Thomas W. Barrett, MD
Perioperative Medicine References
Last updated: November 2004
I. Perioperative Ischemia
1. Mangano DT, Browner WS, Hollenberg M, London MJ, Tubau JF, Tateo IM,
Association of perioperative myocardial ischemia with cardiac morbidity and
mortality in men undergoing noncardiac surgery. The Study of Perioperative
Ischemia Research Group. N Engl J Med 1990;323(26):1781-8
2. Browner WS, Li J, Mangano DT, In-hospital and long-term mortality in male
veterans following noncardiac surgery. The Study of Perioperative Ischemia
Research Group. JAMA. 1992 Jul 8;268(2):228-32
3. Knight AA, Hollenberg M, London MJ, Tubau J, Verrier E, Browner W,
Mangano DT. Perioperative myocardial ischemia: importance of the preoperative
ischemic pattern Anesthesiology. 1988 May;68(5):681-8
4. Knight AA, Hollenberg M, London MJ, Mangano DT. Myocardial ischemia in
patients awaiting coronary artery bypass grafting. Am Heart J. 1989
Jun;117(6):1189-95
5. Mangano DT Perioperative cardiac morbidity Anesthesiology. 1990
Jan;72(1):153-84.
6. Smith RC, Leung JM, Mangano DT Postoperative myocardial ischemia in
patients undergoing coronary artery bypass graft surgery. S.P.I. Research Group
Anesthesiology. 1991 Mar;74(3):464-73
7. Mangano DT, Hollenberg M, Fegert G, Meyer ML, London MJ, Tubau JF,
Krupski WC Perioperative myocardial ischemia in patients undergoing
noncardiac surgery--I: Incidence and severity during the 4 day perioperative
period. The Study of Perioperative Ischemia (SPI) Research Group. J Am Coll
Cardiol. 1991 Mar 15;17(4):843-50
8. Mangano DT, Wong MG, London MJ, Tubau JF, Rapp JA Perioperative
myocardial ischemia in patients undergoing noncardiac surgery--II: Incidence and
severity during the 1st week after surgery. The Study of Perioperative Ischemia
(SPI) Research Group. J Am Coll Cardiol. 1991 Mar 15;17(4):851-7
9. Smith RC, Leung JM, Keith FM, Merrick S, Mangano DT Ventricular
dysrhythmias in patients undergoing coronary artery bypass graft surgery:
incidence, characteristics, and prognostic importance. Study of Perioperative
Ischemia (SPI) Research Group Am Heart J. 1992 Jan;123(1):73-81
10. Hollenberg M, Mangano DT, Browner WS, London MJ, Tubau JF, Tateo IM
Predictors of postoperative myocardial ischemia in patients undergoing
noncardiac surgery.The Study of Perioperative Ischemia Research Group JAMA.
1992 Jul 8;268(2):205-9
11. Mangano DT Perioperative cardiac morbidity--epidemiology, costs, problems,
and solutions West J Med. 1994 Jul;161(1):87-9
12. Bottiger BW, Motsch J, Teschendorf P, Rehmert GC, Gust R, Zorn M, Schweizer
M, Layug EL, Snyder-Ramos SA, Mangano DT, Martin E Postoperative 12-lead
ECG predicts peri-operative myocardial ischaemia associated with myocardial
cell damage. Anaesthesia. 2004 Nov;59(11):1083-90
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Thomas W. Barrett, MD
13. Raby KE, Brull SJ, Timimi F, et al. The effect of heart rate control on myocardial
ischemia among high-risk patients after vascular surgery. Anesth Analg
1999;88:477-482.
14. Marsch S, Schaefer H, Skarvan K, Castelli I, Scheidegger D, Perioperative
myocardial ischemia in patients undergoing elective hip arthroplasty during
lumbar regional anesthesia. Anesthesiology 1992; 76:518-527
15. French G, Lam W, Rashid Z, Sear J, Foex P, Howell S, Perioperative silent
myocardial ischemia in patients undergoing lower limb joint replacement surgery:
An indicator of postoperative morbidity or mortality? Anesthesia 1999; 54:235240
Established perioperative ischemia as best predictor of adverse events after
surgery, 3 fold increase in adverse cardiac outcomes in those pts that had it,
defined as a >0.1 mV ST depression or >0.2 mV ST elevation in a three lead
Holter monitor lasting for at least one minute. Periop ischemia gives a 28 fold
increase in cardiac complications within 6 months after surgery, 15 fold increase
at 1 year, and 14 fold increase at 2 years. 70% of long term adverse outcomes
were preceeded by periop ischemia at least 30 days before the adverse event.
II. Long term outcomes
1. Krupski WC, Layug EL, Reilly LM, Rapp JH, Mangano DT Comparison of
cardiac morbidity rates between aortic and infrainguinal operations: two-year
follow-up. Study of Perioperative Ischemia Research Group. J Vasc Surg. 1993
Oct;18(4):609-15; discussion 615-7
2. Mangano DT, Browner WS, Hollenberg M, Li J, Tateo IM., Long-term cardiac
prognosis following noncardiac surgery. The Study of Perioperative Ischemia
Research Group. JAMA. 1992 Jul 8;268(2):233-9
3. Fleisher LA, Eagle KA, Shaffer T, Anderson GF Perioperative- and long-term
mortality rates after major vascular surgery: the relationship to preoperative
testing in the medicare population. Anesth Analg. 1999 Oct;89(4):849-55’
4. Kertai MD, Boersma E, Westerhout CM, van Domburg R, Klein J, Bax JJ, van
Urk H, Poldermans D Association between long-term statin use and mortality
after successful abdominal aortic aneurysm surgery. Am J Med. 2004 Jan
15;116(2):96-103
5. Kertai MD, Boersma E, Klein J, Van Urk H, Bax JJ, Poldermans D Long-term
prognostic value of asymptomatic cardiac troponin T elevations in patients after
major vascular surgery. Eur J Vasc Endovasc Surg. 2004 Jul;28(1):59-66
6. Kertai MD, Boersma E, Bax JJ, Thomson IR, Cramer MJ, van de Ven LL,
Scheffer MG, Trocino G, Vigna C, Baars HF, van Urk H, Roelandt JR,
Poldermans D; Dutch Echocardiographic Cardiac Risk Evaluation Applying
Stress Echocardiography (DECREASE) Study Group. Optimizing long-term
cardiac management after major vascular surgery: Role of beta-blocker therapy,
clinical characteristics, and dobutamine stress echocardiography to optimize longterm cardiac management after major vascular surgery. Arch Intern Med. 2003
Oct 13;163(18):2230-5
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Thomas W. Barrett, MD
III. Risk indices:
1. Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Polanczyk CA, Cook EF,
Sugarbaker DJ, Donaldson MC, Poss R, Ho KK, Ludwig LE, Pedan A, Goldman
L, Derivation and prospective validation of a simple index for prediction of
cardiac risk of major noncardiac surgery. Circulation. 1999 Sep 7;100(10):1043-9
2. Detsky AS, Abrams HB, McLaughlin JR, Drucker DJ, Sasson Z, Johnston N,
Scott JG, Forbath N, Hilliard JR Predicting cardiac complications in patients
undergoing non-cardiac surgery. J Gen Intern Med. 1986 Jul-Aug;1(4):211-9
3. Detsky AS, Abrams HB, Forbath N, Scott JG, Hilliard JR. Cardiac assessment for
patients undergoing noncardiac surgery. A multifactorial clinical risk index. Arch
Intern Med. 1986 Nov;146(11):2131-4
4. Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B,
Burke DS, O'Malley TA, Goroll AH, Caplan CH, Nolan J, Carabello B, Slater
EE. Multifactorial index of cardiac risk in noncardiac surgical procedures N Engl
J Med. 1977 Oct 20;297(16):845-50
5. Dupuis JY, Wang F, Nathan H, Lam M, Grimes S, Bourke M The cardiac
anesthesia risk evaluation score: a clinically useful predictor of mortality and
morbidity after cardiac surgery. Anesthesiology. 2001 Feb;94(2):194-204
6. L'Italien GJ, Paul SD, Hendel RC, Leppo JA, Cohen MC, Fleisher LA, Brown
KA, Zarich SW, Cambria RP, Cutler BS, Eagle KA. Development and validation
of a Bayesian model for perioperative cardiac risk assessment in a cohort of 1,081
vascular surgical candidates. J Am Coll Cardiol. 1996 Mar 15;27(4):779-86
7. Dripps RD, Lamont A, Eckenhoff JE The role of anesthesia in surgical mortality
JAMA. 1961 Oct 21;178:261-6 (ASA Classification
8. Gilbert K, Larocque BJ, Patrick LT Prospective evaluation of cardiac risk indices
for patients undergoing noncardiac surgeryAnn Intern Med. 2000 Sep
5;133(5):356-9
9. Kertai MD, Boersma E, Bax JJ, Heijenbrok-Kal MH, Hunink MG, L'talien GJ,
Roelandt JR, van Urk H, Poldermans D. A meta-analysis comparing the
prognostic accuracy of six diagnostic tests for predicting perioperative cardiac
risk in patients undergoing major vascular surgery. Heart. 2003 Nov;89(11):132734
10. Daley J, Khuri SF, Henderson W, Hur K, Gibbs JO, Barbour G, Demakis J, Irvin
G 3rd, Stremple JF, Grover F, McDonald G, Passaro E Jr, Fabri PJ, Spencer J,
Hammermeister K, Aust JB, Oprian C, Risk adjustment of the postoperative
morbidity rate for the comparative assessment of the quality of surgical care:
results of the National Veterans Affairs Surgical Risk Study. J Am Coll Surg 1997
Oct;185(4):328-40
11. Gibbs J, Cull W, Henderson W, Daley J, Hur K, Khuri SF, Preoperative serum
albumin level as a predictor of operative mortality and morbidity: results from the
National VA Surgical Risk Study. Arch Surg 1999 Jan;134(1):36-42
12. Khuri SF, Daley J, Henderson W, Hur K, Demakis J, Aust JB, Chong V, Fabri PJ,
Gibbs JO, Grover F, Hammermeister K, Irvin G 3rd, McDonald G, Passaro E Jr,
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Thomas W. Barrett, MD
Phillips L, Scamman F, Spencer J, Stremple JF, The Department of Veterans
Affairs' NSQIP: the first national, validated, outcome-based, risk-adjusted, and
peer-controlled program for the measurement and enhancement of the quality of
surgical care. National VA Surgical Quality Improvement Program. Ann Surg
1998 Oct;228(4):491-507
13. Khuri SF, Daley J, Henderson W, Hur K, Gibbs JO, Barbour G, Demakis J, Irvin
G 3rd, Stremple JF, Grover F, McDonald G, Passaro E Jr, Fabri PJ, Spencer J,
Hammermeister K, Aust JB, Risk adjustment of the postoperative mortality rate
for the comparative assessment of the quality of surgical care: results of the
National Veterans Affairs Surgical Risk Study. J Am Coll Surg 1997
Oct;185(4):315-27
14. Khuri SF, Daley J, Henderson W, Barbour G, Lowry P, Irvin G, Gibbs J, Grover
F, Hammermeister K, Stremple JF, Aust JB, Demakis J, Deykin D, McDonald G,
The National Veterans Administration Surgical Risk Study: risk adjustment for
the comparative assessment of the quality of surgical care. J Am Coll Surg. 1995
May;180(5):607-9.
15. Shroyer AL, Coombs LP, Peterson ED, Eiken MC, DeLong ER, Chen A,
Ferguson TB Jr, Grover FL, Edwards FH; Society of Thoracic Surgeons. The
Society of Thoracic Surgeons: 30-day operative mortality and morbidity risk
models. Ann Thorac Surg. 2003 Jun;75(6):1856-64; discussion 1864-5
16. Rumsfeld JS, Plomondon ME, Peterson ED, Shlipak MG, Maynard C, Grunwald
GK, Grover FL, Shroyer AL. The impact of ethnicity on outcomes following
coronary artery bypass graft surgery in the Veterans Health Administration. J Am
Coll Cardiol. 2002 Nov 20;40(10):1786-93
17. Prause G, Offner A, Ratzenhofer-Komenda B, Vicenzi M, Smolle J, SmolleJuttner F, Comparison of two preoperative indices to predict perioperative
mortality in non-cardiac thoracic surgery. Eur J Cardiothorac Surg. 1997
Apr;11(4):670-5
18. Weaver F, Hynes D, Hopkinson W, Wixson R, Khuri S, Daley J, Henderson WG
Preoperative risks and outcomes of hip and knee arthroplasty in the Veterans
Health Administration. J Arthroplasty. 2003 Sep;18(6):693-708
Subjective risk indices such as ASA classification of the Dripps ref above has
fared as well as more intensive objective risk indices in clinical validation studies.
IV. Preoperative Guidelines
1. American College of Cardiology/ American Heart Association, Guidelines
Update on perioperative cardiovascular evaluation for noncardiac surgery 2002.
Web site. http://www.americanheart.org. and Circulation. 2002 Mar
12;105(10):1257-67
2. American College of Physicians, Guidelines for assessing and managing the
perioperative risk from coronary artery disease associated with major noncardiac
surgery. Ann Intern Med 1997; 127:309-312
3. Mangano DT, Goldman L Preoperative assessment of patients with known or
suspected coronary disease N Engl J Med. 1995 Dec 28;333(26):1750-6
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Thomas W. Barrett, MD
V. Medical interventions to prevent adverse outcomes
A. Beta-Blockers
1. Stone JG, Foex P, Sear JW, Johnson LL, Khambatta HJ, Triner L. Myocardial
ischemia in untreated hypertensive patients: effect of a single small oral dose of a
beta-adrenergic blocking agent. Anesthesiology 1988;68:495-500.
2. Pasternack PF, Imparato AM, Baumann FG, Laub G, Riles TS, Lamparello PJ,
Grossi EA, Berguson P, Becker G, Bear G, The hemodynamics of beta-blockade
in patients undergoing abdominal aortic aneurysm repair. Circulation 1987;76(3
Pt 2):III1-7
3. Yeager RA, Moneta GL, Edwards JM, Taylor LM Jr, McConnell DB, Porter JM,
Reducing perioperative myocardial infarction following vascular surgery. The
potential role of beta-blockade. Arch Surg 1995;130(8):869-72
4. Mangano DT, Layug EL, Wallace A, Tateo I, Effect of atenolol on mortality and
cardiovascular morbidity after noncardiac surgery. Multicenter Study of
Perioperative Ischemia Research Group. N Engl J Med 1996;335(23):1713-20
5. Wallace A, Layug B, Tateo I, Li J, Hollenberg M, Browner W, Miller D,
Mangano DT, Prophylactic atenolol reduces postoperative myocardial ischemia.
McSPI Research Group. Anesthesiology 1998;88(1):7-17
6. Poldermans D, Boersma E, Bax JJ, et al. The effect of bisoprolol on perioperative
mortality and myocardial infarction in high-risk patients undergoing vascular
surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress
Echocardiography Study Group. N Engl J Med 1999;341:1789-1794.
7. Kertai MD, Boersma E, Bax JJ, Thomson IR, Cramer MJ, van de Ven LL,
Scheffer MG, Trocino G, Vigna C, Baars HF, van Urk H, Roelandt JR,
Poldermans D; Dutch Echocardiographic Cardiac Risk Evaluation Applying
Stress Echocardiography (DECREASE) Study Group. Optimizing long-term
cardiac management after major vascular surgery: Role of beta-blocker therapy,
clinical characteristics, and dobutamine stress echocardiography to optimize longterm cardiac management after major vascular surgery Arch Intern Med. 2003 Oct
13;163(18):2230-5
8. Auerbach AD, Goldman L. beta-Blockers and reduction of cardiac events in
noncardiac surgery: scientific review JAMA. 2002 Mar 20;287(11):1435-44
9. Zaugg M, Tagliente T, Lucchinetti E, et al. Beneficial effects from betaadrenergic blockade in elderly patients undergoing noncardiac surgery.
Anesthesiology 1999;91:1674-1686.
10. Urban M, Markowitz S, Gordon M, Urquhart B, Kligfield P, Postoperative
-aderenergic blockers in patients at risk for
myocardial ischemia. Anesth Analg 2000; 90:1257-1261
11. London MJ, Zaugg M, Schaub MC, Spahn DR. Perioperative beta-adrenergic
receptor blockade: physiologic foundations and clinical controversies.
Anesthesiology. 2004 Jan;100(1):170-5
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Thomas W. Barrett, MD
Mangano 1996 NEJM is the landmark first RCT showing use of BB before and after
surgery decreased mortality in non-cardiac surgery by 2 fold. Wallace Anesth 1998
showed BB decreased periop ischemia by 50%. Also safe and cost effective.
B. Alpha-2-agonists
1. Nishina K, Mikawa K, Uesugi T, Obara H, Maekawa M, Kamae I, Nishi N.
Efficacy of clonidine for prevention of perioperative myocardial ischemia: a
critical appraisal and meta-analysis of the literature. Anesthesiology. 2002
Feb;96(2):323-9
2. Stevens RD, Burri H, Tramer MR Pharmacologic myocardial protection in
patients undergoing noncardiac surgery: a quantitative systematic review. Anesth
Analg. 2003 Sep;97(3):623-33
3. Wijeysundera DN, Naik JS, Beattie WS. Alpha-2 adrenergic agonists to prevent
perioperative cardiovascular complications: a meta-analysis. Am J Med. 2003 Jun
15;114(9):742-52
4. Oliver MF, Goldman L, Julian DG, Holme I. Effect of mivazerol on perioperative
cardiac complications during non-cardiac surgery in patients with coronary heart
disease: the European Mivazerol Trial (EMIT). Anesthesiology. 1999
Oct;91(4):951-61
5. McSPI-EUROPE Research Group. Perioperative sympatholysis. Beneficial
effects of the alpha 2-adrenoceptor agonist mivazerol on hemodynamic stability
and myocardial ischemia. McSPI--Europe Research Group Anesthesiology. 1997
Feb;86(2):346-63
6. Stuhmeier KD, Mainzer B, Cierpka J, Sandmann W, Tarnow J, Small, oral dose
of clonidine reduces the incidence of intraoperative myocardial ischemia in
patients having vascular surgery. Anesthesiology 1996;85(4):706-12
C. Statins
1. Poldermans D, Bax JJ, Kertai MD, Krenning B, Westerhout CM, Schinkel AF,
Thomson IR, Lansberg PJ, Fleisher LA, Klein J, van Urk H, Roelandt JR,
Boersma E. Statins are associated with a reduced incidence of perioperative
mortality in patients undergoing major noncardiac vascular surgery. Circulation.
2003 Apr 15;107(14):1848-51
2. Pan W, Pintar T, Anton J, Lee VV, Vaughn WK, Collard CD Statins are
associated with a reduced incidence of perioperative mortality after coronary
artery bypass graft surgery. Circulation. 2004 Sep 14;110(11 Suppl 1):II45-9
3. Lindenauer PK, Pekow P, Wang K, Gutierrez B, Benjamin EM. Lipid-lowering
therapy and in-hospital mortality following major noncardiac surgery JAMA.
2004 May 5;291(17):2092-9
4. Durazzo AE, Machado FS, Ikeoka DT, De Bernoche C, Monachini MC, PuechLeao P, Caramelli B Reduction in cardiovascular events after vascular surgery
with atorvastatin: a randomized trial. J Vasc Surg. 2004 May;39(5):967-75;
discussion 975-6
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Thomas W. Barrett, MD
D. Aspirin
1. Mangano DT; Multicenter Study of Perioperative Ischemia Research Group
Aspirin and mortality from coronary bypass surgery N Engl J Med. 2002 Oct
24;347(17):1309-17
E. Statins and Beta-Blockers
1. Kertai MD, Boersma E, Westerhout CM, Klein J, Van Urk H, Bax JJ, Roelandt
JR, Poldermans D A combination of statins and beta-blockers is independently
associated with a reduction in the incidence of perioperative mortality and
nonfatal myocardial infarction in patients undergoing abdominal aortic aneurysm
surgery. Eur J Vasc Endovasc Surg. 2004 Oct;28(4):343F. Calcium Channel Blockers
1. Wijeysundera DN, Beattie WS, Rao V, Ivanov J, Karkouti K Calcium antagonists
are associated with reduced mortality after cardiac surgery: a propensity analysis.
J Thorac Cardiovasc Surg. 2004 Mar;127(3):755-62
2. Wijeysundera DN, Beattie WS. Calcium channel blockers for reducing cardiac
morbidity after noncardiac surgery: a meta-analysis. Anesth Analg. 2003
Sep;97(3):634-41
3. Wijeysundera DN, Beattie WS, Rao V, Karski J. Calcium antagonists reduce
cardiovascular complications after cardiac surgery: a meta-analysis. J Am Coll
Cardiol. 2003 May 7;41(9):1496-505
G. Beta-Blockers and Quality
1. Schmidt M, Lindenauer PK, Fitzgerald JL, Benjamin EM. Forecasting the impact
of a clinical practice guideline for perioperative beta-blockers to reduce
cardiovascular morbidity and mortality. Arch Intern Med 2002; 162(1):63-9
2. Pollard J, Chow R, Hansen J. Effectiveness of preprinted order forms in
promoting perioperative beta-blocker use. Am J Health-Syst Pharm 2002; 59:35960
3. Lindenauer P, Hospitalists and quality improvement: further tales from the
frontlines. Improving the use of perioperative beta blockers. The Hospitalist 2001;
5(4):12
4. Shojania KG, Duncan BW, McDonald KM, Wachter RM. Matking Health Care
Safer: A Critical Analysis of Patient Safety Practices: Evidence
Report/Technology Assessment No. 43. Rockville, Md: AHRQ Publication 01EO58. 2001
5. Siddiqui AK, Ahmed S, Delbeau H, Conner D, Mattana J, Lack of physician
concordance with guidelines on the perioperative use of beta-blockers. Arch
Intern Med. 2004 Mar 22;164(6):664-7.
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Thomas W. Barrett, MD
6. Lindenauer PK, Fitzgerald J, Hoople N, Benjamin EM, The potential
preventability of postoperative myocardial infarction: underuse of perioperative
beta-adrenergic blockade. Arch Intern Med. 2004 Apr 12;164(7):762-6
7. Schmidt M, Lindenauer PK, Fitzgerald JL, Benjamin EM, Forecasting the impact
of a clinical practice guideline for perioperative beta-blockers to reduce
cardiovascular morbidity and mortality. Arch Intern Med. 2002 Jan 14;162(1):639
8. VanDenKerkhof EG, Milne B, Parlow JL, Knowledge and practice regarding
prophylactic perioperative beta blockade in patients undergoing noncardiac
surgery: a survey of Canadian anesthesiologists. Anesth Analg. 2003
Jun;96(6):1558-65
9. London MJ, Itani KM, Perrino AC Jr, Guarino PD, Schwartz GG, Cunningham F,
Gottlieb SS, Henderson WG, Perioperative beta-blockade: a survey of physician
attitudes in the department of Veterans Affairs. J Cardiothorac Vasc Anesth. 2004
Feb;18(1):14-24
10. Armanious S, Wong DT, Etchells E, Higgins P, Chung F, Successful
implementation of perioperative beta-blockade utilizing a multidisciplinary
approach. Can J Anaesth. 2003 Feb;50(2):131-6.
H. Alpha-2-agonists and Beta-Blockers
1. Licker M, Khatchatourian G, Schweizer A, Bednarkiewicz M, Tassaux D,
Chevalley C The impact of a cardioprotective protocol on the incidence of cardiac
complications after aortic abdominal surgery. Anesth Analg. 2002
Dec;95(6):1525-33
VI. Statement on Perioperative Medicine
1. Mangano DT Perioperative medicine: NHLBI working group deliberations and
recommendations. J Cardiothorac Vasc Anesth. 2004 Feb;18(1):1-6
2. Khan NA, Taher T, McAlister FA, Ferland A, Campbell NR, Ghali WA;
Canadian Perioperative Research Group Development of a perioperative medicine
research agenda: a cross sectional survey BMC Surg. 2004 Sep 20;4(1):11
VII. CNS
1. Newman MF, Wolman R, Kanchuger M, Marschall K, Mora-Mangano C, Roach
G, Smith LR, Aggarwal A, Nussmeier N, Herskowitz A, Mangano DT
Multicenter preoperative stroke risk index for patients undergoing coronary artery
bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI)
Research Group. Circulation. 1996 Nov 1;94(9 Suppl):II74-80
2. Wolman RL, Nussmeier NA, Aggarwal A, Kanchuger MS, Roach GW, Newman
MF, Mangano CM, Marschall KE, Ley C, Boisvert DM, Ozanne GM, Herskowitz
A, Graham SH, Mangano DT. Cerebral injury after cardiac surgery: identification
of a group at extraordinary risk. Multicenter Study of Perioperative Ischemia
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Thomas W. Barrett, MD
3.
4.
5.
6.
7.
Research Group (McSPI) and the Ischemia Research Education Foundation
(IREF) Investigators. Stroke. 1999 Mar;30(3):514-22
Ho PM, Arciniegas DB, Grigsby J, McCarthy M Jr, McDonald GO, Moritz TE,
Shroyer AL, Sethi GK, Henderson WG, London MJ, VillaNueva CB, Grover FL,
Hammermeister KE. Predictors of cognitive decline following coronary artery
bypass graft surgery. Ann Thorac Surg. 2004 Feb;77(2):597-603; discussion 603
Marcantonio ER, Simon SE, Bergmann MA, Jones RN, Murphy KM, Morris JN
Delirium symptoms in post-acute care: prevalent, persistent, and associated with
poor functional recovery. J Am Geriatr Soc. 2003 Jan;51(1):4-9
Marcantonio ER, Flacker JM, Wright RJ, Resnick NM Reducing delirium after
hip fracture: a randomized trial J Am Geriatr Soc. 2001 May;49(5):516-22
Weber JB, Coverdale JH, Kunik ME. Delirium: current trends in prevention and
treatment Intern Med J. 2004 Mar;34(3):115-21
Axelrod DA, Stanley JC, Upchurch GR Jr, Khuri S, Daley J, Henderson W,
Demonner S, Henke PK Risk for stroke after elective noncarotid vascular surgery.
J Vasc Surg. 2004 Jan;39(1):67-72
VIII. Lung
1. Arozullah AM, Khuri SF, Henderson WG, Daley J, Development and validation
of a multifactorial risk index for predicting postoperative pneumonia after major
noncardiac surgery. Ann Intern Med 2001;135(10):847-57
2. Arozullah AM, Daley J, Henderson WG, Khuri SF, Multifactorial risk index for
predicting postoperative respiratory failure in men after noncardiac surgery. The
National Veterans Administration Surgical Quality Improvement Program. Ann
Surg 2000;232(2):242-53
3. McAlister FA, Khan NA, Straus SE, Papaioakim M, Fisher BW, Majumdar SR,
Gajic O, Daniel M, Tomlinson G Accuracy of the preoperative assessment in
predicting pulmonary risk after nonthoracic surgery Am J Respir Crit Care Med.
2003 Mar 1;167(5):741-4. Epub 2002 Dec 04
4. Moller AM, Villebro N, Pedersen T, Tonnesen H. Effect of preoperative smoking
intervention on postoperative complications: a randomised clinical trial Lancet.
2002 Jan 12;359(9301):114-7
5. Arozullah AM, Henderson WG, Khuri SF, Daley J. Postoperative mortality and
pulmonary complication rankings: how well do they correlate at the hospital
level? Med Care. 2003 Aug;41(8):979-91
IX. GI
1. McSweeney ME, Garwood S, Levin J, Marino MR, Wang SX, Kardatzke D,
Mangano DT, Wolman RL; Investigators of the Ischemia Research and Education
Foundation; Multicenter Study of Perioperative Ischemia Research Group
Adverse gastrointestinal complications after cardiopulmonary bypass: can
outcome be predicted from preoperative risk factors? Anesth Analg. 2004
Jun;98(6):1610-7
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Thomas W. Barrett, MD
X. Heme
1. Stover EP, Siegel LC, Parks R, Levin J, Body SC, Maddi R, D'Ambra MN,
Mangano DT, Spiess BD Variability in transfusion practice for coronary artery
bypass surgery persists despite national consensus guidelines: a 24-institution
study. Institutions of the Multicenter Study of Perioperative Ischemia Research
Group. Anesthesiology. 1998 Feb;88(2):327-33
2. Spiess BD, Ley C, Body SC, Siegel LC, Stover EP, Maddi R, D'Ambra M, Jain
U, Liu F, Herskowitz A, Mangano DT, Levin J. Hematocrit value on intensive
care unit entry influences the frequency of Q-wave myocardial infarction after
coronary artery bypass grafting. The Institutions of the Multicenter Study of
Perioperative Ischemia (McSPI) Research Group. J Thorac Cardiovasc Surg. 1998
Sep;116(3):460-7
3. Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM, Perioperative
anemia: an independent risk factor for infection, mortality, and resource
utilization in surgery. J Surg Res 2002;102(2):237-44
XI. VTE Dz
1. William H. Geerts, Graham F. Pineo, John A. Heit, David Bergqvist, Michael R.
Lassen, Clifford W. Colwell, and Joel G. Ray Prevention of Venous
Thromboembolism: The Seventh ACCP Conference on Antithrombotic and
Thrombolytic Therapy Chest 2004;126: 338S-400S
2. Eikelboom JW, Quinlan DJ, Douketis JD Extended-duration prophylaxis against
venous thromboembolism after total hip or knee replacement: a meta-analysis of
the randomised trials Lancet. 2001 Jul 7;358(9275):9-15
3. Alikhan R, Cohen AT, Combe S, Samama MM, Desjardins L, Eldor A, Janbon C,
Leizorovicz A, Olsson CG, Turpie AG; MEDENOX Study Risk factors for
venous thromboembolism in hospitalized patients with acute medical illness:
analysis of the MEDENOX Study Arch Intern Med. 2004 May 10;164(9):963-8
4. Dunn AS, Turpie AG Perioperative management of patients receiving oral
anticoagulants: a systematic review Arch Intern Med. 2003 Apr 28;163(8):901-8
5. Turpie AG, Bauer KA, Eriksson BI, Lassen MR Fondaparinux vs enoxaparin for
the prevention of venous thromboembolism in major orthopedic surgery: a metaanalysis of 4 randomized double-blind studies. Arch Intern Med. 2002 Sep
9;162(16):1833-40
XII. Renal
1. Mangano CM, Diamondstone LS, Ramsay JG, Aggarwal A, Herskowitz A,
Mangano DT. Renal dysfunction after myocardial revascularization: risk factors,
adverse outcomes, and hospital resource utilization. The Multicenter Study of
Perioperative Ischemia Research Group. Ann Intern Med. 1998 Feb 1;128(3):194203
2. Kashyap VS, Cambria RP, Davison JK, L'Italien GJ. Renal failure after
thoracoabdominal aortic surgery. J Vasc Surg. 1997 Dec;26(6):949-55; discussion
955-7
3. Kertai MD, Boersma E, Bax JJ, van den Meiracker AH, van Urk H, Roelandt JR,
Poldermans D. Comparison between serum creatinine and creatinine clearance for
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Thomas W. Barrett, MD
4.
5.
6.
7.
the prediction of postoperative mortality in patients undergoing major vascular
surgery Clin Nephrol. 2003 Jan;59(1):17-23
O'Brien MM, Gonzales R, Shroyer AL, Grunwald GK, Daley J, Henderson WG,
Khuri SF, Anderson RJ. Modest serum creatinine elevation affects adverse
outcome after general surgery. Kidney Int. 2002 Aug;62(2):585-92
O'Hare AM, Sidawy AN, Feinglass J, Merine KM, Daley J, Khuri S, Henderson
WG, Johansen KL. Influence of renal insufficiency on limb loss and mortality
after initial lower extremity surgical revascularization. J Vasc Surg. 2004
Apr;39(4):709-16
O'Hare AM, Feinglass J, Reiber GE, Rodriguez RA, Daley J, Khuri S, Henderson
WG, Johansen KL Postoperative mortality after nontraumatic lower extremity
amputation in patients with renal insufficiency. J Am Soc Nephrol. 2004
Feb;15(2):427-34
O'Hare AM, Feinglass J, Sidawy AN, Bacchetti P, Rodriguez RA, Daley J, Khuri
S, Henderson WG, Johansen KL Impact of renal insufficiency on short-term
morbidity and mortality after lower extremity revascularization: data from the
Department of Veterans Affairs' National Surgical Quality Improvement Program.
J Am Soc Nephrol. 2003 May;14(5):1287-95.
XIII. Quality Improvement/ Resource Utilization
1. Savino JS, Ley C, Boisvert D, Friedman A, Mathew J, Koch C, Starr N, Mangano
CM, Herskowitz A, Browner WS, Mangano DT; Multicenter Study of
Perioperative Ischemia (McSPI) Research Group; Ischemia Research and
Education Foundation (IREF). Practice pattern variability for myocardial
revascularization: impact on resource use across 24 centers. J Cardiothorac Vasc
Anesth. 2002 Apr;16(2):149-56
2. Grover FL, Shroyer AL, Hammermeister K, Edwards FH, Ferguson TB Jr,
Dziuban SW Jr, Cleveland JC Jr, Clark RE, McDonald G A decade's experience
with quality improvement in cardiac surgery using the Veterans Affairs and
Society of Thoracic Surgeons national databases. Ann Surg. 2001
Oct;234(4):464-72; discussion 472-4
3. O'Brien MM, Shroyer AL, Moritz TE, London MJ, Grunwald GK, Villanueva
CB, Thottapurathu LG, MaWhinney S, Marshall G, McCarthy M Jr, Henderson
WG, Sethi GK, Grover FL, Hammermeister KE; VA Cooperative Study Group on
Processes, Structures, and Outcomes of Care in Cardiac Surgery. Relationship
between processes of care and coronary bypass operative mortality and morbidity.
Med Care. 2004 Jan;42(1):59-70
4. Dimick JB, Chen SL, Taheri PA, Henderson WG, Khuri SF, Campbell DA Jr
Hospital costs associated with surgical complications: a report from the privatesector National Surgical Quality Improvement Program. J Am Coll Surg. 2004
Oct;199(4):531-7
5. Best WR, Khuri SF, Phelan M, Hur K, Henderson WG, Demakis JG, Daley J
Identifying patient preoperative risk factors and postoperative adverse events in
administrative databases: results from the Department of Veterans Affairs
National Surgical Quality Improvement Program. J Am Coll Surg. 2002
Mar;194(3):257-66.
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Thomas W. Barrett, MD
XIV. Dysrhythmias/ Valvular Dz/ Heart Failure
1. Mathew JP, Fontes ML, Tudor IC, Ramsay J, Duke P, Mazer CD, Barash PG,
Hsu PH, Mangano DT; Investigators of the Ischemia Research and Education
Foundation; Multicenter Study of Perioperative Ischemia Research Group. A
multicenter risk index for atrial fibrillation after cardiac surgery. JAMA. 2004
Apr 14;291(14):1720-9
2. Kertai MD, Bountioukos M, Boersma E, Bax JJ, Thomson IR, Sozzi F, Klein J,
Roelandt JR, Poldermans D Aortic stenosis: an underestimated risk factor for
perioperative complications in patients undergoing noncardiac surgery. Am J
Med. 2004 Jan 1;116(1):8-13
3. Hernandez AF, Newby LK, O'Connor CM. Preoperative evaluation for major
noncardiac surgery: focusing on heart failure Arch Intern Med. 2004 Sep
13;164(16):1729-36
4. Torsher LC, Shub C, Rettke SR, Brown DL Risk of patients with severe aortic
stenosis undergoing noncardiac surgery Am J Cardiol. 1998 Feb 15;81(4):448-52
XV. Outpatient Surgery
1. Fleisher LA, Pasternak LR, Herbert R, Anderson GF Inpatient hospital admission
and death after outpatient surgery in elderly patients: importance of patient and
system characteristics and location of care. Arch Surg. 2004 Jan;139(1):67-72
2. Schein OD, Katz J, Bass EB, Tielsch JM, Lubomski LH, Feldman MA, Petty BG,
Steinberg EP. The value of routine preoperative medical testing before cataract
surgery. Study of Medical Testing for Cataract Surgery. N Engl J Med. 2000 Jan
20;342(3):168-75.
XVI. Diabetes Mellitus
1. van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M,
Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R Intensive insulin therapy in
the critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67
XVII. Functional Status
1. Girish M, Trayner E Jr, Dammann O, Pinto-Plata V, Celli B Symptom-limited
stair climbing as a predictor of postoperative cardiopulmonary complications after
high-risk surgery. Chest. 2001 Oct;120(4):1147-51
2. Reilly DF, McNeely MJ, Doerner D, Greenberg DL, Staiger TO, Geist MJ,
Vedovatti PA, Coffey JE, Mora MW, Johnson TR, Guray ED, Van Norman GA,
Fihn SD. Self-reported exercise tolerance and the risk of serious perioperative
complications. Arch Intern Med. 1999 Oct 11;159(18):2185-92.
XVIII. Co-Management
1. Huddleston JM, Long KH, Naessens JM, Vanness D, Larson D, Trousdale R,
Plevak M, Cabanela M, Ilstrup D, Wachter RM; Hospitalist-Orthopedic Team
Trial Investigators Medical and surgical comanagement after elective hip and
knee arthroplasty: a randomized, controlled trial. Ann Intern Med. 2004 Jul
6;141(1):28-38
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