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What is VESIsorb®?
Naturally self-assembling colloidal delivery
system that enables us to meet the growing
demand for enhanced bioavailability of
unique science-based formulas taking their
absorption and efficacy to the next level.
Pure Science. Innovative Thinking. Unparalleled Quality
1
Delivers Maximum Benefits
• Consistent advantage under all conditions
• Absorption & bioavailability impacted by
– Aging population = nutrient absorption declines
with age
– Low-Fat Diet…see Omthera study Lovaza vs.
Epanova
– Sickness & Stress negatively impact absorption
– More standard capsules = < efficient absorption
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2
Introducing VESIsorb®
Ultimate Red Yeast Rice
The VESIsorb® Ultimate Red Yeast Rice
is a one-of-a kind formulation, never
before available, with the most clinically
proven, thoroughly tested, safe and
efficacious combination of ingredients
that deliver powerful benefits all in one
patent-pending formulation.
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3
VESIsorb® Ultimate Red Yeast Rice
• No other red yeast rice formulation contains Cholesstrinol™HP
which has been clinically proven to deliver natural support for
healthy total cholesterol, LDL cholesterol, triglycerides, and HDL
cholesterol.
• Cholesstrinol™HP delivers multiple heart health benefits
working synergistically with the organic red yeast rice and
CoQsource® coenzyme Q10, one of the most absorbable and
bioavailable coenzyme Q10 formulations, in the patented
VESIsorb® delivery system.
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4
™
What is Cholesstrinol ?
• Cholesstrinol™ is an award winning platform of proprietary
heart healthy formulas that tells a powerful brand story.
• It pulls together the detailed scientific data in an easy-tounderstand package for the consumer reducing, if not
eliminating, the need for laborious guesswork or research on
their part.
• Branding these combinations under the name – Cholesstrinol™ –
is designed to leverage their scientific basis.
• It is a widely scoped and all-encompassing platform that
provides numerous targeted and customized solutions for
consumers with specific cardiovascular concerns.
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5
Three Different and Complementary Mechanisms
to Modify Cholesterol and Triglycerides
1. Polymethoxylated flavones (PMFs) decrease apoprotein B, a structural protein needed for
endogenous synthesis of LDL cholesterol.
Lipids, Vol 39. no2., 2004
Kurowski and Manthely., 2002
2. PMFs Tangeretin and Nobiletin decrease diacylglycerol acetyl transferase (DGAT), a liver
enzyme needed for endogenous synthesis of triglycerides.
Lipids, Vol 39. no2.,2004
3. Tocotrienols inhibit HMG CoA reductase, a liver enzyme needed for endogenous synthesis of
cholesterol.
Pearce et al ., 1992; Parker et al., 1993; Qureshi et al., 1996
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6
CHOLESTEROL
SYNTHESIS
ACETYL COA
HMG-CoA
STATIN
Reductase
X
HMGCRINCREASE RATE
OF NATURAL
DEGRADATION
HMG-CoA
REDUCTASE
GERANIOL
FARNESOL
TOCOTRIENOL
(Targets Farnesol)
Down Regulates
HMGCR
GERANYL GERANIO
PROTEINS
Pure
Protein ↓ by statin
Science.
May lead toInnovative
myopathy
CHOLESTEROL
CoQ10
CoQ10 ↓ by statin
Thinking.May
Unparalleled
Quality
lead to ↓ energy
7
PMF Mechanism

Fatty Acids
DGAT
X
Triglycerides
LDL Lipoprotein Assembly
MTP
Triglycerides
X
PPAR
Fatty acids
Nascent apo B
ß-ox
Fatty acids
Triglycerides
Pure Science. Innovative Thinking. Unparalleled Quality
Kurowska et al.,2004
8
4-week Clinical Results
TC
0%
% Reduction
-5%
I
ΙΙ ΙΙΙ
LDL
I
ΙΙ ΙΙΙ
TG
I
LDL / HDL
ΙΙ ΙΙΙ
I
ΙΙ ΙΙΙ
-10%
-15%
-20%
-25%
-30%
-35%
Multiple Clinical Study Summary
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Exclusive Partnership with World Leader in Citrus
Bioflavonoids and Polymethoxylated Flavones (PMFs)
•
Through SourceOne’s exclusive partnership
with Ingredients by Nature (IBN), the world
leader in citrus extracts, we have established
ourselves as the principal marketer of Citrus
Bioflavonoids and PMFs with multiple
products, including our award-winning
Cholesstrinol Family of Heart Healthy
Formulas.
–
–
–
Over 80 years of analytical experience and expertise.
New showcase facility and on-site state-of-the-art
laboratory.
Formulation expertise through proprietary blending
granulation and state of the art sterilization.
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10
Published Study Results
Alternative Therapies in Health and Medicine published
the results of several studies that combined the PMFsource™ and TocoSource™, key ingredients found in
Cholesstrinol™. The largest study, a 12-week double
blind, placebo-controlled protocol with 120 subjects,
resulted in significant improvements in total cholesterol
(-30%), LDL (-27%), and triglycerides (-34%).
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11
SourceOne Global Partners
“Delivering the best science nature has to offer.”
- Thank You
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