Scholar: Irfanul Qayoom Guide: Reshi, Abdul Rashid; Najar, M. Saleem ; Banday, Khursheed A; Bhat, M. Ashraf; Wani, Imtiyaz A.; Khan, Khursheed Aslam. Title: Incidence of contrast induced nephropathy in coronary angiography with or without percutaneous coronary intervention. Keywords: Nephropathy-Non-azotemic Patients; Coronary Angiography Degree: M.D Year: 2009 Institution: Dept of Nephrology and Dept of Cardiology, Sher-i-Kashmir Institute of Medical Sciences. Abstract Objectives: To study 1) the incidence of Contrast Induced Nephropathy in non-azotemic patients undergoing Coronary Angiography with or without Percutaneous Coronary Intervention (PCI). 2) Compare the incidence of Contrast Induced Nephropathy in high risk patients undergoing Coronary Angiography vs low risk patients. Study Design: Hospital based prospective study. Materials & Methods: 150 patients undergoing Coronary Angiography with or without PCI were selected randomly during 2006-2009; their renal function (Blood Urea, Serum Creatinine & Creatinine Clearance) were evaluated and compared at baseline (0hrs), 24 hrs and 5 days after the procedure. Contrast Induced Nephropathy (CIN) defined as increase in serum Creatinine of at least 25% or increase in 0.5mg/dl from baseline. Results: Of 150, 73 were females and 77 were males; mean age of the patients was 54.60±11.60. The incidence of CIN was 8.7% at 24 hours and 2% at day 5 after the procedure; CIN was commoner in diabetic patients (23%) than in non diabetic patients (5.6%). Patients suffering from Left Ventricular dysfunction were at increased risk for CIN particularly those patients who had Ejection Fraction less than 60%. The incidence of CIN was 35.3% in hyperuricemic patients as compared to 5.50% patients with normal Uric acid levels (<6mg/dl). In Patients with Contrast Induced Nephropathy Blood Urea at 24 hrs was 39.62±12.95 mg/dl and at 5 days was 40.40±15.10 mg/dl as compared to mean baseline values (34.60±11.92). It was seen that there occurs significant change in Blood urea as compared to Serum Creatinine and Creatinine Clearance in patients who are suffering from CIN. On the other hand Serum Creatinine and Creatinine Clearance of the patients who were suffering from CIN shows change both at 24 hours and 5 days which was statistically insignificant. Conclusions: The incidence of CIN is 8.7% at 24 hours and 2% at day 5 after the procedure. The incidence of CIN in patients with various risk factors like Diabetes Mellitus, CAD, Hyperuricemia, Hypertension is more as compared to patients with two or less risk factors.