Matt Padd
Genetics
How does it occur?
Triple x occurs when there is a third X chromosome
present with two other sex chromosomes in a female.
Therefore, three X’s are present. Normal set’s of
chromosomes have only two sex chromosomes,
however there is an extra X making the cell aneuploid.
Nothing definitely is known about the causes of the
chromosomes irregularity, which leads to nondisjunction as the primary cause of the third X.
History
The first published report of a woman with a 47,XXX
karyotype was by Patricia A. Jacobs, in Edinburgh,
Scotland in 1959. She was a 35-year-old, 5 ft. 9 in., 128
lb. woman who had premature ovarian failure at
age 19; her mother was age 41 and her father was 40 at
the time of her conception.
Occurs more often when older men and women
conceive vs. younger couples.
Inheritance
Triple X syndrome can not be inherited. It is an error
in cell division during early embryonic development. It
has nothing to do with your past. Triple X occurs in 1
out of every 1000 females at birth. Five to ten girls are
born in the U.S. every day with Triple X.
Type of mutation
Triple X is a chromosomal
mutation.
Effects
Learning disabilities.
1. Delayed motor and linguistic development as
well as a delayed emotional maturing.
2. Poor socialization skills.
3. Increased stress
Taller then average development.
History of early back problems.
Small head
Diagnosis
Triple X is diagnosed prenatally through a
CVS(chorionic villus sampling) or Amniocentesis. It
can also be diagnosed through a blood text after a
baby’s birth. All these test’s work by looking at the
karyotype and making the conclusion upon that
viewing.
Treatments
Triple X is an irreversible disorder with no cure.
However Triple X is possible to treat. Treatments
depends on the symptoms of the carrier. Counseling
such as psychological counseling is really the only
treatment to mild the effects of triple X syndrome.
46,XX/47,XXX mosaicism
Three sex chromosomes are only present in some cells
vs. triple X where three sex cells are present in all cells.
Females with Mosaicism usually have fewer effects as
they have less cells with three X chromosomes.
"Triple-X females." Turner Center, 1 Jan. 2008. Web. 10 Nov.
2009.
<http://www.aaa.dk/TURNER/ENGELSK/TRIPLEX.HTM>.
"Triple X syndrome." Triple X syndrome. Genetics Home
Reference, Jan. 2009. Web. 10 Nov. 2009.
<http://ghr.nlm.nih.gov/condition=triplexsyndrome>.
"Triple X syndrome." Triple X syndrome. Mayo Clinic, 15
Aug. 2008. Web. 10 Nov. 2009.
<http://www.mayoclinic.com/health/triple-xsyndrome/DS01090>.
"Triple X syndrome." Triple X syndrome. Genetics Home
Reference, 2008. Web. 10 Nov. 2009.
<http://www.goldbamboo.com/topic-t6931-a16Triple_X_syndrome.html>.
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