Crimean-Congo hemorrhagic
fever virus
Syeda Zainab Ali Bukhari
12-10125
Hemorrhagic fever
A viral disease, disrupts clotting of
the blood thus patients develop
uncontrolled bleeding
CCHF (Crimean–Congo
hemorrhagic fever)
CCHF (Crimean–Congo hemorrhagic
fever) is a widespread tick-borne viral
disease, caused by domestic and wild
animals
Virus circulates in the body of an
infected animal up to 1 week. Clinical
disease is rare in infected animals but
symptoms could be severe in infected
humans.
Crimean Congo hemorrhagic
virus
The virus which causes CCHF is a
Nairovirus.
It is a ssRNA virus
Sporadic infection in people is
caused by Hyalomma tick bite
Many birds are resistant to this
disease. Ostriches are susceptible
Likely to infect…
Majority of cases are seen in those
involved with the livestock
industry i.e. agriculture workers,
slaughterhouse workers and
veterinarians.
Blood, sweat or saliva of infected
patient or infected tissues
Infected from a tick bite.
Symptoms
Fever, myalgia (aching muscles),
dizziness, neck pain and
vomiting, backache, headache, sore
eyes and photophobia.
There may be nausea, vomiting
and sore throat earlier on which
may lead to diarrhea and
generalized abdominal pain.
Symptoms
Hepatomegaly (liver enlargement)
may also result
Other clinical signs may include
tachycardia (fast heart rate),
lymphadenopathy (enlarged lymph
nodes) and a petechial rash (a rash
caused by bleeding into the skin).
CCHF virus spreads after 1-3 day
incubation period. After 9-10 days
patients start recovering. The
mortality rate of CCHF is 30%.
Diagnosis
ELISA is used for the detection of
IgG and IgM in the blood of the
patient from about six days of
illness.
Real time PCR
Virus isolation from blood samples
Treatment
An antiviral drug is given,
ribavirin. Both oral and
intravenous formulations.
Patient is kept in isolation and
constantly monitored for blood
volumes.
Immune plasma from recovered
patients for therapeutic purposes
has been used.
Prevention and Control
Isolate the patient.
Inform and educate people in your
vicinity.
Personal protective measures. Avoid
going to the areas where tick vectors
are abundant.
Prevention and Control
Use repellents on the skin e.g.
DEET.
Specimens of blood or tissues
specimens should be handled
carefully.
Needles and other surgical
instruments should be safely
disposed
Thank you :)