical
management of carotid artery stenosis in patients with previous neck irradiation. Am J
Surg 1996;172:191–5.
Rothwell PM, Slattery J, Warlow CP. Clinical and angiographic predictors of stroke and
death from carotid endarterectomy: systematic review. BMJ 1997;315:1571–7.
Sternbergh WC, III, Garrard CL, Gonze MD, Manord JD, Bowen JC, Money SR. Carotid
endarterectomy in patients with significant renal dysfunction. J Vasc Surg 1999;29:672–
7.
APPENDIX 3: INVESTIGATORS AND INSTITUTIONS PARTICIPATING IN
THE BEACH TRIAL
Investigator
Institution
Christopher White, MD (trial co-primary
Ochsner Clinic Foundation
Investigator
Institution
investigator)
Sriram Iyer, MD (trial co-primary
Lenox Hill Heart and Vascular Institute
investigator)
Gary Ansel, MD/Barry George, MD
Riverside Methodist Hospital
William Bachinsky, MD/
Pinnacle Health at Harrisburg Hospital
Rajesh Dave, MD
Tanvir Bajwa, MD
Aurora St. Luke’s Medical Center
William Brooks, MD
Central Baptist Hospital
Mark Burket, MD
Medical College of Ohio
Wayne Clark, MD
Oregon Health Sciences University
Edward Diethrich, MD
Arizona Heart Institute & Foundation
Douglas Ebersole, MD
Lakeland Regional Medical Center
Richard Fessler, MD
Wayne State University-Harper University
Hospital
Malcolm Foster, MD
Baptist Hospital of East Tennessee
Thomas Grobelny, MD
St. Luke’s Hospital of Kansas City
Patrick Hall, MD
Providence Hospital
Louis Heller, MD
Piedmont Hospital
L. N. Hopkins, MD
Kaleida Health/Millard Fillmore Hospital
Investigator
Institution
John Jacobs, MD
LDS Hospital
James Joye, DO
El Camino Hospital
William Julien, MD
Northwest Medical Center
Barry Katzen, MD
Miami Cardiac and Vascular Institute
William Knopf, MD
St. Joseph’s Hospital of Atlanta
Robert Koenigsberg, DO
MCP-Hahnemann University
Pierre Leimgruber, MD
Deaconess Medical Center
Demetrius Lopes, MD
Rush Presbyterian-St. Luke’s Medical Center
Cameron McDougall, MD
St. Joseph’s Hospital and Medical Center
Gregory Mishkel, MD
St. John’s Hospital
Ali Mortazavi, MD/Mark Skolkin, MD
St. Luke’s Episcopal Hospital-Texas Heart
Institute
Subbarao Myla, MD
Hoag Memorial Hospital
Takao Ohki, MD, PhD
Montefiore Medical Center
George Petrossian, MD
St. Francis Hospital
Kenneth Rosenfield, MD
Massachusetts General Hospital
John Rundback, MD
New York Presbyterian Hospital
Michael Rush, MD
North Ridge Medical Center
Robert Safian, MD
William Beaumont Hospital
Investigator
Institution
Souheil Saddekni, MD
University of Alabama-Birmingham
Lowell Satler, MD
Washington Hospital Center
Michael Silva, MD
Texas Tech University Health Sciences Center
Richard Smalling, MD, PhD
Memorial Hermann Hospital
Anthony Smith, MD
Duke University Medical Center
Scott Standard, MD
Skyline Medical Center
James Swischuk, MD
St. Francis Medical Center
Jay Yadav, MD
Cleveland Clinic & Foundation
Ajay Wakhloo, MD, PhD
University of Miami-Jackson Memorial Hospital
Lawrence Wechsler, MD
UPMC-Pittsburgh Vascular Institute
Michael Wholey, MD/William Wu, MD
Baptist Hospital
Charles Zacharias, MD
St. Mary’s Hospital
Richard Zelman, MD
Cape Cod Hospital