Colimix 120 Sintofarm
(Colistin sulphate)
Colistin is a polypeptide antibiotic , was obtained from a
fermentation broth inoculated with Bacillus polimyxa
var. colistinus which had been isolated from soil
sampled of Fukushima Prefecture , Japan.
Colimix 120 Sintofarm
Anti-bacterial spectrum
Gram-negative :
E.Coli
Shigella spp
Salmonella spp
Enterobacter spp
Pseudomonas aeruginosa
Klebsiella pneumoniae
Campylobacter (vibrio) coli .
Colimix 120 Sintofarm
Characteristics :
1) Colistin is effective against Gram – bacteria such as E.Coli and
Salmonella.
2) Colistin does not select resistant bacteria in vivo and its
resistance is not transferred by the R-factor.
3) Colistin is not absorbed from the digestive tract of poultry hence
no residue is observe.
4) Colistin has a synergistic effect against bacteria when used in
combination with Zinc-bacitracin.
5) Colistin is effective as a growth promoter for broiler. It is also
used in the prevention and control of infectious enteritis in
broiler.
Colimix 120 Sintofarm
Synergism and Antagonism :
Colistin is compatible with tetracyclines, sulfas, imidazoles,
Lincomycin and common feed additives. Sometimes is
showed a good synergism with some antibiotics particularly
with bacitracin .There are no experiences of antagonist
effects between Colistin and other antibiotics.
Palatability :
No "medicinal taste" to deter sick animals from eating or
drinking.
Colimix 120 Sintofarm
+
Zinc bacitracin
Colistin Sulphate premix
Combination use of Colistin sulphate and Zinc bacitracin
show the followings:
1) They have a mutually compensating antibacterial spectrumn.
2) Synergistic action against many bacteria in the digestive tract
Colimix 120 Sintofarm
Colimix 120 premix is :
For prevention and control of infectious enteritis in
broilers and layers .(E.Coli,Salmonella)
For improving feed efficiency and weight gain.
Colimix 120 premix is a barrier against enteritis from
E.Coli and Salmonella in poultry
Colimix 120 Sintofarm
Colimix 120 pemix is :
SAFE
Because it is not absorbed
Because it leaves no residues in the meat
Because it does not present problem of resistance
Because it does not present problem of toxicity
Because it can be associated with all other
antibiotics and sulfa –drugs
STABLE
In the premix for 12-24 months
In the feed for at least 6 months
In mineral feed for at least 4 months
Colimix 120 Sintofarm
Effective
 Because of its activity against Gram - bacteria , specially
E.Coli and Salmonella , even if they are resistant to other
antibacterial substances
 Because it not only checks but treats the disease
 Because it improves animal performance
Because of its bactericide action at low dosage(5-8 mg /kg
live weight)
Because it acts rapidly and can be used in periods when
the sanitary risk is higher
Colimix 120 Sintofarm
Poultry :
For prevention of intestinal diseases (diarrhea)
20-200 g/ton of complete feed .
Poultry :
For therapy 800-1000g/ton of complete feed for
5-15 days
Colimix 120 Sintofarm
Composition for kg :
Colistin sulphate 120 g
Carrier up to 100 g
Withdrawal period : 5 days
Storage : keep in dry place and avoid light
Shelf life : 24 months
Packaging : 25 kg bags
Colimix 120 Sintofarm
Colimix 120 premix Sintofarm has :
1)Broad antibiotic spectrum – has strong activity on
gram-negative bacteria such as E.Coli , Salmonella ecc.
2)Strong bactericidal capacity-its effect mechanism is
to block cell membrane selective permeation function.
3)Good compatibility- better effectiveness in
combination with gram-positive bacteria drug
4)Good stability-it is not affected by feed ,enzyme and
secretive substance.
5)Good security- no side effect , no residue