This toxin causes “bathtub
refinisher’s lung” and is the
largest recognized cause of
occupational asthma
Toluene di-isocyanate (TDI)
This pesticide is best known for
its toxicity involving male
sterility
Dibromochloropropane ((DBCP)
Re: “Da Balls Can’t Produce”
Which solvent is associated with
“degreaser’s flush” and
trigeminal neuralgia?
Trichloroethylene
This intoxicant is a NTE inhibitor
resulting in a sensory-motor
neuropathy. It is linked to large
outbreak of cases in 1960
Morocco but better known for
its link to Ginger Jake
Triorthocresyl phosphate
(TOCP)
What is the leading cause of
lung cancer behind tobacco
smoke?
Radon
What chemical has the smell of
freshly mowed hay?
Phosgene
Name a metal that results in
non-fibrogenic benign
pneumoconiosis with exposure
Tin (Stannosis)
Barium (Baritosis)
Iron (siderosis)
Calcium (Chalitosis)
Molybdenum
What chemical was this worker
using that resulted in his
acroosteolysis
Vinyl chloride
What is the most common
medication associated with
hypersensitivity pneumonitis
Nitrofurantoin
Name the mushroom
responsible for muscle
weakness 24-72 hrs after
ingestion with massive CPK
elevations.
And a 25% mortality to boot!
Tricholoma equestre
What maternal chemical
exposure may result in mental
retardation and “cola-colored”
discoloration at birth?
PCBs
(remember Pepsi-Colored
Babies)
Natural Log (ln)
Drug Concentration
Drug Concentration
Name the order of elimination
Time (hrs)
Time (hrs)
st
1
Order Elimination
Which metal is radiolucent on
plain film radiograph?
Copper
Name the structure
Succimer (DMSA)
What chemical uses urine
hippuric acid for biological
monitoring during worker
exposure?
Toluene
What is the only organic
phosphorus pesticide that
possesses a significant
vapor hazard (i.e., has a high
vapor pressure)?
Dichlorvos
Which natural toxin is
responsible for amnestic
shellfish poisoning?
Domoic acid
(think Dumb-oic acid)
What is reported to be the most
fatal plant species in North
America (30-70% fatality
rate)?
Water Hemlock
Water Gate Candidate Scandal
(Water hemlock, GABA,
Cicutoxin, Seizures)
What part of the action potential
does this plant’s toxin effect?
Nerium oleander
Digitalis – cardiac steroid
Increases resting potential and
effects phase 4 of the cardiac
cycle = increases automaticity
What is the only form of
poisoning caused by
bacterial contamination of
the food?
Scombroid
(Histamine poisoning)
Scombroid
(Histamine poisoning)
Name the plant responsible for
St. Anthony’s Fire and
ergotism
Claviceps purpurea
Name the term for the following
definition:
“The maximum concentration of
a chemical to which workers
may be exposed
continuously for up to 15
minutes without danger to
health or work efficiency and
safety”
STEL
(Short-term exposure limit)
Which sulfonylurea is
associated with SIADH and
disulfiram reactions?
Chlorpropramide
Which antidysrhythmic has
antimuscarinic properties and
causes hypoglycemia in
overdose?
Disopyramide
Name two intoxicants (there are
at least 4) that produce
metaphyseal bands on plainfilm x-ray.
Lead (lead lines)
Yellow phosphorus
Bismuth
Hyervitaminosis D
Name two (there are at least 5)
medications linked to lupuslike syndrome
CHIMP
Chlorpropramide
Hydralazine
Isoniazid
Methyldopa
Procainamide
Which plant species is an
inducer of CYP3A4 isozyme?
St. John’s Wart
(Hypericum perforatum)
Most common cause of
medication-induced contact
dermatitis
Neomycin
What is the biomarker for
benzene exposure in workers?
Urine phenol
Name this plant. Bonus point for
the mechanism of the toxin
Aconitum napellus
Toxin = Aconite Na-channel
opener
What is the only medicationinduced seizure that would
likely respond to phenytoin?
Aminopyridine
Name one toxin or xenobiotic
(there are 3) that causes
biventricular ventricular
tachycardia in toxicity.
Extra point if you can name two.
Cardiac steroids (#1)
Aconitine
Halogenated hydrocarbons
Name the antidote for the following
plaint poisoning
Physostigmine
Datura stramonium
Jimson weed, “Jamestown
weed”, Devil’s apple,
thronapple, locoweed
Contains tropane alkaloids
atropine, hyoscyamine,
scopolamine
Which NSAID is linked to
aplastic anemia?
Phenylbutazone
Name the alkylating agent that
causes hemorrhagic cystitis
and has MESNA as the
antidote.
Cyclophosphamide
Name as many xenobiotics or
chemicals for which urine
alkalinization (ion trapping)
enhances drug elimination
Point for each
Salicylates
Phenobarbital
Methotrexate
Chlropropramide
Chlrophenoxy herbicides
Fluoride
Name the structure
Morphine
Name the most lethal cnidaria,
(linked to death in minutes)
Carukia barnesi
Box jellyfish
What chemical is associated
with Silo Filler’s Disease?
Nitric oxides (NO, NO2)
Name as many basal ganglia
toxins as you can
Point for each (up to 4 points)
Carbon disulfide
Carbon monoxide
Manganese
Methanol
What is the remediation level for
home radon set by the EPA?
4 pc/L
What is the OSHA permissible
exposure limit (PEL) for
benzene?
1 ppm
Name four poisonings for which
vitamin B6 (pyridoxine) could
be used as an antidote. Point
for each up to 4 points
Isoniazid
Gyromitra esculenta
Hydrazines
Ethylene glycol
Name this mushroom responsible
for delayed renal failure.
Bonus point for the toxin.
Cortinarius orellanus
“False Chanterelle”
Orelline, orellanine
Name two plants that contain
colchicine
Colchicum autumnale
Gloriosa superba
Name a commonly used
anticonvulsant (there are two)
that binds to the same site as
batrachotoxin from the poison
dart frog (Phyllobates ssp.)
Phenytoin
Carbamazepine
Name two animals that contain
tetrodotoxin
Puffer fish
Blue-ringed octopus
Toads of the genus Atelopus
Newts (rough-skinned,
California)
Horseshoe crab
Name the chemical implicated
in neonatal gasping syndrome.
Bonus point for the year it
occurred.
Benzyl alcohol
1982
Which nerve agent has the
shortest aging half-life?
Soman
Agent
– Sarin
– Soman
– Tabun
– VX
Odor
GB
GD
GA
VX
None
Fruity
Almonds
None
Aging t½
5 hrs
2 min
> 40 hrs
< 40 hrs
Which antibiotic is associated
with the development of
serotonin syndrome?
Linezolid