Matt Padd
How does it occur?
 Triple x occurs when there is a third X chromosome
present with two other sex chromosomes in a female.
Therefore, three X’s are present. Normal set’s of
chromosomes have only two sex chromosomes,
however there is an extra X making the cell aneuploid.
Nothing definitely is known about the causes of the
chromosomes irregularity, which leads to nondisjunction as the primary cause of the third X.
 The first published report of a woman with a 47,XXX
karyotype was by Patricia A. Jacobs, in Edinburgh,
Scotland in 1959. She was a 35-year-old, 5 ft. 9 in., 128
lb. woman who had premature ovarian failure at
age 19; her mother was age 41 and her father was 40 at
the time of her conception.
 Occurs more often when older men and women
conceive vs. younger couples.
 Triple X syndrome can not be inherited. It is an error
in cell division during early embryonic development. It
has nothing to do with your past. Triple X occurs in 1
out of every 1000 females at birth. Five to ten girls are
born in the U.S. every day with Triple X.
Type of mutation
 Triple X is a chromosomal
 Learning disabilities.
1. Delayed motor and linguistic development as
well as a delayed emotional maturing.
2. Poor socialization skills.
3. Increased stress
 Taller then average development.
 History of early back problems.
 Small head
 Triple X is diagnosed prenatally through a
CVS(chorionic villus sampling) or Amniocentesis. It
can also be diagnosed through a blood text after a
baby’s birth. All these test’s work by looking at the
karyotype and making the conclusion upon that
 Triple X is an irreversible disorder with no cure.
However Triple X is possible to treat. Treatments
depends on the symptoms of the carrier. Counseling
such as psychological counseling is really the only
treatment to mild the effects of triple X syndrome.
46,XX/47,XXX mosaicism
 Three sex chromosomes are only present in some cells
vs. triple X where three sex cells are present in all cells.
Females with Mosaicism usually have fewer effects as
they have less cells with three X chromosomes.
 "Triple-X females." Turner Center, 1 Jan. 2008. Web. 10 Nov.
 "Triple X syndrome." Triple X syndrome. Genetics Home
Reference, Jan. 2009. Web. 10 Nov. 2009.
 "Triple X syndrome." Triple X syndrome. Mayo Clinic, 15
Aug. 2008. Web. 10 Nov. 2009.
 "Triple X syndrome." Triple X syndrome. Genetics Home
Reference, 2008. Web. 10 Nov. 2009.