The health assessment after sexual assault Ambreen Butt Consultant NHS Grampian Immediate Needs (within 7 days) • Immediate safety • Treatment of injuries Should take precedence over clinical management Vaginal tears Palatal Petechaie Clinical Management • Emergency Contraception • STI screening follow up • BBV testing/Serum save • STI Prophylaxis • Hep B prophylaxis • HIV PEPSE The need for any/all of these should start with a detailed sensitively taken sexual history EMERGENCY CONTRACEPTION Offered to all women and adolescents who have had • Unprotected vaginal sexual intercourse • Potential failure of contraceptive method e.g. recent missed pills EMERGENCY CONTRACEPTION • Levonelle 2 • ellaOne • Copper IUCD Fast track client Infections STI identification is unlikely to assume evidential importance except in certain circumstances • Young people – children and adolescents not previously sexually active • Elderly – if no recent consensual sexual activity • Sexually inexperienced orifice Chain of evidence Finding an STI may influence the level of criminal injuries compensation Screening for STIS • What, if any examination required? • What tests to take and from what sites? Infections Most commonly identified STIs after sexual assault • Chlamydia- Dual NAAT • Gonorrhoea – Dual NAAT+/- culture • Trichomoniasis - direct microscopy Offer all clients an examination • if declines then self swab is sufficient to test for chlamydia and gonorrhoea where dual NAAT testing is available – should be done at time of presentation and repeated if necessary after 2 weeks • Remember to sample all sites affected In a Primary Care setting where dual NAAT testing available • If examined –Dual NAAT from all sites affected and in female complaining of vaginal discharge do HVS. • if declines examination then can self swab from all sites affected Consider referral to specialist services if symptomatic STI ANTIBIOTIC PROPHYLAXIS Consider • In situations where patient may default • Unable to tolerate the distress of repeat examination • Requires IUCD for EC STI ANTIBIOTIC PROPHYLAXIS Advantages • Reduce the need for tests • Lesson chance of missed infection • Decrease the chances of detecting a bacterial STI STI ANTIBIOTIC PROPHYLAXIS Disadvantages • Unnecessary treatment • Reinforcing belief that high risk of infection • Missing out on partner notification STI ANTIBIOTIC PROPHYLAXIS First line antibiotics • Cefixime 400mgs • Azithromycin 1g • Metronidazole 2g BBV Screen/Serum save • Offered to all at presentation HEP B VACCINATION Should be offered to victims of sexual assault – risk assessment- if risk unknown then should be given May be of value up to 6 weeks after event Super-accelerated course recommended as more rapid protection and adherence better Vaccination interval 0, 1, 3 weeks and 1 year High risk of hep B- Immunoglobulin ASAP and no later than 7 days PEPSE POST EXPOSURE PROPHYLAXIS FOR HIV FOLLOWING UNPROTECTED SEXUAL EXPOSURE PEPSE RISK OF HIV TRANSMISSION = RISK THAT THE SOURCE IS HIV POSITIVE x RISK OF EXPOSURE* (*including cofactors such as co-existing sexually transmitted infections, high viral load and bleeding/trauma) PEPSE Table 1 Risk that source is HIV positive Community group Homosexual men* London Scotland Elsewhere Heterosexuals (region of birth) UK Rest of Europe North America Central and South America Caribbean North Africa and Middle East Sub-Saharan Africa South Asia East and South East Asia Australasia Injecting drug users* London Elsewhere in the UK HIV seroprevalence (%) 20.30 3.20 3.60 Male (%) Female (%) 0.5 2 2.9 2.4 1.2 0.5 6.9 0.5 0.5 0.8 0.2 0.2 0.1 0.9 1.0 0.4 11.3 0.6 0.7 0.1 2.90 0.50 HPA data, 2004. Contemporaneous prevalence estimates can be obtained at: [www.hpa.org.uk/infections/topics_az/hiv and sti] HPA data 2004, HIV prevalence among GUM attendees by world region of birth in 2003. Prevalence rates for exposures outside of the UK or for individuals recently moved to the UK can be obtained at: [www.unaids.org] BASHH RECOMMENDATION FOR PRESCRIBING PEP BASHH RECOMMENDATION FOR PRESCRIBING PEP Factors influencing the effectiveness of PEP as identified in the BASHH guidelines are: • Delay in starting treatment, with PEP seen as possibly less effective or ineffective after 72 hours but possibly still considered if exposure is ‘high risk’ • Drug-resistant strains of HIV may reduce PEP’s effectiveness with resistance testing of the ‘source’ of infection considered and/or factoring in resistance when prescribing PEP drug combinations • HIV remaining in parts of the body where antiretroviral drugs’ ability to penetrate is variable • Poor adherence to the PEP drug regime PEPSE SIDE EFFECTS Mild • Nausea and diarrhoea- supportive treatment with Domperidone and Loperamide Serious • Lipid abnormalities • Liver problems • Diabetes and insulin resistance PEPSE PRESCRIBING RECOMMENDATIONS • Nucleoside reverse transcriptase inhibitors (NRTIs) • Non-nucleoside reverse transcriptase inhibitors (NNRTIs) • Protease inhibitors (PIs) PEPSE Current pack consists of the following drugs: TRUVADA • Tenofovir 245 mg once daily • Emtricitabine 200mg once daily KALETRA • Ritonavir boosted Lopinavir 2 tablets twice daily Initial pack contains 5 days supply Treatment given for 4 weeks 28 day course cost around £650 Follow up • Repeat STI screen 2 weeks after sexual assault • Pregnancy testing • HIV testing- can be done at 1 and 3 months (4 months if taken PEPSE) • Syphilis testing- 3 months • Hep B and C testing - at 3 and 6 months • Review psychosocial needs and coping BASHH Guidelines Management of adult and adolescent complainants of sexual assault (2011) http://www.bashh.org/documents/ 3275