Legend: Plenary sessions Industry Catering Poster sessions Monday 17 November 8.30-9.30 Registration and coffee, put up posters odd 9.30-9.45 Opening: Ben Feringa, Louis Vertegaal, Rutger van Santen 9.45-10.15 Industry speaker: Emmo Meijer Plenary speaker 1: Arieh Warshel Brabantzaal Room 55-57 Boszaal Room 63/64 Room 65 Parkzaal Auditorium Room 80/81 Room 82/83 Molecular Biology and Biochemistry Catalysis Spectroscopy Industry Meets Science Chemical Engineering Computational Chemistry Materials and nanotechnology Organic chemistry Molecular Biology and Biochemistry Catalysis for synthesis Advanced Spectroscopy Smart foods, Health and Sports Chemical Engineering Ab initio and multiscale modeling Self organisation/Self assembly - I Synthetic Methodology - I Membrane proteins and their lipid environment Systems biology: deconstructing to the single molecules level Chair: Joost Reek Chair: Jennifer Herek Chair: Oscar van den Brink Chair: Frank Peters Chairs: Matthias Bickelhaupt & EvertJan Meijer Chair: Willem Kegel Chair: Jean-Paul Seerden Chair: Alessandra Cambi Chair: Wilhelm Huck 11.10 - 11.30 J. Zecevic (UU) Advanced Design and Electron Microscopy Characterization of Hydrocracking Catalysts Jan-Hein Hooijschuur (VU) Raman Spectroscopy of microorganisms and βcarotene on a mineral background To be confirmed Cees Haringa (TUD) Coupled hydrodynamicmetabolic simulations of fermentation processes Hilde D. de Gier (RUG) Improving the generation of free charges in organic solar cells: a computational study Iullia Vos (RUG) SecA is recruited to the protein translocon via a lipid bound intermediate Maike Hansen (RU) Quantifying noise in cell-free gene expression using droplet microfluidics 11.35 - 11.55 Bi-Shuang Chen (TUD) Biocatalytic diastereo- and enantioselective Michael addition of water Elena Maltseva (UvA) High-resolution molecular beam spectroscopy of polycyclic aromatic hydrocarbons in the 3 μm region: theory meets experiment … or not? 12.00 - 12.20 12.25 - 12.45 Pedro Navarro (LEI) Jiawei Rong (RUG) Role of Chemical Structure of Catalytic asymmetric alkylation Host Molecular Crystals In of acylsilanes: methodology Cryogenic Single-Molecule and mechanism Spectroscopy Lando P. Wolters (VU) d Regime, s Regime and Intrinsic Bite-Angle Flexibility: New Concepts for d10-MLn Catalyst Design Stefano Gottardi (RUG) One-step growth of freestanding graphene on a metal-oxide surface David Valdesueiro (TUD) John Van Duynhoven (Unilever Producing core-shell nanoR&D Vlaardingen) structures using Atomic Layer Analytical enablers for food Deposition in fluidized bed innovation reactors Arthur C. Newton (UvA) Anne Geert Volbeda (LEI) Rotational diffusion affects the Advances in Automated Solid dynamical self-assembly Phase Carbohydrate Synthesis pathways of patchy particles Wagner Homsi brandeburgo Dino van Dissel (LEI) Wolter Jager (TUD) (UvA) Giorgios Guridis (RUG) Reverse engineering and Ioana M. Ilie (UT) Highly efficient synthesis of Dynamical modelling study of Ligand-binding mechanism proteomic analysis of a mutant Simulating Patchy Particles by regioisomerically pure 1,7water reorientation and and substrate delivery in ABC of the enzyme producer Rotational Brownian Dynamics dibromo perylene-3,4,9,10spectral diffusion of a transporter with single Streptomyces lividans with tetracarboxylic acid derivatives tetramethylurea-water molecule resolution improved growth properties mixture Danae Morales Angeles (RUG) Lantibiotic induced sequestration of LipidII results in a collapse of membrane potential. Csaba Daday (UT) Muge Artar (TU/e) A. Bode (Aspen Oss BV) Jan van Hest (RUN) Wavefunction embedding for Consequences of Folding a Impact of filter drying of API’s General Adhesive Tissue Tape excited states: You can’t Single Chain Polymer in Water on downstream processability always get what you want Johan Tiesnitsch (IZI) BodyCooling; do you have the chemical answers to our functional questions? Sandip Pawar (Tu/e) Stochastic Euler-Langrangian Modelling Approach for the Agglomeration Inside a Spray Dryer M.J.Kolb (LEI) Water adsorption structures on the step edge of Pt(533) Volodymyr Shvadchak (AMOLF) α-Synuclein amyloid fibrillization kinetics is determined by fibril breaking Backer lecture: Danny Geerdink 12.45 - 14.15 Poster session odd including lunch in separate rooms: Lectures Case studies of Chemical Process innovation, Talent class NWO on grant writing, Workshop 'Dare to communicate!' 14.15 - 15.00 Plenary speaker 2: David Weitz 15.00 - 15.30 Announcement winner Topsector Chemistry Student competition Brabantzaal Catalysis Catalysis and reactors Chair: Emiel Hensen Room 55-57 Analytical Chemistry Boszaal Industry Meets Science Analytical chemistry enabling Highway and Car of the future life sciences Chairs: Thomas Hankemeier & Rawi Ramautar Daniel Wilffert (RUG) Targeted Protein Analysis in Tim Wezendonk (TUD) Serum and Plasma by LCNew synthetic avenues toward MS/MS at the low- and submetal supported catalysts ng/mL level without the use of Antibodies 16.25 - 16.45 Aura Visan (UT) Modeling intrinsic kinetics in immobilized photocatalytic microreactors 16.50 - 17.10 Sebastiaan A. van den Berg (WUR) Organocatalysis and Microreactors: Investigating the Performance of Mesoporous Silica-Supported Catalysts Andrea Gargano (UvA) Towards HYPERformance Liquid Chromatography 17.15 - 17.35 Marianna Casavola (UU) New avenues towards nanostructured catalysts Floris T.G. van den Brink (UT) Mass spectrometric detection of short-lived phase 1 and phase 2 drug metabolites generated using a miniaturized electrochemical cell Robert-Jan Raterink (LEI) High-throughput profiling of small molecules using mass spectrometry Chair: Irene van Luijken Arij van Berkel (TNO Chemie) Room 63/64 Room 65 Parkzaal Auditorium Room 80/81 Room 82/83 Molecular Biology and Biochemistry Materials and nanotechnology Medicinal Chemistry Materials and nanotechnology Organic chemistry Molecular Biology and Biochemistry (Bio)-active surfaces Computational approaches in medicinal chemistry Self organisation/Self assembly - II Bio-inspired materials Glycoscience: from chemistry to disease Integrative structural cell biology: Structure, Dynamics and Cellular context Chair: Han Zuilhof Chair: Iwan de Esch Chair: Peter Bolhuis Chair: Jasper van der Gucht Chair: Xander de Haan Chair: Anastassis Perrakis Bas G.P. van Ravensteijn (UU) Versatile (Anisotropic) Colloidal Platform with Tunable Surface Chemistry & Interactions A. Bunschoten (LUMC) Hybrid imaging tracer for the specific imaging of bacterial infections Bart Lenselink (LEI) Pauline Neirynck (TU/e) Large Scale Free Energy Supramolecular patterned Pertubation (FEP) predictions bioactive surfaces for dynamic on G protein-coupled cell adhesion receptors: applications, limitations and possibilities. Mark JG Bakkers (UU) Joost C.M. Uitdehaag (NTRC) Structural basis and in vivo Analysis of the cancer gene consequences of the dynamic targeting of clinical kinase interaction between the inhibitor drugs by combining murine coronavirus cellular and biochemical hemagglutinin-esterase and Oprofiling acetylated sialic acid Aline Debrassi (WUR) Fabrizio Chiodo (LUMC) Kai Liu (RUG) Frans Kappen (The EU-PEARLS Albert J. Kooistra (VU) Hande E. Cingil (WUR) Biofunctionalization of Porous Design, construction and Biological thermotropic liquid consortium) Towards understanding GPCREquivalent pathways in Aluminum Oxide for the application of glyco-goldcrystals: from stable New sources of natural rubber ligand binding: selectivity, melting and gelation of wellCapture & Growth of mesophases to energy-saving nanoparticles for intervention as a critical raw material function, and binding kinetics defined biopolymer networks Microorganisms of schistosome infections electrochromics R Ekkebus (NKI) Terminal Alkynes and Activesite Cysteine: Profiling Deubiquitinating Enzymes M. van Dijk (VU) Flexible, accurate and Wouter E. Hendriksen (TUD) automated prediction of Transient assembly of active ligand binding affinities to materials fueled by a chemical Cytochrome P450. Application reaction to the CYP19A1 family of aromatases. Alen Sevsek (UU) Guanidinium iminosugars derivatives as glycosidase inhibitors João P.G.L.M. Rodrigues (UU) Integrative Computational Structural Biology of Biomolecular Complexes Torben Heise (RU) Chemical Tools to Study and Perturb the Sialobiology of Cancer Jesika Schilder (LEI) The Encounter complex: Both sides of the story Bert Jan Lommerts and Irina Cotiugă (Latexfalt) A New Preservation Technology for Porous Asphalt Ellart de Wit (HyGEAR) P. J. Glazer (TUD) Multi-Stimuli Responsive Hydrogel Cilia M. Mondal (RUG) Jenny Brinkmann (UT) Fragment Linking of Inhibitors Dynamic bio-active surfaces of the Aspartic Protease using supramolecular building Endothiapepsin Facilitated by blocks Protein-Catalyzed Click Chemistry Isja de Feijter (TU/e) Controlling colloidal selfsorting by supramolecular binding moieties 17.45 - 18.30 Dinner 18.30 - 19.30 19.30 - 19.45 Announcement winner Start-up of the Year 19.45 - 20.30 Plenary speaker 3: Joanna Aizenberg 20.30 - 21.00 Winner KNCV Gold Medal: Award ceremony and lecture 21.00 - 01.00 Lennart Kester (Hubrecht) Snack break 15.30 - 16.00 16.00 - 16.20 Stefan Scheidelaar (UU) A photosynthetic membrane protein purified by an amphipathic polymer into nanodiscs displays native-like membrane properties and enhanced stability Ivo Hendriks (LUMC) Uncovering Small Ubiquitinlike Modifier Signaling Networks Evening programme Asish Pal (RUG) Self-synthesizing materials with narrow length distribution through living supramolecular polymerization Maarten Jaspers (RU) Polyisocyanide Hydrogels Mimicking the mechanics of biopolymer networks CHAINS-square: innovation market, exhibition by sponsors and partners 10.15-11.00 Legend: Plenary sessions Industry Catering Poster sessions Tuesday 18 November 7.45-8.00 presentation NWO/Fund NCI for group leaders including breakfast Breakfast, put up posters even 8.00-8.40 8.40-8.45 Plenary speaker 4: Stefan Hell 9.30-10.15 Plenary speaker 5: Michael Gratzel Brabantzaal Room 55-57 Boszaal Room 65 Room 63/64 Industry Meets Science Materials and nanotechnology Computational Chemistry Materials and nanotechnology Organic chemistry Understanding catalysis Spectroscopy of Biomolecules 3D-printing & Materials Polymer Self Assembly Classical and quantum dynamics Self organisation/Self assembly - III Synthetic Methodology-II Transporting biomolecules Protein - nucleic acid interactions and chromatin structure and function Chair: Thomas Weber Chair: John Kennis Chair: Arjan Mank Chair: Paul van der Schoot Chairs: Geert Jan Kroes & Francesco Buda Chair: Wim Briels Chair: Jean-Paul Seerden Chair: Arnold Driessen Chair: Edwin Cuppen 10.55-11.15 11.20-11.40 Mu-Chieh Chang (RUG) Ligand-Based Redox Reactions in Formazanate Complexes 11.45-12.05 DLJ Broere (UvA) Roel Tempelaar (RUG) Intramolecular Redox-Active Vibrational beatings conceal Ligand-To-Substrate Single Jaco Saurwalt (ECN/Admatec) evidence of long-lived Electron Transfer: Radical electronic coherence in the Reactivity With A Palladium(II) FMO light-harvesting complex Complex Jonathan Martens (RU) Electron/collsion induced dissociation mechanisms of peptides studied by ion spectroscopy Jan Jager (Stenden Hogeschool) New FDM Thermoplastics André Poot (Medisse) Slav Semerdzhiev (UT) Thomas Eisenmayer (LEI) Alejandro Mendez-Ardoy (UT) Self-Assembly of Protein Fibrils Real-time simulations of photoTowards Molecular into Supra-Fibrillar Aggregates: induced energy, electron and Printboards with Improved Bridging the Nano- and proton transfer in molecular Electrical Contact Mesoscale complexes Joost van den Ende (RU) Solid-solid polymorphic transitions in molecular crystals R. Vlijm (TUD) Srividya Ganapathy (LEI) Hans A. V. Kistemaker (LEI) Nucleosome assembly Spectral modulation of The synthesis of well-defined dynamics involve spontaneous rhodopsin proton pumps with mono- and poly-ADPfluctuations in the handedness retinal analogs ribosylated peptides of tetrasomes Sanne Bouwman (VU) T. Orlova (UT) Highly Stereoselective Molecular switches generating Synthesis of Fluorinated chiral structures in liquid Aminoglycosyl Phosphonates crystals Catarina Esteves (TU/e) Multi-functional surfaces: combining surface chemistry and topography Nicolas Renaud (TUD) Mechanical control of quantum interference in pistack dimer O. Nesterov (RUG) Self-assembly of dense ferroelectric memory bits using periodic domain formation in perovskite materials Jeffrey Buter (RUG) 1-Tuberculosinyl Adenosine from M. tuberculosis: Isolation, Biosynthesis, and Total Synthesis Roman Latsuzbaia (TUD) Engineering combinations of self-assembly processes for the high yield synthesis of monodisperse nanoparticles Francesco Nattino (LEI) Ab Initio Molecular Dynamics Calculations versus Experiments: the Methane Dissociation on Pt(111) Janne-Mieke Meijer (UU) Towards complex nanoarchitectures: Selforganization of cubic colloids Luuk Steemers (UvA) Towards scaffold assisted rotaxane synthesis Dirk Slotboom (RUG) Vitamin uptake by pathogenic bacteria Vera Boersma (NKI) Identification of a critical regulator of DNA repair activity at mammalian telomeres. Edith Houben (VUMC) Saartje Hontelez (RU) The membrane complex of the Chromatin state dynamics of type VII secretion machinery embryonic development Jesús Arenas (UU) A novel protein secretion system in Gram-negative bacteria: the Maf system of Neisseria meningitidis Jessica Zuin (EMC) Keep in touch! How Cohesin and CTCF organize the human genome Poster session even including lunch in separate rooms: Meetings study group leaders, Lecture Case studies of Chemical Process innovation, Workshop 'Dare to communicate!' 12.10-13.45 Brabantzaal Room 55-57 Boszaal Room 63/64 Room 65 Parkzaal Auditorium Room 80/81 Room 82/83 Catalysis Analytical Chemistry Education Materials and nanotechnology Medicinal Chemistry Materials and nanotechnology Organic chemistry Molecular Biology and Biochemistry Molecular Biology and Biochemistry Nanostructured and nanomodified polymers Kinetic and Thermodynamic Aspects of Ligand-Protein interactions 3rd generation solar cells Chemical Biology Metabolism: from chemistry to organismal homeostasis and disease Lipid and protein signaling Chair: Katja Loos Chair: Laura Heitman Chair: Bernard Dam Chair: Luc Brunsveld Chair: Koen van de Wetering Chair: Teun Munnik Jianbing Jiang (LEI) Activity-based profiling of retaining glycosidases Catalysis for biomass, Analytical chemistry enabling renewable hydrogen and solar material sciences fuels 15.00-15.20 Room 82/83 Molecular Biology and Biochemistry Spectroscopy Florian Meirer (UU) Nicoletta Liguori (VU) Anton Hofman (RUG) Metal poisoning of single The C-terminus of LHCSR Daan Kerstens Hierarchical Self-Assembly of catalyst particles as studied drives a peculiar pHwith X-ray nano-tomography: dependent quenching which is (Additive industries & Add lab) Supramolecular Double-Comb Correlating pore network and absent in all related PSII Diblock Copolymers elemental distribution antennae 14.35-14.55 Room 80/81 Catalysis 10.30-10.50 14.10-14.30 Auditorium Molecular Biology and Biochemistry Steven J. Roeters (UvA) Ivo Filot (Tu/e) Amyloid Formation Predictive microkinetic Investigated with a modeling of complex catalytic Combination of Advanced reactions: the Fischer-Tropsch Vibrational Spectroscopy and reaction Electron Microscopy 13.45-14.05 Parkzaal Chair: Elinor Scott Chair: Ernst van Eck Frits van der Klis (WUR) Heterogeneous selective terminal C-C scission of C5carbohydrates Daan de Kort (WUR) Functionalized diffusional nanoprobes for sub-micron structural characterization of heterogeneous hydrogels. Wilson Smith (TUD) Tandem PV/PEC Devices for Solar Fuel Production Monique Jacobs (RUN) Mechanical activation of a latent carbene catalyst at the single molecule level by breaking a covalent bond M. Nasalevich (TUD) Gert Salentijn (RUG) Cobaloxime Encapsulation in a Performance Enhancement of Photo-active Metal-Organic Paper Spray Ionization by Framework for Light-driven H2 Integration into a 3D-Printed Production Cartridge Remco Detz (UvA) Solar to hydrogen devices based on molecular components. Marcel van de Put (TU/e) Bio-inspired silica formation: highly cross-linked silica in an aqueous, room temperature synthesis Chair: To be confirmed Talent programmes Giuseppe Portale (DUBBLE) Structural investigation of novel polymer/metal nanoparticle systems Ewald Edink (UvA) Breaking the equilibrium Janneke Ravensbergen (VU) dissociation constant into Femtosecond to millisecond fragments: The use of binding charge carrier dynamics of kinetics and thermodynamics bismuth vanadate, a new solar in the development of fuel champion material selective ligands using fragment-based drug design Robert Jansen (NKI) N-Lactoyl-amino acids - A novel class of mammalian metabolites formed by reverse proteolysis of lactate and amino acids Sandra de Keijzer (RUNMC) Cortical microtubules shape GPCR spatiotemporal membrane organization and signaling. 'Docent van het jaar' Zhen Liu (TUD) Dual networks of reversibly crosslinking polymers and organically modified clay platelets; Combining selfhealing, and load-bearing properties Dong Guo (LEI) Arjan Geersing (RUG) Structure-affinity and Development and Application M. Aerts (TUD) Celia Berkers (UU) structure-kinetics relationship Efficient carrier multiplication of Novel Molecular Tools for How metabolism controls the study: a new combination the Study of Reactive Oxygen in colloidal PbS nanosheets proteasome strategy in medicinal Species in Living Cells chemistry Dušan Popov-Čeleketić (UU) Spatial organization and mobility of EGF receptor Life-long learning Sonja Castillo (UU) Colloidal cubes: synthesis, function control and applications. Maria Bartel (TU/e) Stabilization instead of inhibition: The surface makes the difference. Tom Savenije (TUD) Charge carrier dynamics in organometal halide perovskites How to connect education with industry Charley Schaeffer (TU/e) Demixing and structuring of Polymer Solutions Upon Forced Evaporation Constantinos Neochoritis (RUG) Targeting intrinsically disordered protein states: Novel p53-MDM2 inhibitors Sidharam Pujari (WUR) Solid-state Molecular Logic Gates: Light, electrons and information 15.20-15.45 Snack break 15.45-16.00 Announcement winners poster prizes 16.00-16.45 Plenary speaker 6: Kim Nasmyth 16.45 Closure S.A. Bode (RU) Controlling the Activity and Specificity of Cell-Penetrating Peptides Joanna Kaplon (NKI) A Critical Role For The Mitochondrial Gatekeeper Pyruvate Dehydrogenase In Oncogene-Induced Senescence Willem Jan Keune (NKI) Autotaxin: beyond hydrolyzing lysophospholipids Matthijs J. van Lint (VU) Acetogenins: Chemoenzymatic Synthesis And Molecular Probing Of Respiratory NADH Dehydrogenases Grzegorz Pawlik (UU) Trans-catalysis by the yeast phospholipid methyltransferase Opi3 Joachim Goedhart (UvA) Visualizing the chemistry of cellular decision making with engineered fluorescent biosensors CHAINS-square: innovation market, exhibition by sponsors and partners 8.45-9.30