MANAGEMENT OF COLORECTAL NEOPLASIA DURING PREGNANCY OR IN THE POSTPARTUM PERIOD Erman Aytac, Gokhan Ozuner, Ozgen Isik, Emre Gorgun, Luca Stocchi Department of Colorectal Surgery Digestive Disease Institute, Cleveland Clinic, Ohio Background: Colorectal cancer during pregnancy is rare, but disease diagnosis and management in such instances is extremely challenging. As two patients with possibly conflicting interests need to be managed, many ethical, psycho emotional and medical issues need to be addressed simultaneously. This study reports our experience in this group of patients. Methods: Patients who were diagnosed with colorectal cancer during pregnancy, or in the immediate postpartum period, between August 1997 and April 2013, and who were seen in our institution’s Department of Colorectal Surgery were included in the study. Patient characteristics, operation, fetal heath and follow-up during pregnancy, type of delivery and oncologic outcomes were analyzed. Results: Eight patients met our study criteria. Median age at the time of diagnosis of colorectal cancer was 31 (24-38). Tumor histology was either adenocarcinoma (n=7) and carcinoid tumor (n=1). Median follow-up after surgery was 36 months (0.2-192). The presenting symptoms, duration of symptoms, tumor location and treatment strategy are listed in the table. Median duration of symptoms before diagnosis was 18 weeks. Three patients were diagnosed with colorectal cancer during pregnancy and underwent surgery prior to delivery. These cases included 1 anterior resection with an end colostomy in the 18th week, 1 low anterior resection in the 24th week and 1 subtotal colectomy with an end ileostomy during the 8th week of pregnancy. Five patients were diagnosed with colorectal cancer within a median of 2.1 months after delivery. A synchronous low anterior resection and liver resection, an extensive left colectomy, a transanal resection, an ileocecal resection, and a right colectomy were performed on those patients. None of the patients received adjuvant treatment during pregnancy. No adverse neonatal outcomes were noted. All deliveries were term, except for one patient who had a low anterior resection during pregnancy (34th week) and delivered pre-term. Two patients underwent cesarean section. Conclusion: Most cancers in this group of patients present at a later stage. There has been a significant delay in the diagnosis of these tumors, which may affect overall prognosis. Surgical intervention did not adversely affect neonatal or maternal outcomes in this group of patients. Patients with advanced disease died during or shortly after delivery. 1