The first building with
more than 2500 m2 of
active area is already
constructed. But there is
no investments for
technological equipment.
The investigations are carried out in the fields
of bioorganic and organic chemistry, molecular
biology and immunology, biochemistry and
biotechnology.
• Founded in 1964
• Previous name
Institute of Biologically Active Substances
• President-Organizer
Academician G.B. Elyakov
. Acting Director (from 2001)
Academician V.A. Stonik
Total - 356 persons
Scientific staff – 183, including:
Academician of RAS - 2
Corresponding member of RAS - 1
Doctor of Science - 22
Ph. D. - 158
Young scientists - 34
Department of Low Molecular Regulators
 Department of the Molecular Immunology
 Laboratory of the Plant Chemotaxonomy
 Laboratory of the Enzyme Chemistry
 Laboratory of the Marine Biochemistry
 Laboratory of the Structural and Analytical Methods
 Laboratory of the Instrumental and Radionuclide Methods
 Laboratory of the Biotechnology
 Group of the N.M.R.-Spectroscopy
 Group of the Phytoimmunity
 Group of the New Medicines and Preventives
 Other Scientific Services

Laboratory of the Chemistry of Marine Natural
Compounds
Laboratory of the Chemistry of Microbial Metabolites
Laboratory of the Peptide Chemistry
Laboratory of the Organic Synthesis
Laboratory of the Chemistry of Natural Quinoid
Compounds
Laboratory of the Microbiology
Laboratory of the Bioassay
Group of the Lipid Chemistry
 Laboratory of the Carbohydrate Chemistry
 Laboratory of the Chemistry of NonInfective Immunity
 Laboratory of the Molecular Basics of
Antibacterial Immunity
 The Marine Experimental Station
 Research Vessel «Akademik Oparin»
 Department of Scientific Information
 Department of Patents
 Vivary
 Pilot Group
 Department of Devices
 Group of Glassware
 Laboratory of the Trade Ecology
 Group of Marketing
(Pacific Institute of Bioorganic Chemistry)
(Official acronym in World Federation
for Culture Collection – WFCC)
Bacteria
Marine fungi
Built for the Pacific
Institute of Bioorganic
Chemistry in Finland
(1985).
Displacement - 2600 t,
Speed, designed – 15.2 knots
Officers and crew - 39
persons, scientific staff – 30
persons.
This unique vessel is specially designed for hydrobiological,
chemical and biochemical studies of marine macro- and
microorganisms to search for organisms producing
physiologically active substances with antibiotic, antitumor,
immunomodulatory, and other types of effects.
Was founded in 1967
Located on the coast of
picturesque Bay of Troitsa (Trinity
Bay) in 100 km to the south of
Vladivostok
There are laboratory building,
diving complex, ships and boats,
dwelling houses
H2N
+ Cl
-
H
N
HN
Over 500 new biologically active
compounds, including 2-3% of total
number of presently known marine
Br
Br
natural
products were isolated and
studied in Institute.
N
N
H
N
H
O
Cl
H2N +
Br
Cl - H
N
H2N +
H
N
Br
N
O
N
H
N
HN
HO
N
O
The peculiarities of their biogenesis,
HN
biological effects, and taxonomical HN
distribution were investigated
2
Br
Cl H
N
H2N +
N
H
N
Br
O
NH
N
O
N
H
N
H
O
Br
N
H
N
H
O
About 200 new biologically active
compounds were isolated from
different plants.
Their biological effects, chemical
properties, and possibilities of using as
chemotaxonomic markers in higher
plants systematics were studied.
Polyphenols of some Far-Eastern plants
possessing an antioxidant activity
OH
OH
O
O
HO
OMe
OH
OH
O
HO
O
O
maackin
HO
O
maackiasin
HO
OH
OH
OH
OMe
OH
OH
HO
OH
H
HO
OMe
OH
H
H
O
OH
HO
OH
maackin А
H
HO
OH
O
H
maackolin
1,3;1,6--D-Glucans
from Laminaria cichorioides
a
b
c
from Fucus evanescens
a
b
c
- nonsubstituted Glc residue
- 3-О-substituted Glc residue
- 6-О-substituted Glc residue
a
b
c
- 3,6-О-di-substituted Glc residue
d
e
Solov’eva T.F., Elyakova L.A., Zvyagintseva T.N., Yermak I.M. Marine Technol. Soc. 1996. 30: 35
Fucoidans of brown seaweeds of the russian Far East.
2 structural types.
→3)-α-L-Fucp-(1→4)-α-L-Fucp-(1→3)-α-L-Fucp-(1→4)-α-L-Fucp-(1→
2
2
2
2
↑
↑
↑
↑
SO3
SO3
SO3
SO3
1. из Fucus evanescens
1→3 : 1→4
1 : 1
→4)-[α-L-Fucp-(1→3)]n-α-L-Fucp-(1→4)-α-L-Fucp-(1→3)-[α-L-Fucp-(1→4)]m -α-L-Fucp-(1→
2
2
2
2
2
↑
SO3
↑
SO3
↑
SO3
↑
SO3
↑
SO3
1→3 : 1→4
3.5 : 1
2. из Laminaria cichorioides
SO3
SO3
SO3
SO3
SO3
SO3
↓
↓
↓
↓
↓
↓
4
4
4
4
4
4
→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→
2
2
2
2
2
2
↑
↑
↑
↑
↑
↑
SO3
SO3
SO3
SO3
SO3
SO3
1,3;1,6--D-glucans and alginic acids are found out in some terrestrial organisms, but in the sea are
distributed much more widely. Fucoidans are family of sulfated homo- and heteropolysaccharides, containing
L-fucose as the basic component, and galactose, mannose, xylose, glucuronic acid in minor amounts.
Fucoidans are found out only in sea organisms.
Endo- and exo-1,3--D-glucanases
Alginat lyases
Fucoidanases
Endo-1,6--D-glucanases
Cellulases
- and -D-Glucosidases
- and -D-Galactosidases
- and -D-Mannosidases
-L-Fucosidases
Sulfatases
Marine invertebrates and seaweeds are the valuable sources
of the biologically active polysaccharides, the enzymes with
unique specificity involved in their transformation and
inhibitors of these enzymes.
So, endo-1,3--D-glucanases of marine organisms, found at
first as hydrolases, catalyze three reactions running
simultaneously and practically with almost equal efficiency.
S''-A
(reaction of
transglycosylation)
A
E+S
ES
ES''
S'
H2O
S''-ОН
(reaction of
hydrolysis)
S
S''-S
(glucanosyl
transferase
activity)
Fractions of 13;16--D-glucans with higher molecular
masses and more branched than initial laminaran were found
among the products of its enzymatic transformation by endo1,3--D-glucanase. These fractions designated as “Antivir" and
“Translam” are the products of the prominent glucanosyl
transferase ability of the enzyme and its ability to catalyze
synthesis not only -13-, but also -16-glucosyl links.
ANTIVIR
phytoimmunostimulator: potato, tobacco,
tomato, soybean
E
LAMINARAN
TRANSLAM
immunomodulator, radioprotector,
antitumor agent, cryoprotector
Glucose and glucooligosaccharides
(Glcn, n=1,2,3 as main
components)
Translam and Antivir are the first
biologically active polysaccharides
obtained by enzymic synthesis.
Preclinic trials of translam as medicine
for acute radiation sickness are being
finished.
Translam belongs to rare medicines possessing
postradiation effect. So, its injection to monkeys,
irradiated with dose close to lethal one, protect about
60% of them against radiation.
Above of 170 Patents and Certificates of Authorship (including several of
International ones) cover processes of obtaining, syntheses and practical
applications of new drugs, food suppliments, veterinary preparations,
enzymes, diagnostics etc. based on the biologically active compounds from
marine organisms and terrestrial higher plants.
More than 20 Patents of PIBOC are used in industry. One of the first-rate
factories of Far-Eastern food industry is named in the honor of our invention
as «Ussuriisky Balsam».
Patent medicine was developed
on the base of enzymatic
preparation isolated from the
crabs’ processing wastes.
Medicine
Perfumery
Leather Industry
Food Industry
A highly effective preparation for
• prophylaxis of reperfusion damages after myocardial infarction
• treating ischemia and infarction in acute forms.
THE RESULTS OF THE CLINICAL TESTS





Reduces the necrotic zone in 1.5-2 fold
Restores the functions of left ventricle
Reduces the frequency of reperfusion arrhythmia
Promotes the restoration of heart’s contraction
Inhibits the erythrocytes aggregation
It is prescribed for treatment of:



Diseases of cornea (to increase epithelization);
Dystrophic damages of retina and diabetic retinopathy as a
retinoprotector;
Proliferous processes, degeneration and hemophthalmia of
various geneses;
 Contusions, burns and
penetrating wounds of eyes;
 Cataract;
 Keratitis;
 Uveitis.
 The therapeutic activity is caused by its favorable effect on the
metabolism, function and structure of the liver damaged.
 Inhibits free radicals and depresses the toxic products of lipid
peroxidation reactions.
 Its activity is higher than that of the well-known drugs from
Silybum marianum Gaerth: Silybor, Legalon, Carsyl.
 High hepato-protecting
activity;
 Hypolipidemic effect;
 Antithrombotic effect;
 Hypocholesterinemic effect;
 Antioxidative effect;
 Antiatherosclerotic effect;
 Non-toxic.
Permitted in Russia as a patented medicinal
and prophylactic supplement to the food stuffs.
 As a food supplement shows antiulcerous effect,
normalizes gastrointestinal functions.
 As enterosorbent is well suitable for endogenous toxicoses after
trauma and some diseases, such as: diseases of internal organs,
acute infections of alimentary canal, suppurative processes,
burns, and radiation sickness.
 Is successful as an antidote and antimutagenous remedy.
 Removes heavy metals from human organism.
 Shows antisclerotic activity lowering cholesterol level in the
blood.
 Can be successful as ancillary antidiabetic remedy.
A series of non-alcoholic balsams, which
are produced from terrestrial and
marine natural products, are unique
remedies for rehabilitation after various
diseases of gastrointestinal tract
(gastritis, ulcer, disbacteriosis, colitis),
cardiovascular system, hypertonia, and
oncological diseases, as well as for
elimination of heavy metals and
radionuclides from human organism.
HERBAMARIN is approved by Food
Institute of the Russian Academy of Medical
Sciences and recommended as a food
supplement.
HERBAMARIN
can be
manufactured with
modifications in
composition as
tablets and
capsules.
from Far-Eastern mussels,
immunomodulator,
anti-inflammatory properties,
hydratant, an ingredient of makeup preparations produced by
Linda, Svoboda and other
factories.
Fucoidan
plus
Polymannuronic acid

FUCOLAM-C
Substance for:
Supplements
Cosmetics
Medicine
Ethanol extract of the brown alga
PROPERTIES:
•Antioxidant
•Antiinflammatory action
•Antitumor action
•Immunomodilator
Use for
•Cosmetics
•In ophthalmology