ORALS AT A GLANCE Plenary Lecture 1 – Stefan W. Hell Chair – Oddmund Bakke Far‐field optical nanoscopy: principles and recent advancements Plenary Lecture 2 – Jiri Lukas Chair – Rein Aasland Monday 16:30 – 17:30 Tuesday 09:15 – 10:00 Spatial and temporal limits of genome surveillance: Implications for cancer origin and treatment Tuesday 10:00 – 10:45 Plenary Lecture 3 – Lars Engstrand Chair – Rein Aasland Dynamics and development of the human gut microbiota and its impact on health and disease Plenary Lecture 4 – Andreas Ladurner Chair – Mathias Ziegler Nucleotides and metabolites directly regulate human chromatin Plenary Lecture 5 – Terje Johansen Chair – Mathias Ziegler Molecular Basis for Selective Autophagy Tuesday 11:15 – 12:00 Tuesday 12:00 – 12:45 Plenary Lecture 6 – Angela Gronenborn Tuesday 15:45 – 16:30 Chair – Aurora Martinez An ingenious cloak for subterfuge – the HIV capsid structure Plenary Lecture 7 – Wieland Huttner Tuesday 16:30 – 17:15 Chair – Aurora Martinez Neural Stem and Progenitor cells and Neocortex Expansion in Development and Evolution Minisession 01 – Cell Biology and Signaling I Wednesday 09:15 – 10:15 Chair – Marc Niere MS01.1 The DNA glycosylase NEIL3 maintains pluripotency and differentiation capacity in iPS cells Georgina Askeland, Wei Wang, Katja Scheffler, Panpan You, Rajikala Suganthan, Gareth Sullivan, Magnar Bjørås, Lars Eide 20
Orals at a Glance
MS01.2 A novel role for ATR during cell‐cycle progression through G1 phase Cathrine A. Bøe, Tine W. Håland, Erik Boye, Beáta Grallert MS01.3 Regulation of α‐tubulin deacetylation by cellular NAD levels Renate Hvidsten Skoge, Christian Dölle, Mathias Ziegler MS01.4 Systematic analysis of the DNA damage response accompanying aberrant mitotic divisions using high‐content microscopy Ronni Sølvhøj Pedersen, Thorkell Gudjonsson, Maj‐Britt Druedahl Rask, Beate Neumann, Jean‐
Karim Heriché, Rainer Pepperkok, Jan Ellenberg, Jiri Lukas, Claudia Lukas Minisession 02 – Biotechnology and Biocatalysis I Wednesday 09:15 – 10:15 Chair – Turid Helen Lunde MS02.1 Highlights from the MARZymes bioprospecting project Bjørn Altermark MS02.2 An enzyme discovery and expression pipeline for the conversion of marine biomasses Gro EK. Bjerga, Hasan Arsin, Øivind Larsen, Runar Stokke, Pål Puntervoll, Ida H. Steen, Hans T. Kleivdal MS02.3 The role of the carbohydrate‐binding domain of the Human Chitotriosidase Linn Wilhelmsen Stockinger, Kristine Bistrup Eide, Anette Israelsen Dybvik, Håvard Sletta, Kjell Morten Vårum, Vincent G. H. Eijsink, Anne Tøndervik, Morten Sørlie MS02.4 Microscopy screen reveals involvement of myosin motors and small GTPases in intercellular organelle transfer Dominik Michael Frei, Erlend Hodneland, Ivan Rios Mondragon, Anne Burtey, Beate Neumann, Jutta Bulkescher, Julia Schölermann, Rainer Pepperkok, Hans‐Hermann Gerdes, Tanja Kögel Minisession 03 – Structural Biology and Biophysics I Chair – K. Kristoffer Andersson Wednesday 09:15 – 10:15 MS03.1 Structural Insight into the Function of Ribonucleotide Reductase Marta Hammerstad, Hans‐Petter Hersleth, Ane B. Tomter, Åsmund K. Røhr, K. Kristoffer Andersson 21
MS03.2 Functional and structural characterization of the human phosphohexomutases PGM1 and PGM3 Paul Hoff Backe, Lene Svendsen Kittelsen, Katja B. P. Elgstøen, Lars Mørkrid, Magnar Bjørås MS03.3 Quantum chemical modeling of chorismate mutase catalysis Daniel Burschowsky, Ute Krengel, Einar Uggerud, David Balcells MS03.4 Preparation and Characterization of Bicelles, for the Investigation of Membrane‐
Peptide Interactions by Liquid‐state NMR Ørjan S. Handegård, Øyvind Strømland, Morten Govasli, Øyvind Halskau Minisession 04 – NFR and Computational Biology I Chair – Knut Teigen MS04.1 Norwegian Research Council Monica Bergem Wednesday 11:15 – 12:30 MS04.2 Identification of genes coding for R3 and Z surface proteins of Streptococcus agalactiae Adriana Sanabria, Konika Chawla, Magnus Steigedal, Finn Drabløs, Jan Egil Afset MS04.3 Allosteric modulation of the human GABAB receptor Thibaud Freyd, Dawid Warszycki, Mari Gabrielsen, Stefan Mordalski, Kurt Kristiansen, Zdzisław Chilmonczyk, Andrzej J. Bojarski, Ingebrigt Sylte MS04.4 Identification of Novel Serotonin Transporter Compounds by Virtual Screening Mari Gabrielsen, Rafał Kurczab, Agata Siwek, Małgorzata Wolak, Aina W. Ravna, Kurt Kristiansen, Irina Kufareva, Ruben Abagyan, Gabriel Nowak, Zdzisław Chilmonczyk, Ingebrigt Sylte, Andrzej J. Bojarski Minisession 05 – Molecular Medicine I Wednesday 11:15 – 12:30 Chair – Veronika Kucharova MS05.1 First Trimester Urine and Serum Metabolomics to Predict Preeclampsia and Gestational Hypertension Marie Austdal, Line Haugstad Tangerås, Ragnhild Bergene Skråstad, Kjell Åsmund Salvesen, Rigmor Austgulen, Ann‐Charlotte Iversen, Tone Frost Bathen 22
Orals at a Glance
MS05.2 Cell‐free DNA as biomarker for neonatal asphyxia damages Sophia Manueldas, Javier Escobar, Torkil Benterud, Håvard T. Garberg, Marianne U. Huun, Rønnaug Solberg, Ola Didrik Saugstad, Lars O. Baumbusch MS05.3 Evaluation of neoadjuvant chemotherapy in breast cancer using MR metabolomics Leslie R. Euceda, Tonje H. Haukaas, Guro F. Giskeødegård, Riyas Vettukattil, Geert Postma, Jasper Engel, Lutgarde M.C. Buydens, Anne‐Lise Børresen‐Dale, Olav Engebråten, Tone F. Bathen MS05.4 TMPRSS2:ERG gene fusion in human prostate cancer show decreased levels of citrate and spermine Ailin Falkmo Hansen, Elise Sandsmark, Morten Beck Rye, Alan Wright, Helena Bertilsson, Torill Eidhammer Sjøbakk, Anna M. Bofin, Anders Angelsen, Kirsten Margrete Selnæs, Tone Frost Bathen, May‐Britt Tessem MS05.5 Combining ‘omics’; metabolic breast cancer subclass correlation with protein and gene expression subtypes Tonje Haukaas, Leslie Euceda, Guro Giskeødegård, Marit Krohn, Ellen Schlichting, Rolf Kåresen, Ole Christian Lingjærde, Sandra Jernström, Miriam Aure, Gordon Mills, Kristine Sahlberg, Anne‐
Lise Børresen‐Dale, Tone Bathen Minisession 06 – Cell Biology and Signaling II Wednesday 11:15 – 12:30 Chair – Øyvind Strømland MS06.1 Melanoma cell plasticity enables invasiveness by de‐differentiation and metabolic reprogramming Saurabh Gorad, Ingrid Bettum, Anna Barkovskaya, Solveig Pettersen, Siver Moestue, Ellen Tenstad, Tove Øyjord, Øystein Risa, Vigdis Nygaard, Gunhild Mælandsmo, Lina Prasmickaite MS06.2 Gcn2, an old dog with new tricks Cathrine A. Bøe, Tine W. Håland, Gro Elise Rødland, Erik Boye, Beáta Grallert MS06.3 The role of GCN2 in cell‐cycle regulation in mammalian cells Tine Weise Håland, Randi Syljuåsen, Erik Boye, Beáta Grallert MS06.4 The role of the NAD‐synthesizing enzyme NMNAT2 in cell differentiation Sergiy Kostenko, Mathias Ziegler 23
MS06.5 Increased lipid oxidation and decreased lipid storage in myotubes lacking the lipid droplet binding protein perilipin2 Yuan Zeng Feng, Irlin Knivsland Knabenes, Siril S. Bakke, Jenny Lund, Yun Kyung Lee, Alan R. Kimmel, Hege Thoresen, Arild C. Rustan, Knut Tomas Dalen Minisession 07 – Proteomics and Protein Regulation Chair – Frode Berven Wednesday 15:00 – 16:15 MS07.1 PROBE: A core facility for mass spectrometry based proteomics Frode S. Berven MS07.2 Protein expression profiling of the chemoresistant AML proteome Elise Aasebø, Marc Vaudel, Maria Hernandez‐Valladares, Olav Mjaavatten, Øystein Bruserud, Frode Selheim, Frode Berven MS07.3 The CSF Proteome Resource as a tool for proteomics biomarker discovery in multiple sclerosis Astrid Guldbrandsen, Yehia Farag, Eystein Oveland, Ann Cathrine Kroksveen, Harald Barsnes, Frode Berven MS07.4 METTL21A‐Catalyzed Lysine Methylation of Hsp70 Proteins: From Molecular Mechanisms to Clinical Implications Magnus E. Jakobsson, Anders Moen, Ben Davidson, Ronald Melki, Pål Falnes MS07.5 The evolution of consciousness Bjørn Grinde Minisession 08 – Biotechnology and Biocatalysis II Wednesday 15:00 – 16:00 Chair – Øyvind Halskau MS08.1 How to change the world with a student competition in synthetic biology Hanna Elina Melteig, Vilde Olsson, William Brynildson, Håkon Høgset, Izadora Lorrany, Stian Lågstad, Sumaya Yusuf, Dirk Linke MS08.2 Enzymes for the production of sialic acids Inger Lin Uttakleiv Ræder 24
Orals at a Glance
MS08.3 The next dimension for STED microscopy: 3D STED over the full spectrum Arnold Giske, Wernher Fouquet, Lars Friedrich, Tanjef Szellas, Ulf Schwarz, Simen G. Owe, Jochen J. Sieber MS08.4 Automated Digital Microscopy for Cellular Research Andreas Rieger, Peter Banks Minisession 09 – Structural Biology and Biophysics II Wednesday 15:00 – 16:15 Chair – Anne Baumann MS09.1 Cholera blood‐group dependence and protection by human milk elucidated by SPR and X‐ray crystallography Julie Elisabeth Heggelund, Kristian Prydz, Vesna Hodnik, Gregor Anderluh, Ute Krengel MS09.2 Can We Overcome ß‐Lactamase‐mediated Antibiotic Resistance Through Inhibitor Screening? Hanna‐Kirsti S. Leiros, Susann Skagseth, Trine Josefine Carlsen, Bjarte Aarmo Lund, Tony Christopeit, Ørjan Samuelsen MS09.3 Exploring the link between loosely folded structural ensambles, lipid membrane composition and the formation of annular oligomers Øyvind Strømland, Morten G. Larsen, Hanzhen Wen, Øyvind Halskau MS09.4 Experimental structures of human 8‐oxoguanine glycosylase 1 in complex with novel inhibitors Mari Eknes Ytre‐Arne, Jarl Underhaug, Irina Cornaciu, Guillaume Hoffmann, Aurora Martinez, Matthew Bowler, Gordon Leonard, Jose Antonio Marquez, Magnar Bjørås, Bjørn Dalhus MS09.5 Managing heat and disorder, calorimetric assays in life sciences Peter Gimeson Minisession 10 – Genetics and Epigenetics Chair – Puja Gupta MS10.1 Advances in Next Generation Sequencing Technologies Alexander Magnon Thursday 09:15 – 10:15 25
MS10.2 Structural changes in the CW domain upon binding to the N‐terminal tail of histone H3 monomethylated on lysine 4 (H3K4me1) Øyvind Ødegård, Øyvind Strømland, Marianne Kristvik‐Holmedal, Carol Issalene, Olena Dobrovolska, Valeria De Marco, Stephen R. Martin, Steven J. Gamblin, Øyvind Halskau, Rein Aasland MS10.3 Oxidative stress promotes healthy aging in C. elegans Henok Kassahun, Alfonso Shiavi, Silvia Maglioni, Nicole L. Brockway, Tanima SenGupta, Suzanne Estes, Lars Eide, Natascia Ventura, Hilde Nilsen MS10.4 Droplet Digital PCR (ddPCRTM) – Absolute Quantification with Unrivalled Precision and Sensitivity Pelle Larshammar Minisession 11 – Cell Biology and Signaling III Thursday 09:15 – 10:15 Chair – Rune Kleppe MS11.1 G2 Checkpoint Signalling in Hypoxic Cells Grete Hasvold, Christin Lund‐Andersen, Malin Lando, Sebastian Patzke, ZhenHe Suo, Heidi Lyng, Randi G. Syljuåsen MS11.2 Distribution of NAD between the different cellular compartments is a key determinant of major metabolic pathways Magali R. VanLinden, Christian Dölle, Mathias Ziegler MS11.3 Sorting through sorting nexin tubes regulates endosome maturation Duarte Mateus, Frode Skjeldal, Oddmund Bakke, Gerbrand Koster MS11.4 A role of the promyelocytic leukemia protein in skin development Anna Polec, Alexander D. Rowe, Rajikala Suganthan, Magnar Bjørås, Stig Ove Bøe Minisession 12 – Computational Biology II Thursday 09:15 – 10:15 Chair – Marie‐Josée Halsør MS12.1 VSEARCH: An open and free tool to search, sort and cluster metagenomic data Torbjørn Rognes, Frédéric Mahé, Tomáš Flouri, Christopher Quince 26
Orals at a Glance
MS12.2 Characterization of a Novel Non‐coding RNA Associated with ALK2 Jillian Wise, Baoyan Bai, Sebastien Walchli, Vera Hilden,June Myklebust, Erlend Smeland MS12.3 ELIXIR.NO ‐ The national technology platform for bioinformatics Nils‐Peder Willassen, Erik Hjerde, Inge Jonassen MS12.4 Non‐ulosonic acid biosynthesis in cold adapted bacteria Marie‐Josée H. Halsør, Inger Lin U. Ræder, Bjørn Altermark, Arne O. Smalås Minisession 13 – Biotechnology and Biocatalysis III Thursday 11:15 – 12:15 Chair – Renate Hvidsten Skoge MS13.1 Prolonging the shelf‐life of spermatozoa by immobilizing technology Fride Berg Standerholen, Anne Hege Alm Kristiansen, Karin Elisabeth Waterhouse, Frøydis Myromslien, Geir Klinkenberg, Elisabeth Kommisrud MS13.2 Mammalian defence against chitin‐containing organisms Linn W. Stockinger MS13.3 Comparative Study of Sperm Motility Characters and ATP in Boar Semen from Two Different Breeds during Liquid Storage Nina Hårdnes Tremoen, Teklu Tewolderbrhan Zeremichael, Ann Helen Gaustad, Frøydis Deinboll Myromslien MS13.4 Recent insights into the structure and function of AA10‐type lytic polysaccharide monooxygenases Zarah Forsberg, Jennifer Loose, Bjørn Dalhus, Alasdair K. Mackenzie, Åsmund K. Røhr, Ronny Helland, Andrew S. Arvai, Morten Sørlie, Vincent G. H. Eijsink, Gustav Vaaje‐Kolstad Minisession 14 – Cell Biology and Signaling IV Thursday 11:15 – 12:30 Chair – Christian Dölle MS14.1 Subtle hematological shift but no evidence of immunological impairment in goat kids naturally devoid of the prion protein Malin R. Reiten, Maren K. Bakkebø, Michael A. Tranulis, Arild Espenes, Preben Boysen MS14.2 The role of Wee1 in the regulation of S phase Silje Anda, Christiane Rothe, Erik Boye, Beata Grallert 27
MS14.3 Growth factor‐induced phosphorylation of Eps15 and Hrs regulates their binding to endosomes and RTK degradation Linda H. Haugen, Frode M. Skjeldal, Trygve Bergeland, Oddmund Bakke MS14.4 Calmodulin‐sensitive NAD kinase controls animal NADP biosynthesis Nick R. Love, Nadine Pollak, Christian Dölle, Marc Niere, Yaoyao Chen, Paola Oliveri, Enrique Amaya , Sandip Patel, Mathias Ziegler MS14.5 Duolink Reagents for Localization and Quantitation of Protein‐Protein Interactions Marko Sankala Minisession 15 – Molecular Medicine II Thursday 11:15 – 12:30 Chair – Piotr Mateusz Mydel MS15.1 Metabolic changes in a novel mouse model for liver fibrosis Xiang Yi Kong, Cecilie K. Nesset, Eili T. Kase, G. Hege Thoresen, Arild C. Rustan, Winnie Eskild MS15.2 In Silico Nano‐dissected Immune Profiles of Breast Tumors Ruth Dannenfelser, David Quigley, Laxmi Silwal‐Pandit, Anita Langerød, Hans Kristian Moen Vollan, Charles Vaske, Josie Ursini Siegel, Carlos Caldas, Allan Balmain, Anne‐Lise Børresen‐Dale, Olga Troyanskaya, Vessela Kristensen MS15.3 PAI‐1 inhibits gastrin induced proliferation of the gastric oxyntic mucosa Shalini Rao, Reidar Fossmark, Bjørn Munkvold, Pieter Boekema, Andrea Varro, Liv Thommesen, Kristin G. Nørsett MS15.4 The inflammatory role of HMGB1 in preeclampsia Gabriela Silva, Line Tangerås, Guro Stødle, Liv CecilieThomsen, Lobke Gierman, Bente Skei, Ragnhild Skråstad, Rigmor Austgulen, Line Bjørge, Ann‐Charlotte Iversen MS15.5 The Intimin periplasmic domain mediates dimerisation and binding to peptidoglycan Jack C. Leo, Philipp Oberhettinger, Manish Chaubey, Monika Schütz, Daniel Kühner, Ute Bertsche, Heinz Schwarz, Friedrich Götz, Ingo B. Autenrieth, Murray Coles, Dirk Linke 28