Dan-Thanh Nguyen
Biology 402
March 20, 2012
Symptoms:
 Fever
 Sore throat
 Weakness
 Headache
 Muscle aches
 Diarrhea
 Vomiting
 Severe hemorrhaging
http://www.all-science-fair-projects.com/science_fair_projects_encyclopedia/Ebola
http://www.reviews-technology.com/2010_08_24_archive.html
http://www.mnzoo.org/faces/fruit-bat/
http://www.who.int/csr/disease/ebola/Global_EbolaOutbreakRisk_20090510.png
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/?tool=pmcentrez
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Zaire (Democratic Republic of Congo)
Sudan
Cote d’Ivoire (Ivory Coast)
Reston
Bundibugyo
http://viralzone.expasy.org/all_by_species/23.html
Nucleoprotein
Virion protein 40
Virion protein 30
Virion protein 35
Virion protein 24
Glycoprotein
Soluble glycoprotein
http://viralzone.expasy.org/all_by_species/23.html
polymerase
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/?tool=pmcentrez
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Hepatocytes
Endothelial cells
Dendritic cells
Monocytes
Macrophages
http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v3/n8/full/nri1154.html#f3
http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v7/n7/full/nri2098.html
http://jid.oxfordjournals.org/content/188/11/1618.full
http://buquad.com/2011/10/17/bu-biolab/
http://www.nationalpost.com/related/topics/Canadian+scientists+develop+Ebola+treatment/3083100/story.html
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Dolnik, O.; L. Kolesnikova, and S. Becker. “Filoviruses: Interactions with the host cell.”
Cellular and Molecular Life Sciences Vol 65. 756-776. 2008.
http://www.springerlink.com/content/fk38279221156248/
“Ebola haemorrhagic fever.” World Health Organization. Dec 2011.
http://www.who.int/mediacentre/factsheets/fs103/en/
“Ebola virus disease.” Wikipedia. http://en.wikipedia.org/wiki/Ebola_virus_disease
Feldmann, Heinz; Steven Jones, Hans-Dieter Klenk; and Hans-Joachim Schnittler. “Ebola
virus: from discovery to vaccine.” Nature Reviews Immunology. Vol 3. 677-685 (August 2003).
http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v3/n8/full/nri1154.html#f3
Geisbert, Thomas et al. “Mechanisms Underlying Coagulation Abnormalities in Ebola
Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages is
a Key Event.” Journal of Infectious Diseases. Vol 188. 1618-1629. 2003.
http://jid.oxfordjournals.org/content/188/11/1618.full.pdf+html
Mohamadzadeh, Mansour; Leiping Chen; and Alan L. Schmaljohn. “How Ebola and
Marburg viruses battle the immune system.” Nature Reviews Immunology. Vol 7. 556-567
(July 2007). http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v7/n7/full/nri2098.html
Takada, Ayato. “Filovirus Tropism: Cellular Molecules for Viral Entry.” Frontiers in
Microbiology. 06 February 2012.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/pdf/fmicb-03-00034.pdf