2013 ACC/AHA Guideline on the Treatment of
Blood Cholesterol to Reduce Atherosclerotic
Cardiovascular Risk in Adults: A Report of the
American College of Cardiology/American
Heart Association Task Force on Practice
Guidelines
published online November 12, 2013;
Circulation. DOI: 10.1161/01.cir.0000437738.63853.7a
Classification of Recommendation and Level of
Evidence
NHLBI Grading the Strength of
Recommendations
NHLBI Grading the Strength of
Recommendations (Conti.... from prev. page)
Quality Rating the Strength of Evidence
4 groups of patients to be treated with statin
(in which the potential for an ASCVD risk reduction benefit clearly exceeds
the potential for adverse effects)
Adults who are:
1. Individuals with clinical ASCVD
2. Individuals with primary elevations of LDL–C ≥190 mg/dL
3. Individuals 40 to 75 years of age with diabetes with LDL-C 70189 mg/dL
4. Individuals without clinical ASCVD or diabetes who are 40 to 75
years of age with LDL-C 70-189 mg/dL and an estimated 10-year
ASCVD risk of 7.5% or higher
ASCVD: AtheroSclerotic CardioVascular Disease, It includes coronary
heart disease (CHD), stroke, and peripheral arterial disease, all of
presumed atherosclerotic origin
High- Moderate- and Low-Intensity Statin
Therapy
Major recommendations for statin therapy for ASCVD
prevention
Major recommendations for statin therapy for ASCVD
prevention (Conti.... from prev. page)
Initiating statin therapy in individuals with
clinical ASCVD
Initiating statin therapy in individuals without
clinical ASCVD
Initiating statin therapy in individuals without
clinical ASCVD (Conti.... from prev. page)
Statin Therapy: Monitoring therapeutic response and
adherence
Summary of Recommendations for Monitoring, Optimizing,
and Insufficient Response to Statin Therapy
Summary of Recommendations for Monitoring, Optimizing,
and Insufficient Response to Statin Therapy
Summary of Recommendations for Monitoring, Optimizing,
and Insufficient Response to Statin Therapy(Conti.... from prev. page)
Statin Safety Recommendations
Statin Safety Recommendations (Conti.... from prev. page)
Statin Safety Recommendations (Conti.... from prev. page)
Statin Safety
Recommendations
(Conti.... from prev. page)
Statin Safety Recommendations (Conti.... from prev. page)
Details of recommendations for statins
No specific targets for LDL/non-HDL anymore!
Details of recommendations for statins
(Conti.... from prev. page)
Details of recommendations for statins
(Conti.... from prev. page)
Details of recommendations for statins
(Conti.... from prev. page)
Details of recommendations for statins
(Conti.... from prev. page)
Details of recommendations for statins
(Conti.... from prev. page)
Safety Recommendations for Nonstatin drugs
(Conti.... from prev. page)
Safety Recommendations for Nonstatin drugs
(Conti.... from prev. page)
Safety Recommendations for Nonstatin drugs
(Conti.... from prev. page)