Advanced International Breast Cancer Course

Section of Oncology
10th Meet the Professor
Advanced International
Breast Cancer Course
Padua, November 6th-7th-8th, 2014
Directors
Pier Franco Conte, Gabriel N. Hortobagyi
Presentation
Breast cancer mortality is declining in most countries; a detailed knowledge of the
mechanisms of cancer progression, phenotypic and genotypic characterization
of the disease, screening programs, advanced imaging, local therapies and
molecularly targeted drugs have all been fundamental to achieve this success.
Nowadays, breast cancer represents the front runner in the path to comparative
effectiveness, where new therapeutic interventions are implemented on the basis
of “average” benefit, to personalized cancer medicine, where the right treatment
is provided to the right patient at the right moment. An updated, multifaceted
approach to our patients is now becoming more and more demanding and
with these goals in mind, the Programme of this international Conference
includes lectures on molecular characterization, updated management of early
and advanced disease, strategies to overcome resistance to available therapies,
innovative therapies, and multimodal treatments for advanced disease.
Clinical case discussions and debates are planned to allow a continuous and
fruitful exchange of experiences and opinions between speakers and participants.
This 10th Breast Cancer Conference includes a highly qualified international
faculty, but will maintain its characteristics of a friendly forum where international
opinion leaders and attendees will exchange experiences and share the most
exiting advances.
In order to reward scientific excellence and to foster international cooperation,
the International Scientific Committee of the 10th AIBCC will award the 4th
International Prize for Breast Cancer Research to a scientist who has published a
breakthrough paper in the previous year and the Monica Boscolo Research Grant
to an Italian scientist for a research project to be conducted in cooperation with
a foreign institution.
We welcome medical oncologists, pathologists, breast surgeons, radiation
oncologists and basic scientists to listen to breast cancer leaders and to exchange
experiences in a friendly atmosphere.
Addressed to
The Meeting is addressed to physicians specialized in: oncology, radiodiagnostics,
radiotherapy, clinical pathology, general surgery, gynaecology and obstetrics,
biologists and nurses.
Programme
Thursday, November 6th
8.00Registration
Introduction to the Conference
Pier Franco Conte, Gabriel N. Hortobagyi
SESSION I - PATHOLOGY
Chairmen: Alberto Amadori, Massimo Rugge
8.45
9.00
Standardization of breast cancer diagnosis: pathology
Anna Sapino
Standardization of breast cancer diagnosis: genomics
Giampaolo Bianchini
SESSION II - LOCOREGIONAL THERAPIES
Chairmen: Nicola Balestrieri, Graziano Meneghini
10.00
Evolving loco-regional management
• Post-mastectomy radiotherapy: a new standard? – Philip Poortmans
• Management of the axilla: an update after recent trials
Carlos A. Garcia-Etienne
• Hypofractionated breast irradiation – Philip Poortmans
9.30
11.00Discussion
11.20
Coffee break
SESSION III - IMAGING
Chairmen: Gabriel N. Hortobagyi, Luigi Pescarini
11.40
Role of MRI in breast cancer diagnosis
Clinical cases will be presented to discuss the following items:
• Is MRI the standard screening procedure in young women? – Enrica Baldan
• Is MRI the gold standard to assess the response to neoadjuvant
therapy? – Ilaria Polico
• Is MRI appropriate to plan the type of surgery? – Alessandro Coran
The audience will be asked to vote. After the vote, two senior speakers
will debate items in favor or contra. The audience will be asked to vote
again after the debate.
Pro: Pietro Panizza
Contra: Petra Steyerova
Conclusive remarks of the Chairmen
13.15
Lunch
SESSION IV - STAGING AND ADJUVANT
Chairman: Philip Poortmans
14.15
Appropriate staging work-up in early breast cancer
Jassem Jacek
Is there a role for adjuvant bisphosphonates?
Robert Coleman
14.45
15.15Discussion
SESSION V - GUIDELINES Chairman: Philip Poortmans
15.30
Role of guidelines in the era of personalized cancer medicine
• Do guidelines impact on patients outcome? – Petra Boelens
• Genomics platforms as decision making tools – Miguel Martin
16.30Adjourn
Ceremony for the presentation of the University of Padua Award for
Advances Breast Cancer 2014 and the Monica Boscolo Research Grant
17.30
18.00
Lecture of the Awardee
18.30
Cocktail
The Ceremony and the cocktail will take place in Palazzo Bo,
Via VIII Febbraio 2, Padua.
Friday, November 7th
SESSION VI - EARLY BREAST CANCER
9.00
Adjuvant – Clinical Case Discussion I
Chairmen: Pier Franco Conte, Miguel Martin
Presenters of the cases: Zora Baretta, Cristina Falci
The presenter will introduce a clinical case and will ask questions to the
audience. The discussants will comment the vote and will review the
state of art
Discussants:
• Fertility preservation – Lucia Del Mastro
• Adjuvant therapy for low risk HER2+ patients – Valentina Guarneri
• Endocrine adjuvant therapy in premenopause – Stephen Johnston
• Extended adjuvant endocrine therapy – Jonas Bergh
10.45Discussion
11.00
Coffee break
11.30
Neoadjuvant – Clinical Case Discussion II
Chairmen: Fernando Bozza, Pier Franco Conte
Presenters of the cases: Silvia Michieletto, Tania Saibene
The presenter will introduce a clinical case and will ask questions to the
audience. The discussants will comment the vote and will review the
state of art.
Discussants:
• Locoregional management – Philip Poortmans
• HR+/HER2 negative – Stephen Johnston
• Triple negative breast cancer – Maria Vittoria Dieci
• Adjuvant therapy in suboptimal responders after neoadjuvant therapy
Pier Franco Conte
13.15Discussion
13.30
Lunch
SESSION VII - ADVANCED BREAST CANCER
Chairmen: Valentina Guarneri, Sibylle Loibl
14.30
Clinical case discussion III
The presenter will introduce a clinical case and will ask questions to the
audience. The discussants will comment the vote and will review the
state of art.
Sequence and duration of anti-HER2 therapy
Presenter: Cristina Falci Discussant: Pier Franco Conte
Therapeutic options for HR+ disease
Presenter: Carlo Alberto Giorgi Discussant: Gabriel N. Hortobagyi
Triple negative advanced breast cancer
Presenter: Giovanni Faggioni Discussant: Sabine Charlotte Linn
16.15Discussion
16.30
Coffee break
Chairmen: Gabriel N. Hortobagyi, Donato Nitti
16.45
Clinical case discussion IV
The presenter will introduce a clinical case and will ask questions to the audience.
The discussants will comment the vote and will review the state of art.
BRCA test as tool for therapy selection
Presenter: Zora Baretta Discussant: Miguel Martin
Surgery of the primary in de novo stage IV disease
Presenter: Antonella Brunello Discussant: Miranda Ernst
18.00Discussion
18.10Adjourn
Saturday, November 8th
SESSION VIII - HIGHLIGHTS OF THE YEAR
Chairmen: Jonas Bergh, Stefania Gori
9.00
Advances in biology
Aleix Prat
9.30
HR+/HER2- disease
Stephen Johnston
10.00
HER2+ disease
Fabio Puglisi
Triple negative disease
Cornelia Liedtke
11.00
Coffee break
SESSION IX - COMING SOON
Chairman: Gabriel N. Hortobagyi
11.30
New promising drugs
Jonas Bergh
10.30
12.00
Trials likely to impact on clinical practice in the near future: EBC
Sibylle Loibl
12.30
Trials likely to impact on clinical practice in the near future: ABC
Paolo Pronzato
13.00Adjourn
and final evaluation questionnaire
Directors
Pier Franco Conte
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Gabriel N. Hortobagyi
Department of Breast Medical Oncology
University of Texas
MD Anderson Cancer Center
Houston (USA)
Scientific Committee
Jonas Bergh
Department of Oncology-Pathology
Karolinska Institute and University Hospital
Stockholm (SW)
Sibylle Loibl
German Breast Group
Department of Medicine and Reasearch
University of Frankfurt (D)
Valentina Guarneri
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology and
Gastroenterology
University of Padua (I)
Miguel Martin
Medical Oncology Service
Hospital Universitario Gregorio Maranon
Madrid (S)
Jacek Jassem
Department of Oncology and Radiotherapy
Medical University of Gdansk (PL)
Stephen Johnston
NIHR Biomedical Research Centre for Cancer
Royal Marsden NHS Foundation Trust &
Institute of Cancer Research
London (UK)
Donato Nitti
Department of Surgery, Oncology and
Gastroenterology
University of Padua (I)
Philip Poortmans
President-elect of ESTRO
Department of Radiation Oncology
Radboud University Medical Centre
Nijmegen (NL)
Speakers
Alberto Amadori
Division of Oncological Molecular Diagnostic
and Immunology
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Enrica Baldan
Breast Unit
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
University of Padua (I)
Nicola Balestrieri
Breast Center
Cà Foncello Regional Hospital ULSS 9
Treviso (I)
Zora Baretta
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
University of Padua (I)
Jonas Bergh
Department of Oncology-Pathology
Karolinska Institute and University Hospital
Stockholm (SW)
Giampaolo Bianchini
Department of Medical Oncology
IRCCS San Raffaele Hospital
Milan (I)
Petra Boelens
Department of Surgery
Leiden University Medical Center
Leiden (NL)
Fernando Bozza
Division of Breast Surgery
Istituto Oncologico Veneto IRCCS
Padua (I)
Antonella Brunello
Division of Medical Oncology 1
Istituto Oncologico Veneto IRCCS
Padua (I)
Robert E. Coleman
Academic Unit of Clinical Oncology
Weston Park Hospital - University of Sheffield
Sheffield (UK)
Pier Franco Conte
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Alessandro Coran
Breast Imaging Unit
Istituto Oncologico Veneto IRCCS
Padua (I)
Lucia Del Mastro
Medical Oncology A- Innovative therapies
development
IRCCS A.O.U. San Martino - IST
Genoa (I)
Maria Vittoria Dieci
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Miranda Ernst
Division of Oncology Surgery
Alexander Monro Clinic
Bilthoven (NL)
Giovanni Faggioni
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Padua (I)
Cristina Falci
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
University of Padua (I)
Carlos A. Garcia-Etienne
Division of Breast Surgery
Humanitas Research Hospital
Rozzano (I)
Carlo Alberto Giorgi
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Padua (I)
Stefania Gori
Department of Medical Oncology
Sacro Cuore - Don Calabria Hospital
Negrar, VR (I)
Valentina Guarneri
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Gabriel N. Hortobagyi
Department of Breast Medical Oncology
University of Texas
MD Anderson Cancer Center
Houston (USA)
Jacek Jassem
Department of Oncology and Radiotherapy
Medical University of Gdansk (PL)
Stephen Johnston
NIHR Biomedical Research Centre for Cancer
Royal Marsden NHS Foundation Trust &
Institute of Cancer Research
London (UK)
Cornelia Liedtke
Campus Lübeck Department of Gynecology
and Obstetrics
University Hospital of Schleswig-Holstein
Lubeck (D)
Sabine Charlotte Linn
Dept. of Medical Oncology
The Netherlands Cancer Institute
Antoni van Leeuwenhoek
Amsterdam (NL)
Sibylle Loibl
German Breast Group
Department of Medicine and Reasearch
University of Frankfurt (D)
Graziano Meneghini
Breast Center
ULSS 5 Ovest Vicentino
Montecchio Maggiore (VI)
Miguel Martin
Medical Oncology Service
Hospital Universitario Gregorio Maranon
Madrid (S)
Silvia Michieletto
Division of Breast Surgery
Istituto Oncologico Veneto IRCCS
Padua (I)
Donato Nitti
Department of Surgery, Oncology and
Gastroenterology
University of Padua (I)
Pietro Panizza
Department of Diagnostic Radiology
IRCCS National Cancer Institute
Milan (I)
Luigi Pescarini
Department of Radiology
Diagnostic Breast Unit
Istituto Oncologico Veneto IRCCS
University of Padua (I)
Ilaria Polico
Breast Imaging Unit
Istituto Oncologico Veneto IRCCS
Padua (I)
Philip Poortmans
President- elect of ESTRO
Department of Radiation Oncology
Radboud University Medical Centre
Nijmegen (NL)
Aleix Prat
Institute of Oncology (VHIO)
Vall d’Hebron
Barcellona (E)
Paolo Pronzato
Medical Oncology
IRCCS A.O.U. San Martino - IST
Genoa (I)
Fabio Puglisi
Department of Oncology
University Hospital of Udine (I)
Massimo Rugge
General Pathology & Cytopathology Unit
Department of Medicine-DIMED
University of Padua (I)
Tania Saibene
Division of Breast Surgery
Istituto Oncologico Veneto IRCCS
Padua (I)
Anna Sapino
Department of Biomedical Science
and Human Oncology
University of Torino (I)
Petra Steyerova
Clinic of Radiology
General University Hospital
Center for Breast Disease of V. Polak
Prague (CZ)
Awards
Monica Boscolo Research Grant
The Scientific Committee will select the winner of the Monica Boscolo Research
Grant. This Research Award is restricted to young Italian researchers (< 40
years) who will carry out a research project at a foreign institution.
UNIVERSITY OF PADUA AWARD FOR ADVANCES IN BREAST CANCER 2014
The Scientific Committee will select young researchers (< 40 years from any
country) who have published in an international peer-reviewed journal, as
the principal author, a manuscript reporting important clinical or biological
advances in breast cancer. Prof. Conte and Prof. Hortobagyi will select the
final winner which will be invited to present his/her study during the annual
Conference
Under 35
Free admission is available for 5 persons “Under 35”. Registration forms
will be accepted on a first-come, first-served basis until spaces are filled.
The Organization Secretariat will confirm the registration by email.
Un’azione sostenibile a favore della formazione
Iscrizione gratuita per i medici UNDER 35 fino a esaurimento posti
CME
Based on the in force Italian regulations, Accademia Nazionale di Medicina
(provider n. 31) will assign to the activity CME (31-99451): 8 CME points.
The Meeting is addressed to physicians specialized in: oncology,
radiodiagnostics, radiotherapy, clinical pathology, general surgery, gynaecology
and obstetrics, biologists and nurses.
It will not be possible to give credits to physicians specialized in different fields.
The credit certification is subject to:
• attendance at the entire Meeting
• the completion of the meeting evaluation form
• the completion of the final questionnaire (at least 75% of correct answers)
We would like to remind to participants that only 1/3 of CME credits acquired
during the years 2014/2016 can come frome a sponsorship.
Official Language
The official language of the Meeting is English. No simultaneous translation will
be provided.
Registration
The registration fee is € 250,00 tax free.
It includes the conference bag, the conference book and all coffee breaks and
lunches. It does not include Hotel accomodation, dinners and travel expenses.
Under the article 54 T.U.I.R and within the limits set out therein, the costs of
participation in this activity are deductible in determining self-employment
income.
To register, please send:
• registration form duly filled out (even when sponsored by a Pharmaceutical Company
• privacy statement and consent to the use of personal data (as in the back of the form)
• payment
to Accademia Nazionale di Medicina – Palazzina CUP II Piano, Via Massarenti 9,
40138 Bologna (fax 0039 051 6364605 – e.mail: info.bologna@accmed.org,
within october 27th, 2014.
Registration quote can be paid by: non-transferable cheque addressed to Accademia
Nazionale di Medicina; bank transfer addressed to: ACCADEMIA NAZIONALE DI
MEDICINA, Banca Intesa Spa - Filiale 2475 –Ge-Marose - IBAN code: IT 27 J 03069
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By submitting the form and the payment, your registration is completed with
the exception of specific decisions of the Meeting Secretariat.
Incomplete registration will NOT be admitted.
The registration will be confirmed by e-mail, please put your e-mail address on
the registration form.
Cancellation
• if the participants minimum number is not reached, Accademia Nazionale
di Medicina will advise by a written communication and proceed with the
total refund of the fee.
• In order to cancel please give advise with a written communication to
Accademia Nazionale di Medicina within 10 days from the beginning. A
70% of the registration fee will be returned. Any cancellation after that
deadline will not be reimbursed.
Meeting Venue
Centro Congressi Padova A. Luciani
Via Forcellini 170/A
Padova
Tel. +39 049/8033711
How to reach the meeting venue:
By Car:
The Highway exits are
Padova Est, 5 Km from the Meeting Venue
Padova Zona Industriale, 6 Km from the Meeting Venue
By Train:
Padova is in the Center of Veneto, it is easy to reach with the trains MilanoVenezia and Bologna-Venezia. The Meeting Venue is 4 Km from the train
station
By Plane
Venezia Airport - Marco-Polo: 43 km (about 40 minutes by car)
Treviso Airport- Canova: 63 km (about 50 minutes by car)
With the patronage of
Institutions
Comune di Padova
Scientific Societies
With the unconditional contribution of
gold SPONSOR
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BRONZE SPONSOR
CONTRIBUTORS
› EISAI
› GENOMIC HEALTH
› MYRIAD GENETICS
› PHARMA MAR
› PIERRE FABRE PHARMA
› SANOFI AVENTIS
Sponsored by
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www.accmed.org
General Manager: Stefania Ledda
Organizing Partner
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