Matt Padd Genetics How does it occur? Triple x occurs when there is a third X chromosome present with two other sex chromosomes in a female. Therefore, three X’s are present. Normal set’s of chromosomes have only two sex chromosomes, however there is an extra X making the cell aneuploid. Nothing definitely is known about the causes of the chromosomes irregularity, which leads to nondisjunction as the primary cause of the third X. History The first published report of a woman with a 47,XXX karyotype was by Patricia A. Jacobs, in Edinburgh, Scotland in 1959. She was a 35-year-old, 5 ft. 9 in., 128 lb. woman who had premature ovarian failure at age 19; her mother was age 41 and her father was 40 at the time of her conception. Occurs more often when older men and women conceive vs. younger couples. Inheritance Triple X syndrome can not be inherited. It is an error in cell division during early embryonic development. It has nothing to do with your past. Triple X occurs in 1 out of every 1000 females at birth. Five to ten girls are born in the U.S. every day with Triple X. Type of mutation Triple X is a chromosomal mutation. Effects Learning disabilities. 1. Delayed motor and linguistic development as well as a delayed emotional maturing. 2. Poor socialization skills. 3. Increased stress Taller then average development. History of early back problems. Small head Diagnosis Triple X is diagnosed prenatally through a CVS(chorionic villus sampling) or Amniocentesis. It can also be diagnosed through a blood text after a baby’s birth. All these test’s work by looking at the karyotype and making the conclusion upon that viewing. Treatments Triple X is an irreversible disorder with no cure. However Triple X is possible to treat. Treatments depends on the symptoms of the carrier. Counseling such as psychological counseling is really the only treatment to mild the effects of triple X syndrome. 46,XX/47,XXX mosaicism Three sex chromosomes are only present in some cells vs. triple X where three sex cells are present in all cells. Females with Mosaicism usually have fewer effects as they have less cells with three X chromosomes. "Triple-X females." Turner Center, 1 Jan. 2008. Web. 10 Nov. 2009. <http://www.aaa.dk/TURNER/ENGELSK/TRIPLEX.HTM>. "Triple X syndrome." Triple X syndrome. Genetics Home Reference, Jan. 2009. Web. 10 Nov. 2009. <http://ghr.nlm.nih.gov/condition=triplexsyndrome>. "Triple X syndrome." Triple X syndrome. Mayo Clinic, 15 Aug. 2008. Web. 10 Nov. 2009. <http://www.mayoclinic.com/health/triple-xsyndrome/DS01090>. "Triple X syndrome." Triple X syndrome. Genetics Home Reference, 2008. Web. 10 Nov. 2009. <http://www.goldbamboo.com/topic-t6931-a16Triple_X_syndrome.html>.